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	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Gene summary for SLC25A45

Gene summary

Gene information	Gene symbol	SLC25A45
	Gene ID	283130
	Gene name	solute carrier family 25 member 45
	Synonyms	-
	Cytomap	11q13.1
	Type of gene	protein-coding
	Description	solute carrier family 25 member 45
	Modification date	20200313
	UniProtAcc	E9PJ15, E9PJQ3, E9PJW2, E9PK53, E9PMF0, Q8N413,
	Context	- 24007662(Quantitative Clinical Proteomic Study of Autopsied Human Infarcted Brain Specimens to Elucidate the Deregulated Pathways in Ischemic Stroke Pathology)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for SLC25A45

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000162241

Differentially expressed gene analysis across multiple brain tissues between AD and control.

***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")

Tissue type	DEG direction	Base mean exp.	log2FC(AD/control)	P-value	Adj. p-value
CB	DOWN	1.592210e+02	-8.151841e-01	8.916671e-07	9.643697e-06

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	DOWN	ENST00000534338.1	SLC25A45-215:retained_intron:SLC25A45	1.079155e+01	-1.018530e+00	3.524320e-04	2.145030e-03
CB	DOWN	ENST00000533629.5	SLC25A45-213:nonsense_mediated_decay:SLC25A45	5.941643e+00	-9.033391e-01	9.513427e-04	4.953575e-03
CB	DOWN	ENST00000529431.1	SLC25A45-209:retained_intron:SLC25A45	3.331658e+00	-9.026269e-01	3.061683e-03	1.312122e-02
CB	DOWN	ENST00000527174.5	SLC25A45-208:protein_coding:SLC25A45	2.132884e+01	-1.039154e+00	8.371994e-03	3.003577e-02
TC	DOWN	ENST00000525944.1	SLC25A45-204:retained_intron:SLC25A45	3.288249e+00	-1.147786e+00	7.651782e-05	1.306053e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SLC25A45

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_104570	chr11	65376818:65377076:65379376:65379561:65379867:65379938	65379376:65379561
exon_skip_125457	chr11	65379458:65379561:65379867:65379938:65380132:65380175	65379867:65379938
exon_skip_143356	chr11	65380132:65380234:65380534:65380632:65381875:65381969	65380534:65380632
exon_skip_15993	chr11	65380132:65380175:65381875:65381969:65382486:65382571	65381875:65381969
exon_skip_160340	chr11	65380132:65380175:65380534:65380622:65381875:65381969	65380534:65380622
exon_skip_201546	chr11	65379376:65379561:65379867:65379938:65380132:65380175	65379867:65379938
exon_skip_216909	chr11	65377062:65377076:65377333:65377423:65379376:65379561	65377333:65377423
exon_skip_268724	chr11	65380132:65380175:65381915:65381969:65382486:65382638	65381915:65381969
exon_skip_288655	chr11	65377062:65377076:65379376:65379561:65379867:65379938	65379376:65379561
exon_skip_293812	chr11	65380132:65380175:65381875:65381969:65382486:65382638	65381875:65381969
exon_skip_38939	chr11	65380132:65380175:65380534:65380632:65381875:65381969	65380534:65380632
exon_skip_5652	chr11	65380132:65380175:65381915:65381969:65382486:65382571	65381915:65381969

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for SLC25A45

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000398802	65381915	65381969	3UTR-3CDS
ENST00000398802	65379376	65379561	In-frame
ENST00000527174	65379376	65379561	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000398802	65381915	65381969	3UTR-3CDS

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000398802	65381915	65381969	3UTR-3CDS
ENST00000398802	65379376	65379561	In-frame
ENST00000527174	65379376	65379561	In-frame
ENST00000398802	65379867	65379938	In-frame
ENST00000527174	65379867	65379938	In-frame

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Infer the effects of exon skipping event on protein functional features for SLC25A45

p-ENSG00000162241_img4.png

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000398802	2303	288	65379376	65379561	358	542	51	112
ENST00000527174	2155	288	65379376	65379561	210	394	51	112

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000398802	2303	288	65379867	65379938	286	356	27	50
ENST00000527174	2155	288	65379867	65379938	138	208	27	50
ENST00000398802	2303	288	65379376	65379561	358	542	51	112
ENST00000527174	2155	288	65379376	65379561	210	394	51	112

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8N413	51	112	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8N413	51	112	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8N413	51	112	52	113	Alternative sequence	ID=VSP_026248;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
Q8N413	51	112	52	113	Alternative sequence	ID=VSP_026248;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
Q8N413	51	112	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
Q8N413	51	112	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
Q8N413	51	112	1	83	Repeat	Note=Solcar 1
Q8N413	51	112	1	83	Repeat	Note=Solcar 1
Q8N413	51	112	97	191	Repeat	Note=Solcar 2
Q8N413	51	112	97	191	Repeat	Note=Solcar 2
Q8N413	51	112	63	83	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8N413	51	112	63	83	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8N413	51	112	100	120	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8N413	51	112	100	120	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8N413	27	50	1	42	Alternative sequence	ID=VSP_026246;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
Q8N413	27	50	1	42	Alternative sequence	ID=VSP_026246;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.1;Dbxref=PMID:15489334
Q8N413	27	50	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8N413	27	50	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8N413	27	50	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
Q8N413	27	50	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
Q8N413	27	50	1	83	Repeat	Note=Solcar 1
Q8N413	27	50	1	83	Repeat	Note=Solcar 1
Q8N413	51	112	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8N413	51	112	28	51	Alternative sequence	ID=VSP_026247;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q8N413	51	112	52	113	Alternative sequence	ID=VSP_026248;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
Q8N413	51	112	52	113	Alternative sequence	ID=VSP_026248;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.1
Q8N413	51	112	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
Q8N413	51	112	1	288	Chain	ID=PRO_0000291826;Note=Solute carrier family 25 member 45
Q8N413	51	112	1	83	Repeat	Note=Solcar 1
Q8N413	51	112	1	83	Repeat	Note=Solcar 1
Q8N413	51	112	97	191	Repeat	Note=Solcar 2
Q8N413	51	112	97	191	Repeat	Note=Solcar 2
Q8N413	51	112	63	83	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8N413	51	112	63	83	Transmembrane	Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8N413	51	112	100	120	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8N413	51	112	100	120	Transmembrane	Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255

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3'-UTR located exon skipping events that lost miRNA binding sites in SLC25A45

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for SLC25A45

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for SLC25A45

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC25A45

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for SLC25A45

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

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RelatedDrugs for SLC25A45

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SLC25A45

Diseases associated with this gene. (DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

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