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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ANGPT1 |
 Gene summary |
| Gene information | Gene symbol | ANGPT1 | Gene ID | 284 |
| Gene name | angiopoietin 1 | |
| Synonyms | AGP1|AGPT|ANG1 | |
| Cytomap | 8q23.1 | |
| Type of gene | protein-coding | |
| Description | angiopoietin-1ANG-1 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ANGPT1 | GO:0001936 | regulation of endothelial cell proliferation | 8980223 |
| ANGPT1 | GO:0002040 | sprouting angiogenesis | 9560344|10218485 |
| ANGPT1 | GO:0002092 | positive regulation of receptor internalization | 19424712 |
| ANGPT1 | GO:0007162 | negative regulation of cell adhesion | 19674970 |
| ANGPT1 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | 19424712 |
| ANGPT1 | GO:0010595 | positive regulation of endothelial cell migration | 12958144 |
| ANGPT1 | GO:0014842 | regulation of skeletal muscle satellite cell proliferation | 19733541 |
| ANGPT1 | GO:0030210 | heparin biosynthetic process | 19297368 |
| ANGPT1 | GO:0031398 | positive regulation of protein ubiquitination | 19689429 |
| ANGPT1 | GO:0034394 | protein localization to cell surface | 19615361 |
| ANGPT1 | GO:0043066 | negative regulation of apoptotic process | 10218485|12958144 |
| ANGPT1 | GO:0043116 | negative regulation of vascular permeability | 14978158|19297368 |
| ANGPT1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 9660821 |
| ANGPT1 | GO:0048014 | Tie signaling pathway | 19689429|19922791 |
| ANGPT1 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 15851516|19689429 |
| ANGPT1 | GO:0050918 | positive chemotaxis | 9660821 |
| ANGPT1 | GO:0051897 | positive regulation of protein kinase B signaling | 18425120|19615361 |
| ANGPT1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 18425120|19615361 |
| ANGPT1 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 19674970 |
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Gene structures and expression levels for ANGPT1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000154188
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| PG | UP | 1.589668e+02 | 1.105941e+00 | 5.281011e-18 | 2.352984e-14 |
| TC | UP | 2.078423e+02 | 9.133341e-01 | 4.249472e-12 | 5.592147e-10 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000517746.6 | ANGPT1-202:protein_coding:ANGPT1 | 1.261780e+02 | 1.156141e+00 | 4.367913e-14 | 1.405813e-10 |
| PG | UP | ENST00000521950.1 | ANGPT1-207:retained_intron:ANGPT1 | 1.390362e+00 | 1.469633e+00 | 7.821375e-05 | 2.290727e-03 |
| PG | UP | ENST00000522400.1 | ANGPT1-208:retained_intron:ANGPT1 | 2.575460e+00 | 8.836096e-01 | 1.484909e-04 | 3.671994e-03 |
| PG | UP | ENST00000520052.1 | ANGPT1-205:protein_coding:ANGPT1 | 6.820480e+00 | 1.575222e+00 | 3.187260e-04 | 6.408029e-03 |
| CB | UP | ENST00000521950.1 | ANGPT1-207:retained_intron:ANGPT1 | 1.253537e+00 | 1.254816e+00 | 9.628100e-04 | 5.003791e-03 |
| TC | UP | ENST00000517746.6 | ANGPT1-202:protein_coding:ANGPT1 | 1.666607e+02 | 8.643771e-01 | 6.887459e-08 | 4.481605e-06 |
| TC | UP | ENST00000297450.7 | ANGPT1-201:protein_coding:ANGPT1 | 3.495637e+01 | 1.185503e+00 | 1.454051e-03 | 1.314321e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ANGPT1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_134870 | chr8 | 107293936:107294037:107303240:107303367:107321899:107321989 | 107303240:107303367 |
| exon_skip_200062 | chr8 | 107293936:107294037:107303240:107303367:107321896:107322128 | 107303240:107303367 |
| exon_skip_86725 | chr8 | 107264221:107264351:107284682:107284848:107293936:107294037 | 107284682:107284848 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ANGPT1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for ANGPT1 |
p-ENSG00000154188_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ANGPT1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ANGPT1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ANGPT1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ANGPT1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ANGPT1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ANGPT1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANGPT1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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