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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for GRM3 |
Gene summary |
Gene information | Gene symbol | GRM3 | Gene ID | 2913 |
Gene name | glutamate metabotropic receptor 3 | |
Synonyms | GLUR3|GPRC1C|MGLUR3|mGlu3 | |
Cytomap | 7q21.11-q21.12 | |
Type of gene | protein-coding | |
Description | metabotropic glutamate receptor 3glutamate receptor, metabotropic 3 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for GRM3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000441140.1 | GRM3-204:protein_coding:GRM3 | 2.204711e+00 | 2.271555e+00 | 3.844206e-03 | 3.804657e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GRM3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_138851 | chr7 | 86644534:86644872:86765006:86765613:86786261:86786691 | 86765006:86765613 |
exon_skip_144716 | chr7 | 86838938:86839905:86850370:86850544:86864282:86864422 | 86850370:86850544 |
exon_skip_157016 | chr7 | 86786261:86787116:86838839:86839905:86850370:86850544 | 86838839:86839905 |
exon_skip_206137 | chr7 | 86786261:86787116:86838839:86839905:86850370:86850444 | 86838839:86839905 |
exon_skip_224825 | chr7 | 86765006:86765613:86786261:86787116:86850370:86850544 | 86786261:86787116 |
exon_skip_242824 | chr7 | 86644842:86644872:86765006:86765613:86786261:86786691 | 86765006:86765613 |
exon_skip_56034 | chr7 | 86838839:86839905:86850370:86850544:86864282:86864422 | 86850370:86850544 |
exon_skip_57445 | chr7 | 86786261:86787116:86850370:86850544:86864282:86864422 | 86850370:86850544 |
exon_skip_96257 | chr7 | 86838839:86839905:86850370:86850544:86864282:86864378 | 86850370:86850544 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for GRM3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000361669 | 86838839 | 86839905 | Frame-shift |
ENST00000361669 | 86850370 | 86850544 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000361669 | 86838839 | 86839905 | Frame-shift |
ENST00000361669 | 86850370 | 86850544 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000361669 | 86838839 | 86839905 | Frame-shift |
ENST00000361669 | 86850370 | 86850544 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for GRM3 |
p-ENSG00000198822_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in GRM3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for GRM3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GRM3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GRM3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for GRM3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | TARDBP | exon_skip_157016 | 5.061778e-01 | 2.128758e-11 |
CB | ZNF326 | exon_skip_157016 | 4.633034e-01 | 1.443671e-09 |
CB | ELAVL1 | exon_skip_157016 | 4.763758e-01 | 4.243114e-10 |
CB | CNOT4 | exon_skip_157016 | 5.441369e-01 | 3.017621e-13 |
CB | MBNL1 | exon_skip_157016 | 4.673468e-01 | 9.939649e-10 |
CB | MATR3 | exon_skip_157016 | 4.324849e-01 | 2.127932e-08 |
CB | PCBP1 | exon_skip_157016 | 4.019497e-01 | 2.378375e-07 |
CB | KHSRP | exon_skip_157016 | 4.456265e-01 | 6.980073e-09 |
CB | RBM23 | exon_skip_157016 | 4.683535e-01 | 9.050717e-10 |
CB | RBM41 | exon_skip_157016 | 4.807221e-01 | 2.791643e-10 |
CB | HNRNPF | exon_skip_157016 | 4.716560e-01 | 6.641655e-10 |
DLPFC | DAZAP1 | exon_skip_157016 | -4.383473e-01 | 7.813259e-17 |
DLPFC | RBM25 | exon_skip_157016 | -5.232426e-01 | 1.891029e-24 |
DLPFC | RBM6 | exon_skip_157016 | -4.036703e-01 | 2.760042e-14 |
DLPFC | SRSF11 | exon_skip_157016 | -4.089944e-01 | 1.171016e-14 |
DLPFC | PCBP4 | exon_skip_157016 | -5.455124e-01 | 7.943755e-27 |
DLPFC | SNRPA | exon_skip_157016 | -4.211911e-01 | 1.549440e-15 |
DLPFC | CELF1 | exon_skip_157016 | -4.347962e-01 | 1.470422e-16 |
DLPFC | NOVA1 | exon_skip_157016 | -4.421274e-01 | 3.953305e-17 |
HCC | RBM3 | exon_skip_157016 | -4.978065e-01 | 2.590871e-18 |
TC | RBMS2 | exon_skip_206137 | 6.658221e-01 | 1.015485e-21 |
TC | MSI1 | exon_skip_206137 | 4.398543e-01 | 6.590138e-09 |
TC | IGF2BP2 | exon_skip_206137 | 4.437597e-01 | 4.667609e-09 |
TC | RBM47 | exon_skip_206137 | 4.336466e-01 | 1.130173e-08 |
TC | RBM41 | exon_skip_206137 | 4.058916e-01 | 1.108321e-07 |
TC | HNRNPF | exon_skip_206137 | 5.468959e-01 | 8.779013e-14 |
TC | NOVA1 | exon_skip_206137 | -4.374010e-01 | 8.166447e-09 |
TC | ZC3H10 | exon_skip_206137 | 5.151667e-01 | 3.708858e-12 |
TC | RBM4B | exon_skip_206137 | 4.430691e-01 | 4.962725e-09 |
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RelatedDrugs for GRM3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GRM3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |