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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CD274 |
 Gene summary |
| Gene information | Gene symbol | CD274 | Gene ID | 29126 |
| Gene name | CD274 molecule | |
| Synonyms | B7-H|B7H1|PD-L1|PDCD1L1|PDCD1LG1|PDL1|hPD-L1 | |
| Cytomap | 9p24.1 | |
| Type of gene | protein-coding | |
| Description | programmed cell death 1 ligand 1B7 homolog 1CD274 antigenPDCD1 ligand 1 | |
| Modification date | 20200329 | |
| UniProtAcc | Q9NZQ7, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CD274 | GO:0006955 | immune response | 10581077 |
| CD274 | GO:0007165 | signal transduction | 10581077 |
| CD274 | GO:0007166 | cell surface receptor signaling pathway | 10581077 |
| CD274 | GO:0031295 | T cell costimulation | 10581077 |
| CD274 | GO:0034097 | response to cytokine | 17489864 |
| CD274 | GO:1905399 | regulation of activated CD4-positive, alpha-beta T cell apoptotic process | 24187568 |
| CD274 | GO:1905404 | positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process | 24187568 |
| CD274 | GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation | 24691993 |
| CD274 | GO:2001181 | positive regulation of interleukin-10 secretion | 10581077 |
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Gene structures and expression levels for CD274 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000120217
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000381573.8 | CD274-201:protein_coding:CD274 | 4.153062e+01 | -1.138236e+00 | 7.626914e-03 | 2.784011e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CD274 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_233238 | chr9 | 5465499:5465606:5466770:5466829:5467840:5467866 | 5466770:5466829 |
| exon_skip_237459 | chr9 | 5450542:5450596:5456100:5456165:5457079:5457420 | 5456100:5456165 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CD274 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381577 | 5456100 | 5456165 | 5CDS-5UTR |
| ENST00000381577 | 5466770 | 5466829 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381577 | 5466770 | 5466829 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CD274 |
p-ENSG00000120217_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000381577 | 3661 | 290 | 5466770 | 5466829 | 878 | 936 | 264 | 283 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000381577 | 3661 | 290 | 5466770 | 5466829 | 878 | 936 | 264 | 283 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NZQ7 | 264 | 283 | 179 | 290 | Alternative sequence | ID=VSP_013737;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15780196;Dbxref=PMID:14702039,PMID:15780196 |
| Q9NZQ7 | 264 | 283 | 19 | 290 | Chain | ID=PRO_0000014553;Note=Programmed cell death 1 ligand 1 |
| Q9NZQ7 | 264 | 283 | 260 | 290 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NZQ7 | 264 | 283 | 179 | 290 | Alternative sequence | ID=VSP_013737;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15780196;Dbxref=PMID:14702039,PMID:15780196 |
| Q9NZQ7 | 264 | 283 | 19 | 290 | Chain | ID=PRO_0000014553;Note=Programmed cell death 1 ligand 1 |
| Q9NZQ7 | 264 | 283 | 260 | 290 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CD274 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CD274 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CD274 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CD274 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CD274 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CD274 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q9NZQ7 | approved|investigational | DB11595 | Atezolizumab | biotech | Q9NZQ7 |
| Q9NZQ7 | approved|investigational | DB11714 | Durvalumab | biotech | Q9NZQ7 |
| Q9NZQ7 | approved|investigational | DB11945 | Avelumab | biotech | Q9NZQ7 |
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RelatedDiseases for CD274 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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