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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for NKIRAS1 |
 Gene summary |
| Gene information | Gene symbol | NKIRAS1 | Gene ID | 28512 |
| Gene name | NFKB inhibitor interacting Ras like 1 | |
| Synonyms | KBRAS1|kappaB-Ras1 | |
| Cytomap | 3p24.2 | |
| Type of gene | protein-coding | |
| Description | NF-kappa-B inhibitor-interacting Ras-like protein 1I-kappa-B-interacting Ras-like protein 1NFKB inhibitor interacting Ras-like protein 1kappa B-Ras protein 1kappa B-ras 1 | |
| Modification date | 20200313 | |
| UniProtAcc | G5E9P3, Q9NYS0, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for NKIRAS1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000197885
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000416026.2 | NKIRAS1-204:protein_coding:NKIRAS1 | 1.627403e+01 | 1.262153e+00 | 4.805273e-06 | 5.659355e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NKIRAS1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_12172 | chr3 | 23910811:23910921:23911329:23911450:23916784:23916924 | 23911329:23911450 |
| exon_skip_126965 | chr3 | 23910888:23910921:23911329:23911446:23916784:23916952 | 23911329:23911446 |
| exon_skip_204628 | chr3 | 23910846:23910921:23911329:23911446:23916784:23916952 | 23911329:23911446 |
| exon_skip_275962 | chr3 | 23910846:23910921:23911329:23911450:23916784:23916952 | 23911329:23911450 |
| exon_skip_292482 | chr3 | 23910811:23910921:23911329:23911446:23916784:23916924 | 23911329:23911446 |
| exon_skip_45485 | chr3 | 23910888:23910921:23911329:23911450:23916784:23916952 | 23911329:23911450 |
| exon_skip_51990 | chr3 | 23893065:23893337:23900808:23901049:23910811:23910921 | 23900808:23901049 |
| exon_skip_61978 | chr3 | 23900808:23901049:23910811:23910921:23916784:23916924 | 23910811:23910921 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for NKIRAS1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000425478 | 23911329 | 23911450 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000425478 | 23911329 | 23911450 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000416026 | 23910811 | 23910921 | 3UTR-3CDS |
| ENST00000425478 | 23911329 | 23911450 | 3UTR-3UTR |
| ENST00000388759 | 23900808 | 23901049 | Frame-shift |
| ENST00000416026 | 23900808 | 23901049 | Frame-shift |
| ENST00000421515 | 23900808 | 23901049 | Frame-shift |
| ENST00000425478 | 23900808 | 23901049 | Frame-shift |
| ENST00000443659 | 23900808 | 23901049 | Frame-shift |
| ENST00000614374 | 23900808 | 23901049 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for NKIRAS1 |
p-ENSG00000197885_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in NKIRAS1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000425478 | 23911329 | 23911450 | hsa-miR-1976 | chr3:23911358-23911365 | 8mer-1a | chr3:23911344-23911365 | 149.00 | -22.56 |
| Mayo | ENST00000425478 | 23911329 | 23911450 | hsa-miR-6747-3p | chr3:23911356-23911363 | 8mer-1a | chr3:23911341-23911363 | 156.00 | -29.17 |
| Mayo | ENST00000425478 | 23911329 | 23911450 | hsa-miR-148b-3p | chr3:23911392-23911399 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| Mayo | ENST00000425478 | 23911329 | 23911450 | hsa-miR-152-3p | chr3:23911392-23911399 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| Mayo | ENST00000425478 | 23911329 | 23911450 | hsa-miR-6787-3p | chr3:23911399-23911406 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| Mayo | ENST00000425478 | 23911329 | 23911450 | hsa-miR-4795-5p | chr3:23911412-23911419 | 8mer-1a | chr3:23911410-23911428 | 163.00 | -28.62 |
| Mayo | ENST00000425478 | 23911329 | 23911450 | hsa-miR-148a-3p | chr3:23911392-23911399 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| Mayo | ENST00000425478 | 23911329 | 23911450 | hsa-miR-500b-3p | chr3:23911427-23911434 | 8mer-1a | chr3:23911416-23911434 | 155.00 | -22.56 |
| MSBB | ENST00000425478 | 23911329 | 23911450 | hsa-miR-1976 | chr3:23911358-23911365 | 8mer-1a | chr3:23911344-23911365 | 149.00 | -22.56 |
| MSBB | ENST00000425478 | 23911329 | 23911450 | hsa-miR-6747-3p | chr3:23911356-23911363 | 8mer-1a | chr3:23911341-23911363 | 156.00 | -29.17 |
| MSBB | ENST00000425478 | 23911329 | 23911450 | hsa-miR-148b-3p | chr3:23911392-23911399 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| MSBB | ENST00000425478 | 23911329 | 23911450 | hsa-miR-152-3p | chr3:23911392-23911399 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| MSBB | ENST00000425478 | 23911329 | 23911450 | hsa-miR-6787-3p | chr3:23911399-23911406 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| MSBB | ENST00000425478 | 23911329 | 23911450 | hsa-miR-4795-5p | chr3:23911412-23911419 | 8mer-1a | chr3:23911410-23911428 | 163.00 | -28.62 |
| MSBB | ENST00000425478 | 23911329 | 23911450 | hsa-miR-148a-3p | chr3:23911392-23911399 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| MSBB | ENST00000425478 | 23911329 | 23911450 | hsa-miR-500b-3p | chr3:23911427-23911434 | 8mer-1a | chr3:23911416-23911434 | 155.00 | -22.56 |
| ROSMAP | ENST00000425478 | 23911329 | 23911450 | hsa-miR-1976 | chr3:23911358-23911365 | 8mer-1a | chr3:23911344-23911365 | 149.00 | -22.56 |
| ROSMAP | ENST00000425478 | 23911329 | 23911450 | hsa-miR-6747-3p | chr3:23911356-23911363 | 8mer-1a | chr3:23911341-23911363 | 156.00 | -29.17 |
| ROSMAP | ENST00000425478 | 23911329 | 23911450 | hsa-miR-148b-3p | chr3:23911392-23911399 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| ROSMAP | ENST00000425478 | 23911329 | 23911450 | hsa-miR-152-3p | chr3:23911392-23911399 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| ROSMAP | ENST00000425478 | 23911329 | 23911450 | hsa-miR-6787-3p | chr3:23911399-23911406 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| ROSMAP | ENST00000425478 | 23911329 | 23911450 | hsa-miR-4795-5p | chr3:23911412-23911419 | 8mer-1a | chr3:23911410-23911428 | 163.00 | -28.62 |
| ROSMAP | ENST00000425478 | 23911329 | 23911450 | hsa-miR-148a-3p | chr3:23911392-23911399 | 8mer-1a | chr3:23911385-23911409 | 164.00 | -24.68 |
| ROSMAP | ENST00000425478 | 23911329 | 23911450 | hsa-miR-500b-3p | chr3:23911427-23911434 | 8mer-1a | chr3:23911416-23911434 | 155.00 | -22.56 |
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SNVs in the skipped exons for NKIRAS1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for NKIRAS1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NKIRAS1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for NKIRAS1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for NKIRAS1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NKIRAS1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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