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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for HID1 |
 Gene summary |
| Gene information | Gene symbol | HID1 | Gene ID | 283987 |
| Gene name | HID1 domain containing | |
| Synonyms | 17orf28|C17orf28|DMC1|HID-1 | |
| Cytomap | 17q25.1 | |
| Type of gene | protein-coding | |
| Description | protein HID1HID1 domain-containing proteinUPF0663 transmembrane protein C17orf28down-regulated in multiple cancers 1downregulated in multiple cancer 1protein hid-1 homolog | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for HID1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000167861
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000318565.11 | HID1-201:protein_coding:HID1 | 8.734494e+00 | 1.028804e+00 | 1.309127e-04 | 1.299380e-02 |
| CB | UP | ENST00000525128.5 | HID1-203:retained_intron:HID1 | 2.362744e+02 | 8.606198e-01 | 7.340700e-14 | 1.787868e-11 |
| CB | UP | ENST00000530857.1 | HID1-205:protein_coding:HID1 | 6.463372e+01 | 1.332595e+00 | 2.592717e-13 | 4.863050e-11 |
| CB | UP | ENST00000583244.1 | HID1-214:retained_intron:HID1 | 3.772649e+01 | 8.517997e-01 | 1.007370e-08 | 3.021781e-07 |
| CB | DOWN | ENST00000532909.5 | CHID1-220:nonsense_mediated_decay:CHID1 | 1.526878e+01 | -8.212722e-01 | 1.406207e-05 | 1.404811e-04 |
| CB | DOWN | ENST00000529539.5 | CHID1-216:protein_coding:CHID1 | 6.692551e+00 | -8.378066e-01 | 2.261220e-04 | 1.477737e-03 |
| CB | DOWN | ENST00000525225.1 | CHID1-208:protein_coding:CHID1 | 7.541153e-01 | -1.185002e+00 | 5.396081e-03 | 2.096743e-02 |
| TC | DOWN | ENST00000534480.5 | HID1-210:nonsense_mediated_decay:HID1 | 1.349807e+01 | -9.577530e-01 | 9.657362e-05 | 1.568569e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HID1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101961 | chr17 | 74962973:74963078:74963740:74963910:74972591:74972630 | 74963740:74963910 |
| exon_skip_108187 | chr17 | 74962973:74963078:74963740:74963910:74972591:74972771 | 74963740:74963910 |
| exon_skip_118354 | chr17 | 74958203:74958219:74958327:74958763:74958911:74959001 | 74958327:74958763 |
| exon_skip_12092 | chr17 | 74953006:74953086:74953545:74953651:74954138:74954312 | 74953545:74953651 |
| exon_skip_126888 | chr17 | 74963740:74963910:74964483:74964632:74972591:74972630 | 74964483:74964632 |
| exon_skip_130239 | chr17 | 74962987:74963081:74963771:74963910:74964483:74964632 | 74963771:74963910 |
| exon_skip_149419 | chr17 | 74959881:74959937:74960026:74960248:74961873:74961989 | 74960026:74960248 |
| exon_skip_156213 | chr17 | 74958327:74958478:74958673:74958763:74958911:74958994 | 74958673:74958763 |
| exon_skip_159561 | chr17 | 74953006:74953086:74953545:74953651:74954138:74954365 | 74953545:74953651 |
| exon_skip_172856 | chr17 | 74962965:74963078:74963740:74963910:74972591:74972669 | 74963740:74963910 |
| exon_skip_185203 | chr17 | 74963844:74963910:74964483:74964632:74972591:74972771 | 74964483:74964632 |
| exon_skip_193811 | chr17 | 74955821:74955956:74958141:74958219:74958327:74958478 | 74958141:74958219 |
| exon_skip_201966 | chr17 | 74953006:74953086:74953545:74953651:74954138:74954364 | 74953545:74953651 |
| exon_skip_241808 | chr17 | 74963771:74963910:74964483:74964632:74972591:74972716 | 74964483:74964632 |
| exon_skip_260391 | chr17 | 74964483:74964632:74967806:74967933:74972591:74972730 | 74967806:74967933 |
| exon_skip_278168 | chr17 | 74963740:74963910:74964483:74964632:74972591:74972669 | 74964483:74964632 |
| exon_skip_285613 | chr17 | 74964483:74964632:74967806:74967933:74972591:74972630 | 74967806:74967933 |
| exon_skip_288912 | chr17 | 74958203:74958219:74958327:74958791:74958911:74959001 | 74958327:74958791 |
| exon_skip_296362 | chr17 | 74963740:74963910:74964483:74964632:74972591:74972771 | 74964483:74964632 |
| exon_skip_30264 | chr17 | 74958327:74958478:74958673:74958763:74958911:74959001 | 74958673:74958763 |
| exon_skip_40914 | chr17 | 74962987:74963081:74963740:74963910:74964483:74964632 | 74963740:74963910 |
| exon_skip_50708 | chr17 | 74964483:74964632:74967806:74967933:74972591:74972669 | 74967806:74967933 |
| exon_skip_50804 | chr17 | 74958976:74959051:74959881:74959937:74960026:74960089 | 74959881:74959937 |
