|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for TAGLN3 |
 Gene summary |
| Gene information | Gene symbol | TAGLN3 | Gene ID | 29114 |
| Gene name | transgelin 3 | |
| Synonyms | NP22|NP24|NP25 | |
| Cytomap | 3q13.2 | |
| Type of gene | protein-coding | |
| Description | transgelin-3neuronal protein 22neuronal protein NP25 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for TAGLN3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000144834
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| PG | DOWN | 1.089151e+03 | -8.680013e-01 | 4.437798e-08 | 1.951269e-06 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
 |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000478951.6 | TAGLN3-205:protein_coding:TAGLN3 | 5.651429e+02 | -9.558749e-01 | 1.828158e-07 | 2.442786e-05 |
| PG | DOWN | ENST00000393917.6 | TAGLN3-202:protein_coding:TAGLN3 | 1.013677e+02 | -9.190252e-01 | 4.181015e-05 | 1.435204e-03 |
| CB | DOWN | ENST00000486460.1 | TAGLN3-206:protein_coding:TAGLN3 | 1.894540e+02 | -7.465937e+00 | 1.228968e-13 | 2.673231e-11 |
| TC | DOWN | ENST00000469385.1 | TAGLN3-204:protein_coding:TAGLN3 | 1.756365e+02 | -1.226945e+00 | 2.923597e-04 | 3.766585e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TAGLN3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_111753 | chr3 | 112000772:112000946:112011763:112011865:112013410:112013474 | 112011763:112011865 |
| exon_skip_117340 | chr3 | 112000772:112000946:112011763:112011865:112013410:112013509 | 112011763:112011865 |
| exon_skip_133204 | chr3 | 112000772:112000946:112011763:112011865:112013410:112013438 | 112011763:112011865 |
| exon_skip_150545 | chr3 | 111999421:111999602:112000772:112000946:112011763:112011792 | 112000772:112000946 |
| exon_skip_161469 | chr3 | 112000772:112000946:112011763:112011865:112013410:112013444 | 112011763:112011865 |
| exon_skip_165463 | chr3 | 111998922:111999114:111999421:111999602:112000772:112000946 | 111999421:111999602 |
| exon_skip_181582 | chr3 | 112000772:112000946:112011763:112011865:112013410:112013422 | 112011763:112011865 |
| exon_skip_234445 | chr3 | 112000772:112000946:112011763:112011865:112013410:112013424 | 112011763:112011865 |
| exon_skip_243868 | chr3 | 111998922:111999114:111999326:111999602:112000772:112000946 | 111999326:111999602 |
| exon_skip_285434 | chr3 | 112000772:112000946:112011763:112011865:112013410:112013720 | 112011763:112011865 |
| exon_skip_33300 | chr3 | 111999423:111999602:112000772:112000946:112011763:112011865 | 112000772:112000946 |
| exon_skip_40414 | chr3 | 111999421:111999602:112000772:112000946:112011763:112011865 | 112000772:112000946 |
| exon_skip_69581 | chr3 | 112000772:112000946:112011763:112011865:112013410:112013523 | 112011763:112011865 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for TAGLN3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000273368 | 111999326 | 111999602 | 5CDS-5UTR |
| ENST00000478951 | 111999421 | 111999602 | 5CDS-5UTR |
| ENST00000273368 | 112000772 | 112000946 | Frame-shift |
| ENST00000393917 | 112000772 | 112000946 | Frame-shift |
| ENST00000455401 | 112000772 | 112000946 | Frame-shift |
| ENST00000478951 | 112000772 | 112000946 | Frame-shift |
| ENST00000273368 | 112011763 | 112011865 | Frame-shift |
| ENST00000393917 | 112011763 | 112011865 | Frame-shift |
| ENST00000455401 | 112011763 | 112011865 | Frame-shift |
| ENST00000478951 | 112011763 | 112011865 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000273368 | 112011763 | 112011865 | Frame-shift |
| ENST00000393917 | 112011763 | 112011865 | Frame-shift |
| ENST00000455401 | 112011763 | 112011865 | Frame-shift |
| ENST00000478951 | 112011763 | 112011865 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000273368 | 112000772 | 112000946 | Frame-shift |
| ENST00000393917 | 112000772 | 112000946 | Frame-shift |
| ENST00000455401 | 112000772 | 112000946 | Frame-shift |
| ENST00000478951 | 112000772 | 112000946 | Frame-shift |
| ENST00000273368 | 112011763 | 112011865 | Frame-shift |
| ENST00000393917 | 112011763 | 112011865 | Frame-shift |
| ENST00000455401 | 112011763 | 112011865 | Frame-shift |
| ENST00000478951 | 112011763 | 112011865 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for TAGLN3 |
p-ENSG00000144834_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in TAGLN3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for TAGLN3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for TAGLN3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TAGLN3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_161469 | rs3749310 | chr3:112011699 | 1.046429e-09 | 8.604287e-07 |
Top |
Correlation with RNA binding proteins (RBPs) for TAGLN3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for TAGLN3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TAGLN3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|