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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for UBE2T |
 Gene summary |
| Gene information | Gene symbol | UBE2T | Gene ID | 29089 |
| Gene name | ubiquitin conjugating enzyme E2 T | |
| Synonyms | FANCT|HSPC150|PIG50 | |
| Cytomap | 1q32.1 | |
| Type of gene | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 TE2 ubiquitin-conjugating enzyme THSPC150 protein similar to ubiquitin-conjugating enzymecell proliferation-inducing gene 50 proteinubiquitin carrier protein Tubiquitin conjugating enzyme E2Tubiquitin-conjugating enzy | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| UBE2T | GO:0006513 | protein monoubiquitination | 16916645|17938197|19111657 |
| UBE2T | GO:0035519 | protein K29-linked ubiquitination | 20061386 |
| UBE2T | GO:0044314 | protein K27-linked ubiquitination | 20061386 |
| UBE2T | GO:0051865 | protein autoubiquitination | 16916645|19111657 |
| UBE2T | GO:0070534 | protein K63-linked ubiquitination | 20061386 |
| UBE2T | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| UBE2T | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
| UBE2T | GO:0085020 | protein K6-linked ubiquitination | 20061386 |
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Gene structures and expression levels for UBE2T |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000077152
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for UBE2T |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_103658 | chr1 | 202333010:202333093:202333237:202333335:202333450:202333464 | 202333237:202333335 |
| exon_skip_106835 | chr1 | 202333450:202333555:202334989:202335058:202335642:202335818 | 202334989:202335058 |
| exon_skip_138145 | chr1 | 202333010:202333093:202333237:202333335:202333450:202333555 | 202333237:202333335 |
| exon_skip_259501 | chr1 | 202333450:202333555:202334989:202335058:202335646:202335818 | 202334989:202335058 |
| exon_skip_85801 | chr1 | 202333451:202333555:202334989:202335058:202335642:202335818 | 202334989:202335058 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for UBE2T |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000646651 | 202334989 | 202335058 | Frame-shift |
| ENST00000646651 | 202333237 | 202333335 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000646651 | 202333237 | 202333335 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000646651 | 202334989 | 202335058 | Frame-shift |
| ENST00000646651 | 202333237 | 202333335 | In-frame |
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Infer the effects of exon skipping event on protein functional features for UBE2T |
p-ENSG00000077152_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000646651 | 895 | 197 | 202333237 | 202333335 | 392 | 489 | 95 | 127 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000646651 | 895 | 197 | 202333237 | 202333335 | 392 | 489 | 95 | 127 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000646651 | 895 | 197 | 202333237 | 202333335 | 392 | 489 | 95 | 127 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NPD8 | 95 | 127 | 1 | 197 | Chain | ID=PRO_0000082509;Note=Ubiquitin-conjugating enzyme E2 T |
| Q9NPD8 | 95 | 127 | 104 | 116 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ |
| Q9NPD8 | 95 | 127 | 126 | 134 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ |
| Q9NPD8 | 95 | 127 | 99 | 101 | Mutagenesis | Note=No effect on FANCL-binding%2C nor on FANCL-dependent monoubiquitination of FANCD2. RPS->SPR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24389026;Dbxref=PMID:24389026 |
| Q9NPD8 | 95 | 127 | 93 | 95 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NPD8 | 95 | 127 | 1 | 197 | Chain | ID=PRO_0000082509;Note=Ubiquitin-conjugating enzyme E2 T |
| Q9NPD8 | 95 | 127 | 104 | 116 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ |
| Q9NPD8 | 95 | 127 | 126 | 134 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ |
| Q9NPD8 | 95 | 127 | 99 | 101 | Mutagenesis | Note=No effect on FANCL-binding%2C nor on FANCL-dependent monoubiquitination of FANCD2. RPS->SPR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24389026;Dbxref=PMID:24389026 |
| Q9NPD8 | 95 | 127 | 93 | 95 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NPD8 | 95 | 127 | 1 | 197 | Chain | ID=PRO_0000082509;Note=Ubiquitin-conjugating enzyme E2 T |
| Q9NPD8 | 95 | 127 | 104 | 116 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ |
| Q9NPD8 | 95 | 127 | 126 | 134 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ |
| Q9NPD8 | 95 | 127 | 99 | 101 | Mutagenesis | Note=No effect on FANCL-binding%2C nor on FANCL-dependent monoubiquitination of FANCD2. RPS->SPR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24389026;Dbxref=PMID:24389026 |
| Q9NPD8 | 95 | 127 | 93 | 95 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5OJJ |
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3'-UTR located exon skipping events that lost miRNA binding sites in UBE2T |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for UBE2T |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for UBE2T |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for UBE2T |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for UBE2T |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for UBE2T |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2T |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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