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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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3'-UTR located exon skipping events lost miRNA binding sites

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SNVs in the skipped exons with depth of coverage

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AD stage-associated exon skipping events

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Correlation with RNA binding proteins (RBPs)

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Related drugs with this gene

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Related diseases with this gene

Gene summary for ANK3

check button Gene summary
Gene informationGene symbol

ANK3

Gene ID

288

Gene nameankyrin 3
SynonymsANKYRIN-G|MRT37
Cytomap

10q21.2

Type of geneprotein-coding
Descriptionankyrin-3ankyrin 3, node of Ranvier (ankyrin G)
Modification date20200313
UniProtAcc

A0A087WTE8,

A0A087WTF3,

A0A087WTP5,

A0A087WVC2,

A0A087WWI5,

A0A087WX55,

A0A087WY90,

A0A087WZ26,

A0A087WZ65,

A0A087X0B4,

A0A087X0L3,

A8KA62,

B1AQT1,

D6RBY7,

D6RF31,

D6RFK6,

D6RHY3,

H0Y3A4,

H0Y8Z4,

H0Y951,

H0Y9E9,

H0YA66,

H0YAH5,

Q12955,

Context- 18163421(Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Gene structures and expression levels for ANK3

check buttonSkipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

ENSG00000151150
check button Differentially expressed gene analysis across multiple brain tissues between AD and control.
Tissue typeDEG directionBase mean exp.log2FC(AD/control)P-valueAdj. p-value

check button Differentially expressed isoform analysis across multiple brain tissues between AD and control.
gencode gene structure
Tissue typeDEG directionENSTTranscript info.Base mean exp.log2FC(AD/control)P-valueAdjc. p-value
PGUPENST00000593331.1KANK3-202:retained_intron:KANK34.543013e+001.277433e+006.915961e-052.093467e-03
PGUPENST00000330915.7KANK3-201:protein_coding:KANK35.153636e+018.390027e-013.889867e-047.386157e-03
PGUPENST00000610351.1KANK3-205:protein_coding:KANK31.942930e+001.505488e+004.426567e-048.103810e-03
CBUPENST00000465749.2ANK3-208:retained_intron:ANK34.747594e+001.050153e+002.313882e-098.751633e-08
CBDOWNENST00000373827.6ANK3-205:protein_coding:ANK32.551906e+03-8.381772e-011.494552e-072.980256e-06
CBUPENST00000618080.4ANK3-230:protein_coding:ANK32.381094e+001.355224e+006.499957e-071.039540e-05
CBUPENST00000622427.4ANK3-232:nonsense_mediated_decay:ANK33.930345e+029.568698e-018.941663e-071.363239e-05
CBUPENST00000467420.6ANK3-209:protein_coding:ANK37.324715e+018.849167e-013.534266e-064.381332e-05
CBUPENST00000610321.4ANK3-224:protein_coding:ANK31.154322e+039.634341e-011.111698e-051.152130e-04
CBUPENST00000503925.1ANK3-217:protein_coding:ANK31.921249e+001.550192e+006.086467e-054.861128e-04
CBUPENST00000621739.1ANK3-231:nonsense_mediated_decay:ANK34.228503e+021.207525e+002.207747e-041.448140e-03
TCUPENST00000618080.4ANK3-230:protein_coding:ANK31.855868e+008.690351e-011.860078e-042.638871e-03
TCUPENST00000503366.5ANK3-216:protein_coding:ANK32.362258e+019.134730e-011.932887e-031.635927e-02

check button Landscape of isoform expressions across multiple brain tissues between AD and control.
gencode gene structure

