|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for HRAS |
 Gene summary |
| Gene information | Gene symbol | HRAS | Gene ID | 3265 |
| Gene name | HRas proto-oncogene, GTPase | |
| Synonyms | C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras | |
| Cytomap | 11p15.5 | |
| Type of gene | protein-coding | |
| Description | GTPase HRasGTP- and GDP-binding peptide BHa-Ras1 proto-oncoproteinHarvey rat sarcoma viral oncogene homologHarvey rat sarcoma viral oncoproteinRas family small GTP binding protein H-Rasc-has/bas p21 proteinp19 H-RasIDX proteintransformation gene: | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HRAS | GO:0001934 | positive regulation of protein phosphorylation | 22065586 |
| HRAS | GO:0007050 | cell cycle arrest | 9054499 |
| HRAS | GO:0007093 | mitotic cell cycle checkpoint | 9054499 |
| HRAS | GO:0007265 | Ras protein signal transduction | 23027131 |
| HRAS | GO:0008284 | positive regulation of cell proliferation | 9765203 |
| HRAS | GO:0008285 | negative regulation of cell proliferation | 9054499 |
| HRAS | GO:0010629 | negative regulation of gene expression | 23027131 |
| HRAS | GO:0010863 | positive regulation of phospholipase C activity | 11022048 |
| HRAS | GO:0030335 | positive regulation of cell migration | 23027131 |
| HRAS | GO:0034260 | negative regulation of GTPase activity | 23027131 |
| HRAS | GO:0043406 | positive regulation of MAP kinase activity | 23027131 |
| HRAS | GO:0043410 | positive regulation of MAPK cascade | 9765203 |
| HRAS | GO:0043547 | positive regulation of GTPase activity | 23027131 |
| HRAS | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22065586|23027131 |
| HRAS | GO:0046330 | positive regulation of JNK cascade | 22065586 |
| HRAS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
| HRAS | GO:0071480 | cellular response to gamma radiation | 16213212 |
| HRAS | GO:0090303 | positive regulation of wound healing | 23027131 |
| HRAS | GO:0090398 | cellular senescence | 9054499 |
| HRAS | GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | 12202034 |
| HRAS | GO:1900029 | positive regulation of ruffle assembly | 23027131 |
| HRAS | GO:2000251 | positive regulation of actin cytoskeleton reorganization | 23027131 |
| HRAS | GO:2000630 | positive regulation of miRNA metabolic process | 23027131 |
Top |
Gene structures and expression levels for HRAS |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000174775
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000462734.1 | HRAS-206:lncRNA:HRAS | 1.934647e+02 | -8.023262e-01 | 1.460289e-09 | 5.949068e-08 |
| CB | UP | ENST00000451590.5 | HRAS-205:protein_coding:HRAS | 3.800432e+00 | 4.213711e+00 | 7.302137e-03 | 2.686291e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HRAS |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_117663 | chr11 | 532246:532522:532631:532755:533453:533595 | 532631:532755 |
| exon_skip_149062 | chr11 | 533795:533944:534212:534375:535416:535538 | 534212:534375 |
| exon_skip_207967 | chr11 | 533795:533944:534212:534375:535416:535436 | 534212:534375 |
| exon_skip_277682 | chr11 | 532729:532755:533277:533358:533453:533595 | 533277:533358 |
| exon_skip_278836 | chr11 | 533453:533612:533766:533944:534212:534375 | 533766:533944 |
| exon_skip_284222 | chr11 | 532642:532755:533277:533358:533453:533595 | 533277:533358 |
| exon_skip_32187 | chr11 | 532652:532755:533277:533358:533453:533595 | 533277:533358 |
| exon_skip_95084 | chr11 | 532733:532755:533277:533358:533453:533595 | 533277:533358 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for HRAS |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
Top |
Infer the effects of exon skipping event on protein functional features for HRAS |
p-ENSG00000174775_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in HRAS |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for HRAS |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for HRAS |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HRAS |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for HRAS |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| DLPFC | SFPQ | exon_skip_95084 | -4.989916e-01 | 9.103933e-17 |
| DLPFC | PCBP2 | exon_skip_95084 | -4.592061e-01 | 3.945551e-14 |
| DLPFC | EWSR1 | exon_skip_95084 | -4.671662e-01 | 1.246098e-14 |
| DLPFC | SRSF5 | exon_skip_95084 | -4.576606e-01 | 4.918136e-14 |
| DLPFC | HNRNPH2 | exon_skip_95084 | -5.397247e-01 | 7.567199e-20 |
| DLPFC | EIF4B | exon_skip_95084 | -4.033065e-01 | 5.842352e-11 |
| HCC | EIF4B | exon_skip_277682 | -4.094562e-01 | 1.846825e-12 |
| TC | RBM6 | exon_skip_277682 | 4.537180e-01 | 1.686922e-09 |
| TC | HNRNPH2 | exon_skip_277682 | -4.023049e-01 | 1.338869e-07 |
Top |
RelatedDrugs for HRAS |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for HRAS |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|