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	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Gene summary for HLA-A

Gene summary

Gene information	Gene symbol	HLA-A
	Gene ID	3105
	Gene name	major histocompatibility complex, class I, A
	Synonyms	HLAA
	Cytomap	6p22.1
	Type of gene	protein-coding
	Description	HLA class I histocompatibility antigen, A alpha chainHLA class I histocompatibility antigen, A-1 alpha chainMHC class I antigen HLA-A heavy chainleukocyte antigen class I-A
	Modification date	20200328
	UniProtAcc	A0A024J3X2, A0A060AF62, A0A060AQ09, A0A060CYB7, A0A060CZ20, A0A060GQ71, A0A060GTH2, A0A060GVB3, A0A060H0F8, A0A060N342, A0A060VCP5, A0A060VCP8, A0A060VCU0, A0A060VCU4, A0A060VCV9, A0A060VCW6, A0A060VCW9, A0A060VCX0, A0A060VCX2, A0A060VCY5, A0A060VCY6, A0A060VCY7, A0A060VCY8, A0A060VCY9, A0A060VCZ1, A0A060VCZ3, A0A060VD05, A0A060VD08, A0A060VD10, A0A060VD16, A0A060VG17, A0A060VG20, A0A060VG23, A0A060VG36, A0A060VG38, A0A060VG42, A0A060VG47, A0A060VHC2, A0A060VHD0, A0A060VHD9, A0A060VHE9, A0A060VHF3, A0A060VHF9, A0A060VHG8, A0A060VHJ3, A0A061A7U0, A0A061CVW2, A0A061DD14, A0A061DEB5, A0A068B103, A0A068B426, A0A068B6T4, A0A068ESS8, A0A076JS26, A0A076JT77, A0A076JXB7, A0A076L0P9, A0A076V2L0, A0A076V371, A0A076V5S4, A0A076V7U7, A0A076VF41, A0A077XLA2, A0A077YFH3, A0A077YIJ7, A0A078BBY8, A0A078BNH2, A0A078BPG3, A0A078BRA4, A0A078BSN2, A0A078N1N5, A0A078N209, A0A090CXP3, A0A090D8A2, A0A090GS47, A0A090JY51, A0A090KEX7, A0A090KFS3, A0A090KI70, A0A090KKC3, A0A090KKK5, A0A090MEX8, A0A090MF36, A0A096XJR7, A0A096XJU1, A0A097PED7, A0A098F6N4, A0A0A0YLW6, A0A0A1E6D6, A0A0A1EAW8, A0A0A1IX34, A0A0A7C3M7, A0A0A7C3M9, A0A0A7C3N2, A0A0A7C3N4, A0A0A7C3N7, A0A0A7C3N9, A0A0A7C3P2, A0A0A7C3P3, A0A0A7C3P5, A0A0A7C3P7, A0A0A7C3P8, A0A0A7C3Q0, A0A0A7C3Q1, A0A0A7C3Q3, A0A0A7C3Q5, A0A0A7C3Q6, A0A0A7C3Q8, A0A0A7C3R0, A0A0A7C3R2, A0A0A7C3R3, A0A0A7C3R4, A0A0A7C3R6, A0A0A7C3R8, A0A0A7C3R9, A0A0A7C3S1, A0A0A7C3S2, A0A0A7C3S3, A0A0A7C3S5, A0A0A7C3S8, A0A0A7C3S9, A0A0A7C3T1, A0A0A7C3T3, A0A0A7C3T5, A0A0A7C3T7, A0A0A7C3T9, A0A0A7C3U1, A0A0A7C3U3, A0A0A7C3U6, A0A0A7C3U7, A0A0A7C3U9, A0A0A7C3V2, A0A0A7C3V4, A0A0A7C3V6, A0A0A7C3V9, A0A0A7C3W0, A0A0A7C3W3, A0A0A7C3W4, A0A0A7C3W7, A0A0A7C3W8, A0A0A7C3X2, A0A0A7C3X3, A0A0A7C3X6, A0A0A7C3X8, A0A0A7C3Y0, A0A0A7C3Y2, A0A0A7C3Y5, A0A0A7C3Y6, A0A0A7C3Y8, A0A0A7C3Z1, A0A0A7C3Z2, A0A0A7C3Z5, A0A0A7C3Z6, A0A0A7C400, A0A0A7C401, A0A0A7C403, A0A0A7C406, A0A0A7C408, A0A0A7C413, A0A0A7C417, A0A0A7C421, A0A0A7C425, A0A0A7C4B9, A0A0A7C4C4, A0A0A7C4C5, A0A0A7C4C9, A0A0A7C4D3, A0A0A7C4D6, A0A0A7C4E0, A0A0A7C4E2, A0A0A7C4E6, A0A0A7C4E9, A0A0A7C4F2, A0A0A7C4F5, A0A0A7C4F8, A0A0A7C4G2, A0A0A7C4G4, A0A0A7C4G8, A0A0A7C4H1, A0A0A7C4H4, A0A0A7C4H8, A0A0A7C4I1, A0A0A7C4I4, A0A0A7C4I8, A0A0A7C4J0, A0A0A7C4J5, A0A0A7C4J7, A0A0A7C4K2, A0A0A7C4K5, A0A0A7C4K8, A0A0A7C4L1, A0A0A7C4L4, A0A0A7C4L8, A0A0A7C4M1, A0A0A7C4M4, A0A0A7C4M9, A0A0A7C4N1, A0A0A7C4W8, A0A0A7C4X0, A0A0A7C4X2, A0A0A7C4X6, A0A0A7C4X7, A0A0A7C4Y2, A0A0A7C4Y3, A0A0A7C4Y6, A0A0A7C4Y8, A0A0A7C4Z0, A0A0A7C4Z4, A0A0A7C4Z6, A0A0A7C4Z9, A0A0A7C502, A0A0A7C505, A0A0A7C510, A0A0A7C512, A0A0A7C516, A0A0A7C520, A0A0A7C524, A0A0A7C529, A0A0A7C533, A0A0A7C539, A0A0A7C543, A0A0A7C548, A0A0A7C551, A0A0A7C557, A0A0A7C561, A0A0A7C565, A0A0A7C570, A0A0A7C576, A0A0A7C579, A0A0A7C584, A0A0A7C590, A0A0A7C594, A0A0A7C5E4, A0A0A7C5E9, A0A0A7C5F4, A0A0A7C5F6, A0A0A7C5G0, A0A0A7C5G4, A0A0A7C5G6, A0A0A7C5H1, A0A0A7C5H4, A0A0A7C5H8, A0A0A7C5I2, A0A0A7C5I5, A0A0A7C5I8, A0A0A7C5J3, A0A0A7C5J5, A0A0A7C5K0, A0A0A7C5K4, A0A0A7C5K7, A0A0A7C5L1, A0A0A7C5L4, A0A0A7C5L7, A0A0A7C5M0, A0A0A7C5M4, A0A0A7C5M8, A0A0A7C5N1, A0A0A7C5N4, A0A0A7C5N8, A0A0A7C5P1, A0A0A7C5P5, A0A0A7C5Q0, A0A0A7C5Q4, A0A0A7C5Q9, A0A0A7C5R3, A0A0A7C5R7, A0A0A7C5S2, A0A0A7C6L4, A0A0A7C6L9, A0A0A7C6M3, A0A0A7C6M8, A0A0A7C6N4, A0A0A7C6N8, A0A0A7C6P2, A0A0A7C6P7, A0A0A7C6Q0, A0A0A7C6Q2, A0A0A7C6Q5, A0A0A7C6Q6, A0A0A7C6Q9, A0A0A7C6R0, A0A0A7C6R3, A0A0A7C6R4, A0A0A7C6R7, A0A0A7C6R8, A0A0A7C6S1, A0A0A7C6S2, A0A0A7C6S5, A0A0A7C6S6, A0A0A7C6S8, A0A0A7C6T0, A0A0A7C6T2, A0A0A7C6T4, A0A0A7C6T6, A0A0A7C6T8, A0A0A7C6U0, A0A0A7C6U2, A0A0A7C6U3, A0A0A7C6U6, A0A0A7C6U7, A0A0A7C6V0, A0A0A7C6V2, A0A0A7C6V5, A0A0A7C6V6, A0A0A7C6W0, A0A0A7C6W1, A0A0A7C6W4, A0A0A7C6W5, A0A0A7C6W9, A0A0A7C6X0, A0A0A7C6X5, A0A0A7C6X6, A0A0A7C6Y0, A0A0A7C6Y2, A0A0A7C6Y6, A0A0A7C6Y7, A0A0A7C6Z1, A0A0A7C6Z3, A0A0A7C6Z6, A0A0A7C6Z7, A0A0A7C701, A0A0A7C702, A0A0A7C706, A0A0A7C707, A0A0A7C710, A0A0A7C711, A0A0A7C714, A0A0A7C716, A0A0A7C720, A0A0A7C721, A0A0A7C725, A0A0A7C726, A0A0A7C729, A0A0A7C730, A0A0A7C735, A0A0A7C736, A0A0A7C741, A0A0A7C742, A0A0A7C747, A0A0A7C748, A0A0A7C752, A0A0A7C754, A0A0A7C759, A0A0A7C760, A0A0A7C765, A0A0A7C766, A0A0A7C770, A0A0A7C772, A0A0A7C776, A0A0A7C778, A0A0A7C783, A0A0A7C788, A0A0A7C794, A0A0A7C7A1, A0A0A7C7A3, A0A0A7C7A7, A0A0A7C7A8, A0A0A7C7B2, A0A0A7C7B3, A0A0A7C7B5, A0A0A7C7C0, A0A0A7C7C2, A0A0A7C7C8, A0A0A7C7D1, A0A0A7C7D6, A0A0A7C7D8, A0A0A7C7E3, A0A0A7C7E7, A0A0A7C7F2, A0A0A7C7F4, A0A0A7C7F9, A0A0A7C7G1, A0A0A7C7G5, A0A0A7C7H0, A0A0A7C7H5, A0A0A7C7I0, A0A0A7C7I3, A0A0A7C7I7, A0A0A7C7J2, A0A0A7C7J7, A0A0A7C7K0, A0A0A7C7K4, A0A0A7C7K8, A0A0A7C7L3, A0A0A7C7L7, A0A0A7C7M1, A0A0A7C7M6, A0A0A7C7N0, A0A0A7C7N4, A0A0A7C7N7, A0A0A7C7P1, A0A0A7C7P5, A0A0A7C7P9, A0A0A7C7Q3, A0A0A7C7Q9, A0A0A7C7R2, A0A0A7C7R7, A0A0A7C7S1, A0A0A7C7S7, A0A0A7C7T2, A0A0A7C7T4, A0A0A7C7W7, A0A0A7C7X1, A0A0A7C7X5, A0A0A7C7X7, A0A0A7C7Y3, A0A0A7C7Y7, A0A0A7C7Z2, A0A0A7C7Z6, A0A0A7C801, A0A0A7C805, A0A0A7C811, A0A0A7C816, A0A0A7C820, A0A0A7C825, A0A0A7C830, A0A0A7C834, A0A0A7C838, A0A0A7C842, A0A0A7C848, A0A0A7C852, A0A0A7C857, A0A0A7C861, A0A0A7C865, A0A0A7C871, A0A0A7C876, A0A0A7C881, A0A0A7C887, A0A0A7C890, A0A0A7C894, A0A0A7C899, A0A0A7C8A3, A0A0A7C8A9, A0A0A7C8B2, A0A0A7C8B8, A0A0A7C8C5, A0A0A7C8C9, A0A0A7C8D4, A0A0A7C8E0, A0A0A7C8E6, A0A0A7C8F2, A0A0A7C8F7, A0A0A7C8G2, A0A0A7C8G6, A0A0A7C8H1, A0A0A7C8I7, A0A0A7C8J1, A0A0A7C8J4, A0A0A7C8J7, A0A0A7C8K2, A0A0A7C8K7, A0A0A7C8L1, A0A0A7C8L5, A0A0A7C8M1, A0A0A7C8M4, A0A0A7C8N0, A0A0A7C8N4, A0A0A7C8N8, A0A0A7C8P3, A0A0A7C8P7, A0A0A7C8Q3, A0A0A7C8Q8, A0A0A7C8R2, A0A0A7C8R7, A0A0A7C8S1, A0A0A7C8S5, A0A0A7C8T0, A0A0A7C8T4, A0A0A7C8T7, A0A0A7C8U3, A0A0A7C8U8, A0A0A7C8V2, A0A0A7C8V6, A0A0A7C8W0, A0A0A7C8W6, A0A0A7C8X0, A0A0A7C8X5, A0A0A7C8Y0, A0A0A7C8Y3, A0A0A7C8Y9, A0A0A7C8Z3, A0A0A7C8Z8, A0A0A7C903, A0A0A7C908, A0A0A7C910, A0A0A7C915, A0A0A7C921, A0A0A7C926, A0A0A7C930, A0A0A7EBW5, A0A0A7UWW0, A0A0A7UZB1, A0A0A7V3H7, A0A0A8R645, A0A0A8R968, A0A0A8WIM0, A0A0C5BI36, A0A0D4CZE3, A0A0D6E067, A0A0D6E0U1, A0A0D6E142, A0A0D6K959, A0A0D6K972, A0A0D6K976, A0A0D6K978, A0A0D6K9D0, A0A0D6K9D3, A0A0D6K9K6, A0A0D6K9K8, A0A0D6K9L7, A0A0D6K9L8, A0A0E3DBY5, A0A0E3DBY6, A0A0E3DBY7, A0A0E3DBY8, A0A0E3DBY9, A0A0E3DBZ0, A0A0E3DBZ1, A0A0E3DBZ2, A0A0E3DBZ3, A0A0E3DBZ4, A0A0E3DBZ5, A0A0E3DBZ6, A0A0E3DBZ7, A0A0E