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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TRIQK |
 Gene summary |
| Gene information | Gene symbol | TRIQK | Gene ID | 286144 |
| Gene name | triple QxxK/R motif containing | |
| Synonyms | C8orf83|PRO0845|UPF0599 | |
| Cytomap | 8q22.1 | |
| Type of gene | protein-coding | |
| Description | triple QxxK/R motif-containing proteinprotein TRIQKtriple repetitive-sequence of QXXK/R protein homolog | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TRIQK |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000205133
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000524107.5 | TRIQK-221:protein_coding:TRIQK | 4.883101e+00 | 1.172125e+00 | 1.297322e-08 | 3.758729e-07 |
| CB | UP | ENST00000521617.5 | TRIQK-213:protein_coding:TRIQK | 1.022316e+01 | 1.278848e+00 | 4.935366e-05 | 4.067952e-04 |
| CB | UP | ENST00000517540.5 | TRIQK-202:lncRNA:TRIQK | 4.377335e+00 | 1.627937e+00 | 6.388149e-04 | 3.547163e-03 |
| CB | UP | ENST00000520384.5 | TRIQK-210:lncRNA:TRIQK | 1.987297e+00 | 9.206580e-01 | 9.155876e-03 | 3.235332e-02 |
| CB | UP | ENST00000522903.5 | TRIQK-215:protein_coding:TRIQK | 1.058185e+00 | 8.116639e-01 | 1.040736e-02 | 3.592164e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TRIQK |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_10576 | chr8 | 92891989:92892074:92916929:92917007:92966007:92966074 | 92916929:92917007 |
| exon_skip_110449 | chr8 | 92916929:92917010:92954406:92954564:92965808:92965988 | 92954406:92954564 |
| exon_skip_139115 | chr8 | 92916967:92917007:92921503:92921660:92966007:92966074 | 92921503:92921660 |
| exon_skip_15270 | chr8 | 92916967:92917007:92954406:92954564:92966007:92966074 | 92954406:92954564 |
| exon_skip_176530 | chr8 | 92916967:92917007:92921503:92921660:92966007:92966111 | 92921503:92921660 |
| exon_skip_250705 | chr8 | 92891989:92892074:92954406:92954564:92966007:92966074 | 92954406:92954564 |
| exon_skip_257045 | chr8 | 92921503:92921660:92954406:92954564:92966007:92966111 | 92954406:92954564 |
| exon_skip_427 | chr8 | 92921503:92921660:92954406:92954564:92966007:92966074 | 92954406:92954564 |
| exon_skip_50118 | chr8 | 92916929:92917010:92921503:92921660:92966007:92966111 | 92921503:92921660 |
| exon_skip_53950 | chr8 | 92891989:92892074:92916929:92917010:92954406:92954564 | 92916929:92917010 |
| exon_skip_56449 | chr8 | 92891989:92892074:92916929:92917007:92954406:92954564 | 92916929:92917007 |
| exon_skip_58500 | chr8 | 92916967:92917007:92921503:92921660:92954406:92954564 | 92921503:92921660 |
| exon_skip_62014 | chr8 | 92916929:92917010:92921503:92921660:92966007:92966074 | 92921503:92921660 |
| exon_skip_66525 | chr8 | 92916929:92917010:92954406:92954564:92966007:92966074 | 92954406:92954564 |
| exon_skip_76626 | chr8 | 92954406:92954564:92960501:92960719:92966007:92966074 | 92960501:92960719 |
| exon_skip_7723 | chr8 | 92954406:92954564:92960501:92960719:92966007:92966143 | 92960501:92960719 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TRIQK |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000518748 | 92916929 | 92917007 | 3UTR-3CDS |
| ENST00000519969 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000520686 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000521988 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000524107 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000378861 | 92921503 | 92921660 | 3UTR-3UTR |
| ENST00000520430 | 92921503 | 92921660 | 3UTR-3UTR |
| ENST00000378861 | 92954406 | 92954564 | 3UTR-3UTR |
| ENST00000518748 | 92954406 | 92954564 | 3UTR-3UTR |
| ENST00000521988 | 92954406 | 92954564 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000518748 | 92916929 | 92917007 | 3UTR-3CDS |
| ENST00000519969 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000520686 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000521988 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000524107 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000378861 | 92921503 | 92921660 | 3UTR-3UTR |
| ENST00000520430 | 92921503 | 92921660 | 3UTR-3UTR |
| ENST00000378861 | 92954406 | 92954564 | 3UTR-3UTR |
| ENST00000518748 | 92954406 | 92954564 | 3UTR-3UTR |
| ENST00000521988 | 92954406 | 92954564 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000518748 | 92916929 | 92917007 | 3UTR-3CDS |
| ENST00000519969 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000520686 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000521617 | 92916929 | 92917007 | 3UTR-3CDS |
| ENST00000521988 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000524107 | 92916929 | 92917010 | 3UTR-3CDS |
| ENST00000378861 | 92921503 | 92921660 | 3UTR-3UTR |
| ENST00000520430 | 92921503 | 92921660 | 3UTR-3UTR |
| ENST00000378861 | 92954406 | 92954564 | 3UTR-3UTR |
| ENST00000518748 | 92954406 | 92954564 | 3UTR-3UTR |
| ENST00000521988 | 92954406 | 92954564 | 3UTR-3UTR |
| ENST00000524107 | 92954406 | 92954564 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for TRIQK |
p-ENSG00000205133_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TRIQK |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000520430 | 92921503 | 92921660 | hsa-miR-488-5p | chr8:92921531-92921538 | 8mer-1a | chr8:92921525-92921549 | 163.00 | -17.39 |
| Mayo | ENST00000520430 | 92921503 | 92921660 | hsa-miR-1252-3p | chr8:92921525-92921532 | 8mer-1a | chr8:92921525-92921549 | 163.00 | -17.39 |
| Mayo | ENST00000524107 | 92954406 | 92954564 | hsa-miR-5006-5p | chr8:92954511-92954518 | 8mer-1a | chr8:92954498-92954518 | 150.00 | -20.33 |
| Mayo | ENST00000520430 | 92921503 | 92921660 | hsa-miR-433-3p | chr8:92921601-92921608 | 8mer-1a | chr8:92921585-92921608 | 148.00 | -15.21 |
| Mayo | ENST00000520430 | 92921503 | 92921660 | hsa-miR-136-5p | chr8:92921542-92921549 | 8mer-1a | chr8:92921525-92921549 | 163.00 | -17.39 |
| Mayo | ENST00000524107 | 92954406 | 92954564 | hsa-miR-147b-5p | chr8:92954466-92954473 | 8mer-1a | chr8:92954459-92954483 | 164.00 | -23.80 |
| Mayo | ENST00000524107 | 92954406 | 92954564 | hsa-miR-4261 | chr8:92954466-92954473 | 8mer-1a | chr8:92954459-92954483 | 164.00 | -23.80 |
| Mayo | ENST00000524107 | 92954406 | 92954564 | hsa-miR-7702 | chr8:92954432-92954439 | 8mer-1a | chr8:92954428-92954447 | 152.00 | -20.44 |
| MSBB | ENST00000520430 | 92921503 | 92921660 | hsa-miR-488-5p | chr8:92921531-92921538 | 8mer-1a | chr8:92921525-92921549 | 163.00 | -17.39 |
| MSBB | ENST00000520430 | 92921503 | 92921660 | hsa-miR-1252-3p | chr8:92921525-92921532 | 8mer-1a | chr8:92921525-92921549 | 163.00 | -17.39 |
| MSBB | ENST00000521988 | 92954406 | 92954564 | hsa-miR-5006-5p | chr8:92954511-92954518 | 8mer-1a | chr8:92954498-92954518 | 150.00 | -20.33 |
| MSBB | ENST00000520430 | 92921503 | 92921660 | hsa-miR-433-3p | chr8:92921601-92921608 | 8mer-1a | chr8:92921585-92921608 | 148.00 | -15.21 |
| MSBB | ENST00000520430 | 92921503 | 92921660 | hsa-miR-136-5p | chr8:92921542-92921549 | 8mer-1a | chr8:92921525-92921549 | 163.00 | -17.39 |
| MSBB | ENST00000521988 | 92954406 | 92954564 | hsa-miR-147b-5p | chr8:92954466-92954473 | 8mer-1a | chr8:92954459-92954483 | 164.00 | -23.80 |
| MSBB | ENST00000521988 | 92954406 | 92954564 | hsa-miR-4261 | chr8:92954466-92954473 | 8mer-1a | chr8:92954459-92954483 | 164.00 | -23.80 |
| MSBB | ENST00000521988 | 92954406 | 92954564 | hsa-miR-7702 | chr8:92954432-92954439 | 8mer-1a | chr8:92954428-92954447 | 152.00 | -20.44 |
| ROSMAP | ENST00000520430 | 92921503 | 92921660 | hsa-miR-488-5p | chr8:92921531-92921538 | 8mer-1a | chr8:92921525-92921549 | 163.00 | -17.39 |
| ROSMAP | ENST00000520430 | 92921503 | 92921660 | hsa-miR-1252-3p | chr8:92921525-92921532 | 8mer-1a | chr8:92921525-92921549 | 163.00 | -17.39 |
| ROSMAP | ENST00000521988 | 92954406 | 92954564 | hsa-miR-5006-5p | chr8:92954511-92954518 | 8mer-1a | chr8:92954498-92954518 | 150.00 | -20.33 |
| ROSMAP | ENST00000520430 | 92921503 | 92921660 | hsa-miR-433-3p | chr8:92921601-92921608 | 8mer-1a | chr8:92921585-92921608 | 148.00 | -15.21 |
| ROSMAP | ENST00000520430 | 92921503 | 92921660 | hsa-miR-136-5p | chr8:92921542-92921549 | 8mer-1a | chr8:92921525-92921549 | 163.00 | -17.39 |
| ROSMAP | ENST00000521988 | 92954406 | 92954564 | hsa-miR-147b-5p | chr8:92954466-92954473 | 8mer-1a | chr8:92954459-92954483 | 164.00 | -23.80 |
| ROSMAP | ENST00000521988 | 92954406 | 92954564 | hsa-miR-4261 | chr8:92954466-92954473 | 8mer-1a | chr8:92954459-92954483 | 164.00 | -23.80 |
| ROSMAP | ENST00000521988 | 92954406 | 92954564 | hsa-miR-7702 | chr8:92954432-92954439 | 8mer-1a | chr8:92954428-92954447 | 152.00 | -20.44 |
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SNVs in the skipped exons for TRIQK |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TRIQK |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIQK |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TRIQK |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | CNOT4 | exon_skip_56449 | -4.660298e-01 | 1.389857e-08 |
| CB | TRA2A | exon_skip_56449 | -4.630320e-01 | 1.767670e-08 |
| IFG | DAZAP1 | exon_skip_15270 | -4.423608e-01 | 3.454718e-02 |
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RelatedDrugs for TRIQK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIQK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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