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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ANXA11 |
 Gene summary |
| Gene information | Gene symbol | ANXA11 | Gene ID | 311 |
| Gene name | annexin A11 | |
| Synonyms | ALS23|ANX11|CAP-50|CAP50 | |
| Cytomap | 10q22.3 | |
| Type of gene | protein-coding | |
| Description | annexin A1156 kDa autoantigenannexin XIannexin-11calcyclin-associated annexin 50epididymis secretory sperm binding protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ANXA11 | GO:0051592 | response to calcium ion | 9188810|12601007 |
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Gene structures and expression levels for ANXA11 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000122359
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000463340.1 | ANXA11-207:lncRNA:ANXA11 | 6.096006e+01 | -1.051989e+00 | 3.379955e-08 | 8.479563e-07 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ANXA11 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_123186 | chr10 | 80167226:80167313:80168969:80169358:80170800:80170915 | 80168969:80169358 |
| exon_skip_144422 | chr10 | 80155859:80155912:80156378:80156498:80157641:80157763 | 80156378:80156498 |
| exon_skip_151997 | chr10 | 80170800:80170915:80171613:80171881:80172807:80172871 | 80171613:80171881 |
| exon_skip_176325 | chr10 | 80155640:80155912:80156378:80156498:80157641:80157713 | 80156378:80156498 |
| exon_skip_198802 | chr10 | 80155884:80155912:80157641:80157763:80157967:80158018 | 80157641:80157763 |
| exon_skip_211281 | chr10 | 80155640:80155912:80156378:80156498:80157641:80157763 | 80156378:80156498 |
| exon_skip_224821 | chr10 | 80155588:80155912:80157641:80157763:80157967:80158018 | 80157641:80157763 |
| exon_skip_237266 | chr10 | 80163349:80163405:80163534:80163613:80164053:80164143 | 80163534:80163613 |
| exon_skip_23956 | chr10 | 80176107:80176155:80180941:80181136:80205343:80205572 | 80180941:80181136 |
| exon_skip_253936 | chr10 | 80166084:80166197:80166890:80166984:80167226:80167313 | 80166890:80166984 |
| exon_skip_256126 | chr10 | 80155640:80155912:80157641:80157763:80157967:80158018 | 80157641:80157763 |
| exon_skip_288514 | chr10 | 80166890:80166984:80167226:80167313:80168969:80169087 | 80167226:80167313 |
| exon_skip_33586 | chr10 | 80155884:80155912:80156378:80156498:80157641:80157763 | 80156378:80156498 |
| exon_skip_34309 | chr10 | 80176107:80176155:80180941:80181455:80205343:80205522 | 80180941:80181455 |
| exon_skip_36006 | chr10 | 80163349:80163405:80163534:80163613:80164053:80164093 | 80163534:80163613 |
| exon_skip_39879 | chr10 | 80172834:80172869:80176107:80176155:80180941:80181136 | 80176107:80176155 |
| exon_skip_56175 | chr10 | 80170800:80170915:80171613:80171881:80172807:80172869 | 80171613:80171881 |
| exon_skip_94241 | chr10 | 80157641:80157763:80157967:80158025:80159100:80159195 | 80157967:80158025 |
| exon_skip_9679 | chr10 | 80155859:80155912:80157641:80157763:80157967:80158018 | 80157641:80157763 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ANXA11 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000372231 | 80163534 | 80163613 | Frame-shift |
| ENST00000422982 | 80163534 | 80163613 | Frame-shift |
| ENST00000438331 | 80163534 | 80163613 | Frame-shift |
| ENST00000372231 | 80157641 | 80157763 | In-frame |
| ENST00000422982 | 80157641 | 80157763 | In-frame |
| ENST00000438331 | 80157641 | 80157763 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000372231 | 80157641 | 80157763 | In-frame |
| ENST00000422982 | 80157641 | 80157763 | In-frame |
| ENST00000438331 | 80157641 | 80157763 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000438331 | 80176107 | 80176155 | 3UTR-3UTR |
| ENST00000438331 | 80180941 | 80181136 | 3UTR-3UTR |
| ENST00000372231 | 80157967 | 80158025 | Frame-shift |
| ENST00000422982 | 80157967 | 80158025 | Frame-shift |
| ENST00000438331 | 80157967 | 80158025 | Frame-shift |
| ENST00000372231 | 80163534 | 80163613 | Frame-shift |
| ENST00000422982 | 80163534 | 80163613 | Frame-shift |
| ENST00000438331 | 80163534 | 80163613 | Frame-shift |
| ENST00000372231 | 80166890 | 80166984 | Frame-shift |
| ENST00000422982 | 80166890 | 80166984 | Frame-shift |
| ENST00000438331 | 80166890 | 80166984 | Frame-shift |
| ENST00000372231 | 80167226 | 80167313 | Frame-shift |
| ENST00000422982 | 80167226 | 80167313 | Frame-shift |
| ENST00000438331 | 80167226 | 80167313 | Frame-shift |
| ENST00000372231 | 80157641 | 80157763 | In-frame |
| ENST00000422982 | 80157641 | 80157763 | In-frame |
| ENST00000438331 | 80157641 | 80157763 | In-frame |
| ENST00000372231 | 80168969 | 80169358 | In-frame |
| ENST00000422982 | 80168969 | 80169358 | In-frame |
| ENST00000438331 | 80168969 | 80169358 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ANXA11 |
p-ENSG00000122359_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000372231 | 6737 | 505 | 80157641 | 80157763 | 1574 | 1695 | 445 | 485 |
| ENST00000422982 | 2551 | 505 | 80157641 | 80157763 | 1623 | 1744 | 445 | 485 |
| ENST00000438331 | 6982 | 505 | 80157641 | 80157763 | 1819 | 1940 | 445 | 485 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000372231 | 6737 | 505 | 80157641 | 80157763 | 1574 | 1695 | 445 | 485 |
| ENST00000422982 | 2551 | 505 | 80157641 | 80157763 | 1623 | 1744 | 445 | 485 |
| ENST00000438331 | 6982 | 505 | 80157641 | 80157763 | 1819 | 1940 | 445 | 485 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000372231 | 6737 | 505 | 80168969 | 80169358 | 410 | 798 | 57 | 186 |
| ENST00000422982 | 2551 | 505 | 80168969 | 80169358 | 459 | 847 | 57 | 186 |
| ENST00000438331 | 6982 | 505 | 80168969 | 80169358 | 655 | 1043 | 57 | 186 |
| ENST00000372231 | 6737 | 505 | 80157641 | 80157763 | 1574 | 1695 | 445 | 485 |
| ENST00000422982 | 2551 | 505 | 80157641 | 80157763 | 1623 | 1744 | 445 | 485 |
| ENST00000438331 | 6982 | 505 | 80157641 | 80157763 | 1819 | 1940 | 445 | 485 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P50995 | 445 | 485 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 445 | 485 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 445 | 485 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 445 | 485 | 479 | 479 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P50995 | 445 | 485 | 479 | 479 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P50995 | 445 | 485 | 479 | 479 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P50995 | 445 | 485 | 457 | 457 | Natural variant | ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932 |
| P50995 | 445 | 485 | 457 | 457 | Natural variant | ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932 |
| P50995 | 445 | 485 | 457 | 457 | Natural variant | ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932 |
| P50995 | 445 | 485 | 440 | 500 | Repeat | Note=Annexin 4 |
| P50995 | 445 | 485 | 440 | 500 | Repeat | Note=Annexin 4 |
| P50995 | 445 | 485 | 440 | 500 | Repeat | Note=Annexin 4 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P50995 | 445 | 485 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 445 | 485 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 445 | 485 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 445 | 485 | 479 | 479 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P50995 | 445 | 485 | 479 | 479 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P50995 | 445 | 485 | 479 | 479 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P50995 | 445 | 485 | 457 | 457 | Natural variant | ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932 |
| P50995 | 445 | 485 | 457 | 457 | Natural variant | ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932 |
| P50995 | 445 | 485 | 457 | 457 | Natural variant | ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932 |
| P50995 | 445 | 485 | 440 | 500 | Repeat | Note=Annexin 4 |
| P50995 | 445 | 485 | 440 | 500 | Repeat | Note=Annexin 4 |
| P50995 | 445 | 485 | 440 | 500 | Repeat | Note=Annexin 4 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P50995 | 57 | 186 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 57 | 186 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 57 | 186 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 57 | 186 | 175 | 175 | Natural variant | ID=VAR_080655;Note=In ALS23%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28469040;Dbxref=dbSNP:rs754594235,PMID:28469040 |
| P50995 | 57 | 186 | 175 | 175 | Natural variant | ID=VAR_080655;Note=In ALS23%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28469040;Dbxref=dbSNP:rs754594235,PMID:28469040 |
| P50995 | 57 | 186 | 175 | 175 | Natural variant | ID=VAR_080655;Note=In ALS23%3B unknown pathological significance. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28469040;Dbxref=dbSNP:rs754594235,PMID:28469040 |
| P50995 | 445 | 485 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 445 | 485 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 445 | 485 | 1 | 505 | Chain | ID=PRO_0000067510;Note=Annexin A11 |
| P50995 | 445 | 485 | 479 | 479 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P50995 | 445 | 485 | 479 | 479 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P50995 | 445 | 485 | 479 | 479 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P50995 | 445 | 485 | 457 | 457 | Natural variant | ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932 |
| P50995 | 445 | 485 | 457 | 457 | Natural variant | ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932 |
| P50995 | 445 | 485 | 457 | 457 | Natural variant | ID=VAR_012007;Note=I->V;Dbxref=dbSNP:rs1802932 |
| P50995 | 445 | 485 | 440 | 500 | Repeat | Note=Annexin 4 |
| P50995 | 445 | 485 | 440 | 500 | Repeat | Note=Annexin 4 |
| P50995 | 445 | 485 | 440 | 500 | Repeat | Note=Annexin 4 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ANXA11 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-492 | chr10:80181122-80181129 | 8mer-1a | chr10:80181114-80181130 | 162.00 | -26.08 |
| Mayo | ENST00000438331 | 80176107 | 80176155 | hsa-miR-4700-5p | chr10:80176141-80176148 | 8mer-1a | chr10:80176133-80176155 | 165.00 | -23.18 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-1253 | chr10:80181006-80181013 | 8mer-1a | chr10:80180998-80181019 | 175.00 | -27.70 |
| Mayo | ENST00000438331 | 80176107 | 80176155 | hsa-miR-4725-3p | chr10:80176139-80176146 | 8mer-1a | chr10:80176133-80176155 | 165.00 | -23.18 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-21-5p | chr10:80181035-80181042 | 8mer-1a | chr10:80181020-80181042 | 155.00 | -12.94 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-516b-5p | chr10:80181016-80181023 | 8mer-1a | chr10:80181001-80181023 | 163.00 | -21.83 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-3128 | chr10:80180985-80180992 | 8mer-1a | chr10:80180973-80180994 | 147.00 | -19.38 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-4775 | chr10:80181091-80181098 | 8mer-1a | chr10:80181077-80181098 | 156.00 | -8.57 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-6809-5p | chr10:80180983-80180990 | 8mer-1a | chr10:80180973-80180994 | 147.00 | -19.38 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-4535 | chr10:80181123-80181130 | 8mer-1a | chr10:80181114-80181130 | 162.00 | -26.08 |
| Mayo | ENST00000438331 | 80176107 | 80176155 | hsa-miR-4271 | chr10:80176139-80176146 | 8mer-1a | chr10:80176133-80176155 | 165.00 | -23.18 |
| Mayo | ENST00000438331 | 80176107 | 80176155 | hsa-miR-8089 | chr10:80176141-80176148 | 8mer-1a | chr10:80176133-80176155 | 165.00 | -23.18 |
| Mayo | ENST00000438331 | 80176107 | 80176155 | hsa-miR-6780b-5p | chr10:80176139-80176146 | 8mer-1a | chr10:80176133-80176155 | 165.00 | -23.18 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-2113 | chr10:80181087-80181094 | 8mer-1a | chr10:80181076-80181094 | 160.00 | -18.30 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-4284 | chr10:80181026-80181033 | 8mer-1a | chr10:80181020-80181042 | 155.00 | -12.94 |
| Mayo | ENST00000438331 | 80180941 | 80181136 | hsa-miR-590-5p | chr10:80181035-80181042 | 8mer-1a | chr10:80181020-80181042 | 155.00 | -12.94 |
| Mayo | ENST00000438331 | 80176107 | 80176155 | hsa-miR-4667-5p | chr10:80176141-80176148 | 8mer-1a | chr10:80176133-80176155 | 165.00 | -23.18 |
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SNVs in the skipped exons for ANXA11 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ANXA11 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ANXA11 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ANXA11 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM4 | exon_skip_34309 | 5.100584e-01 | 3.552195e-11 |
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RelatedDrugs for ANXA11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANXA11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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