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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for SLC43A3 |
 Gene summary |
| Gene information | Gene symbol | SLC43A3 | Gene ID | 29015 |
| Gene name | solute carrier family 43 member 3 | |
| Synonyms | EEG1|ENBT1|FOAP-13|PRO1659|SEEEG-1 | |
| Cytomap | 11q12.1 | |
| Type of gene | protein-coding | |
| Description | solute carrier family 43 member 3likely ortholog of mouse embryonic epithelial gene 1 | |
| Modification date | 20200313 | |
| UniProtAcc | E9PJL1, E9PJL3, E9PJT6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SLC43A3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000134802
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000625097.1 | SLC43A3-226:TEC:SLC43A3 | 7.074673e+00 | 1.688583e+00 | 3.412500e-07 | 1.175536e-04 |
| HCC | UP | ENST00000625097.1 | SLC43A3-226:TEC:SLC43A3 | 5.481768e+00 | 9.447576e-01 | 2.327550e-04 | 1.267556e-02 |
| PG | UP | ENST00000625097.1 | SLC43A3-226:TEC:SLC43A3 | 4.466681e+00 | 8.891400e-01 | 2.393633e-03 | 2.713144e-02 |
| TC | UP | ENST00000395124.5 | SLC43A3-203:protein_coding:SLC43A3 | 1.824711e+02 | 8.337298e-01 | 1.141542e-03 | 1.095581e-02 |
| TC | UP | ENST00000528098.5 | SLC43A3-209:lncRNA:SLC43A3 | 2.332605e+00 | 8.760823e-01 | 2.775338e-03 | 2.151183e-02 |
| TC | UP | ENST00000528187.5 | SLC43A3-210:protein_coding:SLC43A3 | 9.680007e-01 | 1.429975e+00 | 4.371871e-03 | 3.027777e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SLC43A3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_160602 | chr11 | 57425989:57426316:57426588:57426652:57427062:57427100 | 57426588:57426652 |
| exon_skip_221408 | chr11 | 57425989:57426316:57426588:57426652:57427062:57427119 | 57426588:57426652 |
| exon_skip_235045 | chr11 | 57423982:57424028:57425541:57425670:57425989:57426352 | 57425541:57425670 |
| exon_skip_240925 | chr11 | 57426168:57426352:57426588:57426652:57426886:57426945 | 57426588:57426652 |
| exon_skip_255583 | chr11 | 57426168:57426352:57426588:57426652:57427062:57427100 | 57426588:57426652 |
| exon_skip_51505 | chr11 | 57423982:57424028:57425541:57425709:57425989:57426352 | 57425541:57425709 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SLC43A3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395123 | 57426588 | 57426652 | 3UTR-3UTR |
| ENST00000395124 | 57426588 | 57426652 | 3UTR-3UTR |
| ENST00000352187 | 57425541 | 57425670 | Frame-shift |
| ENST00000395123 | 57425541 | 57425670 | Frame-shift |
| ENST00000395124 | 57425541 | 57425670 | Frame-shift |
| ENST00000529554 | 57425541 | 57425670 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395123 | 57426588 | 57426652 | 3UTR-3UTR |
| ENST00000395124 | 57426588 | 57426652 | 3UTR-3UTR |
| ENST00000352187 | 57425541 | 57425670 | Frame-shift |
| ENST00000395123 | 57425541 | 57425670 | Frame-shift |
| ENST00000395124 | 57425541 | 57425670 | Frame-shift |
| ENST00000529554 | 57425541 | 57425670 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for SLC43A3 |
p-ENSG00000134802_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in SLC43A3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000395124 | 57426588 | 57426652 | hsa-miR-892c-5p | chr11:57426638-57426645 | 8mer-1a | chr11:57426632-57426652 | 147.00 | -20.56 |
| ROSMAP | ENST00000395124 | 57426588 | 57426652 | hsa-miR-892c-5p | chr11:57426638-57426645 | 8mer-1a | chr11:57426632-57426652 | 147.00 | -20.56 |
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SNVs in the skipped exons for SLC43A3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SLC43A3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC43A3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SLC43A3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for SLC43A3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC43A3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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