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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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3'-UTR located exon skipping events lost miRNA binding sites

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SNVs in the skipped exons with depth of coverage

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AD stage-associated exon skipping events

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Correlation with RNA binding proteins (RBPs)

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Related drugs with this gene

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Related diseases with this gene

Gene summary for NBPF15

check button Gene summary
Gene informationGene symbol

NBPF15

Gene ID

284565

Gene nameNBPF member 15
SynonymsAB14|AG3|NBPF16
Cytomap

1q21.1

Type of geneprotein-coding
Descriptionneuroblastoma breakpoint family member 15neuroblastoma breakpoint family, member 16
Modification date20200313
UniProtAcc

Q8N660,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Gene structures and expression levels for NBPF15

check buttonSkipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

ENSG00000266338
check button Differentially expressed gene analysis across multiple brain tissues between AD and control.
Tissue typeDEG directionBase mean exp.log2FC(AD/control)P-valueAdj. p-value

check button Differentially expressed isoform analysis across multiple brain tissues between AD and control.
Tissue typeDEG directionENSTTranscript info.Base mean exp.log2FC(AD/control)P-valueAdjc. p-value

check button Landscape of isoform expressions across multiple brain tissues between AD and control.
gencode gene structure

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for NBPF15

check button Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).
boxplot

check button All exon skipping events in AD cohorts.
Exon skip IDchrExons involved in exon skippingSkipped exon
exon_skip_116719chr1144427818:144427990:144428606:144428657:144429700:144429863144428606:144428657
exon_skip_123430chr1144459366:144459483:144460843:144460961:144461381:144461558144460843:144460961
exon_skip_12406chr1144435781:144435853:144436895:144437109:144437945:144438047144436895:144437109
exon_skip_138859chr1144459366:144459483:144460843:144460961:144461381:144461410144460843:144460961
exon_skip_142137chr1144448857:144448916:144450772:144450870:144456537:144456761144450772:144450870
exon_skip_144167chr1144436895:144437109:144437945:144438047:144439829:144440038144437945:144438047
exon_skip_164184chr1144448826:144448916:144450772:144450802:144456537:144456761144450772:144450802
exon_skip_174141chr1144456537:144456805:144459366:144459483:144461381:144461410144459366:144459483
exon_skip_175263chr1144456537:144456805:144459366:144459483:144461381:144461558144459366:144459483
exon_skip_194208chr1144448826:144448916:144450772:144450870:144456537:144456761144450772:144450870
exon_skip_233555chr1144448857:144448916:144450772:144450802:144456537:144456761144450772:144450802
exon_skip_257799chr1144440209:144440295:144448775:144448916:144450772:144450802144448775:144448916
exon_skip_268696chr1144440141:144440295:144440402:144440581:144442670:144442917144440402:144440581
exon_skip_270688chr1144428606:144428657:144429700:144429863:144433773:144433824144429700:144429863
exon_skip_272197chr1144440209:144440295:144448775:144448916:144456537:144456761144448775:144448916
exon_skip_49146chr1144440209:144440295:144440402:144440581:144442670:144442917144440402:144440581
exon_skip_57448chr1144440209:144440295:144440402:144440581:144442670:144442920144440402:144440581
exon_skip_76357chr1144440402:144440581:144442670:144442920:144448775:144448916144442670:144442920

check button Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.
psi tcga
Exon skipping informationTissue typeAvg(PSIs) in ADAvg(PSIs) in controlDifference (PSI)Adj. p-value
exon_skip_233555Mayo_CB3.242500e-014.516393e-01-1.273893e-011.064423e-06
exon_skip_142137Mayo_CB4.179012e-016.004478e-01-1.825465e-011.341225e-07
exon_skip_131671Mayo_CB2.153947e-013.183636e-01-1.029689e-011.003621e-06


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Open reading frame (ORF) annotation in the exon skipping event for NBPF15

check button Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000005774121444404021444405813UTR-3UTR
ENST000005774121444426701444429203UTR-3UTR
ENST000004880311444507721444508023UTR-3UTR
ENST000005774121444507721444508023UTR-3UTR
ENST00000488031144428606144428657Frame-shift
ENST00000577412144428606144428657Frame-shift
ENST00000581897144428606144428657Frame-shift
ENST00000488031144429700144429863Frame-shift
ENST00000577412144429700144429863Frame-shift
ENST00000581897144429700144429863Frame-shift
ENST00000488031144437945144438047Frame-shift
ENST00000577412144437945144438047Frame-shift
ENST00000581897144437945144438047Frame-shift

check button Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000005774121444404021444405813UTR-3UTR
ENST000004880311444487751444489163UTR-3UTR
ENST000005818971444487751444489163UTR-3UTR
ENST000004880311444507721444508023UTR-3UTR
ENST000005774121444507721444508023UTR-3UTR
ENST00000488031144428606144428657Frame-shift
ENST00000577412144428606144428657Frame-shift
ENST00000581897144428606144428657Frame-shift
ENST00000488031144436895144437109Frame-shift
ENST00000577412144436895144437109Frame-shift
ENST00000581897144436895144437109Frame-shift
ENST00000488031144437945144438047Frame-shift
ENST00000577412144437945144438047Frame-shift
ENST00000581897144437945144438047Frame-shift

check button Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000005774121444404021444405813UTR-3UTR
ENST000004880311444507721444508023UTR-3UTR
ENST000005774121444507721444508023UTR-3UTR
ENST00000488031144429700144429863Frame-shift
ENST00000577412144429700144429863Frame-shift
ENST00000581897144429700144429863Frame-shift
ENST00000488031144437945144438047Frame-shift
ENST00000577412144437945144438047Frame-shift
ENST00000581897144437945144438047Frame-shift

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Infer the effects of exon skipping event on protein functional features for NBPF15

p-ENSG00000266338_img4.png
boxplot

check button Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end

check button Lost protein functional features of individual exon skipping events in ROSMAP.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature

check button Lost protein functional features of individual exon skipping events in MSBB.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature

check button Lost protein functional features of individual exon skipping events in Mayo.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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3'-UTR located exon skipping events that lost miRNA binding sites in NBPF15

check button 3'-UTR exon skipping evnets lost miRNA binding.
Tissue typeENSTExon skip startExon skip endmicroRNABinding site by TargetScanBinding type by TargetScanBdinding site by miRandaScore of miRandaEnergy by miRanda
MayoENST00000577412144440402144440581hsa-miR-1256chr1:144440469-1444404768mer-1achr1:144440456-144440483157.00-16.66
MayoENST00000577412144440402144440581hsa-miR-4425chr1:144440563-1444405708mer-1achr1:144440560-144440579150.00-10.46
MayoENST00000577412144440402144440581hsa-miR-6733-5pchr1:144440488-1444404958mer-1achr1:144440474-144440495155.00-19.04
MayoENST00000577412144440402144440581hsa-miR-6738-3pchr1:144440550-1444405578mer-1achr1:144440543-144440565154.00-17.96
MayoENST00000577412144440402144440581hsa-miR-6739-5pchr1:144440488-1444404958mer-1achr1:144440474-144440495155.00-19.04
MayoENST00000577412144440402144440581hsa-miR-4693-3pchr1:144440441-1444404488mer-1achr1:144440432-144440454162.00-15.76
MayoENST00000577412144440402144440581hsa-let-7a-2-3pchr1:144440533-1444405408mer-1achr1:144440520-144440540148.00-11.98
MayoENST00000577412144440402144440581hsa-miR-1252-5pchr1:144440428-1444404358mer-1achr1:144440427-144440447154.00-15.44
MayoENST00000577412144440402144440581hsa-miR-3613-5pchr1:144440535-1444405428mer-1achr1:144440534-144440557149.00-11.68
MayoENST00000577412144450772144450802hsa-miR-6809-5pchr1:144450794-1444508018mer-1achr1:144450783-144450802155.00-12.01
MayoENST00000577412144440402144440581hsa-miR-5001-3pchr1:144440549-1444405568mer-1achr1:144440543-144440565154.00-17.96
MayoENST00000577412144440402144440581hsa-miR-649chr1:144440568-1444405758mer-1achr1:144440560-144440579150.00-10.46
MayoENST00000577412144440402144440581hsa-let-7g-3pchr1:144440533-1444405408mer-1achr1:144440520-144440540148.00-11.98
MayoENST00000577412144440402144440581hsa-miR-4457chr1:144440461-1444404688mer-1achr1:144440456-144440483157.00-16.66
MayoENST00000577412144440402144440581hsa-miR-3153chr1:144440488-1444404958mer-1achr1:144440474-144440495155.00-19.04
MSBBENST00000577412144440402144440581hsa-miR-1256chr1:144440469-1444404768mer-1achr1:144440456-144440483157.00-16.66
MSBBENST00000577412144440402144440581hsa-miR-4425chr1:144440563-1444405708mer-1achr1:144440560-144440579150.00-10.46
MSBBENST00000577412144440402144440581hsa-miR-6733-5pchr1:144440488-1444404958mer-1achr1:144440474-144440495155.00-19.04
MSBBENST00000577412144440402144440581hsa-miR-6738-3pchr1:144440550-1444405578mer-1achr1:144440543-144440565154.00-17.96
MSBBENST00000577412144440402144440581hsa-miR-6739-5pchr1:144440488-1444404958mer-1achr1:144440474-144440495155.00-19.04
MSBBENST00000577412144440402144440581hsa-miR-4693-3pchr1:144440441-1444404488mer-1achr1:144440432-144440454162.00-15.76
MSBBENST00000577412144440402144440581hsa-let-7a-2-3pchr1:144440533-1444405408mer-1achr1:144440520-144440540148.00-11.98
MSBBENST00000577412144440402144440581hsa-miR-1252-5pchr1:144440428-1444404358mer-1achr1:144440427-144440447154.00-15.44
MSBBENST00000581897144448775144448916hsa-miR-619-3pchr1:144448872-1444488798mer-1achr1:144448857-144448879150.00-27.62
MSBBENST00000577412144440402144440581hsa-miR-3613-5pchr1:144440535-1444405428mer-1achr1:144440534-144440557149.00-11.68
MSBBENST00000581897144448775144448916hsa-miR-92a-1-5pchr1:144448838-1444488458mer-1achr1:144448821-144448845152.00-21.79
MSBBENST00000581897144448775144448916hsa-miR-487a-3pchr1:144448877-1444488848mer-1achr1:144448861-144448884155.00-17.77
MSBBENST00000581897144448775144448916hsa-miR-154-3pchr1:144448877-1444488848mer-1achr1:144448861-144448884155.00-17.77
MSBBENST00000581897144448775144448916hsa-miR-769-3pchr1:144448797-1444488048mer-1achr1:144448786-144448807156.00-22.86
MSBBENST00000577412144450772144450802hsa-miR-6809-5pchr1:144450794-1444508018mer-1achr1:144450783-144450802155.00-12.01
MSBBENST00000577412144440402144440581hsa-miR-5001-3pchr1:144440549-1444405568mer-1achr1:144440543-144440565154.00-17.96
MSBBENST00000577412144440402144440581hsa-miR-649chr1:144440568-1444405758mer-1achr1:144440560-144440579150.00-10.46
MSBBENST00000577412144440402144440581hsa-let-7g-3pchr1:144440533-1444405408mer-1achr1:144440520-144440540148.00-11.98
MSBBENST00000577412144440402144440581hsa-miR-4457chr1:144440461-1444404688mer-1achr1:144440456-144440483157.00-16.66
MSBBENST00000577412144440402144440581hsa-miR-3153chr1:144440488-1444404958mer-1achr1:144440474-144440495155.00-19.04
MSBBENST00000581897144448775144448916hsa-miR-450b-3pchr1:144448797-1444488048mer-1achr1:144448786-144448807156.00-22.86
ROSMAPENST00000577412144440402144440581hsa-miR-1256chr1:144440469-1444404768mer-1achr1:144440456-144440483157.00-16.66
ROSMAPENST00000577412144440402144440581hsa-miR-4425chr1:144440563-1444405708mer-1achr1:144440560-144440579150.00-10.46
ROSMAPENST00000577412144440402144440581hsa-miR-6733-5pchr1:144440488-1444404958mer-1achr1:144440474-144440495155.00-19.04
ROSMAPENST00000577412144440402144440581hsa-miR-6738-3pchr1:144440550-1444405578mer-1achr1:144440543-144440565154.00-17.96
ROSMAPENST00000577412144440402144440581hsa-miR-6739-5pchr1:144440488-1444404958mer-1achr1:144440474-144440495155.00-19.04
ROSMAPENST00000577412144440402144440581hsa-miR-4693-3pchr1:144440441-1444404488mer-1achr1:144440432-144440454162.00-15.76
ROSMAPENST00000577412144440402144440581hsa-let-7a-2-3pchr1:144440533-1444405408mer-1achr1:144440520-144440540148.00-11.98
ROSMAPENST00000577412144440402144440581hsa-miR-1252-5pchr1:144440428-1444404358mer-1achr1:144440427-144440447154.00-15.44
ROSMAPENST00000577412144440402144440581hsa-miR-3613-5pchr1:144440535-1444405428mer-1achr1:144440534-144440557149.00-11.68
ROSMAPENST00000577412144442670144442920hsa-miR-5007-3pchr1:144442849-1444428568mer-1achr1:144442832-144442856151.00-12.96
ROSMAPENST00000577412144442670144442920hsa-miR-5189-3pchr1:144442737-1444427448mer-1achr1:144442725-144442744145.00-21.31
ROSMAPENST00000577412144442670144442920hsa-miR-6791-5pchr1:144442689-1444426968mer-1achr1:144442678-144442696149.00-28.09
ROSMAPENST00000577412144450772144450802hsa-miR-6809-5pchr1:144450794-1444508018mer-1achr1:144450783-144450802155.00-12.01
ROSMAPENST00000577412144440402144440581hsa-miR-5001-3pchr1:144440549-1444405568mer-1achr1:144440543-144440565154.00-17.96
ROSMAPENST00000577412144440402144440581hsa-miR-649chr1:144440568-1444405758mer-1achr1:144440560-144440579150.00-10.46
ROSMAPENST00000577412144440402144440581hsa-let-7g-3pchr1:144440533-1444405408mer-1achr1:144440520-144440540148.00-11.98
ROSMAPENST00000577412144442670144442920hsa-miR-4446-5pchr1:144442692-1444426998mer-1achr1:144442679-144442703154.00-19.55
ROSMAPENST00000577412144440402144440581hsa-miR-4457chr1:144440461-1444404688mer-1achr1:144440456-144440483157.00-16.66
ROSMAPENST00000577412144442670144442920hsa-miR-4652-5pchr1:144442869-1444428768mer-1achr1:144442857-144442878159.00-23.06
ROSMAPENST00000577412144442670144442920hsa-miR-1207-3pchr1:144442717-1444427248mer-1achr1:144442715-144442738155.00-24.33
ROSMAPENST00000577412144440402144440581hsa-miR-3153chr1:144440488-1444404958mer-1achr1:144440474-144440495155.00-19.04
ROSMAPENST00000577412144442670144442920hsa-miR-455-3pchr1:144442770-1444427778mer-1achr1:144442766-144442787159.00-23.17
ROSMAPENST00000577412144442670144442920hsa-miR-4292chr1:144442689-1444426968mer-1achr1:144442678-144442696149.00-28.09
ROSMAPENST00000577412144442670144442920hsa-miR-3915chr1:144442702-1444427098mer-1achr1:144442689-144442709141.00-13.79

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SNVs in the skipped exons for NBPF15

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Depth of Coverage in the skipped exon of the mutated samples.

check button - Sashimi plot in the skipped exon of the mutated samples.

check button - Non-synonymous mutations located in the skipped exons.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

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AD stage-associated exon skippint events for NBPF15

check button Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).
AD stage infoCohortTissueSE idCoefficient P-valueChromosomeStrandE1 startE1 endSkipped startSkipped endE2 startE2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NBPF15

check button sQTL information located at the skipped exons.
Tissue typeExon skip IDSNP idLocationP-valueFDR

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Correlation with RNA binding proteins (RBPs) for NBPF15

check button Correlated RBP and related information.
Tissue typeRBP nameExon skip IDCorrelation coeifficientP-value
CBRBM6exon_skip_2721974.372590e-017.388790e-07
CBRBM3exon_skip_272197-4.010746e-016.767989e-06
CBPCBP1exon_skip_233555-4.493710e-012.276691e-08
CBCNOT4exon_skip_142137-5.698505e-014.066590e-14
CBPCBP1exon_skip_142137-4.374611e-012.704600e-08
CBTRA2Aexon_skip_142137-6.186712e-015.325993e-17
CBRBM45exon_skip_1421377.095098e-015.935197e-24
CBCNOT4exon_skip_131671-4.597508e-013.311121e-08
CBRBM45exon_skip_1316716.365213e-013.062604e-16

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RelatedDrugs for NBPF15

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NBPF15

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource