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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for HNRNPF |
 Gene summary |
| Gene information | Gene symbol | HNRNPF | Gene ID | 3185 |
| Gene name | heterogeneous nuclear ribonucleoprotein F | |
| Synonyms | HNRPF|OK/SW-cl.23|mcs94-1 | |
| Cytomap | 10q11.21 | |
| Type of gene | protein-coding | |
| Description | heterogeneous nuclear ribonucleoprotein FHnRNP F proteinnucleolin-like protein mcs94-1 | |
| Modification date | 20200327 | |
| UniProtAcc | A0A1B0GW42, P52597, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HNRNPF | GO:0043484 | regulation of RNA splicing | 20526337 |
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Gene structures and expression levels for HNRNPF |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000169813
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000356053.7 | HNRNPF-202:protein_coding:HNRNPF | 3.018864e+01 | 1.045750e+00 | 2.369387e-03 | 2.695276e-02 |
| TC | UP | ENST00000477108.5 | HNRNPF-205:protein_coding:HNRNPF | 2.293620e+01 | 1.527777e+00 | 1.183450e-04 | 1.849894e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HNRNPF |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_17662 | chr10 | 43387643:43387936:43394630:43394688:43396456:43396590 | 43394630:43394688 |
| exon_skip_77699 | chr10 | 43394630:43394688:43396456:43396590:43407717:43407819 | 43396456:43396590 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for HNRNPF |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337970 | 43394630 | 43394688 | 3UTR-3UTR |
| ENST00000356053 | 43394630 | 43394688 | 3UTR-3UTR |
| ENST00000357065 | 43394630 | 43394688 | 3UTR-3UTR |
| ENST00000544000 | 43394630 | 43394688 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337970 | 43394630 | 43394688 | 3UTR-3UTR |
| ENST00000356053 | 43394630 | 43394688 | 3UTR-3UTR |
| ENST00000357065 | 43394630 | 43394688 | 3UTR-3UTR |
| ENST00000544000 | 43394630 | 43394688 | 3UTR-3UTR |
| ENST00000357065 | 43396456 | 43396590 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for HNRNPF |
p-ENSG00000169813_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in HNRNPF |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000357065 | 43396456 | 43396590 | hsa-miR-6727-5p | chr10:43396516-43396523 | 8mer-1a | chr10:43396501-43396523 | 157.00 | -28.34 |
| Mayo | ENST00000544000 | 43394630 | 43394688 | hsa-miR-605-3p | chr10:43394648-43394655 | 8mer-1a | chr10:43394643-43394664 | 161.00 | -26.00 |
| Mayo | ENST00000357065 | 43396456 | 43396590 | hsa-miR-6763-3p | chr10:43396555-43396562 | 8mer-1a | chr10:43396539-43396562 | 158.00 | -27.61 |
| Mayo | ENST00000357065 | 43396456 | 43396590 | hsa-miR-4508 | chr10:43396515-43396522 | 8mer-1a | chr10:43396501-43396523 | 157.00 | -28.34 |
| Mayo | ENST00000357065 | 43396456 | 43396590 | hsa-miR-4520-5p | chr10:43396542-43396549 | 8mer-1a | chr10:43396539-43396562 | 158.00 | -27.61 |
| Mayo | ENST00000357065 | 43396456 | 43396590 | hsa-miR-6804-3p | chr10:43396567-43396574 | 8mer-1a | chr10:43396555-43396576 | 156.00 | -21.14 |
| Mayo | ENST00000357065 | 43396456 | 43396590 | hsa-miR-3194-5p | chr10:43396501-43396508 | 8mer-1a | chr10:43396486-43396509 | 162.00 | -30.28 |
| Mayo | ENST00000357065 | 43396456 | 43396590 | hsa-miR-647 | chr10:43396506-43396513 | 8mer-1a | chr10:43396501-43396523 | 157.00 | -28.34 |
| Mayo | ENST00000544000 | 43394630 | 43394688 | hsa-miR-532-3p | chr10:43394656-43394663 | 8mer-1a | chr10:43394643-43394664 | 161.00 | -26.00 |
| ROSMAP | ENST00000544000 | 43394630 | 43394688 | hsa-miR-605-3p | chr10:43394648-43394655 | 8mer-1a | chr10:43394643-43394664 | 161.00 | -26.00 |
| ROSMAP | ENST00000544000 | 43394630 | 43394688 | hsa-miR-532-3p | chr10:43394656-43394663 | 8mer-1a | chr10:43394643-43394664 | 161.00 | -26.00 |
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SNVs in the skipped exons for HNRNPF |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for HNRNPF |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HNRNPF |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for HNRNPF |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for HNRNPF |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HNRNPF |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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