ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for JAKMIP3

Gene summary

Gene information	Gene symbol	JAKMIP3
	Gene ID	282973
	Gene name	Janus kinase and microtubule interacting protein 3
	Synonyms	C10orf14\|C10orf39\|Jamip3\|NECC2\|bA140A10.5
	Cytomap	10q26.3
	Type of gene	protein-coding
	Description	janus kinase and microtubule-interacting protein 3neuroendocrine long coiled-coil 2neuroendocrine long coiled-coil protein 2
	Modification date	20200313
	UniProtAcc	A0A590UIU4, A0A590UJ09, A0A590UJ61, A0A590UJC8, A0A590UJF4, A0A590UJG1, A0A590UJH1, A0A590UJQ3, A0A590UJS0, A0A590UJT1, A0A590UK11, A0A590UK42, A0A590UK98, Q5VZ66,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Gene structures and expression levels for JAKMIP3

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000188385

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	UP	ENST00000658847.1	JAKMIP3-209:protein_coding:JAKMIP3	4.351666e+01	1.834884e+00	1.271361e-08	3.691522e-07
CB	UP	ENST00000669241.1	JAKMIP3-221:lncRNA:JAKMIP3	4.581748e+00	8.532913e-01	2.606770e-05	2.369356e-04
CB	UP	ENST00000666974.1	JAKMIP3-218:protein_coding:JAKMIP3	1.175029e+02	1.239203e+00	7.097179e-05	5.538953e-04

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for JAKMIP3

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_101686	chr10	132167984:132169033:132169717:132171255:132182357:132183145	132169717:132171255
exon_skip_104012	chr10	132168338:132169033:132169856:132170252:132182357:132184814	132169856:132170252
exon_skip_105022	chr10	132149982:132150035:132152958:132153023:132153759:132153827	132152958:132153023
exon_skip_107378	chr10	132066015:132066061:132104672:132104943:132117077:132117574	132104672:132104943
exon_skip_118718	chr10	132164670:132164735:132166983:132167055:132167953:132168078	132166983:132167055
exon_skip_129839	chr10	132167984:132169033:132169717:132169932:132182357:132182542	132169717:132169932
exon_skip_134719	chr10	132167953:132169033:132169717:132171255:132182357:132183145	132169717:132171255
exon_skip_155584	chr10	132167984:132169033:132169910:132171255:132182357:132183145	132169910:132171255
exon_skip_162961	chr10	132167984:132169033:132169856:132170252:132182357:132182542	132169856:132170252
exon_skip_177785	chr10	132117514:132117574:132133312:132133527:132135047:132135160	132133312:132133527
exon_skip_181971	chr10	132168338:132169033:132169910:132171255:132182357:132183145	132169910:132171255
exon_skip_209204	chr10	132167953:132169033:132169717:132170915:132182357:132184805	132169717:132170915
exon_skip_209371	chr10	132168341:132169033:132169717:132171255:132182357:132183145	132169717:132171255
exon_skip_219254	chr10	132140528:132140579:132141920:132142042:132145107:132145190	132141920:132142042
exon_skip_226943	chr10	132164670:132164735:132167014:132167055:132167953:132168271	132167014:132167055
exon_skip_228690	chr10	132149982:132150041:132152958:132153023:132153759:132153827	132152958:132153023
exon_skip_239124	chr10	132168338:132169033:132169717:132171255:132182357:132183145	132169717:132171255
exon_skip_239686	chr10	132168341:132169033:132169717:132169932:132182357:132184847	132169717:132169932
exon_skip_251621	chr10	132153924:132153990:132163209:132163412:132164670:132164735	132163209:132163412
exon_skip_256607	chr10	132168338:132169033:132169717:132170915:132182357:132184805	132169717:132170915
exon_skip_262280	chr10	132168338:132169033:132169717:132170915:132182357:132183145	132169717:132170915
exon_skip_265287	chr10	132153913:132153990:132163209:132163412:132164670:132164735	132163209:132163412
exon_skip_275109	chr10	132167953:132169033:132169856:132170252:132182357:132184814	132169856:132170252
exon_skip_27657	chr10	132168341:132169033:132169910:132171255:132182357:132183145	132169910:132171255
exon_skip_277547	chr10	132153913:132153990:132163251:132163412:132164670:132164735	132163251:132163412
exon_skip_286596	chr10	132153924:132153990:132163251:132163412:132164670:132164735	132163251:132163412
exon_skip_291513	chr10	132140528:132140579:132141920:132142048:132145107:132145190	132141920:132142048
exon_skip_38	chr10	132168338:132169033:132169717:132169932:132182357:132184847	132169717:132169932
exon_skip_42819	chr10	132167984:132169033:132169717:132170915:132182357:132182542	132169717:132170915
exon_skip_43492	chr10	132168341:132169033:132169856:132170252:132182357:132183145	132169856:132170252
exon_skip_45233	chr10	132164670:132164735:132167014:132167055:132167953:132168078	132167014:132167055
exon_skip_46515	chr10	132117514:132117574:132133312:132133527:132135041:132135160	132133312:132133527
exon_skip_5452	chr10	132168341:132169033:132169717:132170915:132182357:132183145	132169717:132170915
exon_skip_59533	chr10	132065946:132066061:132104672:132104943:132117077:132117574	132104672:132104943
exon_skip_73843	chr10	132167984:132169033:132169717:132170915:132182357:132183145	132169717:132170915
exon_skip_80956	chr10	132167953:132169033:132169717:132169932:132182357:132184847	132169717:132169932
exon_skip_90194	chr10	132164670:132164735:132166983:132167055:132167953:132168271	132166983:132167055

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for JAKMIP3

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000298622	132169856	132170252	3UTR-3UTR
ENST00000298622	132133312	132133527	In-frame
ENST00000298622	132152958	132153023	In-frame
ENST00000298622	132163209	132163412	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000298622	132169856	132170252	3UTR-3UTR
ENST00000298622	132133312	132133527	In-frame
ENST00000298622	132152958	132153023	In-frame
ENST00000298622	132163209	132163412	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000298622	132166983	132167055	3UTR-3CDS
ENST00000298622	132169856	132170252	3UTR-3UTR
ENST00000298622	132133312	132133527	In-frame
ENST00000298622	132141920	132142048	In-frame
ENST00000298622	132152958	132153023	In-frame
ENST00000298622	132163209	132163412	In-frame

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Infer the effects of exon skipping event on protein functional features for JAKMIP3

p-ENSG00000188385_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000298622	6643	844	132133312	132133527	773	987	211	283
ENST00000298622	6643	844	132152958	132153023	2141	2205	667	689
ENST00000298622	6643	844	132163209	132163412	2354	2556	738	806

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000298622	6643	844	132133312	132133527	773	987	211	283
ENST00000298622	6643	844	132152958	132153023	2141	2205	667	689
ENST00000298622	6643	844	132163209	132163412	2354	2556	738	806

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000298622	6643	844	132133312	132133527	773	987	211	283
ENST00000298622	6643	844	132141920	132142048	1613	1740	491	534
ENST00000298622	6643	844	132152958	132153023	2141	2205	667	689
ENST00000298622	6643	844	132163209	132163412	2354	2556	738	806

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q5VZ66	211	283	1	563	Alternative sequence	ID=VSP_031998;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q5VZ66	211	283	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	211	283	8	258	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	667	689	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	667	689	683	834	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	738	806	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	738	806	683	834	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	738	806	795	795	Natural variant	ID=VAR_039473;Note=In a breast cancer sample%3B somatic mutation. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q5VZ66	211	283	1	563	Alternative sequence	ID=VSP_031998;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q5VZ66	211	283	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	211	283	8	258	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	667	689	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	667	689	683	834	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	738	806	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	738	806	683	834	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	738	806	795	795	Natural variant	ID=VAR_039473;Note=In a breast cancer sample%3B somatic mutation. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q5VZ66	211	283	1	563	Alternative sequence	ID=VSP_031998;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q5VZ66	211	283	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	211	283	8	258	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	491	534	1	563	Alternative sequence	ID=VSP_031998;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q5VZ66	491	534	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	491	534	493	621	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	491	534	493	493	Natural variant	ID=VAR_054016;Note=M->V;Dbxref=dbSNP:rs11592585
Q5VZ66	667	689	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	667	689	683	834	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	738	806	1	844	Chain	ID=PRO_0000323011;Note=Janus kinase and microtubule-interacting protein 3
Q5VZ66	738	806	683	834	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
Q5VZ66	738	806	795	795	Natural variant	ID=VAR_039473;Note=In a breast cancer sample%3B somatic mutation. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:16959974;Dbxref=PMID:16959974

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3'-UTR located exon skipping events that lost miRNA binding sites in JAKMIP3

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
Mayo	ENST00000298622	132169856	132170252	hsa-miR-1915-5p	chr10:132170231-132170238	8mer-1a	chr10:132170231-132170251	166.00	-32.20
Mayo	ENST00000298622	132169856	132170252	hsa-miR-604	chr10:132170242-132170249	8mer-1a	chr10:132170231-132170251	166.00	-32.20
Mayo	ENST00000298622	132169856	132170252	hsa-miR-3085-3p	chr10:132170244-132170251	8mer-1a	chr10:132170231-132170251	166.00	-32.20
Mayo	ENST00000298622	132169856	132170252	hsa-miR-3165	chr10:132170002-132170009	8mer-1a	chr10:132169985-132170009	147.00	-29.79
Mayo	ENST00000298622	132169856	132170252	hsa-miR-4696	chr10:132169901-132169908	8mer-1a	chr10:132169893-132169914	163.00	-26.89
Mayo	ENST00000298622	132169856	132170252	hsa-miR-3922-3p	chr10:132170031-132170038	8mer-1a	chr10:132170029-132170052	172.00	-29.29
Mayo	ENST00000298622	132169856	132170252	hsa-miR-4700-5p	chr10:132170167-132170174	8mer-1a	chr10:132170154-132170174	152.00	-26.63
Mayo	ENST00000298622	132169856	132170252	hsa-miR-654-5p	chr10:132170136-132170143	8mer-1a	chr10:132170125-132170147	165.00	-26.30
Mayo	ENST00000298622	132169856	132170252	hsa-miR-485-5p	chr10:132170024-132170031	8mer-1a	chr10:132170013-132170034	168.00	-27.04
Mayo	ENST00000298622	132169856	132170252	hsa-miR-541-3p	chr10:132170136-132170143	8mer-1a	chr10:132170125-132170147	165.00	-26.30
Mayo	ENST00000298622	132169856	132170252	hsa-miR-3176	chr10:132170031-132170038	8mer-1a	chr10:132170029-132170052	172.00	-29.29
Mayo	ENST00000298622	132169856	132170252	hsa-miR-6504-5p	chr10:132170244-132170251	8mer-1a	chr10:132170231-132170251	166.00	-32.20
Mayo	ENST00000298622	132169856	132170252	hsa-miR-4722-5p	chr10:132169995-132170002	8mer-1a	chr10:132169987-132170008	159.00	-22.42
Mayo	ENST00000298622	132169856	132170252	hsa-miR-4520-3p	chr10:132170093-132170100	8mer-1a	chr10:132170089-132170111	158.00	-27.71
Mayo	ENST00000298622	132169856	132170252	hsa-miR-6884-5p	chr10:132170024-132170031	8mer-1a	chr10:132170013-132170034	168.00	-27.04
Mayo	ENST00000298622	132169856	132170252	hsa-miR-3064-5p	chr10:132170244-132170251	8mer-1a	chr10:132170231-132170251	166.00	-32.20
Mayo	ENST00000298622	132169856	132170252	hsa-miR-4267	chr10:132170195-132170202	8mer-1a	chr10:132170187-132170211	147.00	-20.28
Mayo	ENST00000298622	132169856	132170252	hsa-miR-9899	chr10:132170012-132170019	8mer-1a	chr10:132170012-132170033	153.00	-22.98
Mayo	ENST00000298622	132169856	132170252	hsa-miR-544b	chr10:132170146-132170153	8mer-1a	chr10:132170133-132170154	160.00	-17.98
Mayo	ENST00000298622	132169856	132170252	hsa-miR-6131	chr10:132170076-132170083	8mer-1a	chr10:132170076-132170095	156.00	-28.04
Mayo	ENST00000298622	132169856	132170252	hsa-miR-1271-3p	chr10:132170018-132170025	8mer-1a	chr10:132170013-132170034	168.00	-27.04
Mayo	ENST00000298622	132169856	132170252	hsa-miR-8089	chr10:132170167-132170174	8mer-1a	chr10:132170154-132170174	152.00	-26.63
Mayo	ENST00000298622	132169856	132170252	hsa-miR-4648	chr10:132170183-132170190	8mer-1a	chr10:132170170-132170190	150.00	-31.72
Mayo	ENST00000298622	132169856	132170252	hsa-miR-6874-5p	chr10:132170202-132170209	8mer-1a	chr10:132170187-132170211	147.00	-20.28
Mayo	ENST00000298622	132169856	132170252	hsa-miR-550a-3-5p	chr10:132170018-132170025	8mer-1a	chr10:132170013-132170034	168.00	-27.04
Mayo	ENST00000298622	132169856	132170252	hsa-miR-550a-5p	chr10:132170018-132170025	8mer-1a	chr10:132170013-132170034	168.00	-27.04
Mayo	ENST00000298622	132169856	132170252	hsa-miR-661	chr10:132170016-132170023	8mer-1a	chr10:132170013-132170034	168.00	-27.04
Mayo	ENST00000298622	132169856	132170252	hsa-miR-4667-5p	chr10:132170167-132170174	8mer-1a	chr10:132170154-132170174	152.00	-26.63
Mayo	ENST00000298622	132169856	132170252	hsa-miR-2861	chr10:132170133-132170140	8mer-1a	chr10:132170125-132170147	165.00	-26.30
Mayo	ENST00000298622	132169856	132170252	hsa-miR-1184	chr10:132170045-132170052	8mer-1a	chr10:132170029-132170052	172.00	-29.29
MSBB	ENST00000298622	132169856	132170252	hsa-miR-1915-5p	chr10:132170231-132170238	8mer-1a	chr10:132170231-132170251	166.00	-32.20
MSBB	ENST00000298622	132169856	132170252	hsa-miR-604	chr10:132170242-132170249	8mer-1a	chr10:132170231-132170251	166.00	-32.20
MSBB	ENST00000298622	132169856	132170252	hsa-miR-3085-3p	chr10:132170244-132170251	8mer-1a	chr10:132170231-132170251	166.00	-32.20
MSBB	ENST00000298622	132169856	132170252	hsa-miR-3165	chr10:132170002-132170009	8mer-1a	chr10:132169985-132170009	147.00	-29.79
MSBB	ENST00000298622	132169856	132170252	hsa-miR-4696	chr10:132169901-132169908	8mer-1a	chr10:132169893-132169914	163.00	-26.89
MSBB	ENST00000298622	132169856	132170252	hsa-miR-3922-3p	chr10:132170031-132170038	8mer-1a	chr10:132170029-132170052	172.00	-29.29
MSBB	ENST00000298622	132169856	132170252	hsa-miR-4700-5p	chr10:132170167-132170174	8mer-1a	chr10:132170154-132170174	152.00	-26.63
MSBB	ENST00000298622	132169856	132170252	hsa-miR-654-5p	chr10:132170136-132170143	8mer-1a	chr10:132170125-132170147	165.00	-26.30
MSBB	ENST00000298622	132169856	132170252	hsa-miR-485-5p	chr10:132170024-132170031	8mer-1a	chr10:132170013-132170034	168.00	-27.04
MSBB	ENST00000298622	132169856	132170252	hsa-miR-541-3p	chr10:132170136-132170143	8mer-1a	chr10:132170125-132170147	165.00	-26.30
MSBB	ENST00000298622	132169856	132170252	hsa-miR-3176	chr10:132170031-132170038	8mer-1a	chr10:132170029-132170052	172.00	-29.29
MSBB	ENST00000298622	132169856	132170252	hsa-miR-6504-5p	chr10:132170244-132170251	8mer-1a	chr10:132170231-132170251	166.00	-32.20
MSBB	ENST00000298622	132169856	132170252	hsa-miR-4722-5p	chr10:132169995-132170002	8mer-1a	chr10:132169987-132170008	159.00	-22.42
MSBB	ENST00000298622	132169856	132170252	hsa-miR-4520-3p	chr10:132170093-132170100	8mer-1a	chr10:132170089-132170111	158.00	-27.71
MSBB	ENST00000298622	132169856	132170252	hsa-miR-6884-5p	chr10:132170024-132170031	8mer-1a	chr10:132170013-132170034	168.00	-27.04
MSBB	ENST00000298622	132169856	132170252	hsa-miR-3064-5p	chr10:132170244-132170251	8mer-1a	chr10:132170231-132170251	166.00	-32.20
MSBB	ENST00000298622	132169856	132170252	hsa-miR-4267	chr10:132170195-132170202	8mer-1a	chr10:132170187-132170211	147.00	-20.28
MSBB	ENST00000298622	132169856	132170252	hsa-miR-9899	chr10:132170012-132170019	8mer-1a	chr10:132170012-132170033	153.00	-22.98
MSBB	ENST00000298622	132169856	132170252	hsa-miR-544b	chr10:132170146-132170153	8mer-1a	chr10:132170133-132170154	160.00	-17.98
MSBB	ENST00000298622	132169856	132170252	hsa-miR-6131	chr10:132170076-132170083	8mer-1a	chr10:132170076-132170095	156.00	-28.04
MSBB	ENST00000298622	132169856	132170252	hsa-miR-1271-3p	chr10:132170018-132170025	8mer-1a	chr10:132170013-132170034	168.00	-27.04
MSBB	ENST00000298622	132169856	132170252	hsa-miR-8089	chr10:132170167-132170174	8mer-1a	chr10:132170154-132170174	152.00	-26.63
MSBB	ENST00000298622	132169856	132170252	hsa-miR-4648	chr10:132170183-132170190	8mer-1a	chr10:132170170-132170190	150.00	-31.72
MSBB	ENST00000298622	132169856	132170252	hsa-miR-6874-5p	chr10:132170202-132170209	8mer-1a	chr10:132170187-132170211	147.00	-20.28
MSBB	ENST00000298622	132169856	132170252	hsa-miR-550a-3-5p	chr10:132170018-132170025	8mer-1a	chr10:132170013-132170034	168.00	-27.04
MSBB	ENST00000298622	132169856	132170252	hsa-miR-550a-5p	chr10:132170018-132170025	8mer-1a	chr10:132170013-132170034	168.00	-27.04
MSBB	ENST00000298622	132169856	132170252	hsa-miR-661	chr10:132170016-132170023	8mer-1a	chr10:132170013-132170034	168.00	-27.04
MSBB	ENST00000298622	132169856	132170252	hsa-miR-4667-5p	chr10:132170167-132170174	8mer-1a	chr10:132170154-132170174	152.00	-26.63
MSBB	ENST00000298622	132169856	132170252	hsa-miR-2861	chr10:132170133-132170140	8mer-1a	chr10:132170125-132170147	165.00	-26.30
MSBB	ENST00000298622	132169856	132170252	hsa-miR-1184	chr10:132170045-132170052	8mer-1a	chr10:132170029-132170052	172.00	-29.29
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-1915-5p	chr10:132170231-132170238	8mer-1a	chr10:132170231-132170251	166.00	-32.20
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-604	chr10:132170242-132170249	8mer-1a	chr10:132170231-132170251	166.00	-32.20
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-3085-3p	chr10:132170244-132170251	8mer-1a	chr10:132170231-132170251	166.00	-32.20
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-3165	chr10:132170002-132170009	8mer-1a	chr10:132169985-132170009	147.00	-29.79
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-4696	chr10:132169901-132169908	8mer-1a	chr10:132169893-132169914	163.00	-26.89
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-3922-3p	chr10:132170031-132170038	8mer-1a	chr10:132170029-132170052	172.00	-29.29
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-4700-5p	chr10:132170167-132170174	8mer-1a	chr10:132170154-132170174	152.00	-26.63
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-654-5p	chr10:132170136-132170143	8mer-1a	chr10:132170125-132170147	165.00	-26.30
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-485-5p	chr10:132170024-132170031	8mer-1a	chr10:132170013-132170034	168.00	-27.04
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-541-3p	chr10:132170136-132170143	8mer-1a	chr10:132170125-132170147	165.00	-26.30
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-3176	chr10:132170031-132170038	8mer-1a	chr10:132170029-132170052	172.00	-29.29
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-6504-5p	chr10:132170244-132170251	8mer-1a	chr10:132170231-132170251	166.00	-32.20
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-4722-5p	chr10:132169995-132170002	8mer-1a	chr10:132169987-132170008	159.00	-22.42
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-4520-3p	chr10:132170093-132170100	8mer-1a	chr10:132170089-132170111	158.00	-27.71
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-6884-5p	chr10:132170024-132170031	8mer-1a	chr10:132170013-132170034	168.00	-27.04
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-3064-5p	chr10:132170244-132170251	8mer-1a	chr10:132170231-132170251	166.00	-32.20
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-4267	chr10:132170195-132170202	8mer-1a	chr10:132170187-132170211	147.00	-20.28
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-9899	chr10:132170012-132170019	8mer-1a	chr10:132170012-132170033	153.00	-22.98
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-544b	chr10:132170146-132170153	8mer-1a	chr10:132170133-132170154	160.00	-17.98
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-6131	chr10:132170076-132170083	8mer-1a	chr10:132170076-132170095	156.00	-28.04
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-1271-3p	chr10:132170018-132170025	8mer-1a	chr10:132170013-132170034	168.00	-27.04
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-8089	chr10:132170167-132170174	8mer-1a	chr10:132170154-132170174	152.00	-26.63
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-4648	chr10:132170183-132170190	8mer-1a	chr10:132170170-132170190	150.00	-31.72
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-6874-5p	chr10:132170202-132170209	8mer-1a	chr10:132170187-132170211	147.00	-20.28
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-550a-3-5p	chr10:132170018-132170025	8mer-1a	chr10:132170013-132170034	168.00	-27.04
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-550a-5p	chr10:132170018-132170025	8mer-1a	chr10:132170013-132170034	168.00	-27.04
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-661	chr10:132170016-132170023	8mer-1a	chr10:132170013-132170034	168.00	-27.04
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-4667-5p	chr10:132170167-132170174	8mer-1a	chr10:132170154-132170174	152.00	-26.63
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-2861	chr10:132170133-132170140	8mer-1a	chr10:132170125-132170147	165.00	-26.30
ROSMAP	ENST00000298622	132169856	132170252	hsa-miR-1184	chr10:132170045-132170052	8mer-1a	chr10:132170029-132170052	172.00	-29.29

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SNVs in the skipped exons for JAKMIP3

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for JAKMIP3

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for JAKMIP3

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
HCC	exon_skip_155584	rs2101613	chr10:132189263	1.143528e-05	1.412320e-03
HCC	exon_skip_155584	rs7915260	chr10:132164027	1.192441e-05	1.464804e-03
HCC	exon_skip_155584	rs4880341	chr10:132179185	1.397832e-05	1.685371e-03
HCC	exon_skip_155584	rs7094598	chr10:132174724	7.645815e-05	7.272991e-03
HCC	exon_skip_155584	rs4880348	chr10:132215263	4.924371e-04	3.348708e-02
PCC	exon_skip_181971	rs2101613	chr10:132189263	3.171612e-04	4.270324e-02

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Correlation with RNA binding proteins (RBPs) for JAKMIP3

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	TARDBP	exon_skip_181971	4.009392e-01	3.368601e-07
CB	ZNF638	exon_skip_181971	4.628655e-01	2.178201e-09
CB	RBM6	exon_skip_181971	4.021018e-01	3.092197e-07
CB	RBM45	exon_skip_181971	-4.364956e-01	2.109552e-08
CB	RBM4	exon_skip_181971	5.677570e-01	2.914761e-14
CB	RBM4B	exon_skip_181971	4.383606e-01	1.807871e-08
TC	RBM6	exon_skip_42819	4.098319e-01	2.308667e-07
TC	RBM6	exon_skip_239124	4.034237e-01	3.695560e-07

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RelatedDrugs for JAKMIP3

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for JAKMIP3

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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