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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CD209 |
Gene summary |
Gene information | Gene symbol | CD209 | Gene ID | 30835 |
Gene name | CD209 molecule | |
Synonyms | CDSIGN|CLEC4L|DC-SIGN|DC-SIGN1 | |
Cytomap | 19p13.2 | |
Type of gene | protein-coding | |
Description | CD209 antigenC-type lectin domain family 4 member LHIV gpl20-binding proteindendritic cell-specific ICAM-3-grabbing non-integrin 1dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrindendritic cell-specific intracellular adh | |
Modification date | 20200327 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
CD209 | GO:0042102 | positive regulation of T cell proliferation | 12421943 |
CD209 | GO:0042129 | regulation of T cell proliferation | 12456590 |
CD209 | GO:0097323 | B cell adhesion | 12421943 |
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Gene structures and expression levels for CD209 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
STG | UP | 1.405016e+01 | 8.080141e-01 | 3.316197e-04 | 1.096192e-02 |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000315599.12 | CD209-203:protein_coding:CD209 | 8.808649e+00 | 1.265473e+00 | 3.240800e-04 | 2.160010e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CD209 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_142471 | chr19 | 7745518:7746087:7746460:7746531:7747306:7747365 | 7746460:7746531 |
exon_skip_24199 | chr19 | 7743175:7743240:7744941:7745092:7745518:7746087 | 7744941:7745092 |
exon_skip_256612 | chr19 | 7743175:7743240:7744107:7744219:7744941:7745092 | 7744107:7744219 |
exon_skip_46291 | chr19 | 7745942:7746087:7746460:7746531:7747306:7747365 | 7746460:7746531 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CD209 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000315599 | 7746460 | 7746531 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000315599 | 7746460 | 7746531 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000315599 | 7744107 | 7744219 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CD209 |
p-ENSG00000090659_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000315599 | 4300 | 404 | 7746460 | 7746531 | 130 | 200 | 35 | 59 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000315599 | 4300 | 404 | 7746460 | 7746531 | 130 | 200 | 35 | 59 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NNX6 | 35 | 59 | 16 | 59 | Alternative sequence | ID=VSP_010038;Note=In isoform 7 and isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11337487;Dbxref=PMID:11337487 |
Q9NNX6 | 35 | 59 | 35 | 404 | Alternative sequence | ID=VSP_010040;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11337487;Dbxref=PMID:11337487 |
Q9NNX6 | 35 | 59 | 36 | 59 | Alternative sequence | ID=VSP_010041;Note=In isoform 6%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11337487,ECO:0000303|PubMed:15489334;Dbxref=PMID:11337487,PMID:15489334 |
Q9NNX6 | 35 | 59 | 1 | 404 | Chain | ID=PRO_0000046595;Note=CD209 antigen |
Q9NNX6 | 35 | 59 | 1 | 37 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NNX6 | 35 | 59 | 59 | 404 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NNX6 | 35 | 59 | 38 | 58 | Transmembrane | Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9NNX6 | 35 | 59 | 16 | 59 | Alternative sequence | ID=VSP_010038;Note=In isoform 7 and isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11337487;Dbxref=PMID:11337487 |
Q9NNX6 | 35 | 59 | 35 | 404 | Alternative sequence | ID=VSP_010040;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11337487;Dbxref=PMID:11337487 |
Q9NNX6 | 35 | 59 | 36 | 59 | Alternative sequence | ID=VSP_010041;Note=In isoform 6%2C isoform 10%2C isoform 11 and isoform 12. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11337487,ECO:0000303|PubMed:15489334;Dbxref=PMID:11337487,PMID:15489334 |
Q9NNX6 | 35 | 59 | 1 | 404 | Chain | ID=PRO_0000046595;Note=CD209 antigen |
Q9NNX6 | 35 | 59 | 1 | 37 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NNX6 | 35 | 59 | 59 | 404 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Q9NNX6 | 35 | 59 | 38 | 58 | Transmembrane | Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CD209 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CD209 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CD209 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CD209 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CD209 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CD209 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CD209 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |