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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for APC |
 Gene summary |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| APC | GO:0006974 | cellular response to DNA damage stimulus | 14728717 |
| APC | GO:0007026 | negative regulation of microtubule depolymerization | 11166179 |
| APC | GO:0007050 | cell cycle arrest | 8521819 |
| APC | GO:0008285 | negative regulation of cell proliferation | 8521819 |
| APC | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 8521819 |
| APC | GO:0065003 | protein-containing complex assembly | 16188939 |
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Gene structures and expression levels for APC |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000134982
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000508624.5 | APC-208:nonsense_mediated_decay:APC | 1.459357e+01 | 1.852309e+00 | 4.868908e-12 | 5.505151e-10 |
| CB | UP | ENST00000505350.1 | APC-205:nonsense_mediated_decay:APC | 2.680520e+01 | 8.709307e-01 | 9.148470e-11 | 5.875339e-09 |
| CB | UP | ENST00000507379.5 | APC-206:protein_coding:APC | 1.118735e+01 | 1.294714e+00 | 3.862322e-08 | 9.482382e-07 |
| CB | UP | ENST00000508376.6 | APC-207:protein_coding:APC | 1.777846e+03 | 1.481424e+00 | 2.926185e-06 | 3.735992e-05 |
| CB | UP | ENST00000509732.5 | APC-209:protein_coding:APC | 2.018260e+00 | 9.192945e-01 | 1.659211e-04 | 1.136808e-03 |
| CB | UP | ENST00000504915.2 | APC-203:protein_coding:APC | 4.038372e+00 | 8.958076e-01 | 1.130235e-03 | 5.729101e-03 |
| TC | UP | ENST00000508624.5 | APC-208:nonsense_mediated_decay:APC | 7.393828e+00 | 1.197580e+00 | 1.578822e-05 | 3.725792e-04 |
| TC | UP | ENST00000508376.6 | APC-207:protein_coding:APC | 1.163962e+03 | 9.297386e-01 | 1.238460e-04 | 1.919522e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for APC |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116730 | chr5 | 112754873:112755025:112766326:112766410:112767189:112767255 | 112766326:112766410 |
| exon_skip_129181 | chr5 | 112780790:112780903:112801279:112801383:112815495:112815593 | 112801279:112801383 |
| exon_skip_163291 | chr5 | 112801279:112801383:112815495:112815593:112818966:112819344 | 112815495:112815593 |
| exon_skip_164329 | chr5 | 112780790:112780903:112792446:112792529:112801279:112801383 | 112792446:112792529 |
| exon_skip_168160 | chr5 | 112801281:112801383:112810126:112810311:112815495:112815593 | 112810126:112810311 |
| exon_skip_178175 | chr5 | 112707522:112707882:112754873:112755025:112766326:112766383 | 112754873:112755025 |
| exon_skip_178767 | chr5 | 112815495:112815593:112818966:112819344:112821896:112821991 | 112818966:112819344 |
| exon_skip_228800 | chr5 | 112737895:112737925:112738353:112738460:112754873:112755025 | 112738353:112738460 |
| exon_skip_232607 | chr5 | 112801279:112801383:112810126:112810311:112815495:112815593 | 112810126:112810311 |
| exon_skip_236400 | chr5 | 112792446:112792529:112801279:112801383:112815495:112815593 | 112801279:112801383 |
| exon_skip_288387 | chr5 | 112821896:112821991:112823307:112823360:112827108:112827247 | 112823307:112823360 |
| exon_skip_294245 | chr5 | 112780790:112780903:112792446:112792529:112801279:112801372 | 112792446:112792529 |
| exon_skip_52537 | chr5 | 112738353:112738460:112754873:112755025:112766326:112766383 | 112754873:112755025 |
| exon_skip_77238 | chr5 | 112737895:112737925:112754873:112755025:112766326:112766383 | 112754873:112755025 |
| exon_skip_96841 | chr5 | 112754873:112755025:112766326:112766410:112767189:112767322 | 112766326:112766410 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for APC |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000257430 | 112754873 | 112755025 | 5CDS-5UTR |
| ENST00000508376 | 112754873 | 112755025 | 5CDS-5UTR |
| ENST00000508376 | 112738353 | 112738460 | 5UTR-5UTR |
| ENST00000257430 | 112766326 | 112766410 | Frame-shift |
| ENST00000508376 | 112766326 | 112766410 | Frame-shift |
| ENST00000257430 | 112818966 | 112819344 | Frame-shift |
| ENST00000508376 | 112818966 | 112819344 | Frame-shift |
| ENST00000257430 | 112792446 | 112792529 | In-frame |
| ENST00000508376 | 112792446 | 112792529 | In-frame |
| ENST00000257430 | 112801279 | 112801383 | In-frame |
| ENST00000508376 | 112801279 | 112801383 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000257430 | 112754873 | 112755025 | 5CDS-5UTR |
| ENST00000508376 | 112754873 | 112755025 | 5CDS-5UTR |
| ENST00000508376 | 112738353 | 112738460 | 5UTR-5UTR |
| ENST00000257430 | 112766326 | 112766410 | Frame-shift |
| ENST00000508376 | 112766326 | 112766410 | Frame-shift |
| ENST00000257430 | 112818966 | 112819344 | Frame-shift |
| ENST00000508376 | 112818966 | 112819344 | Frame-shift |
| ENST00000257430 | 112792446 | 112792529 | In-frame |
| ENST00000508376 | 112792446 | 112792529 | In-frame |
| ENST00000257430 | 112815495 | 112815593 | In-frame |
| ENST00000508376 | 112815495 | 112815593 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000257430 | 112754873 | 112755025 | 5CDS-5UTR |
| ENST00000508376 | 112754873 | 112755025 | 5CDS-5UTR |
| ENST00000508376 | 112738353 | 112738460 | 5UTR-5UTR |
| ENST00000257430 | 112766326 | 112766410 | Frame-shift |
| ENST00000508376 | 112766326 | 112766410 | Frame-shift |
| ENST00000257430 | 112818966 | 112819344 | Frame-shift |
| ENST00000508376 | 112818966 | 112819344 | Frame-shift |
| ENST00000257430 | 112792446 | 112792529 | In-frame |
| ENST00000508376 | 112792446 | 112792529 | In-frame |
| ENST00000257430 | 112801279 | 112801383 | In-frame |
| ENST00000508376 | 112801279 | 112801383 | In-frame |
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Infer the effects of exon skipping event on protein functional features for APC |
p-ENSG00000134982_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000257430 | 10718 | 2843 | 112792446 | 112792529 | 703 | 785 | 215 | 243 |
| ENST00000508376 | 10636 | 2843 | 112792446 | 112792529 | 804 | 886 | 215 | 243 |
| ENST00000257430 | 10718 | 2843 | 112801279 | 112801383 | 787 | 890 | 243 | 278 |
| ENST00000508376 | 10636 | 2843 | 112801279 | 112801383 | 888 | 991 | 243 | 278 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000257430 | 10718 | 2843 | 112792446 | 112792529 | 703 | 785 | 215 | 243 |
| ENST00000508376 | 10636 | 2843 | 112792446 | 112792529 | 804 | 886 | 215 | 243 |
| ENST00000257430 | 10718 | 2843 | 112815495 | 112815593 | 892 | 989 | 278 | 311 |
| ENST00000508376 | 10636 | 2843 | 112815495 | 112815593 | 993 | 1090 | 278 | 311 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000257430 | 10718 | 2843 | 112792446 | 112792529 | 703 | 785 | 215 | 243 |
| ENST00000508376 | 10636 | 2843 | 112792446 | 112792529 | 804 | 886 | 215 | 243 |
| ENST00000257430 | 10718 | 2843 | 112801279 | 112801383 | 787 | 890 | 243 | 278 |
| ENST00000508376 | 10636 | 2843 | 112801279 | 112801383 | 888 | 991 | 243 | 278 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P25054 | 215 | 243 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 215 | 243 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 215 | 243 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 215 | 243 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 215 | 243 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 215 | 243 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 215 | 243 | 1 | 730 | Compositional bias | Note=Leu-rich |
| P25054 | 215 | 243 | 1 | 730 | Compositional bias | Note=Leu-rich |
| P25054 | 215 | 243 | 208 | 238 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M5I |
| P25054 | 215 | 243 | 208 | 238 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M5I |
| P25054 | 243 | 278 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 243 | 278 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 243 | 278 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 243 | 278 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 243 | 278 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 243 | 278 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 243 | 278 | 1 | 730 | Compositional bias | Note=Leu-rich |
| P25054 | 243 | 278 | 1 | 730 | Compositional bias | Note=Leu-rich |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P25054 | 215 | 243 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 215 | 243 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 215 | 243 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 215 | 243 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 215 | 243 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 215 | 243 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 215 | 243 | 1 | 730 | Compositional bias | Note=Leu-rich |
| P25054 | 215 | 243 | 1 | 730 | Compositional bias | Note=Leu-rich |
| P25054 | 215 | 243 | 208 | 238 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M5I |
| P25054 | 215 | 243 | 208 | 238 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M5I |
| P25054 | 278 | 311 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 278 | 311 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 278 | 311 | 1 | 730 | Compositional bias | Note=Leu-rich |
| P25054 | 278 | 311 | 1 | 730 | Compositional bias | Note=Leu-rich |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P25054 | 215 | 243 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 215 | 243 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 215 | 243 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 215 | 243 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 215 | 243 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 215 | 243 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 215 | 243 | 1 | 730 | Compositional bias | Note=Leu-rich |
| P25054 | 215 | 243 | 1 | 730 | Compositional bias | Note=Leu-rich |
| P25054 | 215 | 243 | 208 | 238 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M5I |
| P25054 | 215 | 243 | 208 | 238 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1M5I |
| P25054 | 243 | 278 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 243 | 278 | 217 | 244 | Alternative sequence | ID=VSP_059028;Note=In isoform 1B. Missing |
| P25054 | 243 | 278 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 243 | 278 | 2 | 2843 | Chain | ID=PRO_0000064627;Note=Adenomatous polyposis coli protein |
| P25054 | 243 | 278 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 243 | 278 | 127 | 248 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P25054 | 243 | 278 | 1 | 730 | Compositional bias | Note=Leu-rich |
| P25054 | 243 | 278 | 1 | 730 | Compositional bias | Note=Leu-rich |
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3'-UTR located exon skipping events that lost miRNA binding sites in APC |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for APC |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for APC |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_228800 | 4.465089e-01 | 1.722561e-02 | chr5 | + | 112737895 | 112737925 | 112738353 | 112738460 | 112754873 | 112755025 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for APC |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for APC |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| FL | ELAVL4 | exon_skip_178175 | -4.910399e-01 | 4.791351e-13 |
| FL | MATR3 | exon_skip_178175 | -4.361602e-01 | 2.554259e-10 |
| FL | G3BP2 | exon_skip_178175 | -4.853504e-01 | 9.688019e-13 |
| FL | SRSF2 | exon_skip_77238 | -4.575691e-01 | 1.979917e-11 |
| FL | MSI1 | exon_skip_77238 | 4.852692e-01 | 7.442898e-13 |
| FL | ELAVL4 | exon_skip_77238 | -5.375169e-01 | 6.425414e-16 |
| FL | MATR3 | exon_skip_77238 | -5.188608e-01 | 9.172938e-15 |
| FL | ILF2 | exon_skip_77238 | -4.542923e-01 | 2.863498e-11 |
| FL | G3BP2 | exon_skip_77238 | -5.661425e-01 | 7.785759e-18 |
| FL | SRSF9 | exon_skip_77238 | -4.549930e-01 | 2.647127e-11 |
| FL | NOVA1 | exon_skip_77238 | -4.045870e-01 | 4.888408e-09 |
| FL | MSI1 | exon_skip_288387 | 4.289397e-01 | 2.882801e-10 |
| FL | SRSF9 | exon_skip_288387 | -4.240565e-01 | 4.800004e-10 |
| HCC | MSI1 | exon_skip_178175 | 5.199329e-01 | 1.412614e-18 |
| HCC | RBM6 | exon_skip_178175 | 4.886481e-01 | 2.738951e-16 |
| HCC | RBM5 | exon_skip_178175 | 4.701793e-01 | 4.810635e-15 |
| HCC | RBM47 | exon_skip_178175 | 4.419082e-01 | 2.804631e-13 |
| HCC | G3BP2 | exon_skip_178175 | -5.965414e-01 | 2.702168e-25 |
| HCC | MSI1 | exon_skip_77238 | 5.813530e-01 | 2.881617e-25 |
| HCC | RBM6 | exon_skip_77238 | 5.239893e-01 | 5.096007e-20 |
| HCC | RBM5 | exon_skip_77238 | 5.021557e-01 | 2.855600e-18 |
| HCC | RBM47 | exon_skip_77238 | 4.909963e-01 | 2.005092e-17 |
| HCC | G3BP2 | exon_skip_77238 | -5.672227e-01 | 7.046807e-24 |
| HCC | RBM47 | exon_skip_68909 | 4.233278e-01 | 3.741914e-11 |
| HCC | G3BP2 | exon_skip_68909 | -4.351916e-01 | 9.113429e-12 |
| IFG | ELAVL4 | exon_skip_178175 | -4.387508e-01 | 1.950982e-02 |
| IFG | ILF2 | exon_skip_178175 | -4.102498e-01 | 3.013291e-02 |
| IFG | G3BP2 | exon_skip_178175 | -4.891756e-01 | 8.247763e-03 |
| IFG | HNRNPDL | exon_skip_178175 | -4.310774e-01 | 2.200816e-02 |
| IFG | HNRNPK | exon_skip_18197 | 5.105308e-01 | 1.280345e-02 |
| IFG | EWSR1 | exon_skip_18197 | 4.859206e-01 | 1.873387e-02 |
| IFG | RBM47 | exon_skip_77238 | 4.940986e-01 | 7.530615e-03 |
| IFG | MATR3 | exon_skip_52537 | -5.637725e-01 | 1.782092e-03 |
| IFG | ILF2 | exon_skip_52537 | -4.008008e-01 | 3.454308e-02 |
| IFG | G3BP2 | exon_skip_52537 | -4.661247e-01 | 1.241626e-02 |
| IFG | HNRNPDL | exon_skip_52537 | -5.715840e-01 | 1.486205e-03 |
| IFG | SRSF9 | exon_skip_52537 | -4.558696e-01 | 1.476785e-02 |
| PCC | MSI1 | exon_skip_178175 | 4.492761e-01 | 9.983803e-11 |
| PCC | ELAVL4 | exon_skip_178175 | -6.084294e-01 | 2.019616e-20 |
| PCC | MATR3 | exon_skip_178175 | -4.577834e-01 | 3.973221e-11 |
| PCC | ILF2 | exon_skip_178175 | -4.148236e-01 | 3.245157e-09 |
| PCC | G3BP2 | exon_skip_178175 | -7.040590e-01 | 1.848491e-29 |
| PCC | NOVA1 | exon_skip_178175 | -4.552007e-01 | 5.269780e-11 |
| PCC | MSI1 | exon_skip_77238 | 4.364594e-01 | 1.161216e-10 |
| PCC | ELAVL4 | exon_skip_77238 | -4.919976e-01 | 1.583240e-13 |
| PCC | RBM47 | exon_skip_77238 | 4.184912e-01 | 7.699327e-10 |
| PCC | G3BP2 | exon_skip_77238 | -6.007262e-01 | 6.638950e-21 |
| PCC | G3BP2 | exon_skip_52537 | -4.313234e-01 | 3.795801e-10 |
| PG | ELAVL4 | exon_skip_178175 | -6.340930e-01 | 5.880838e-21 |
| PG | MATR3 | exon_skip_178175 | -4.803166e-01 | 1.986507e-11 |
| PG | ILF2 | exon_skip_178175 | -4.510509e-01 | 4.212169e-10 |
| PG | G3BP2 | exon_skip_178175 | -5.728664e-01 | 1.460494e-16 |
| PG | NOVA1 | exon_skip_178175 | -4.310392e-01 | 2.896095e-09 |
| PG | ELAVL4 | exon_skip_77238 | -5.894430e-01 | 5.642009e-19 |
| PG | MATR3 | exon_skip_77238 | -4.219700e-01 | 1.627170e-09 |
| PG | G3BP2 | exon_skip_77238 | -5.371044e-01 | 1.924659e-15 |
| STG | MSI1 | exon_skip_178175 | 4.627950e-01 | 6.383852e-06 |
| STG | ELAVL4 | exon_skip_178175 | -4.011121e-01 | 1.180195e-04 |
| STG | IGF2BP2 | exon_skip_178175 | 4.341053e-01 | 2.660407e-05 |
| STG | RBM47 | exon_skip_178175 | 4.652018e-01 | 5.629847e-06 |
| STG | SRSF2 | exon_skip_77238 | -4.155168e-01 | 6.276701e-05 |
| STG | ELAVL4 | exon_skip_77238 | -5.479701e-01 | 3.942337e-08 |
| STG | MATR3 | exon_skip_77238 | -5.243305e-01 | 1.863702e-07 |
| STG | ILF2 | exon_skip_77238 | -4.083268e-01 | 8.633134e-05 |
| STG | G3BP2 | exon_skip_77238 | -5.741039e-01 | 6.118678e-09 |
| STG | HNRNPDL | exon_skip_77238 | -4.312506e-01 | 3.045265e-05 |
| STG | NUP42 | exon_skip_77238 | -4.306323e-01 | 3.135191e-05 |
| STG | SRSF1 | exon_skip_77238 | -4.046099e-01 | 1.015100e-04 |
| STG | SRSF9 | exon_skip_77238 | -4.353160e-01 | 2.511333e-05 |
| STG | NOVA1 | exon_skip_77238 | -4.700422e-01 | 4.359708e-06 |
| STG | MATR3 | exon_skip_52537 | -4.027467e-01 | 5.470902e-04 |
| TC | ELAVL4 | exon_skip_178175 | -5.720443e-01 | 1.077214e-11 |
| TC | MATR3 | exon_skip_178175 | -4.770084e-01 | 4.145869e-08 |
| TC | G3BP2 | exon_skip_178175 | -4.810505e-01 | 3.065478e-08 |
| TC | NUP42 | exon_skip_178175 | -4.232547e-01 | 1.620103e-06 |
| TC | NOVA1 | exon_skip_178175 | -5.278338e-01 | 6.893409e-10 |
| TC | MSI1 | exon_skip_77238 | 4.661925e-01 | 3.318743e-08 |
| TC | ELAVL4 | exon_skip_77238 | -5.639482e-01 | 5.062396e-12 |
| TC | RBM6 | exon_skip_77238 | 4.097916e-01 | 1.715964e-06 |
| TC | G3BP2 | exon_skip_77238 | -4.002198e-01 | 3.131065e-06 |
| TC | NUP42 | exon_skip_77238 | -4.074128e-01 | 1.996072e-06 |
| TC | NOVA1 | exon_skip_77238 | -4.549530e-01 | 7.719407e-08 |
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RelatedDrugs for APC |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for APC |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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