3DBZ8, A0A0E3DBZ9, A0A0E3DC00, A0A0E3DC01, A0A0E3DC02, A0A0E3DC03, A0A0E3DC04, A0A0E3DC05, A0A0E3DC07, A0A0E3DC08, A0A0E3DC10, A0A0E3DC11, A0A0E3DC21, A0A0E3DC23, A0A0E3DC25, A0A0E3DC27, A0A0E3DC29, A0A0E3DC32, A0A0E3DC34, A0A0E3DC35, A0A0E3DC37, A0A0E3DC39, A0A0E3DC42, A0A0E3DC43, A0A0E3DC45, A0A0E3DC47, A0A0E3DC49, A0A0E3DC51, A0A0E3DC53, A0A0E3DC55, A0A0E3DC57, A0A0E3DC58, A0A0E3DC60, A0A0E3DC63, A0A0E3DC65, A0A0E3DC67, A0A0E3DC69, A0A0E3DC70, A0A0E3DCK8, A0A0E3DCL1, A0A0E3DCL3, A0A0E3DCL5, A0A0E3DCL7, A0A0E3DCL9, A0A0E3DCM1, A0A0E3DCM3, A0A0E3DCM6, A0A0E3DCM8, A0A0E3DCN0, A0A0E3DCN3, A0A0E3DCN7, A0A0E3DCP0, A0A0E3DCP2, A0A0E3DCP5, A0A0E3DCP9, A0A0E3DCQ2, 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A0A1G4HPZ1, A0A1G4HQ05, A0A1G4HQ08, A0A1G4NQQ7, A0A1G4NQS3, A0A1G4NQV4, A0A1G4P1W1, A0A1L2BM07, A0A1L2BM09, A0A1L2BM11, A0A1L2BM12, A0A1L2BM14, A0A1L2BM15, A0A1L2BM16, A0A1L2BM17, A0A1L2BM18, A0A1L2BM19, A0A1L2BM20, A0A1L2BM21, A0A1L2BM22, A0A1L2BM23, A0A1L2BM24, A0A1L2BM25, A0A1L2BM26, A0A1L2BM27, A0A1L2BM28, A0A1L2BM29, A0A1L2BM30, A0A1L2BM31, A0A1L2BM32, A0A1L2BM33, A0A1L2BM34, A0A1L2BM35, A0A1L2BM36, A0A1L2BM37, A0A1L2BM38, A0A1L2BM39, A0A1L2BM40, A0A1L2BM41, A0A1L2BM42, A0A1L2BM43, A0A1L2BM44, A0A1L2BM45, A0A1L2BM46, A0A1L2BM47, A0A1L2BM48, A0A1L2BM49, A0A1L2BM50, A0A1L2BM51, A0A1L2BM52, A0A1L2BM53, A0A1L2BM54, A0A1L2BM55, A0A1L2BM56, A0A1L2BM57, A0A1L2BM58, A0A1L2BM59, A0A1L7NQ70, A0A1L7NQ88, A0A1L7SAQ6, A0A1M4NEL5, A0A1M4NEL8, A0A1M4NEL9, A0A1M4NF67, A0A1M4NFK5, A0A1P7ZSR8, A0A1P7ZSS7, A0A1P8SNK9, A0A1P8SNL2, A0A1S5QQP6, A0A1S5QQP8, A0A1S5QQQ1, A0A1S5QQQ2, A0A1S5QQQ3, A0A1S5QQQ4, A0A1S5QQQ5, A0A1S5QQQ6, A0A1S5QQQ7, A0A1S5QQQ8, A0A1S5QQR0, A0A1S5QQR1, A0A1S5QQR2, A0A1S5QQR3, A0A1S5QQR4, A0A1S5QQR5, A0A1S5QQR6, A0A1S5QQR7, A0A1S5QQR8, A0A1S5QQR9, A0A1S5QQS0, A0A1S5QQS1, A0A1S5QQS2, A0A1S5QQS3, A0A1S5QQS4, A0A1S5QQS5, A0A1S5QQS6, A0A1S5QQS7, A0A1S5QQS8, A0A1S5QQS9, A0A1S5QQT0, A0A1S5QQT1, A0A1S5QQT2, A0A1S5QQT3, A0A1S5QQT4, A0A1S5QQT5, A0A1S5QQT6, A0A1S5QQT7, A0A1S5QQT8, A0A1S5QQT9, A0A1S5QQU0, A0A1S5QQU1, A0A1S5QQU2, A0A1S5QQU3, A0A1S5QQU4, A0A1S5QQU5, A0A1S5QQU6, A0A1S5QQU7, A0A1S5QQU8, A0A1S5QQU9, A0A1S5QQV0, A0A1S5QQV1, A0A1S5QQV2, A0A1S5QQV3, A0A1S5QQV4, A0A1S5QQV5, A0A1S5QQV6, A0A1S5QQV7, A0A1S5QQV8, A0A1S5QQV9, A0A1S5QQW0, A0A1S5QQW2, A0A1S5QQW7, A0A1S5QQW9, A0A1S5UX46, A0A1S5UXJ4, A0A1S5UYW8, A0A1S6GKZ1, A0A1S6KJP4, A0A1S6Q4A9, A0A1S6Q4B3, A0A1S6Q4B8, A0A1S7SKC6, A0A1S7SKC8, A0A1S7SKF3, A0A1T4J273, A0A1T4J2C1, A0A1V0EFF1, A0A1V0EFF2, A0A1V0EFF3, A0A1V0EFF9, A0A1V0EFG6, A0A1V0EFI3, A0A1V0S7J8, A0A1V1IFP3, A0A1W1B5B7, A0A1W1B5J3, A0A1W1B5K0, A0A1W1B5L8, A0A1W1B5M6, A0A1W1B5N1, A0A1W1B5P4, A0A1W1B5Q4, A0A1W1B5Q9, A0A1W1B5R0, A0A1W1B5S1, A0A1W1B5T2, A0A1W1B5W5, A0A1W1B5W6, A0A1W1B5X9, A0A1W1B5Y6, A0A1W1B640, A0A1W1B663, A0A1W1B686, A0A1W1B695, A0A1W1B6A8, A0A1W1B6F7, A0A1W1B6J1, A0A1W1B6K1, A0A1W1B6Q0, A0A1W1RMX8, A0A1W1RMZ0, A0A1W1RN09, A0A1W1RN11, A0A1W2PPF8, A0A1W2PPQ2, A0A1W2PQD0, A0A1W2PQS8, A0A1W2PR61, A0A1W2PRT9, A0A1W2PS24, A0A1W2PS39, A0A1W2PSE7, A0A1W6C2K7, A0A1W6C2M7, A0A1W6C2M8, A0A1W7IP21, A0A1X6WJD8, A0A1X9I3I5, A0A1X9I3I8, A0A1X9I3K2, A0A1X9I3K3, A0A1X9I3K4, A0A1X9I3L1, A0A1X9I3L4, A0A1X9I3L5, A0A1X9I3L6, A0A1X9I3M3, A0A1X9I3M4, A0A1X9I3N3, A0A1X9I3N4, A0A1X9I3N9, A0A1X9I3P0, A0A1X9I3P1, A0A1X9I3P7, A0A1X9I3P8, A0A1X9I3Q0, A0A1X9I3Q1, A0A1X9I3Q5, A0A1X9I3Q7, A0A1X9I3R4, A0A1X9I3R5, A0A1X9I3R8, A0A1X9I3R9, A0A1X9I3S3, A0A1X9I3S5, A0A1X9I3S8, A0A1X9I3T0, A0A1X9I3T2, A0A1X9I3T7, A0A1X9I3T8, A0A1X9I3T9, A0A1X9I3U0, A0A1X9I3U1, A0A1X9I3U3, A0A1X9I3U6, A0A1X9I3U9, A0A1X9I3V1, A0A1X9I3V5, A0A1X9I3W0, A0A1X9I3W1, A0A1X9I3W2, A0A1X9I3X2, A0A1X9I3X3, A0A1X9I3X4, A0A1X9I3X9, A0A1X9I3Y2, A0A1X9I3Y6, A0A1X9I3Y9, A0A1X9I3Z3, A0A1X9I3Z6, A0A1X9I402, A0A1X9I403, A0A1X9I406, A0A1X9I410, A0A1X9I412, A0A1X9I415, A0A1X9I420, A0A1X9I425, A0A1X9I468, A0A1X9I479, A0A1X9I488, A0A1X9I498, A0A1X9I4A5, A0A1X9I4B6, A0A1X9I4C3, A0A1X9I4D6, A0A1X9I4E7, A0A1X9I4G2, A0A1X9I4H8, A0A1X9I4I8, A0A1X9I4J7, A0A1X9I4K7, A0A1X9I4L5, A0A1X9I4M6, A0A1X9I4P2, A0A1X9I5B7, A0A1X9I5C7, A0A1X9I5D8, A0A1X9I5E3, A0A1X9I5F5, A0A1X9I5G1, A0A1X9I5H3, A0A1X9I5I4, A0A1X9PY90, A0A1Y5VQX9, A0A1Y5VRC7, A0A1Y6MTK5, A0A1Z1EGK5, A0A1Z1VXE9, A0A1Z1VXF1, A0A1Z1VXF6, A0A1Z1VXF7, A0A1Z1VXF8, A0A1Z1W2A7, A0A1Z2R875, A0A1Z2R893, A0A1Z2RP15, A0A1Z2RP28, A0A1Z2RP38, A0A1Z2RTJ0, A0A1Z2RTJ5, A0A1Z2RTK1, A0A1Z2RTK2, A0A1Z2RTK7, A0A1Z2RTL3, A0A1Z2RTN7, A0A1Z2RTN8, A0A1Z2RTP1, A0A1Z2RTQ8, A0A1Z2RTQ9, A0A212MH17, A0A218N9T3, A0A220A3H0, A0A220IGB9, A0A222YTD5, A0A223FKV7, A0A223FKW4, A0A223FKW9, A0A223FKX1, A0A223FKY8, A0A223FKZ7, A0A223FL01, A0A223FL07, A0A223FL08, A0A223FL14, A0A223FL67, A0A223FL72, A0A223FL78, A0A223FL85, A0A223FL90, A0A223FLI6, A0A223FLI8, A0A223PK90, A0A238DAL8, A0A238HCM2, A0A238HDN6, A0A238TQ66, A0A286LD90, A0A286LD92, A0A286LD94, A0A286LD96, A0A286LD97, A0A286LD98, A0A286LDA0, A0A286LDA1, A0A286LDA3, A0A286LDA4, A0A286LDA5, A0A286LDA6, A0A286LDA7, A0A286LDA8, A0A286LDA9, A0A286LDB0, A0A286LDB1, A0A286LDB2, A0A286LDB3, A0A286LDB4, A0A286LDB6, A0A286LDB8, A0A286LDB9, A0A286LDC0, A0A286LDC1, A0A286LDC2, A0A286LDC3, A0A286LDD2, A0A286MC51, A0A286MC52, A0A286MC54, A0A286R104, A0A286R107, A0A286RNF0, A0A286RNF2, A0A286RNF6, A0A286RNF9, A0A286RNG0, A0A286RNG2, A0A286RNG3, A0A286RNG4, A0A286RNG5, A0A286RNG6, A0A286RNG7, A0A286RNG8, A0A286RNG9, A0A286RNH0, A0A286RNH2, A0A286RNH6, A0A286RNH8, A0A286RNH9, A0A286RNI0, A0A286RNI5, A0A286RNI7, A0A286RYQ4, A0A288Q8S1, A0A288Q8S4, A0A288Q8S9, A0A288Q8T6, A0A288Q8T9, A0A288Q8U2, A0A288Q8U7, A0A288Q8V2, A0A288Q8V4, A0A288Q8V9, A0A288Q8W0, A0A288Q8W7, A0A288Q8X5, A0A288Q9J8, A0A288Q9K5, A0A288Q9L3, A0A288Q9L9, A0A288Q9M5, A0A288Q9N3, A0A288Q9P2, A0A288QBX4, A0A288QBY1, A0A288QBZ0, A0A288QC03, A0A288QC11, A0A288QC20, A0A288QC30, A0A288QCN9, A0A288QCP7, A0A288QCQ8, A0A288QCR4, A0A288QCS1, A0A288QCS8, A0A288QCT7, A0A288QER0, A0A288QER7, A0A288QES5, A0A288QET2, A0A288QEU0, A0A288QEU7, A0A288QEV6, A0A288QRC2, A0A288QRC9, A0A288QRD7, A0A288QRE4, A0A288QRF2, A0A288QRF9, A0A288QRG6, A0A288QXR8, A0A288QXS9, A0A288QXT9, A0A288QXV2, A0A288QXW0, A0A288QXX0, A0A288R0D9, A0A288R0E7, A0A288R0F2, A0A288R0F9, A0A288R0G6, A0A288R0H2, A0A288R0I0, A0A288R129, A0A288R136, A0A288R146, A0A288R155, A0A288R159, A0A288R166, A0A288R173, A0A291HVI4, A0A291NGJ9, A0A291NGK6, A0A291NGN0, A0A291NMV1, A0A2D1CBM7, A0A2D1CHG2, A0A2D1WB98, A0A2D1WB99, A0A2D1WBC6, A0A2H4FZ96, A0A2H4FZ98, A0A2H4FZA1, A0A2H4FZA4, A0A2H4FZA5, A0A2H4FZA6, A0A2H4FZA7, A0A2H4FZA8, A0A2H4FZB0, A0A2H4FZB4, A0A2H4FZB5, A0A2H4FZB6, A0A2H4FZB7, A0A2H4FZB8, A0A2H4FZB9, A0A2H4FZC2, A0A2H4FZC3, A0A2H4FZC5, A0A2H4FZC6, A0A2H4FZC7, A0A2H4FZC9, A0A2H4FZD1, A0A2H4FZD2, A0A2H4FZD3, A0A2H4FZD6, A0A2H4FZD7, A0A2H4FZD8, A0A2H4FZE1, 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E1U673, E1U674, E1U675, E1U676, E1U677, E1Y422, E1Y6M4, E1Y6U1, E1Y7D1, E1Y7G0, E2D5K9, E2D5L0, E2D5L1, E2D5L2, E2D5L3, E2D5L4, E2D5L5, E2D5L6, E2D5L7, E2D5L8, E2D5L9, E2D5M0, E2D5M1, E2D5M2, E2D5M3, E2D5M4, E2D5M5, E2D5M6, E2D5M7, E2D5M8, E2D5M9, E2D5N0, E2D5N1, E2D5N2, E2D5N3, E2D5N4, E2D5N5, E2D5N6, E2D5N7, E2DH70, E2DH71, E2DH72, E2DH73, E2DH74, E2DH75, E2DH76, E2DH77, E2DH78, E2DH79, E2DH80, E2DH81, E2DH82, E2DH83, E2FIL8, E2G792, E2GD50, E2GHW7, E2GJD2, E2GJD3, E2GJD4, E2GJD5, E2GJD6, E2GJD7, E2GJD8, E2GJD9, E2GJE0, E2GJE1, E2GJE2, E2GJE3, E2GJE4, E2GJE5, E2GJE6, E2GJE7, E2GJE8, E2GJE9, E2GJF0, E2GJF1, E2GJF2, E2GJF3, E2GJF4, E2GJF5, E2GJF6, E2GJF7, E2GJF8, E2GJF9, E2GJG0, E2GJG1, E2GJG2, E2GJG3, E2GJG4, E2GJR3, E2GJR8, E2GJR9, E2GJS0, E2GJS1, E2GJS2, E3Q0X4, E3Q0X5, E3Q1L4, E3Q1V2, E3SG78, E3SG79, E3SG80, E3SG81, E3SG82, E3SG83, E3SG84, E3SG85, E3SG86, E3SG87, E3SG88, E3SG89, E3SG90, E3SWF4, E3SWF5, E3SWF6, E3SWF7, E3SWF8, E3SWF9, E3SWG0, E3SWG1, E3SWG2, E3SWG3, E3SWG4, E3SWG5, E3SWG6, E3SWG7, E3SWG8, E3SWG9, E3SWH0, E3SWH1, E3T0V4, E3T0V5, E3T0V6, E3T0V7, E3T0V8, E3T0V9, E3T0W0, E3T0W1, E3UM70, E3UN97, E3WH33, E3WH34, E3WH35, E5BBI6, E5D6K2, E5D6K3, E5D6K4, E5D6K5, E5D6K6, E5D6K7, E5D6K8, E5DCL6, E5DCL7, E5DCL8, E5DCL9, E5DCM0, E5DCM1, E5DCM2, E5DCM3, E5DCM4, E5DCM5, E5DCM6, E5FQ45, E5FQ47, E5FQ49, E5FXC2, E5FYM9, E5G0X0, E5G0X3, E5G0X4, E5G0X5, E5G0X6, E5G0X7, E5G0Y0, E5G0Y1, E5G0Y2, E5G0Y3, E5G0Y4, E5G0Y5, E5G0Y6, E5G0Y7, E5G0Y8, E5G0Y9, E5G6F9, E5G6I4, E5G6I5, E5G961, E7AJF9, E7BBA1, E7BBA3, E7BDE1, E7BJ52, E7BY85, E7BY86, E7BY87, E7BY88, E7BY89, E7BY90, E7BY91, E7BY92, E7BY93, E7BY94, E7BY95, E7CYP4, E7D4X3, E7DZI6, E7DZZ8, E7EAU7, E7EF84, E8ZF50, E8ZF51, E8ZF52, E8ZF53, E8ZF54, E9ABI2, E9ABI3, E9ABX3, E9BVB6, E9LXY0, E9LXY1, E9LXY2, E9LXY3, E9LXY4, E9LXY5, E9LXY6, E9LXY7, E9LXY8, E9LXY9, E9LXZ0, E9LXZ1, E9LXZ2, E9LXZ3, E9LXZ4, E9LXZ5, E9LXZ6, E9LXZ7, E9LXZ8, E9LXZ9, E9LY00, E9LY01, E9LY02, E9LY03, E9LY04, E9LY05, E9LY06, E9LY07, E9LY08, E9LY09, E9LY10, E9LY11, E9LY12, E9LY13, E9LY14, E9LY15, E9LY16, E9LY17, E9LY18, E9LY19, E9LY20, E9RK91, F0VRV7, F0VRV9, F1AQK5, F1AQK6, F1AQK7, F1AQK8, F1AQK9, F1AQL0, F1AQL1, F1AQL2, F1AQL3, F1AQL4, F1AQL5, F1AQL6, F1AQL7, F1AQL8, F1AQL9, F1C3G8, F1C5F3, F1CCR2, F1CCR3, F1CCR4, F1CCR5, F1CK26, F1CK27, F2RM39, F2VNB6, F2VNB7, F2VNB8, F2VNB9, F2VNC0, F2VNC1, F2VNC2, F2VNC3, F2VNC4, F2VNC5, F2VNC6, F2VNC7, F2VNC8, F2VNC9, F2VND0, F2VND1, F2VND2, F2VND3, F2VND4, F2VND5, F2VND6, F2VND7, F2VND8, F2VND9, F2VNE0, F2VNE1, F2VNE2, F2VNE3, F2VNE4, F2VNE5, F2VNE6, F2VNE7, F2VNE8, F2VNE9, F2VNF0, F2VNF1, F2VNF2, F2VNF3, F2VNF4, F2VNF5, F2VNF6, F2VNF7, F2VNF8, F2VNF9, F2VNG0, F2VNG1, F2VNG2, F2VNG3, F2VNG4, F2VNG5, F2VNG6, F2VNG7, F2VNG8, F2VNG9, F2VNH0, F2VNH1, F2VNH2, F2VNH3, F2VNH4, F2VNH5, F2VNH6, F2VNH7, F2VNH8, F2VNH9, F2VNI0, F2VNI1, F2VNI2, F2VNI3, F2VNI4, F2VNI5, F2VNI6, F2VNI7, F2VNI8, F2VNI9, F2VNJ0, F2VNJ1, F2VNJ2, F2VNJ3, F2VNJ4, F2VNJ5, F2VNJ6, F2VNJ7, F2VNJ8, F2VP50, F2VP51, F2VP52, F2VP53, F2VP54, F2VP55, F2VP56, F2VP57, F2VP58, F2VP59, F2VP60, F2VP61, F2VP62, F2VP63, F2VP64, F2VP65, F2VP66, F2VP67, F2VP68, F2VP69, F2VP70, F2VPU7, F2VYH2, F2VYH3, F2VYH4, F2VYH5, F2VYH6, F2VYH7, F2VYH8, F2VYH9, F2VYI0, F2VYI1, F2VYI2, F2VYI3, F2VYI4, F2VYI5, F2VYI6, F2VYI7, F2VYI8, F2X5P6, F2X5X0, F2X5X1, F2X5X2, F2X5X3, F2X5X4, F2X5X5, F2X5X6, F2X5X7, F2X5X8, F2X5X9, F2X5Y0, F2X5Y1, F2X5Y2, F2X5Y3, F2X5Y4, F2X5Y5, F2X5Y6, F2X5Y7, F2X5Y8, F2X5Y9, F2X5Z0, F2X5Z1, F2X5Z2, F2X5Z3, F2X5Z4, F2X5Z5, F2X5Z6, F2X5Z7, F2X5Z8, F2X5Z9, F2X600, F2X601, F2X602, F2X603, F2X604, F2X605, F2X606, F2X607, F2X608, F2X609, F2X610, F2X611, F2X612, F2X613, F2X614, F2X8C1, F2XI28, F2XI29, F2XI30, F2XI31, F2XI32, F2XI33, F2XI34, F2XI35, F2XI36, F4NC94, F4NCR9, F4YU05, F4YU06, F4YU07, F4YU08, F4YU09, F4YU10, F4YU11, F4YU12, F4YU13, F4YU14, F4YU15, F4YU16, F4YU17, F4YU18, F4YU19, F4YU20, F4YU21, F4YU22, F4YU23, F4YU24, F4YU25, F4YU26, F4YU27, F4YU28, F4YU29, F4YU30, F4YU31, F4YZT0, F4YZT1, F4YZT2, F4YZT3, F4YZT4, F4ZZU3, F5A552, F5ATC5, F5BZ30, F5CIU1, F6IB50, F6IB64, F6IB65, F6IQR9, F6IQS0, F6IQS1, F6IQS2, F6IQS3, F6IQS4, F6IQS5, F6IQS6, F6IQS7, F6IQS8, F6IQS9, F6IQT0, F6IQT1, F6IQT2, F6IQT3, F6IQT4, F6IQT5, F6IQT6, F6IQT7, F6IQT8, F6IQT9, F6IQU0, F6IQU1, F6IQU2, F6IQU3, F6IQU4, F6IQU5, F6IQU6, F6IQU7, F6IQU8, F6IQU9, F6IQV0, F6IQV1, F6IQV2, F6IQV3, F6IQV4, F6IQV5, F6IQV6, F6IQV7, F6IQV8, F6IQV9, F6IQW0, F6IQW1, F6IQW2, F6IQW3, F6IQW4, F6IQW5, F6IQW6, F6IQW7, F6IQW8, F6IQW9, F6IQX0, F6IQX1, F6IQX2, F6IQX3, F6IQX4, F6IQX5, F6IQX6, F6IQX7, F6IQX8, F6IQX9, F6IQY0, F6IQY1, F6IQY2, F6IQY3, F6IQY4, F6IQY5, F6IQY6, F6IQY7, F6IQY8, F6IQY9, F6IQZ0, F6IQZ1, F6IQZ2, F6IQZ3, F6IQZ4, F6IQZ5, F6IQZ6, F6IQZ7, F6IQZ8, F6IQZ9, F6IR00, F6IR01, F6IR02, F6IR03, F6IR04, F6IR05, F6IR06, F6IR07, F6IR08, F6IR09, F6IR10, F6IR11, F6IR12, F6IR13, F6IR14, F6IR15, F6IR16, F6IR17, F6IR18, F6IR19, F6IR20, F6IR21, F6IR22, F6IR23, F6IR24, F6IR25, F6IR26, F6IR27, F6IR28, F6IR29, F6IR30, F6IR31, F6IR32, F6IR33, F6IR34, F6IR35, F6IR36, F6IR37, F6IR38, F6IR39, F6IR40, F6IR41, F6IR42, F6IR43, F6IR44, F6IR45, F6IR46, F6IR47, F6IR48, F6IR49, F6IR50, F6IR51, F6IR52, F6IR53, F6IR54, F6IR55, F6IR56, F6IR57, F6IR58, F6KPP2, F6KRI8, F6KRI9, F6KRJ0, F6KRJ1, F6KRJ2, F6KRJ3, F6KRJ4, F6KRJ5, F6KRJ6, F6KRJ7, F6KRJ8, F6KRJ9, F6KRK0, F6KRK1, F6KRK2, F6KRK3, F6KRK4, F6KRK5, F6KRK6, F6KRK7, F6KRK8, F6KRK9, F6KRL0, F6KRL1, F6KRL2, F6KRL3, F6KRL4, F6KRL5, F6KRL6, F6KRL7, F6KRL8, F6KRL9, F6KRM0, F6KRM1, F6KRM2, F6KRM3, F6KRM4, F6KRM5, F6KRM6, F6KRM7, F6KRM8, F6KRM9, F6KRN0, F6KRN1, F6KRN2, F6KRN3, F6KRN4, F6KRN5, F6KRN6, F6KRN7, F6KRN8, F6KRN9, F6KRP0, F6KRP1, F6KRP2, F6KRP3, F6KRP4, F6KRP5, F6KRP6, F6KRP7, F6KTD6, F8KA50, F8LSV2, F8LSV3, F8LSY1, F8LSY2, F8R0Z7, F8R0Z8, F8R0Z9, F8R100, F8R101, F8R102, F8R103, F8R104, F8R105, F8R106, F8R107, F8R108, F8R109, F8R110, F8R111, F8R112, F8R113, F8R114, F8R115, F8R116, F8R117, F8R118, F8R119, F8R120, F8R121, F8R122, F8R123, F8R124, F8R125, F8R126, F8R127, F8R128, F8R129, F8R130, F8R131, F8R132, F8R133, F8R134, F8R135, F8R136, F8R137, F8R138, F8R139, F8R140, F8R141, F8R142, F8R143, F8R144, F8R145, F8R8G4, F8R8G5, F8R8G6, F8R8G7, F8R8G8, F8R8G9, F8R8H0, F8R8H1, F8R8H2, F8R8H3, F8R8H4, F8R8H5, F8R8H6, F8R8H7, F8R8H8, F8R8H9, F8R8I0, F8R8I1, F8R8I2, F8R8I3, F8R8I4, F8R8I5, F8R8I6, F8R8I7, F8R8I8, F8RHB8, F8RHB9, F8RHC0, F8RHC1, F8RHC2, F8RHC3, F8RHC4, F8RHC5, F8RHC6, F8RHC7, F8RHC8, F8RHC9, F8RHD0, F8RHD1, F8RHD2, F8RHD3, F8RHD4, F8RHD5, F8RHD6, F8RHD7, F8RHD8, F8RHD9, F8RHE0, F8SKT2, F8SKT3, F8SKT4, F8SKT5, F8SKT6, F8SKT7, F8SKT8, F8SKT9, F8SKU0, F8SKU1, F8SKU2, F8SKU3, F8SKU4, F8SKU5, F8SKU6, F8SKU7, F8SKU8, F8SKU9, F8SKV0, F8SKV1, F8SKV2, F8SKV3, F8SKV4, F8SKV5, F8SKV6, F8SKV7, F8SKV8, F8SWL5, F8T1H2, F8T955, F8T956, F8T959, F8WS75, F8WSC6, F8WSC7, F8WSJ2, G0KXG7, G0KXG8, G0KXG9, G0KXH0, G0KXH1, G0KXH2, G0KXH3, G0KXH4, G0KXH5, G0KXH6, G0KXH7, G0KXH8, G0KXH9, G0KXI0, G0KXI1, G0KXI2, G0KXI3, G0KXI4, G0KXI5, G0KXI6, G0KXI7, G0KXI8, G0KXI9, G0M6G1, G0M6G2, G0UE14, G0W2J0, G0WV99, 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U5YBS4, U5YBS8, U5YBT3, U5YBT8, U5YBV5, U5YBW6, U5YBX1, U5YC91, U5YC96, U5YCA1, U5YCA6, U5YCB1, U5YCB5, U5YCC0, U5YCC5, U5YCD0, U5YCD5, U5YCE0, U5YCE5, U5YCF1, U5YCF5, U5YCF9, U5YCG4, U5YCH0, U5YCH5, U5YCI0, U5YCI5, U5YCJ1, U5YCJ6, U5YCK3, U5YCK8, U5YCL3, U5YCN4, U5YCP4, U5YCP9, U5YCQ3, U5YE56, U5YE73, U5YE78, U5YE82, U5YE88, U5YE94, U5YE97, U5YEA3, U5YEA7, U5YEB4, U5YEB7, U5YEB8, U5YEC1, U5YEC2, U5YEC4, U5YEC6, U5YEC8, U5YED1, U5YED5, U5YED6, U5YED9, U5YEE0, U5YEE3, U5YEE4, U5YEE6, U5YEE9, U5YEF0, U5YEF3, U5YEF5, U5YEF8, U5YEG0, U5YEG3, U5YEG4, U5YEG8, U5YEG9, U5YEH3, U5YEH4, U5YEH8, U5YEI0, U5YEI2, U5YEI4, U5YEI7, U5YEJ0, U5YEJ4, U5YEJ8, U5YEK1, U5YEK2, U5YEK5, U5YEK8, U5YEL0, U5YEL1, U5YEL4, U5YEL6, U5YEL7, U5YEM9, U5YEP2, U5YEP7, U5YEQ3, U5YJG6, U5YJH0, U5YJH4, U5YJH8, U5YJI3, U5YJI7, U5YJJ1, U5YJJ6, U5YJK1, U5YJK6, U5YJL1, U5YJL3, U5YJL8, U5YJM1, U5YJM7, U5YJN1, U5YJN4, U5YJN8, U5YJP1, U5YJP4, U5YJP8, U5YJQ0, U5YJQ4, U5YJQ7, U5YJR3, U5YJR6, U5YKC3, U5YKC8, U5YKD2, U5YKD6, U5YKE0, U5YKE3, U5YKE8, U5YKF4, U5YKF9, U5YKG4, U5YKG9, U5YKH4, U5YKI0, U5YME5, U5YMF0, U5YMF4, U5YMF9, U5YMG4, U5YMG9, U5YMH5, U5YMI0, U5YMI4, U5YMI9, U5YMJ4, U5YMJ8, U5YMK3, U5YML8, U5YMM3, U5YMM6, U5YMN1, U5YMN5, U5YMP0, U5YMP4, U5YMP9, U5YMQ3, U5YMQ8, U5YMR3, U5YMR8, U5YQI8, U5YQQ7, U5YRJ1, U5YTN0, U6A3P1, U6BZQ8, U6ER51, U6ERM7, U6EV21, U6JME0, U6JMI6, V5J9X6, V5J9X8, V5JA12, V5JA64, V5JA85, V5JAA3, V5JAA9, V5JAD1, V5JAE0, V5JAN7, V5JAP4, V5JAQ5, V5L197, V5L1W2, V5LD31, V5LD35, V5LD40, V5LD45, V5LD49, V5LD53, V5LD58, V5LDE0, V5LDE6, V5LDF1, V5LDF6, V5LDG2, V5LDG7, V5LDH2, V5LDH8, V5LDR8, V5LDS3, V5LDS6, V5LDT2, V5LDT4, V5LDT8, V5LDU3, V5LDU7, V5LDX0, V5LDX5, V5LDX8, V5LDY3, V5LDY9, V5LDZ4, V5LDZ9, V5LE04, V5LEQ5, V5LER0, V5LER4, V5LER9, V5LES4, V5LET0, V5LET5, V5LEU0, V5N2H8, V5NE49, V5P5S1, V5V1E3, V6A6U0, V6BNY6, V6BQN6, V6BQN7, V6BQQ4, V6BQS2, V6CKU4, V9N2U2, V9N2X1, V9N323, V9N358, V9N3G0, V9VYY9, V9W2L5, W0FBM8, W0FF27, W0G8I7, W0HE34, W0HE38, W0HE66, W0HE70, W0HE75, W0HHL7, W0HHM2, W0HII0, W0HII4, W0HIR6, W0HIR9, W0NPW3, W0NPY2, W0NQ20, W0NT88, W0NTA5, W0NTM2, W0NUB3, W0NUD2, W0T236, W0UTP4, W1I6E7, W1IAW1, W1IB93, W5REB9, W5REC9, W5RED8, W5ZPB5, W6JNQ2, W6RT42, W6SIV4, W6SNC0, W6SQV0, W8E988, W8NKM3, W8NKP1, W8NKY4, W8SKC0, W8Y4A2, W8YM39, W9AAG4, X2J3V4, X2J8Y7, X2KUP9, X2KUQ3, X2KXS0, X2KXS7, X2KYQ5, X2KYR1, X2KYU6, X2KYV2, X2L4W9, X2L4X5, X2L7S8, X4YT82, X4YZB9, X5CHJ2, X5D2K4, X5EM81, X5JBB1, X5LKD6, X5LRQ8, X5M4Y6, X5M4Z2, X5MBH2, X5MBH5, X5MBH7, X5MFD7, X5MFE4, X5MFE7, X5MI15, X5MI18, X5MI21, X5MNS3, X5MNS5, X5MPH1, X5MPH3, X5MPH4,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
HLA-A	GO:0001913	T cell mediated cytotoxicity	7504010
HLA-A	GO:0002419	T cell mediated cytotoxicity directed against tumor cell target	1402688|17189421|20364150
HLA-A	GO:0002726	positive regulation of T cell cytokine production	24643698
HLA-A	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	1402688|20364150|24643698
HLA-A	GO:0036037	CD8-positive, alpha-beta T cell activation	1402688|2784196|7504010|8630735|12138174|17189421|20364150
HLA-A	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	7504010|12138174
HLA-A	GO:0050852	T cell receptor signaling pathway	10435578
HLA-A	GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	24643698

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Gene structures and expression levels for HLA-A

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000206503

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PG	UP	ENST00000376809.10	HLA-A-203:protein_coding:HLA	1.747429e+02	8.484248e-01	4.016650e-03	3.921272e-02
CB	UP	ENST00000638375.1	HLA-A-209:protein_coding:HLA	1.477663e+01	1.263165e+00	8.615386e-04	4.555500e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HLA-A

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_193776	chr6	29943285:29943543:29944122:29944397:29944500:29944616	29944122:29944397
exon_skip_201021	chr6	29944122:29944397:29944500:29944616:29945059:29945091	29944500:29944616
exon_skip_277188	chr6	29944122:29944397:29944500:29945091:29945234:29945280	29944500:29945091
exon_skip_66179	chr6	29944122:29944397:29945059:29945091:29945234:29945280	29945059:29945091
exon_skip_80209	chr6	29944122:29944397:29944500:29944634:29945059:29945091	29944500:29944634

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for HLA-A

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

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Infer the effects of exon skipping event on protein functional features for HLA-A

p-ENSG00000206503_img4.png

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

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3'-UTR located exon skipping events that lost miRNA binding sites in HLA-A

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for HLA-A

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for HLA-A

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HLA-A

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
CB	exon_skip_201021	rs9258750	chr6:29861195	7.433882e-06	2.029300e-03

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Correlation with RNA binding proteins (RBPs) for HLA-A

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

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RelatedDrugs for HLA-A

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for HLA-A

Diseases associated with this gene. (DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

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