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ANK3

check button Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).
boxplot

check button All exon skipping events in AD cohorts.
Exon skip IDchrExons involved in exon skippingSkipped exon
exon_skip_101729chr1060145968:60146021:60166591:60166653:60166824:6016687560166591:60166653
exon_skip_10519chr1060234688:60234786:60261859:60261957:60263835:6026402060261859:60261957
exon_skip_117427chr1060186715:60186912:60196145:60196243:60196527:6019662160196145:60196243
exon_skip_118719chr1060108901:60109054:60111734:60111766:60114225:6011424660111734:60111766
exon_skip_122357chr1060042672:60042756:60055658:60056036:60059340:6005943060055658:60056036
exon_skip_144923chr1060044265:60044348:60051475:60051561:60053677:6005372760051475:60051561
exon_skip_154939chr1060134271:60134358:60137342:60137353:60138964:6013908760137342:60137353
exon_skip_157048chr1060108830:60109054:60111734:60111766:60114225:6011433160111734:60111766
exon_skip_157906chr1060067935:60068009:60068637:60076448:60080537:6008061860068637:60076448
exon_skip_165684chr1060056000:60056036:60059340:60059430:60063111:6006325460059340:60059430
exon_skip_169609chr1060056000:60056036:60059340:60059430:60059698:6006000660059340:60059430
exon_skip_174994chr1060200129:60200227:60203002:60203100:60205792:6020589060203002:60203100
exon_skip_180746chr1060073872:60076454:60080537:60080618:60082615:6008268660080537:60080618
exon_skip_180809chr1060138964:60139087:60145968:60146021:60166824:6016687560145968:60146021
exon_skip_187426chr1060198340:60198537:60200129:60200263:60203002:6020310060200129:60200263
exon_skip_188012chr1060067935:60068009:60080537:60080618:60082615:6008268660080537:60080618
exon_skip_201038chr1060106022:60106059:60108188:60108286:60108830:6010885160108188:60108286
exon_skip_21269chr1060059392:60059430:60059698:60060033:60063111:6006325460059698:60060033
exon_skip_216179chr1060064157:60064288:60067935:60068009:60080537:6008061860067935:60068009
exon_skip_217278chr1060138964:60139087:60166824:60166896:60172308:6017240360166824:60166896
exon_skip_222063chr1060064157:60064288:60067935:60068009:60073872:6007645460067935:60068009
exon_skip_23356chr1060080573:60080618:60082150:60082176:60082615:6008268660082150:60082176
exon_skip_241233chr1060067935:60068009:60073872:60076454:60080537:6008061860073872:60076454
exon_skip_246147chr1060059392:60059430:60059698:60060006:60063111:6006325460059698:60060006
exon_skip_248518chr1060198340:60198537:60200129:60200227:60203002:6020310060200129:60200227
exon_skip_249595chr1060067935:60068009:60068649:60068869:60069978:6007256960068649:60068869
exon_skip_257526chr1060106022:60106059:60108830:60109054:60114225:6011424660108830:60109054
exon_skip_260272chr1060106022:60106059:60108188:60108286:60108830:6010905460108188:60108286
exon_skip_263080chr1060173088:60173186:60181329:60181427:60186715:6018691260181329:60181427
exon_skip_26469chr1060056000:60056036:60059340:60060006:60063111:6006325460059340:60060006
exon_skip_267067chr1060044265:60044348:60051475:60051561:60055658:6005591760051475:60051561
exon_skip_269609chr1060067935:60068009:60068649:60068869:60069978:6007028360068649:60068869
exon_skip_273367chr1060138964:60139087:60166591:60166653:60166824:6016687560166591:60166653
exon_skip_277939chr1060108982:60109054:60111734:60111766:60114225:6011424660111734:60111766
exon_skip_281529chr1060186715:60186912:60196145:60196243:60196527:6019662560196145:60196243
exon_skip_284005chr1060042691:60042759:60053677:60053727:60055658:6005583260053677:60053727
exon_skip_286843chr1060261859:60261957:60263835:60264020:60270131:6027022960263835:60264020
exon_skip_293479chr1060063111:60063254:60064157:60064288:60067935:6006800960064157:60064288
exon_skip_49416chr1060134271:60134373:60137342:60137353:60138964:6013908760137342:60137353
exon_skip_49463chr1060064157:60064288:60067935:60068009:60069978:6007028360067935:60068009
exon_skip_58058chr1060278774:60278872:60279050:60279148:60279538:6027963960279050:60279148
exon_skip_61905chr1060172308:60172403:60172900:60172998:60173088:6017318660172900:60172998
exon_skip_63818chr1060051475:60051561:60053677:60053727:60055658:6005591760053677:60053727
exon_skip_66868chr1060106022:60106059:60108188:60108286:60108830:6010904260108188:60108286
exon_skip_71541chr1060213412:60213510:60234688:60234786:60261859:6026195760234688:60234786
exon_skip_72840chr1060138964:60139087:60145968:60146021:60166591:6016664460145968:60146021
exon_skip_87033chr1060082615:60082737:60083492:60083617:60084602:6008471560083492:60083617
exon_skip_95565chr1060172900:60172998:60173088:60173186:60181329:6018142760173088:60173186
exon_skip_97950chr1060138964:60139087:60145968:60146021:60166591:6016665360145968:60146021

