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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ANXA5 |
 Gene summary |
| Gene information | Gene symbol | ANXA5 | Gene ID | 308 |
| Gene name | annexin A5 | |
| Synonyms | ANX5|ENX2|HEL-S-7|PP4|RPRGL3 | |
| Cytomap | 4q27 | |
| Type of gene | protein-coding | |
| Description | annexin A5CBP-IPAP-IVAC-alphaanchorin CIIannexin Vannexin-5calphobindin Iendonexin IIepididymis secretory protein Li 7lipocortin Vplacental anticoagulant protein 4placental anticoagulant protein Ithromboplastin inhibitorvascular anticoagulan | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 32301581(Proteomic and Biological Profiling of Extracellular Vesicles From Alzheimer's Disease Human Brain Tissues) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ANXA5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000164111
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000501272.6 | ANXA5-202:protein_coding:ANXA5 | 1.942517e+01 | 5.740290e+00 | 8.343601e-06 | 4.394261e-04 |
| CB | DOWN | ENST00000501272.6 | ANXA5-202:protein_coding:ANXA5 | 8.317502e+01 | -2.191664e+00 | 6.522187e-03 | 2.448742e-02 |
| TC | DOWN | ENST00000501272.6 | ANXA5-202:protein_coding:ANXA5 | 4.292355e+01 | -3.291576e+00 | 1.742819e-04 | 2.502978e-03 |
| TC | DOWN | ENST00000515017.5 | ANXA5-210:protein_coding:ANXA5 | 1.271065e+01 | -3.171463e+00 | 1.949320e-03 | 1.646247e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ANXA5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_118785 | chr4 | 121677894:121677950:121678352:121678494:121681671:121681761 | 121678352:121678494 |
| exon_skip_129683 | chr4 | 121686288:121686372:121696581:121696624:121696863:121696992 | 121696581:121696624 |
| exon_skip_132756 | chr4 | 121683364:121683477:121686288:121686372:121696581:121696624 | 121686288:121686372 |
| exon_skip_164939 | chr4 | 121686288:121686372:121696581:121696624:121696863:121696962 | 121696581:121696624 |
| exon_skip_232046 | chr4 | 121677894:121677950:121678415:121678494:121681671:121681761 | 121678415:121678494 |
| exon_skip_245972 | chr4 | 121683364:121683477:121684677:121684771:121686288:121686371 | 121684677:121684771 |
| exon_skip_257541 | chr4 | 121683364:121683477:121684677:121684771:121686288:121686372 | 121684677:121684771 |
| exon_skip_272548 | chr4 | 121681671:121681761:121683364:121683477:121696581:121696624 | 121683364:121683477 |
| exon_skip_280135 | chr4 | 121681671:121681761:121683364:121683477:121686288:121686372 | 121683364:121683477 |
| exon_skip_46242 | chr4 | 121684677:121684771:121686288:121686372:121696581:121696624 | 121686288:121686372 |
| exon_skip_53465 | chr4 | 121681671:121681761:121683364:121683477:121684677:121684771 | 121683364:121683477 |
| exon_skip_68558 | chr4 | 121668246:121668527:121669602:121669724:121669954:121670012 | 121669602:121669724 |
| exon_skip_92840 | chr4 | 121669954:121670012:121671547:121671642:121672533:121672558 | 121671547:121671642 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ANXA5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296511 | 121678415 | 121678494 | Frame-shift |
| ENST00000296511 | 121684677 | 121684771 | Frame-shift |
| ENST00000296511 | 121686288 | 121686372 | Frame-shift |
| ENST00000296511 | 121669602 | 121669724 | In-frame |
| ENST00000296511 | 121671547 | 121671642 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296511 | 121684677 | 121684771 | Frame-shift |
| ENST00000296511 | 121671547 | 121671642 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000296511 | 121678415 | 121678494 | Frame-shift |
| ENST00000296511 | 121684677 | 121684771 | Frame-shift |
| ENST00000296511 | 121686288 | 121686372 | Frame-shift |
| ENST00000296511 | 121669602 | 121669724 | In-frame |
| ENST00000296511 | 121671547 | 121671642 | In-frame |
| ENST00000296511 | 121683364 | 121683477 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ANXA5 |
p-ENSG00000164111_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296511 | 1779 | 320 | 121671547 | 121671642 | 912 | 1006 | 208 | 240 |
| ENST00000296511 | 1779 | 320 | 121669602 | 121669724 | 1067 | 1188 | 260 | 300 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296511 | 1779 | 320 | 121671547 | 121671642 | 912 | 1006 | 208 | 240 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000296511 | 1779 | 320 | 121683364 | 121683477 | 476 | 588 | 63 | 100 |
| ENST00000296511 | 1779 | 320 | 121671547 | 121671642 | 912 | 1006 | 208 | 240 |
| ENST00000296511 | 1779 | 320 | 121669602 | 121669724 | 1067 | 1188 | 260 | 300 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P08758 | 208 | 240 | 2 | 320 | Chain | ID=PRO_0000067487;Note=Annexin A5 |
| P08758 | 208 | 240 | 203 | 217 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 208 | 240 | 221 | 228 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 208 | 240 | 231 | 245 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 208 | 240 | 180 | 240 | Repeat | Note=Annexin 3 |
| P08758 | 260 | 300 | 260 | 263 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 260 | 300 | 292 | 294 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HVG |
| P08758 | 260 | 300 | 2 | 320 | Chain | ID=PRO_0000067487;Note=Annexin A5 |
| P08758 | 260 | 300 | 266 | 276 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 260 | 300 | 281 | 290 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 260 | 300 | 296 | 303 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 260 | 300 | 290 | 290 | Modified residue | Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48036 |
| P08758 | 260 | 300 | 255 | 315 | Repeat | Note=Annexin 4 |
| P08758 | 260 | 300 | 279 | 279 | Sequence conflict | Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P08758 | 260 | 300 | 277 | 280 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P08758 | 208 | 240 | 2 | 320 | Chain | ID=PRO_0000067487;Note=Annexin A5 |
| P08758 | 208 | 240 | 203 | 217 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 208 | 240 | 221 | 228 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 208 | 240 | 231 | 245 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 208 | 240 | 180 | 240 | Repeat | Note=Annexin 3 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P08758 | 63 | 100 | 2 | 320 | Chain | ID=PRO_0000067487;Note=Annexin A5 |
| P08758 | 63 | 100 | 65 | 72 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 63 | 100 | 75 | 85 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 63 | 100 | 88 | 100 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 63 | 100 | 70 | 70 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P08758 | 63 | 100 | 76 | 76 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P08758 | 63 | 100 | 79 | 79 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P08758 | 63 | 100 | 97 | 97 | Modified residue | Note=N6-acetyllysine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861 |
| P08758 | 63 | 100 | 24 | 84 | Repeat | Note=Annexin 1 |
| P08758 | 63 | 100 | 96 | 156 | Repeat | Note=Annexin 2 |
| P08758 | 208 | 240 | 2 | 320 | Chain | ID=PRO_0000067487;Note=Annexin A5 |
| P08758 | 208 | 240 | 203 | 217 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 208 | 240 | 221 | 228 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 208 | 240 | 231 | 245 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 208 | 240 | 180 | 240 | Repeat | Note=Annexin 3 |
| P08758 | 260 | 300 | 260 | 263 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 260 | 300 | 292 | 294 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1HVG |
| P08758 | 260 | 300 | 2 | 320 | Chain | ID=PRO_0000067487;Note=Annexin A5 |
| P08758 | 260 | 300 | 266 | 276 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 260 | 300 | 281 | 290 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 260 | 300 | 296 | 303 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
| P08758 | 260 | 300 | 290 | 290 | Modified residue | Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48036 |
| P08758 | 260 | 300 | 255 | 315 | Repeat | Note=Annexin 4 |
| P08758 | 260 | 300 | 279 | 279 | Sequence conflict | Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P08758 | 260 | 300 | 277 | 280 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1ANX |
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3'-UTR located exon skipping events that lost miRNA binding sites in ANXA5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ANXA5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ANXA5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ANXA5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ANXA5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ANXA5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P08758 | approved|investigational|vet_approved | DB00591 | Fluocinolone acetonide | small molecule | P08758 |
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RelatedDiseases for ANXA5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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