| exon_skip_56319 | chr17 | 74960026:74960248:74961873:74961989:74962234:74962340 | 74961873:74961989 |
| exon_skip_72131 | chr17 | 74962973:74963078:74963740:74963910:74972591:74972716 | 74963740:74963910 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_12092 | Mayo_CB | 7.835366e-01 | 9.018182e-01 | -1.182816e-01 | 7.160302e-08 |
| exon_skip_130239 | Mayo_CB | 8.280822e-01 | 9.325424e-01 | -1.044602e-01 | 3.516034e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for HID1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000425042 | 74953545 | 74953651 | Frame-shift |
| ENST00000425042 | 74958673 | 74958763 | Frame-shift |
| ENST00000425042 | 74960026 | 74960248 | Frame-shift |
| ENST00000425042 | 74961873 | 74961989 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000425042 | 74953545 | 74953651 | Frame-shift |
| ENST00000425042 | 74961873 | 74961989 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000425042 | 74953545 | 74953651 | Frame-shift |
| ENST00000425042 | 74958141 | 74958219 | Frame-shift |
| ENST00000425042 | 74958673 | 74958763 | Frame-shift |
| ENST00000425042 | 74960026 | 74960248 | Frame-shift |
| ENST00000425042 | 74959881 | 74959937 | In-frame |
| ENST00000425042 | 74961873 | 74961989 | In-frame |
| ENST00000425042 | 74963740 | 74963910 | In-frame |
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Infer the effects of exon skipping event on protein functional features for HID1 |
p-ENSG00000167861_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000425042 | 3288 | 788 | 74961873 | 74961989 | 690 | 805 | 204 | 242 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000425042 | 3288 | 788 | 74961873 | 74961989 | 690 | 805 | 204 | 242 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000425042 | 3288 | 788 | 74963740 | 74963910 | 295 | 464 | 72 | 128 |
| ENST00000425042 | 3288 | 788 | 74961873 | 74961989 | 690 | 805 | 204 | 242 |
| ENST00000425042 | 3288 | 788 | 74959881 | 74959937 | 1030 | 1085 | 317 | 335 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IV36 | 204 | 242 | 30 | 257 | Alternative sequence | ID=VSP_014472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8IV36 | 204 | 242 | 2 | 788 | Chain | ID=PRO_0000079296;Note=Protein HID1 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IV36 | 204 | 242 | 30 | 257 | Alternative sequence | ID=VSP_014472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8IV36 | 204 | 242 | 2 | 788 | Chain | ID=PRO_0000079296;Note=Protein HID1 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IV36 | 72 | 128 | 30 | 257 | Alternative sequence | ID=VSP_014472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8IV36 | 72 | 128 | 2 | 788 | Chain | ID=PRO_0000079296;Note=Protein HID1 |
| Q8IV36 | 204 | 242 | 30 | 257 | Alternative sequence | ID=VSP_014472;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8IV36 | 204 | 242 | 2 | 788 | Chain | ID=PRO_0000079296;Note=Protein HID1 |
| Q8IV36 | 317 | 335 | 2 | 788 | Chain | ID=PRO_0000079296;Note=Protein HID1 |
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3'-UTR located exon skipping events that lost miRNA binding sites in HID1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for HID1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for HID1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HID1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for HID1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_12092 | -5.445718e-01 | 1.170545e-13 |
| CB | TRA2A | exon_skip_130239 | -4.306257e-01 | 2.550710e-07 |
| CB | RBM4 | exon_skip_130239 | -5.642627e-01 | 1.843342e-12 |
| CB | RBM4B | exon_skip_130239 | -4.454006e-01 | 8.726907e-08 |
| IFG | PCBP2 | exon_skip_56319 | -5.284192e-01 | 5.519578e-03 |
| TC | RBM6 | exon_skip_12092 | -5.589401e-01 | 1.576193e-14 |
| TC | G3BP2 | exon_skip_12092 | 4.266410e-01 | 1.849176e-08 |
| TC | HNRNPH2 | exon_skip_12092 | 4.848110e-01 | 8.228245e-11 |
| TC | ESRP1 | exon_skip_12092 | 4.242118e-01 | 2.269298e-08 |
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RelatedDrugs for HID1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HID1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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