check button Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.
psi tcga
Exon skipping informationTissue typeAvg(PSIs) in ADAvg(PSIs) in controlDifference (PSI)Adj. p-value
exon_skip_246147MSBB_PG3.774101e-012.337500e-011.436601e-014.070127e-07
exon_skip_273367MSBB_PG4.167606e-012.487273e-011.680333e-016.550028e-07


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Open reading frame (ORF) annotation in the exon skipping event for ANK3

check button Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF

check button Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF

check button Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF

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Infer the effects of exon skipping event on protein functional features for ANK3

p-ENSG00000151150_img4.png
boxplot

check button Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Lost protein functional features of individual exon skipping events in ROSMAP.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature

check button Lost protein functional features of individual exon skipping events in MSBB.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature

check button Lost protein functional features of individual exon skipping events in Mayo.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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3'-UTR located exon skipping events that lost miRNA binding sites in ANK3

check button 3'-UTR exon skipping evnets lost miRNA binding.
Tissue typeENSTExon skip startExon skip endmicroRNABinding site by TargetScanBinding type by TargetScanBdinding site by miRandaScore of miRandaEnergy by miRanda

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SNVs in the skipped exons for ANK3

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Depth of Coverage in the skipped exon of the mutated samples.

check button - Sashimi plot in the skipped exon of the mutated samples.

check button - Non-synonymous mutations located in the skipped exons.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

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AD stage-associated exon skippint events for ANK3

check button Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).
AD stage infoCohortTissueSE idCoefficient P-valueChromosomeStrandE1 startE1 endSkipped startSkipped endE2 startE2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ANK3

check button sQTL information located at the skipped exons.
Tissue typeExon skip IDSNP idLocationP-valueFDR

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Correlation with RNA binding proteins (RBPs) for ANK3

check button Correlated RBP and related information.
Tissue typeRBP nameExon skip IDCorrelation coeifficientP-value
CBSAMD4Aexon_skip_2461474.689567e-014.527570e-10
CBPCBP4exon_skip_246147-4.473383e-013.389678e-09
CBDAZAP1exon_skip_1579064.575027e-015.689704e-09
CBTARDBPexon_skip_1579065.669410e-017.110760e-14
CBRBFOX2exon_skip_1579065.372563e-012.288839e-12
CBZNF326exon_skip_1579064.617108e-013.953015e-09
CBELAVL1exon_skip_1579066.262059e-012.215155e-17
CBRBM28exon_skip_1579064.014373e-014.674200e-07
CBSAMD4Aexon_skip_1579064.319253e-014.695336e-08
CBU2AF2exon_skip_1579065.106464e-013.902413e-11
CBCNOT4exon_skip_1579065.663017e-017.691043e-14
CBMBNL1exon_skip_1579064.354567e-013.544595e-08
CBFXR2exon_skip_1579064.871440e-013.927205e-10
CBPCBP1exon_skip_1579064.748067e-011.232542e-09
CBRC3H1exon_skip_1579064.344986e-013.826746e-08
CBG3BP2exon_skip_1579064.968535e-011.545376e-10
CBSF1exon_skip_1579065.569820e-012.368294e-13
CBFUBP1exon_skip_1579064.567697e-016.059275e-09
CBKHSRPexon_skip_1579065.609833e-011.467546e-13
CBHNRNPA0exon_skip_1579064.022103e-014.421868e-07
CBPUM1exon_skip_1579065.422833e-011.302033e-12
CBHNRNPA2B1exon_skip_1579065.421115e-011.327578e-12
CBHNRNPABexon_skip_1579065.158972e-012.273398e-11
CBHNRNPCexon_skip_1579064.699652e-011.907230e-09
CBEIF4G2exon_skip_1579065.868067e-015.697156e-15
CBHNRNPLexon_skip_1579064.437972e-011.801400e-08
CBCPEB4exon_skip_1579064.835487e-015.506530e-10
CBCELF1exon_skip_1579064.979528e-011.387935e-10
CBRBM23exon_skip_1579065.405741e-011.578975e-12
CBEWSR1exon_skip_1579065.100287e-014.156005e-11
CBSRSF1exon_skip_1579065.438494e-011.090091e-12
CBSRSF4exon_skip_1579065.134320e-012.933206e-11
CBRBM41exon_skip_1579065.390860e-011.866004e-12
CBHNRNPFexon_skip_1579065.088812e-014.670099e-11
CBSART3exon_skip_1579064.080955e-012.884723e-07
CBRBM4exon_skip_1579065.137104e-012.850301e-11
CBRBM4Bexon_skip_1579065.469299e-017.665117e-13
CBZNF326exon_skip_1167554.198464e-011.790886e-07
CBU2AF2exon_skip_1167554.498157e-011.740421e-08
CBCNOT4exon_skip_1167554.173789e-012.148538e-07
CBKHSRPexon_skip_1167554.227832e-011.439228e-07
CBRBM23exon_skip_1167554.643107e-015.185943e-09
CBRBM4exon_skip_1167554.564786e-011.004590e-08
CBRBM4Bexon_skip_1167554.694917e-013.317881e-09
CBELAVL1exon_skip_2412334.543789e-013.642908e-09
CBCNOT4exon_skip_2412334.573949e-012.785552e-09
CBPCBP1exon_skip_2412334.359868e-011.770518e-08
CBTRA2Aexon_skip_2412334.254994e-014.185644e-08
CBKHSRPexon_skip_2412334.099783e-011.418957e-07
CBHNRNPABexon_skip_2412335.272635e-012.522701e-12
CBRBM23exon_skip_2412334.933897e-019.185149e-11
CBSRSF4exon_skip_2412334.301901e-012.858907e-08
CBRBM4exon_skip_2412336.948652e-012.216545e-23
CBRBM4Bexon_skip_2412335.965974e-014.032558e-16
DLPFCRBMS2exon_skip_2733675.867834e-011.085292e-23
DLPFCRBMS2exon_skip_241233-5.233003e-013.859398e-22
DLPFCRBFOX2exon_skip_2412336.007946e-012.496223e-30
DLPFCZNF326exon_skip_241233-4.513092e-013.291683e-16
DLPFCRBM6exon_skip_241233-4.472204e-016.517900e-16
DLPFCKHDRBS2exon_skip_2412335.141665e-012.623490e-21
DLPFCELAVL4exon_skip_246147-5.763746e-012.599926e-31
DLPFCCNOT4exon_skip_246147-4.005506e-011.861782e-14
DLPFCG3BP2exon_skip_246147-6.133077e-012.645810e-36
DLPFCKHDRBS2exon_skip_246147-6.416675e-011.310120e-40
DLPFCKHDRBS3exon_skip_246147-4.746058e-012.172129e-20
DLPFCENOX1exon_skip_246147-4.488792e-013.666385e-18
DLPFCKHSRPexon_skip_246147-5.226293e-014.370071e-25
DLPFCHNRNPA0exon_skip_246147-4.268221e-012.134862e-16
DLPFCHNRNPDexon_skip_246147-4.084750e-015.039895e-15
DLPFCRALYLexon_skip_246147-4.624887e-012.566869e-19
DLPFCHNRNPLexon_skip_246147-4.299075e-011.230638e-16
DLPFCEIF4Bexon_skip_246147-5.309927e-015.543683e-26
DLPFCRBMS2exon_skip_157906-5.151376e-014.151130e-20
DLPFCRBFOX2exon_skip_1579064.982300e-011.009241e-18
DLPFCPABPN1exon_skip_157906-4.425276e-011.156369e-14
DLPFCZNF326exon_skip_157906-4.871786e-017.399015e-18
DLPFCRBM6exon_skip_157906-4.217574e-012.493392e-13
DLPFCSRSF11exon_skip_157906-4.525638e-012.428242e-15
DLPFCRC3H1exon_skip_1579064.424081e-011.177706e-14
DLPFCKHDRBS2exon_skip_1579064.688403e-011.728150e-16
DLPFCPTBP1exon_skip_157906-4.608014e-016.487388e-16
DLPFCHNRNPFexon_skip_157906-4.512965e-012.965659e-15
DLPFCRC3H1exon_skip_2602724.473748e-018.350088e-14
DLPFCHNRNPFexon_skip_260272-4.071784e-011.752346e-11
FLELAVL4exon_skip_246147-4.221212e-017.167597e-10
FLEWSR1exon_skip_1579064.135097e-011.562228e-08
HCCDAZAP1exon_skip_2461475.582285e-019.132730e-24
HCCRBMS3exon_skip_2461474.041254e-013.781993e-12
HCCMSI1exon_skip_2461474.670502e-013.384167e-16
HCCPABPN1exon_skip_2461474.725308e-011.366757e-16
HCCRBM25exon_skip_2461474.079672e-012.259089e-12
HCCRBM28exon_skip_2461474.197839e-014.440284e-13
HCCRBM6exon_skip_2461476.028078e-012.128921e-28
HCCSRSF11exon_skip_2461475.136752e-018.769841e-20
HCCSAMD4Aexon_skip_2461474.576780e-011.537047e-15
HCCTIA1exon_skip_2461474.965062e-012.126872e-18
HCCRBM5exon_skip_2461475.701777e-016.130859e-25
HCCIGF2BP2exon_skip_2461474.274491e-011.493138e-13
HCCTRNAU1APexon_skip_2461474.922623e-014.551773e-18
HCCPCBP4exon_skip_2461476.433832e-012.693539e-33
HCCUNKexon_skip_2461475.628081e-013.285614e-24
HCCG3BP2exon_skip_246147-4.183324e-015.441280e-13
HCCKHDRBS2exon_skip_246147-4.006808e-015.969604e-12
HCCSF1exon_skip_2461474.157429e-017.800933e-13
HCCKHDRBS3exon_skip_2461475.210517e-012.106785e-20
HCCFUBP3exon_skip_2461474.828127e-012.385996e-17
HCCHNRNPA2B1exon_skip_2461474.424564e-011.629563e-14
HCCPTBP1exon_skip_2461476.208802e-011.717941e-30
HCCSRSF4exon_skip_2461474.266583e-011.672951e-13
HCCSRSF5exon_skip_2461474.486046e-016.368693e-15
HCCRBM41exon_skip_2461474.163594e-017.161822e-13
HCCHNRNPFexon_skip_2461475.109837e-011.463080e-19
HCCDAZAP1exon_skip_157906-5.183697e-014.162044e-20
HCCRBMS2exon_skip_157906-4.980336e-011.863684e-18
HCCRBMS3exon_skip_157906-5.002332e-011.250420e-18
HCCMSI1exon_skip_157906-4.259267e-012.057350e-13
HCCPABPN1exon_skip_157906-4.526984e-013.787501e-15
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TCNUP42exon_skip_2602726.446724e-013.620810e-20
TCRALYLexon_skip_2602727.041854e-012.830747e-25
TCEWSR1exon_skip_2602724.047019e-011.109317e-07
TCHNRNPH2exon_skip_2602726.538981e-016.952722e-21
TCELAVL4exon_skip_154939-4.297291e-014.148770e-07
TCHNRNPDexon_skip_273367-5.652161e-018.394555e-15

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RelatedDrugs for ANK3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANK3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource