ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for BIN1

Gene summary

Gene information	Gene symbol	BIN1
	Gene ID	274
	Gene name	bridging integrator 1
	Synonyms	AMPH2\|AMPHL\|CNM2\|SH3P9
	Cytomap	2q14.3
	Type of gene	protein-coding
	Description	myc box-dependent-interacting protein 1amphiphysin IIamphiphysin-like proteinbox dependant MYC interacting protein 1box-dependent myc-interacting protein 1
	Modification date	20200322
	UniProtAcc	A0A024RAE9, A0A024RAF0, A0A024RAF1, A0A024RAF6, A0A024RAG8, A0A024RAG9, A0A024RAI4, A0A024RAI5, A0A024RAI6, A0A024RAJ2, A0A024RAJ3, O00499, Q9BTH3,
	Context	- 32500121(Bridging Integrator-1 protein loss in Alzheimer's disease promotes synaptic tau accumulation and disrupts tau release)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
BIN1	GO:0033292	T-tubule organization	24755653
BIN1	GO:0043065	positive regulation of apoptotic process	16530520
BIN1	GO:0071156	regulation of cell cycle arrest	10412034

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Gene structures and expression levels for BIN1

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000136717

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
STG	UP	ENST00000484253.1	BIN1-214:lncRNA:BIN1	9.580109e+00	6.414734e+00	5.396743e-05	7.721675e-03
PG	UP	ENST00000393040.7	BIN1-209:protein_coding:BIN1	8.730635e+01	1.082166e+00	1.795128e-03	2.212174e-02
CB	DOWN	ENST00000376113.6	BIN1-208:protein_coding:BIN1	8.152477e+01	-2.640907e+00	1.344304e-05	1.352815e-04
CB	DOWN	ENST00000346226.7	BIN1-203:protein_coding:BIN1	2.870894e+01	-1.055051e+00	3.037758e-03	1.303847e-02
TC	DOWN	ENST00000376113.6	BIN1-208:protein_coding:BIN1	2.202627e+02	-1.225656e+00	3.146039e-05	6.406462e-04

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for BIN1

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_104202	chr2	127052255:127052362:127057473:127057601:127059011:127059155	127057473:127057601
exon_skip_106622	chr2	127053905:127054012:127057473:127057601:127059011:127059155	127057473:127057601
exon_skip_119180	chr2	127051172:127051243:127057473:127057601:127059011:127059155	127057473:127057601
exon_skip_138841	chr2	127059011:127059155:127062115:127062197:127063571:127063646	127062115:127062197
exon_skip_139142	chr2	127050891:127050912:127051154:127051243:127052255:127052362	127051154:127051243
exon_skip_142967	chr2	127051154:127051243:127052255:127052362:127059011:127059155	127052255:127052362
exon_skip_143171	chr2	127059011:127059155:127062115:127062197:127063571:127063638	127062115:127062197
exon_skip_143461	chr2	127050421:127050522:127050802:127050912:127059011:127059155	127050802:127050912
exon_skip_166807	chr2	127063933:127064018:127068924:127069031:127069995:127070090	127068924:127069031
exon_skip_168516	chr2	127053921:127054012:127057473:127057601:127059011:127059155	127057473:127057601
exon_skip_172610	chr2	127052352:127052362:127057473:127057601:127059011:127059155	127057473:127057601
exon_skip_183403	chr2	127059124:127059155:127060596:127060640:127062115:127062188	127060596:127060640
exon_skip_183557	chr2	127051172:127051243:127052255:127052362:127059011:127059155	127052255:127052362
exon_skip_189970	chr2	127050802:127050912:127051154:127051243:127052255:127052362	127051154:127051243
exon_skip_191641	chr2	127070762:127070816:127076626:127076706:127106860:127107001	127076626:127076706
exon_skip_199835	chr2	127068924:127069031:127069995:127070090:127070553:127070647	127069995:127070090
exon_skip_200446	chr2	127063977:127064018:127068163:127068255:127068924:127069031	127068163:127068255
exon_skip_207101	chr2	127051154:127051243:127057473:127057601:127059011:127059155	127057473:127057601
exon_skip_210011	chr2	127050891:127050912:127051154:127051243:127057473:127057601	127051154:127051243
exon_skip_211309	chr2	127050891:127050912:127051154:127051243:127059011:127059155	127051154:127051243
exon_skip_219361	chr2	127050809:127050912:127051154:127051243:127059011:127059155	127051154:127051243
exon_skip_221656	chr2	127050802:127050912:127051154:127051243:127059011:127059155	127051154:127051243
exon_skip_232751	chr2	127051154:127051243:127052255:127052362:127057473:127057601	127052255:127052362
exon_skip_24050	chr2	127069995:127070090:127070553:127070647:127070762:127070816	127070553:127070647
exon_skip_249093	chr2	127051154:127051243:127052255:127052362:127053422:127053445	127052255:127052362
exon_skip_254986	chr2	127050802:127050912:127051154:127051243:127057473:127057601	127051154:127051243
exon_skip_269992	chr2	127048038:127048633:127050421:127050522:127050802:127050912	127050421:127050522
exon_skip_276378	chr2	127059011:127059155:127060596:127060640:127062115:127062188	127060596:127060640
exon_skip_281489	chr2	127052255:127052362:127053422:127053445:127053905:127054012	127053422:127053445
exon_skip_290692	chr2	127063933:127064018:127068163:127068255:127068924:127069031	127068163:127068255
exon_skip_293008	chr2	127051172:127051243:127052255:127052362:127053422:127053445	127052255:127052362
exon_skip_31297	chr2	127051172:127051243:127052255:127052362:127057473:127057601	127052255:127052362
exon_skip_54905	chr2	127059011:127059155:127060596:127060640:127062115:127062197	127060596:127060640
exon_skip_63247	chr2	127053422:127053445:127053905:127054012:127057473:127057601	127053905:127054012
exon_skip_78995	chr2	127051172:127051243:127059011:127059155:127062115:127062188	127059011:127059155
exon_skip_79464	chr2	127053422:127053445:127053905:127054012:127059011:127059155	127053905:127054012

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_81163	Mayo_CB	5.091358e-01	3.729730e-01	1.361628e-01	1.986033e-04
exon_skip_176526	Mayo_CB	3.110976e-01	1.750649e-01	1.360326e-01	2.765265e-06

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Open reading frame (ORF) annotation in the exon skipping event for BIN1

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000316724	127062115	127062197	Frame-shift
ENST00000316724	127050421	127050522	In-frame
ENST00000316724	127052255	127052362	In-frame
ENST00000316724	127053905	127054012	In-frame
ENST00000316724	127057473	127057601	In-frame
ENST00000316724	127068163	127068255	In-frame
ENST00000316724	127069995	127070090	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000316724	127052255	127052362	In-frame
ENST00000316724	127057473	127057601	In-frame
ENST00000316724	127068163	127068255	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000316724	127062115	127062197	Frame-shift
ENST00000316724	127070553	127070647	Frame-shift
ENST00000316724	127050421	127050522	In-frame
ENST00000316724	127051154	127051243	In-frame
ENST00000316724	127052255	127052362	In-frame
ENST00000316724	127053422	127053445	In-frame
ENST00000316724	127053905	127054012	In-frame
ENST00000316724	127057473	127057601	In-frame
ENST00000316724	127068163	127068255	In-frame
ENST00000316724	127069995	127070090	In-frame
ENST00000316724	127076626	127076706	In-frame

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Infer the effects of exon skipping event on protein functional features for BIN1

p-ENSG00000136717_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000316724	2710	593	127069995	127070090	728	822	105	136
ENST00000316724	2710	593	127068163	127068255	932	1023	173	203
ENST00000316724	2710	593	127057473	127057601	1415	1542	334	376
ENST00000316724	2710	593	127053905	127054012	1544	1650	377	412
ENST00000316724	2710	593	127052255	127052362	1676	1782	421	456
ENST00000316724	2710	593	127050421	127050522	1985	2085	524	557

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000316724	2710	593	127068163	127068255	932	1023	173	203
ENST00000316724	2710	593	127057473	127057601	1415	1542	334	376
ENST00000316724	2710	593	127052255	127052362	1676	1782	421	456

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000316724	2710	593	127076626	127076706	497	576	28	54
ENST00000316724	2710	593	127069995	127070090	728	822	105	136
ENST00000316724	2710	593	127068163	127068255	932	1023	173	203
ENST00000316724	2710	593	127057473	127057601	1415	1542	334	376
ENST00000316724	2710	593	127053905	127054012	1544	1650	377	412
ENST00000316724	2710	593	127052255	127052362	1676	1782	421	456
ENST00000316724	2710	593	127051154	127051243	1784	1872	457	486
ENST00000316724	2710	593	127050421	127050522	1985	2085	524	557

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O00499	105	136	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	105	136	29	276	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00361
O00499	105	136	97	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2FIC
O00499	105	136	123	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2FIC
O00499	105	136	133	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2FIC
O00499	105	136	2	122	Region	Note=Interaction with BIN2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:10903846;Dbxref=PMID:10903846
O00499	173	203	174	204	Alternative sequence	ID=VSP_000246;Note=In isoform IIB%2C isoform IIC2%2C isoform II2%2C isoform II3%2C isoform BIN1%2C isoform BIN1+12A%2C isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0
O00499	173	203	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	173	203	193	267	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00499	173	203	29	276	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00361
O00499	334	376	335	487	Alternative sequence	ID=VSP_000251;Note=In isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9395479;Dbxref=PMID:9395479
O00499	334	376	335	457	Alternative sequence	ID=VSP_000250;Note=In isoform II3 and isoform BIN1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8782822,ECO:0000303\|PubMed:9182667,ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:8782
O00499	334	376	335	421	Alternative sequence	ID=VSP_000249;Note=In isoform IIC1 and isoform IIC2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	334	376	335	377	Alternative sequence	ID=VSP_000248;Note=In isoform IID. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	334	376	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	377	412	335	487	Alternative sequence	ID=VSP_000251;Note=In isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9395479;Dbxref=PMID:9395479
O00499	377	412	335	457	Alternative sequence	ID=VSP_000250;Note=In isoform II3 and isoform BIN1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8782822,ECO:0000303\|PubMed:9182667,ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:8782
O00499	377	412	335	421	Alternative sequence	ID=VSP_000249;Note=In isoform IIC1 and isoform IIC2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	377	412	335	377	Alternative sequence	ID=VSP_000248;Note=In isoform IID. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	377	412	378	457	Alternative sequence	ID=VSP_000253;Note=In isoform II2 and isoform BIN1+12A. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:9223448,PMID:9395479
O00499	377	412	378	421	Alternative sequence	ID=VSP_000252;Note=In isoform IIB. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	377	412	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	377	412	378	421	Region	Note=Clathrin-binding
O00499	421	456	335	487	Alternative sequence	ID=VSP_000251;Note=In isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9395479;Dbxref=PMID:9395479
O00499	421	456	335	457	Alternative sequence	ID=VSP_000250;Note=In isoform II3 and isoform BIN1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8782822,ECO:0000303\|PubMed:9182667,ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:8782
O00499	421	456	335	421	Alternative sequence	ID=VSP_000249;Note=In isoform IIC1 and isoform IIC2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	421	456	378	457	Alternative sequence	ID=VSP_000253;Note=In isoform II2 and isoform BIN1+12A. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:9223448,PMID:9395479
O00499	421	456	378	421	Alternative sequence	ID=VSP_000252;Note=In isoform IIB. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	421	456	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	421	456	378	421	Region	Note=Clathrin-binding
O00499	524	557	523	527	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1MUZ
O00499	524	557	535	537	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1MUZ
O00499	524	557	546	549	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1MUZ
O00499	524	557	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	524	557	520	593	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
O00499	524	557	555	557	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1MUZ
O00499	524	557	528	528	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
O00499	524	557	528	528	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O00499	173	203	174	204	Alternative sequence	ID=VSP_000246;Note=In isoform IIB%2C isoform IIC2%2C isoform II2%2C isoform II3%2C isoform BIN1%2C isoform BIN1+12A%2C isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0
O00499	173	203	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	173	203	193	267	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00499	173	203	29	276	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00361
O00499	334	376	335	487	Alternative sequence	ID=VSP_000251;Note=In isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9395479;Dbxref=PMID:9395479
O00499	334	376	335	457	Alternative sequence	ID=VSP_000250;Note=In isoform II3 and isoform BIN1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8782822,ECO:0000303\|PubMed:9182667,ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:8782
O00499	334	376	335	421	Alternative sequence	ID=VSP_000249;Note=In isoform IIC1 and isoform IIC2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	334	376	335	377	Alternative sequence	ID=VSP_000248;Note=In isoform IID. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	334	376	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	421	456	335	487	Alternative sequence	ID=VSP_000251;Note=In isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9395479;Dbxref=PMID:9395479
O00499	421	456	335	457	Alternative sequence	ID=VSP_000250;Note=In isoform II3 and isoform BIN1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8782822,ECO:0000303\|PubMed:9182667,ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:8782
O00499	421	456	335	421	Alternative sequence	ID=VSP_000249;Note=In isoform IIC1 and isoform IIC2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	421	456	378	457	Alternative sequence	ID=VSP_000253;Note=In isoform II2 and isoform BIN1+12A. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:9223448,PMID:9395479
O00499	421	456	378	421	Alternative sequence	ID=VSP_000252;Note=In isoform IIB. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	421	456	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	421	456	378	421	Region	Note=Clathrin-binding

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O00499	28	54	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	28	54	15	42	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00499	28	54	29	276	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00361
O00499	28	54	8	33	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2RMY
O00499	28	54	43	89	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2FIC
O00499	28	54	35	35	Natural variant	ID=VAR_037425;Note=In CNM2%3B abolishes membrane tubulation. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17676042;Dbxref=dbSNP:rs121909273,PMID:17676042
O00499	28	54	2	122	Region	Note=Interaction with BIN2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:10903846;Dbxref=PMID:10903846
O00499	105	136	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	105	136	29	276	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00361
O00499	105	136	97	121	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2FIC
O00499	105	136	123	131	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2FIC
O00499	105	136	133	161	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2FIC
O00499	105	136	2	122	Region	Note=Interaction with BIN2;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:10903846;Dbxref=PMID:10903846
O00499	173	203	174	204	Alternative sequence	ID=VSP_000246;Note=In isoform IIB%2C isoform IIC2%2C isoform II2%2C isoform II3%2C isoform BIN1%2C isoform BIN1+12A%2C isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0
O00499	173	203	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	173	203	193	267	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00499	173	203	29	276	Domain	Note=BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00361
O00499	334	376	335	487	Alternative sequence	ID=VSP_000251;Note=In isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9395479;Dbxref=PMID:9395479
O00499	334	376	335	457	Alternative sequence	ID=VSP_000250;Note=In isoform II3 and isoform BIN1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8782822,ECO:0000303\|PubMed:9182667,ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:8782
O00499	334	376	335	421	Alternative sequence	ID=VSP_000249;Note=In isoform IIC1 and isoform IIC2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	334	376	335	377	Alternative sequence	ID=VSP_000248;Note=In isoform IID. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	334	376	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	377	412	335	487	Alternative sequence	ID=VSP_000251;Note=In isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9395479;Dbxref=PMID:9395479
O00499	377	412	335	457	Alternative sequence	ID=VSP_000250;Note=In isoform II3 and isoform BIN1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8782822,ECO:0000303\|PubMed:9182667,ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:8782
O00499	377	412	335	421	Alternative sequence	ID=VSP_000249;Note=In isoform IIC1 and isoform IIC2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	377	412	335	377	Alternative sequence	ID=VSP_000248;Note=In isoform IID. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	377	412	378	457	Alternative sequence	ID=VSP_000253;Note=In isoform II2 and isoform BIN1+12A. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:9223448,PMID:9395479
O00499	377	412	378	421	Alternative sequence	ID=VSP_000252;Note=In isoform IIB. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	377	412	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	377	412	378	421	Region	Note=Clathrin-binding
O00499	421	456	335	487	Alternative sequence	ID=VSP_000251;Note=In isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9395479;Dbxref=PMID:9395479
O00499	421	456	335	457	Alternative sequence	ID=VSP_000250;Note=In isoform II3 and isoform BIN1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8782822,ECO:0000303\|PubMed:9182667,ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:8782
O00499	421	456	335	421	Alternative sequence	ID=VSP_000249;Note=In isoform IIC1 and isoform IIC2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	421	456	378	457	Alternative sequence	ID=VSP_000253;Note=In isoform II2 and isoform BIN1+12A. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:9223448,PMID:9395479
O00499	421	456	378	421	Alternative sequence	ID=VSP_000252;Note=In isoform IIB. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9603201;Dbxref=PMID:9603201
O00499	421	456	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	421	456	378	421	Region	Note=Clathrin-binding
O00499	457	486	335	487	Alternative sequence	ID=VSP_000251;Note=In isoform BIN1-10-13 and isoform BIN1-13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:9395479;Dbxref=PMID:9395479
O00499	457	486	335	457	Alternative sequence	ID=VSP_000250;Note=In isoform II3 and isoform BIN1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8782822,ECO:0000303\|PubMed:9182667,ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:8782
O00499	457	486	378	457	Alternative sequence	ID=VSP_000253;Note=In isoform II2 and isoform BIN1+12A. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:9223448,ECO:0000303\|PubMed:9395479;Dbxref=PMID:9223448,PMID:9395479
O00499	457	486	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	457	486	474	474	Sequence conflict	Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305
O00499	457	486	481	481	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
O00499	457	486	481	481	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
O00499	457	486	481	481	Sequence conflict	Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
O00499	524	557	523	527	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1MUZ
O00499	524	557	535	537	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1MUZ
O00499	524	557	546	549	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1MUZ
O00499	524	557	2	593	Chain	ID=PRO_0000192951;Note=Myc box-dependent-interacting protein 1
O00499	524	557	520	593	Domain	Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00192
O00499	524	557	555	557	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1MUZ
O00499	524	557	528	528	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305
O00499	524	557	528	528	Sequence conflict	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305

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3'-UTR located exon skipping events that lost miRNA binding sites in BIN1

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for BIN1

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for BIN1

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info	Cohort	Tissue	SE id	Coefficient	P-value	Chromosome	Strand	E1 start	E1 end	Skipped start	Skipped end	E2 start	E2 end
ADstage	MSBB	IFG	exon_skip_268228	-4.291255e-01	2.268376e-02	chr2	-	127051154	127051243	127052255	127054012	127059011	127059155
CDR	MSBB	IFG	exon_skip_268228	-5.154216e-01	5.000037e-03	chr2	-	127051154	127051243	127052255	127054012	127059011	127059155
CDR	MSBB	IFG	exon_skip_221656	4.609356e-01	1.356383e-02	chr2	-	127050802	127050912	127051154	127051243	127059011	127059155
CDR	MSBB	IFG	exon_skip_282074	4.194551e-01	2.628550e-02	chr2	-	127050802	127050912	127051154	127057601	127059011	127059155

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for BIN1

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
TC	exon_skip_200446	rs17014784	chr2:127034897	9.951003e-05	1.629857e-02

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Correlation with RNA binding proteins (RBPs) for BIN1

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	CNOT4	exon_skip_293008	-4.618251e-01	8.934012e-10
CB	PCBP1	exon_skip_293008	-4.233934e-01	2.690862e-08
CB	PCBP4	exon_skip_293008	4.528345e-01	2.058856e-09
CB	RBM4B	exon_skip_293008	-4.525015e-01	2.122536e-09
CB	HNRNPA0	exon_skip_129221	4.134125e-01	8.358696e-07
CB	SRSF2	exon_skip_113472	4.420977e-01	5.408496e-09
CB	TIA1	exon_skip_113472	4.440229e-01	4.559629e-09
CB	HNRNPA1	exon_skip_113472	5.210853e-01	1.899616e-12
CB	HNRNPA0	exon_skip_113472	4.341763e-01	1.079792e-08
CB	RBM45	exon_skip_113472	4.419464e-01	5.481296e-09
CB	NUP42	exon_skip_113472	5.702039e-01	4.319430e-15
CB	RALYL	exon_skip_113472	5.090657e-01	7.293919e-12
CB	SRSF9	exon_skip_113472	4.139956e-01	5.812429e-08
CB	DAZAP1	exon_skip_105675	4.408933e-01	6.014842e-09
CB	ELAVL1	exon_skip_105675	4.643102e-01	7.062432e-10
CB	CNOT4	exon_skip_105675	4.145221e-01	5.570440e-08
CB	FXR2	exon_skip_105675	5.229996e-01	1.525718e-12
CB	PCBP1	exon_skip_105675	4.334492e-01	1.149527e-08
CB	RBM23	exon_skip_105675	4.128526e-01	6.373017e-08
CB	EWSR1	exon_skip_105675	4.258131e-01	2.198407e-08
CB	SRSF4	exon_skip_105675	4.317915e-01	1.325079e-08
CB	RBM4	exon_skip_105675	5.514827e-01	4.943427e-14
CB	RBM4B	exon_skip_105675	4.551459e-01	1.665002e-09
CB	ZNF638	exon_skip_81163	4.679941e-01	8.244832e-10
CB	RBM6	exon_skip_81163	4.308706e-01	2.188155e-08
CB	FXR2	exon_skip_81163	4.670808e-01	8.980446e-10
CB	PCBP1	exon_skip_81163	4.267706e-01	3.069886e-08
CB	HNRNPA2B1	exon_skip_81163	4.219002e-01	4.563255e-08
CB	RBM45	exon_skip_81163	-4.207876e-01	4.991384e-08
CB	PTBP1	exon_skip_81163	4.206124e-01	5.062238e-08
CB	RBM4	exon_skip_81163	6.067826e-01	5.838381e-17
CB	RBM4B	exon_skip_81163	4.616100e-01	1.490522e-09
CB	DAZAP1	exon_skip_176526	5.232724e-01	1.478636e-12
CB	ELAVL1	exon_skip_176526	4.185529e-01	4.012722e-08
CB	ZNF638	exon_skip_176526	5.922524e-01	1.993123e-16
CB	RBM6	exon_skip_176526	5.667389e-01	6.861343e-15
CB	SAMD4A	exon_skip_176526	4.695618e-01	4.270768e-10
CB	CNOT4	exon_skip_176526	4.686954e-01	4.643012e-10
CB	FXR2	exon_skip_176526	4.252964e-01	2.295664e-08
CB	PCBP1	exon_skip_176526	4.276739e-01	1.879882e-08
CB	TRA2A	exon_skip_176526	5.145348e-01	3.980443e-12
CB	FUBP1	exon_skip_176526	4.627690e-01	8.172696e-10
CB	HNRNPA2B1	exon_skip_176526	4.825066e-01	1.191181e-10
CB	RBM45	exon_skip_176526	-5.725118e-01	3.164056e-15
CB	PTBP1	exon_skip_176526	4.720793e-01	3.345568e-10
CB	SRSF4	exon_skip_176526	4.711123e-01	3.675361e-10
CB	RBM4	exon_skip_176526	7.460591e-01	1.590427e-29
CB	RBM4B	exon_skip_176526	5.314198e-01	5.722887e-13
CB	RBM6	exon_skip_119180	4.751703e-01	2.472229e-10
CB	NUP42	exon_skip_119180	-4.368524e-01	8.565621e-09
DLPFC	TARDBP	exon_skip_198282	4.090855e-01	2.918911e-11
DLPFC	SRSF2	exon_skip_198282	4.763785e-01	3.160826e-15
DLPFC	RBFOX2	exon_skip_198282	5.409957e-01	5.970212e-20
DLPFC	SFPQ	exon_skip_198282	4.187193e-01	8.908861e-12
DLPFC	CNOT4	exon_skip_198282	4.529878e-01	9.510200e-14
DLPFC	TIA1	exon_skip_198282	4.469325e-01	2.202286e-13
DLPFC	RBM5	exon_skip_198282	4.324849e-01	1.528828e-12
DLPFC	MBNL1	exon_skip_198282	4.230238e-01	5.178237e-12
DLPFC	MATR3	exon_skip_198282	5.289996e-01	5.376888e-19
DLPFC	FXR2	exon_skip_198282	4.783012e-01	2.361497e-15
DLPFC	PCBP1	exon_skip_198282	4.404045e-01	5.345944e-13
DLPFC	ILF2	exon_skip_198282	4.573150e-01	5.165729e-14
DLPFC	HNRNPK	exon_skip_198282	4.558756e-01	6.334575e-14
DLPFC	PCBP2	exon_skip_198282	4.380728e-01	7.304826e-13
DLPFC	G3BP2	exon_skip_198282	5.720340e-01	1.321273e-22
DLPFC	HNRNPA1	exon_skip_198282	4.491322e-01	1.626415e-13
DLPFC	RBM24	exon_skip_198282	5.038970e-01	4.071404e-17
DLPFC	ENOX1	exon_skip_198282	4.887431e-01	4.693910e-16
DLPFC	HNRNPA0	exon_skip_198282	5.290732e-01	5.306218e-19
DLPFC	PUM1	exon_skip_198282	5.061534e-01	2.799574e-17
DLPFC	PPRC1	exon_skip_198282	4.256186e-01	3.719672e-12
DLPFC	HNRNPA1L2	exon_skip_198282	4.492157e-01	1.607741e-13
DLPFC	HNRNPA2B1	exon_skip_198282	4.009206e-01	7.750478e-11
DLPFC	PUF60	exon_skip_198282	4.608881e-01	3.100404e-14
DLPFC	NUP42	exon_skip_198282	5.176672e-01	3.963896e-18
DLPFC	RALYL	exon_skip_198282	5.655718e-01	4.976236e-22
DLPFC	EIF4G2	exon_skip_198282	5.030904e-01	4.651497e-17
DLPFC	PTBP3	exon_skip_198282	4.495027e-01	1.545137e-13
DLPFC	HNRNPL	exon_skip_198282	4.933037e-01	2.277716e-16
DLPFC	CPEB2	exon_skip_198282	4.015782e-01	7.171212e-11
DLPFC	CELF1	exon_skip_198282	4.373611e-01	8.031392e-13
DLPFC	RBM23	exon_skip_198282	4.431216e-01	3.704360e-13
DLPFC	EWSR1	exon_skip_198282	4.533461e-01	9.044473e-14
DLPFC	SRSF1	exon_skip_198282	4.675593e-01	1.176233e-14
DLPFC	FUS	exon_skip_198282	4.129591e-01	1.819548e-11
DLPFC	SRSF4	exon_skip_198282	4.105210e-01	2.451677e-11
DLPFC	SRSF9	exon_skip_198282	4.916282e-01	2.974537e-16
DLPFC	SRSF5	exon_skip_198282	4.754360e-01	3.643975e-15
DLPFC	HNRNPH2	exon_skip_198282	5.531358e-01	5.893703e-21
DLPFC	EIF4B	exon_skip_198282	4.733391e-01	4.992760e-15
DLPFC	ESRP1	exon_skip_198282	4.889100e-01	4.572209e-16
DLPFC	NOVA1	exon_skip_198282	5.458403e-01	2.396501e-20
DLPFC	TARDBP	exon_skip_113472	5.252116e-01	1.057178e-18
DLPFC	SRSF2	exon_skip_113472	6.806633e-01	1.485549e-34
DLPFC	RBFOX2	exon_skip_113472	8.198937e-01	1.511940e-60
DLPFC	ELAVL1	exon_skip_113472	4.756047e-01	3.552507e-15
DLPFC	SFPQ	exon_skip_113472	5.965454e-01	6.559481e-25
DLPFC	ZNF638	exon_skip_113472	4.080051e-01	3.326617e-11
DLPFC	SRSF11	exon_skip_113472	-4.015641e-01	7.183171e-11
DLPFC	CNOT4	exon_skip_113472	5.609915e-01	1.251769e-21
DLPFC	TIA1	exon_skip_113472	4.588165e-01	4.171332e-14
DLPFC	RBM5	exon_skip_113472	6.010060e-01	2.377350e-25
DLPFC	MBNL1	exon_skip_113472	4.913896e-01	3.089397e-16
DLPFC	MATR3	exon_skip_113472	6.686744e-01	5.495520e-33
DLPFC	TRNAU1AP	exon_skip_113472	5.041291e-01	3.918009e-17
DLPFC	FXR2	exon_skip_113472	7.122852e-01	4.491080e-39
DLPFC	PCBP1	exon_skip_113472	6.446785e-01	4.664199e-30
DLPFC	ILF2	exon_skip_113472	6.292836e-01	2.592491e-28
DLPFC	HNRNPK	exon_skip_113472	5.802844e-01	2.328295e-23
DLPFC	PCBP4	exon_skip_113472	5.107551e-01	1.293092e-17
DLPFC	PCBP2	exon_skip_113472	5.741124e-01	8.571441e-23
DLPFC	RC3H1	exon_skip_113472	5.095449e-01	1.586149e-17
DLPFC	G3BP2	exon_skip_113472	7.402853e-01	1.281968e-43
DLPFC	SNRPA	exon_skip_113472	6.154931e-01	7.866898e-27
DLPFC	HNRNPA1	exon_skip_113472	6.228454e-01	1.302647e-27
DLPFC	RBM24	exon_skip_113472	6.635818e-01	2.422228e-32
DLPFC	ENOX1	exon_skip_113472	6.496173e-01	1.223336e-30
DLPFC	HNRNPA0	exon_skip_113472	7.744465e-01	5.003016e-50
DLPFC	PUM1	exon_skip_113472	6.256322e-01	6.506539e-28
DLPFC	PPRC1	exon_skip_113472	6.689841e-01	5.016726e-33
DLPFC	HNRNPA1L2	exon_skip_113472	6.294201e-01	2.504221e-28
DLPFC	HNRNPA2B1	exon_skip_113472	4.094898e-01	2.779225e-11
DLPFC	RBM45	exon_skip_113472	4.763223e-01	3.187813e-15
DLPFC	PUF60	exon_skip_113472	7.456083e-01	1.503392e-44
DLPFC	NUP42	exon_skip_113472	6.414078e-01	1.116431e-29
DLPFC	RALYL	exon_skip_113472	7.122790e-01	4.500962e-39
DLPFC	EIF4G2	exon_skip_113472	5.608419e-01	1.289749e-21
DLPFC	PTBP3	exon_skip_113472	5.685439e-01	2.713934e-22
DLPFC	HNRNPL	exon_skip_113472	7.300256e-01	6.903688e-42
DLPFC	CPEB2	exon_skip_113472	4.583992e-01	4.427211e-14
DLPFC	CELF1	exon_skip_113472	6.838380e-01	5.546708e-35
DLPFC	RBM23	exon_skip_113472	5.885787e-01	3.865799e-24
DLPFC	EWSR1	exon_skip_113472	7.201766e-01	2.677971e-40
DLPFC	SRSF1	exon_skip_113472	5.723810e-01	1.229432e-22
DLPFC	SRSF4	exon_skip_113472	5.223698e-01	1.745952e-18
DLPFC	SRSF9	exon_skip_113472	6.394974e-01	1.849798e-29
DLPFC	SRSF5	exon_skip_113472	6.171984e-01	5.205935e-27
DLPFC	HNRNPH2	exon_skip_113472	7.181857e-01	5.504239e-40
DLPFC	EIF4B	exon_skip_113472	6.428085e-01	7.692499e-30
DLPFC	ESRP1	exon_skip_113472	5.730952e-01	1.059747e-22
DLPFC	NOVA1	exon_skip_113472	7.329578e-01	2.251622e-42
DLPFC	ZC3H10	exon_skip_113472	4.615921e-01	2.801780e-14
DLPFC	MBNL1	exon_skip_40539	4.108627e-01	1.005553e-11
DLPFC	RC3H1	exon_skip_40539	4.252985e-01	1.551369e-12
DLPFC	MBNL1	exon_skip_66937	4.851257e-01	2.347114e-21
DLPFC	RC3H1	exon_skip_66937	4.848512e-01	2.489873e-21
DLPFC	PTBP3	exon_skip_66937	4.350761e-01	4.828809e-17
DLPFC	EIF4B	exon_skip_66937	4.390422e-01	2.329940e-17
DLPFC	MATR3	exon_skip_81163	4.129845e-01	1.813872e-11
DLPFC	FXR2	exon_skip_81163	5.102471e-01	1.408996e-17
DLPFC	PCBP1	exon_skip_81163	4.429949e-01	3.768542e-13
DLPFC	ILF2	exon_skip_81163	4.420456e-01	4.285213e-13
DLPFC	PUF60	exon_skip_81163	4.136714e-01	1.666973e-11
DLPFC	CELF1	exon_skip_81163	4.021597e-01	6.694305e-11
DLPFC	EWSR1	exon_skip_81163	4.541028e-01	8.132948e-14
DLPFC	SRSF9	exon_skip_81163	4.215783e-01	6.218451e-12
DLPFC	HNRNPH2	exon_skip_81163	4.085506e-01	3.114311e-11
DLPFC	NOVA1	exon_skip_81163	4.275926e-01	2.886585e-12
DLPFC	PCBP4	exon_skip_183557	4.509102e-01	1.270962e-13
DLPFC	DAZAP1	exon_skip_105675	5.247165e-01	1.154139e-18
DLPFC	TARDBP	exon_skip_105675	4.076435e-01	3.475073e-11
DLPFC	SRSF2	exon_skip_105675	5.438733e-01	3.477772e-20
DLPFC	RBFOX2	exon_skip_105675	8.055244e-01	6.371496e-57
DLPFC	ELAVL1	exon_skip_105675	4.247145e-01	4.175468e-12
DLPFC	SFPQ	exon_skip_105675	4.910699e-01	3.250138e-16
DLPFC	CNOT4	exon_skip_105675	5.330122e-01	2.602900e-19
DLPFC	RBM5	exon_skip_105675	4.436442e-01	3.450750e-13
DLPFC	MBNL1	exon_skip_105675	4.961658e-01	1.438860e-16
DLPFC	MATR3	exon_skip_105675	6.149377e-01	8.994423e-27
DLPFC	FXR2	exon_skip_105675	5.833160e-01	1.215065e-23
DLPFC	PCBP1	exon_skip_105675	6.836586e-01	5.866225e-35
DLPFC	ILF2	exon_skip_105675	4.959087e-01	1.499721e-16
DLPFC	HNRNPK	exon_skip_105675	5.491682e-01	1.269224e-20
DLPFC	PCBP2	exon_skip_105675	5.912333e-01	2.152325e-24
DLPFC	RC3H1	exon_skip_105675	4.522255e-01	1.058035e-13
DLPFC	G3BP2	exon_skip_105675	6.830674e-01	7.053226e-35
DLPFC	KHDRBS2	exon_skip_105675	7.082506e-01	1.830578e-38
DLPFC	SNRPA	exon_skip_105675	5.802386e-01	2.351181e-23
DLPFC	SF1	exon_skip_105675	5.468383e-01	1.982057e-20
DLPFC	KHDRBS3	exon_skip_105675	7.130579e-01	3.421989e-39
DLPFC	HNRNPA1	exon_skip_105675	4.601054e-01	3.469029e-14
DLPFC	RBM24	exon_skip_105675	6.091853e-01	3.545527e-26
DLPFC	FUBP1	exon_skip_105675	4.121598e-01	2.006941e-11
DLPFC	ENOX1	exon_skip_105675	6.746198e-01	9.367068e-34
DLPFC	HNRNPA0	exon_skip_105675	6.166485e-01	5.948861e-27
DLPFC	PUM1	exon_skip_105675	6.252304e-01	7.194608e-28
DLPFC	PPRC1	exon_skip_105675	6.069882e-01	5.943074e-26
DLPFC	HNRNPA1L2	exon_skip_105675	4.858538e-01	7.380453e-16
DLPFC	HNRNPA2B1	exon_skip_105675	4.310873e-01	1.835102e-12
DLPFC	RBM45	exon_skip_105675	4.614844e-01	2.845558e-14
DLPFC	PUF60	exon_skip_105675	5.718264e-01	1.379385e-22
DLPFC	NUP42	exon_skip_105675	5.081843e-01	1.993737e-17
DLPFC	RALYL	exon_skip_105675	6.634255e-01	2.533899e-32
DLPFC	EIF4G2	exon_skip_105675	5.680741e-01	2.988103e-22
DLPFC	RBM42	exon_skip_105675	4.999686e-01	7.763645e-17
DLPFC	PTBP3	exon_skip_105675	5.458495e-01	2.392310e-20
DLPFC	HNRNPL	exon_skip_105675	5.796449e-01	2.668370e-23
DLPFC	CELF1	exon_skip_105675	5.702054e-01	1.928588e-22
DLPFC	RBM23	exon_skip_105675	4.598639e-01	3.591156e-14
DLPFC	EWSR1	exon_skip_105675	5.280192e-01	6.410250e-19
DLPFC	SRSF1	exon_skip_105675	4.895552e-01	4.130091e-16
DLPFC	FUS	exon_skip_105675	5.061085e-01	2.820611e-17
DLPFC	SRSF4	exon_skip_105675	4.577841e-01	4.832464e-14
DLPFC	SRSF9	exon_skip_105675	5.231254e-01	1.528607e-18
DLPFC	SRSF5	exon_skip_105675	4.860429e-01	7.166049e-16
DLPFC	HNRNPH2	exon_skip_105675	6.094512e-01	3.329735e-26
DLPFC	EIF4B	exon_skip_105675	5.084432e-01	1.908986e-17
DLPFC	ESRP1	exon_skip_105675	4.764704e-01	3.117240e-15
DLPFC	NOVA1	exon_skip_105675	7.010005e-01	2.154780e-37
DLPFC	RBM4	exon_skip_105675	4.726800e-01	5.509799e-15
DLPFC	RBM4B	exon_skip_105675	4.591541e-01	3.974988e-14
DLPFC	PCBP4	exon_skip_119180	-4.588358e-01	4.159909e-14
DLPFC	PCBP4	exon_skip_31297	4.680184e-01	1.246667e-14
DLPFC	MBNL1	exon_skip_290692	4.455988e-01	3.903888e-18
DLPFC	KHDRBS2	exon_skip_290692	7.882909e-01	6.562924e-74
DLPFC	PTBP3	exon_skip_290692	4.564507e-01	4.691811e-19
DLPFC	KHDRBS3	exon_skip_176526	4.109714e-01	2.320688e-11
DLPFC	RBM4	exon_skip_176526	5.322023e-01	3.015724e-19
DLPFC	PCBP4	exon_skip_293008	4.345696e-01	1.162468e-12
DLPFC	RBFOX2	exon_skip_282074	4.564506e-01	6.576267e-14
DLPFC	PCBP1	exon_skip_282074	4.090991e-01	3.199960e-11
DLPFC	G3BP2	exon_skip_282074	4.303885e-01	2.231160e-12
DLPFC	KHDRBS2	exon_skip_282074	4.712478e-01	7.748347e-15
DLPFC	KHDRBS3	exon_skip_282074	4.492622e-01	1.791632e-13
DLPFC	ENOX1	exon_skip_282074	4.392498e-01	6.961652e-13
DLPFC	PUM1	exon_skip_282074	4.096570e-01	2.991318e-11
DLPFC	RALYL	exon_skip_282074	4.404272e-01	5.948298e-13
DLPFC	EIF4G2	exon_skip_282074	4.089386e-01	3.262545e-11
DLPFC	NOVA1	exon_skip_282074	4.400540e-01	6.252865e-13
DLPFC	RBM4B	exon_skip_282074	4.093784e-01	3.093789e-11
DLPFC	RBFOX2	exon_skip_194803	4.157644e-01	9.990469e-16
DLPFC	MBNL1	exon_skip_194803	4.066814e-01	4.706215e-15
DLPFC	RC3H1	exon_skip_194803	4.524259e-01	1.166288e-18
DLPFC	G3BP2	exon_skip_194803	4.285858e-01	1.033050e-16
DLPFC	KHDRBS2	exon_skip_194803	4.572456e-01	4.510156e-19
DLPFC	PUM1	exon_skip_194803	4.211389e-01	3.904842e-16
FL	SRSF2	exon_skip_12587	-4.047083e-01	3.667904e-09
FL	ZNF638	exon_skip_12587	-4.291768e-01	3.120642e-10
FL	SRSF11	exon_skip_12587	-4.408563e-01	8.962171e-11
FL	TIA1	exon_skip_12587	-5.393147e-01	2.921819e-16
FL	TRNAU1AP	exon_skip_12587	-4.057170e-01	3.326452e-09
FL	FUBP1	exon_skip_12587	-4.546780e-01	1.923161e-11
FL	RBM45	exon_skip_12587	-5.165915e-01	7.810725e-15
FL	CPEB2	exon_skip_12587	-4.122668e-01	1.749724e-09
FL	RBM23	exon_skip_12587	-4.160304e-01	1.201988e-09
FL	SRSF9	exon_skip_12587	-5.151873e-01	9.493594e-15
FL	EIF4B	exon_skip_12587	-4.322723e-01	2.252389e-10
FL	RBM3	exon_skip_194803	-4.214531e-01	1.154615e-08
HCC	ZNF326	exon_skip_198282	-4.668278e-01	5.780055e-16
HCC	SFPQ	exon_skip_198282	-4.207918e-01	5.731293e-13
HCC	RBM6	exon_skip_198282	-4.431154e-01	2.300027e-14
HCC	SAMD4A	exon_skip_198282	-4.698689e-01	3.528911e-16
HCC	TIA1	exon_skip_198282	-4.055214e-01	4.527973e-12
HCC	RBM5	exon_skip_198282	-4.227303e-01	4.375356e-13
HCC	FUBP1	exon_skip_198282	-4.411929e-01	3.062509e-14
HCC	PTBP1	exon_skip_198282	-5.292565e-01	8.042500e-21
HCC	HNRNPF	exon_skip_198282	-4.762815e-01	1.226674e-16
HCC	ZC3H10	exon_skip_198282	-4.504276e-01	7.613276e-15
HCC	ZNF326	exon_skip_132997	-4.449591e-01	9.387783e-14
HCC	RBM6	exon_skip_132997	-4.189002e-01	3.254816e-12
HCC	SRSF11	exon_skip_132997	-4.160033e-01	4.739113e-12
HCC	SAMD4A	exon_skip_132997	-4.788758e-01	5.767782e-16
HCC	TRNAU1AP	exon_skip_132997	-4.276374e-01	1.025264e-12
HCC	FUBP1	exon_skip_132997	-4.181848e-01	3.572469e-12
HCC	EIF4G2	exon_skip_132997	-4.033934e-01	2.333404e-11
HCC	PTBP1	exon_skip_132997	-5.264483e-01	1.641867e-19
HCC	SRSF4	exon_skip_132997	-4.022437e-01	2.689526e-11
HCC	HNRNPF	exon_skip_132997	-5.326962e-01	5.094431e-20
HCC	RBM3	exon_skip_282074	-5.059759e-01	3.746525e-19
HCC	PTBP1	exon_skip_161556	-4.044710e-01	4.333534e-12
HCC	TARDBP	exon_skip_17003	-4.151403e-01	8.479440e-13
HCC	RBFOX2	exon_skip_17003	4.911370e-01	5.559416e-18
HCC	RBM25	exon_skip_17003	-4.051337e-01	3.305726e-12
HCC	ZNF326	exon_skip_17003	-6.508132e-01	2.830520e-34
HCC	SFPQ	exon_skip_17003	-6.012304e-01	3.195796e-28
HCC	ZNF638	exon_skip_17003	-5.225581e-01	1.567737e-20
HCC	RBM6	exon_skip_17003	-6.502267e-01	3.389182e-34
HCC	SRSF11	exon_skip_17003	-5.500467e-01	5.457212e-23
HCC	SAMD4A	exon_skip_17003	-6.489016e-01	5.084143e-34
HCC	CNOT4	exon_skip_17003	-4.017984e-01	5.150854e-12
HCC	TIA1	exon_skip_17003	-5.321010e-01	2.329020e-21
HCC	RBM5	exon_skip_17003	-6.153179e-01	7.828187e-30
HCC	IGF2BP2	exon_skip_17003	-4.083451e-01	2.146689e-12
HCC	TRNAU1AP	exon_skip_17003	-4.521904e-01	3.649678e-15
HCC	PCBP1	exon_skip_17003	-4.154795e-01	8.090694e-13
HCC	PCBP4	exon_skip_17003	-4.139015e-01	1.005983e-12
HCC	G3BP2	exon_skip_17003	4.361064e-01	4.216320e-14
HCC	FUBP1	exon_skip_17003	-4.970402e-01	1.931230e-18
HCC	ENOX1	exon_skip_17003	-4.486184e-01	6.355197e-15
HCC	HNRNPA2B1	exon_skip_17003	-5.459415e-01	1.313851e-22
HCC	RBM45	exon_skip_17003	-5.457630e-01	1.364637e-22
HCC	EIF4G2	exon_skip_17003	-6.002641e-01	4.094190e-28
HCC	PTBP1	exon_skip_17003	-7.345435e-01	1.507925e-47
HCC	SRSF1	exon_skip_17003	-4.375298e-01	3.413006e-14
HCC	SRSF4	exon_skip_17003	-5.513138e-01	4.150752e-23
HCC	HNRNPF	exon_skip_17003	-6.227231e-01	1.032427e-30
HCC	RBM4	exon_skip_17003	-5.320072e-01	2.373803e-21
HCC	ZC3H10	exon_skip_17003	-6.042041e-01	1.483169e-28
HCC	RBM4B	exon_skip_17003	-6.045386e-01	1.359760e-28
HCC	DAZAP1	exon_skip_12587	-5.441909e-01	1.904048e-22
HCC	TARDBP	exon_skip_12587	-4.438791e-01	1.313379e-14
HCC	RBFOX2	exon_skip_12587	4.165556e-01	6.969387e-13
HCC	MSI1	exon_skip_12587	-4.980467e-01	1.609346e-18
HCC	ZNF326	exon_skip_12587	-5.957174e-01	1.298748e-27
HCC	SFPQ	exon_skip_12587	-5.117692e-01	1.260672e-19
HCC	ZNF638	exon_skip_12587	-4.810612e-01	3.225545e-17
HCC	RBM28	exon_skip_12587	-4.079210e-01	2.273222e-12
HCC	RBM6	exon_skip_12587	-5.518387e-01	3.704664e-23
HCC	SRSF11	exon_skip_12587	-5.192743e-01	2.980172e-20
HCC	SAMD4A	exon_skip_12587	-5.770322e-01	1.238115e-25
HCC	TIA1	exon_skip_12587	-4.844877e-01	1.785454e-17
HCC	RBM5	exon_skip_12587	-5.051427e-01	4.374503e-19
HCC	TRNAU1AP	exon_skip_12587	-4.535522e-01	2.949079e-15
HCC	PCBP1	exon_skip_12587	-4.567875e-01	1.770469e-15
HCC	PCBP4	exon_skip_12587	-4.902069e-01	6.555042e-18
HCC	TRA2A	exon_skip_12587	-4.239215e-01	2.474073e-13
HCC	PCBP2	exon_skip_12587	-4.179768e-01	5.718275e-13
HCC	SF1	exon_skip_12587	-4.367168e-01	3.851421e-14
HCC	KHDRBS3	exon_skip_12587	-4.787218e-01	4.811950e-17
HCC	FUBP1	exon_skip_12587	-4.530000e-01	3.215679e-15
HCC	HNRNPA2B1	exon_skip_12587	-5.498779e-01	5.659326e-23
HCC	RBM45	exon_skip_12587	-4.810750e-01	3.217920e-17
HCC	EIF4G2	exon_skip_12587	-5.268661e-01	6.678501e-21
HCC	PTBP1	exon_skip_12587	-6.653904e-01	2.820858e-36
HCC	SRSF1	exon_skip_12587	-4.004344e-01	6.166444e-12
HCC	SRSF4	exon_skip_12587	-5.049371e-01	4.544663e-19
HCC	HNRNPF	exon_skip_12587	-6.544366e-01	9.219268e-35
HCC	RBM4	exon_skip_12587	-4.466256e-01	8.635463e-15
HCC	ZC3H10	exon_skip_12587	-5.188828e-01	3.215886e-20
HCC	RBM4B	exon_skip_12587	-5.042325e-01	5.178852e-19
HCC	EIF4G2	exon_skip_207101	4.064798e-01	2.760041e-12
HCC	SFPQ	exon_skip_66937	-4.283418e-01	2.198799e-13
HCC	ZNF638	exon_skip_66937	-4.010147e-01	8.934580e-12
HCC	RBM6	exon_skip_66937	-4.387392e-01	4.907462e-14
HCC	RBM5	exon_skip_66937	-4.562234e-01	3.501090e-15
HCC	PCBP4	exon_skip_66937	-5.508086e-01	1.153638e-22
HCC	RBM45	exon_skip_66937	-4.227633e-01	4.814530e-13
HCC	PTBP1	exon_skip_66937	-4.444604e-01	2.103079e-14
HCC	PCBP4	exon_skip_40539	-4.877077e-01	8.710451e-15
HCC	RBM3	exon_skip_194803	-4.246767e-01	3.685655e-13
HCC	PCBP4	exon_skip_194803	-6.510637e-01	1.049838e-33
HCC	PUF60	exon_skip_194803	-4.200137e-01	7.047397e-13
HCC	RBM42	exon_skip_194803	-4.039489e-01	6.098749e-12
HCC	SRSF5	exon_skip_194803	-4.305226e-01	1.612185e-13
HCC	RBM6	exon_skip_290692	-5.045854e-01	4.851065e-19
HCC	QKI	exon_skip_290692	-5.975339e-01	8.206854e-28
HCC	SF1	exon_skip_290692	-4.140747e-01	9.822705e-13
HCC	RBM42	exon_skip_290692	-4.254225e-01	1.997142e-13
HCC	PABPC1	exon_skip_290692	-4.006503e-01	5.993593e-12
HCC	SRSF5	exon_skip_290692	-4.193363e-01	4.728076e-13
IFG	ESRP1	exon_skip_221656	-5.113382e-01	5.418827e-03
IFG	RBM28	exon_skip_282074	4.003844e-01	3.474875e-02
IFG	SAMD4A	exon_skip_282074	4.567399e-01	1.455494e-02
IFG	RBM3	exon_skip_282074	-8.016462e-01	2.940791e-07
IFG	ENOX1	exon_skip_282074	4.128381e-01	2.900784e-02
IFG	ESRP2	exon_skip_282074	4.491421e-01	1.650241e-02
IFG	CNOT4	exon_skip_142967	-4.324973e-01	2.152711e-02
IFG	PCBP1	exon_skip_142967	-4.012652e-01	3.431484e-02
IFG	EIF4G2	exon_skip_142967	-4.173554e-01	2.712587e-02
IFG	RBFOX2	exon_skip_17003	4.738663e-01	1.085524e-02
IFG	ZNF326	exon_skip_17003	-4.567050e-01	1.456343e-02
IFG	ZNF638	exon_skip_17003	-4.266718e-01	2.355701e-02
IFG	RBM6	exon_skip_17003	-4.420374e-01	1.851350e-02
IFG	SAMD4A	exon_skip_17003	-6.260481e-01	3.659816e-04
IFG	TIA1	exon_skip_17003	-4.535617e-01	1.534501e-02
IFG	IGF2BP2	exon_skip_17003	-5.584917e-01	2.009807e-03
IFG	MATR3	exon_skip_17003	4.604844e-01	1.366765e-02
IFG	G3BP2	exon_skip_17003	6.481021e-01	1.920695e-04
IFG	RBM24	exon_skip_17003	4.442325e-01	1.787170e-02
IFG	RALYL	exon_skip_17003	4.129524e-01	2.895892e-02
IFG	PTBP1	exon_skip_17003	-5.856220e-01	1.060191e-03
IFG	HNRNPH2	exon_skip_17003	4.307876e-01	2.210743e-02
IFG	ESRP1	exon_skip_17003	5.064704e-01	5.956608e-03
IFG	ESRP2	exon_skip_17003	-4.194261e-01	2.629697e-02
IFG	HNRNPF	exon_skip_17003	-4.195377e-01	2.625287e-02
IFG	RBFOX2	exon_skip_12587	7.854799e-01	7.376702e-07
IFG	MATR3	exon_skip_12587	7.148928e-01	1.916066e-05
IFG	FXR2	exon_skip_12587	5.872040e-01	1.019614e-03
IFG	G3BP2	exon_skip_12587	7.139730e-01	1.986354e-05
IFG	KHDRBS2	exon_skip_12587	7.750690e-01	1.281097e-06
IFG	KHDRBS3	exon_skip_12587	6.230141e-01	3.984140e-04
IFG	RBM24	exon_skip_12587	8.065758e-01	2.184807e-07
IFG	ENOX1	exon_skip_12587	4.103619e-01	3.008344e-02
IFG	HNRNPA0	exon_skip_12587	6.300055e-01	3.271764e-04
IFG	PUM1	exon_skip_12587	6.246064e-01	3.810914e-04
IFG	NUP42	exon_skip_12587	4.087674e-01	3.079299e-02
IFG	RALYL	exon_skip_12587	8.687676e-01	2.047455e-09
IFG	EIF4G2	exon_skip_12587	5.523291e-01	2.306890e-03
IFG	CELF1	exon_skip_12587	4.915071e-01	7.901266e-03
IFG	SRSF9	exon_skip_12587	4.779393e-01	1.010214e-02
IFG	ESRP1	exon_skip_12587	4.127846e-01	2.903071e-02
IFG	NOVA1	exon_skip_12587	6.813265e-01	6.568253e-05
IFG	SAMD4A	exon_skip_66937	-5.734374e-01	1.766499e-03
IFG	PCBP4	exon_skip_66937	-5.313983e-01	4.339777e-03
IFG	HNRNPA1	exon_skip_66937	-5.665397e-01	2.063921e-03
IFG	HNRNPA2B1	exon_skip_66937	-4.809781e-01	1.109318e-02
IFG	SRSF1	exon_skip_66937	-4.385029e-01	2.213863e-02
IFG	RBFOX2	exon_skip_194803	7.017120e-01	4.530737e-05
IFG	ELAVL1	exon_skip_194803	4.684398e-01	1.372321e-02
IFG	MATR3	exon_skip_194803	5.101638e-01	6.554245e-03
IFG	FXR2	exon_skip_194803	5.239190e-01	5.033053e-03
IFG	PCBP4	exon_skip_194803	-4.156482e-01	3.106719e-02
IFG	G3BP2	exon_skip_194803	5.094747e-01	6.639672e-03
IFG	KHDRBS2	exon_skip_194803	7.359419e-01	1.214712e-05
IFG	KHDRBS3	exon_skip_194803	6.048293e-01	8.318779e-04
IFG	RBM24	exon_skip_194803	6.173599e-01	6.023494e-04
IFG	PUM1	exon_skip_194803	5.462329e-01	3.202080e-03
IFG	RBM45	exon_skip_194803	4.517511e-01	1.800577e-02
IFG	RALYL	exon_skip_194803	7.927879e-01	8.216802e-07
IFG	EIF4G2	exon_skip_194803	5.122253e-01	6.304202e-03
IFG	PTBP3	exon_skip_194803	4.066944e-01	3.527202e-02
IFG	CELF1	exon_skip_194803	4.150370e-01	3.134076e-02
IFG	SRSF9	exon_skip_194803	5.236933e-01	5.055354e-03
IFG	NOVA1	exon_skip_194803	6.194410e-01	5.701479e-04
IFG	RBM4	exon_skip_194803	4.358194e-01	2.306337e-02
IFG	QKI	exon_skip_290692	-4.983559e-01	6.953524e-03
IFG	KHDRBS2	exon_skip_290692	7.631589e-01	2.327370e-06
IFG	HNRNPA0	exon_skip_290692	5.732712e-01	1.428208e-03
PCC	RBFOX2	exon_skip_113472	6.752289e-01	7.682229e-30
PCC	ZNF326	exon_skip_113472	-4.943243e-01	1.379687e-14
PCC	RBM6	exon_skip_113472	-4.857330e-01	4.541933e-14
PCC	SAMD4A	exon_skip_113472	-5.794342e-01	1.376856e-20
PCC	G3BP2	exon_skip_113472	7.094201e-01	4.715210e-34
PCC	PUM1	exon_skip_113472	5.292514e-01	7.584515e-17
PCC	RALYL	exon_skip_113472	4.387134e-01	1.765194e-11
PCC	PTBP1	exon_skip_113472	-6.980556e-01	1.378545e-32
PCC	SRSF4	exon_skip_113472	-4.097395e-01	4.524483e-10
PCC	HNRNPF	exon_skip_113472	-5.630056e-01	2.714783e-19
PCC	RBFOX2	exon_skip_264734	4.664121e-01	6.663551e-13
PCC	ZNF326	exon_skip_264734	-4.455174e-01	8.814067e-12
PCC	RBM6	exon_skip_264734	-4.262112e-01	8.234716e-11
PCC	SAMD4A	exon_skip_264734	-4.390940e-01	1.883127e-11
PCC	G3BP2	exon_skip_264734	5.161525e-01	6.701702e-16
PCC	PTBP1	exon_skip_264734	-5.709446e-01	8.011360e-20
PCC	HNRNPF	exon_skip_264734	-4.772748e-01	1.621331e-13
PCC	RBFOX2	exon_skip_12587	6.645868e-01	9.028071e-29
PCC	ZNF326	exon_skip_12587	-5.010113e-01	4.603766e-15
PCC	RBM6	exon_skip_12587	-4.351716e-01	2.397129e-11
PCC	SAMD4A	exon_skip_12587	-4.971078e-01	8.060556e-15
PCC	PCBP4	exon_skip_12587	-4.235223e-01	9.082351e-11
PCC	G3BP2	exon_skip_12587	6.023671e-01	1.276218e-22
PCC	PUM1	exon_skip_12587	4.435782e-01	8.878017e-12
PCC	RALYL	exon_skip_12587	4.112383e-01	3.505333e-10
PCC	PTBP1	exon_skip_12587	-6.467726e-01	7.294589e-27
PCC	HNRNPF	exon_skip_12587	-5.971550e-01	3.641150e-22
PCC	PCBP4	exon_skip_194803	-4.128630e-01	6.961407e-10
PCC	RBM6	exon_skip_290692	-4.024109e-01	8.949065e-10
PCC	QKI	exon_skip_290692	-4.894406e-01	2.372699e-14
PCC	PABPC1	exon_skip_290692	-4.050130e-01	6.808065e-10
PG	RBFOX2	exon_skip_12587	4.492497e-01	4.468460e-11
PG	SNRPA	exon_skip_12587	4.205633e-01	9.278571e-10
PG	HNRNPA1	exon_skip_12587	4.717219e-01	3.379694e-12
PG	HNRNPA1L2	exon_skip_12587	4.219173e-01	8.091660e-10
PG	EWSR1	exon_skip_12587	4.884269e-01	4.372761e-13
PG	PCBP4	exon_skip_194803	-4.057308e-01	3.428205e-07
PG	PCBP1	exon_skip_290692	4.551054e-01	1.283765e-11
PG	KHDRBS2	exon_skip_290692	5.695908e-01	1.349636e-18
STG	RBM3	exon_skip_282074	-4.228510e-01	4.056572e-05
STG	RBFOX2	exon_skip_17003	4.806476e-01	3.843634e-05
STG	G3BP2	exon_skip_17003	4.577720e-01	9.822397e-05
STG	RALYL	exon_skip_17003	4.446774e-01	1.632313e-04
STG	PTBP1	exon_skip_17003	-5.233647e-01	5.513192e-06
STG	ESRP2	exon_skip_17003	-4.519897e-01	1.232323e-04
TC	RBFOX2	exon_skip_267356	6.990991e-01	8.656076e-25
TC	ZNF326	exon_skip_267356	-4.057950e-01	1.017641e-07
TC	MATR3	exon_skip_267356	5.708795e-01	3.228357e-15
TC	FXR2	exon_skip_267356	4.259163e-01	1.965971e-08
TC	ILF2	exon_skip_267356	4.345951e-01	9.351730e-09
TC	G3BP2	exon_skip_267356	5.725889e-01	2.559171e-15
TC	RBM24	exon_skip_267356	7.365943e-01	1.253141e-28
TC	HNRNPA0	exon_skip_267356	5.715161e-01	2.961287e-15
TC	PUM1	exon_skip_267356	5.480218e-01	6.363336e-14
TC	NUP42	exon_skip_267356	6.588727e-01	2.787958e-21
TC	RALYL	exon_skip_267356	7.713310e-01	8.052172e-33
TC	CELF1	exon_skip_267356	5.030446e-01	1.209188e-11
TC	HNRNPH2	exon_skip_267356	5.831819e-01	5.884597e-16
TC	ESRP1	exon_skip_267356	5.443536e-01	1.005588e-13
TC	NOVA1	exon_skip_267356	4.642532e-01	6.270120e-10
TC	RBFOX2	exon_skip_197612	4.515097e-01	2.612170e-09
TC	RBM24	exon_skip_197612	4.939411e-01	4.251698e-11
TC	NUP42	exon_skip_197612	4.462350e-01	4.194731e-09
TC	RALYL	exon_skip_197612	5.294323e-01	8.549903e-13
TC	SRSF2	exon_skip_121932	-4.011165e-01	1.468921e-07
TC	PCBP4	exon_skip_31297	4.155091e-01	4.663617e-08
TC	SRSF2	exon_skip_183557	4.273667e-01	1.738916e-08
TC	PCBP4	exon_skip_183557	4.439344e-01	4.105572e-09
TC	SRSF2	exon_skip_113472	4.469612e-01	3.127294e-09
TC	RBFOX2	exon_skip_113472	8.264265e-01	2.946028e-41
TC	ZNF326	exon_skip_113472	-4.980729e-01	2.062860e-11
TC	RBM6	exon_skip_113472	-4.166816e-01	4.237326e-08
TC	MATR3	exon_skip_113472	6.556676e-01	5.033215e-21
TC	FXR2	exon_skip_113472	4.236101e-01	2.386738e-08
TC	ILF2	exon_skip_113472	4.636474e-01	6.643410e-10
TC	G3BP2	exon_skip_113472	6.841844e-01	2.012599e-23
TC	RBM24	exon_skip_113472	7.680158e-01	2.174231e-32
TC	HNRNPA0	exon_skip_113472	6.919930e-01	3.969100e-24
TC	PUM1	exon_skip_113472	6.122428e-01	7.831077e-18
TC	HNRNPA1L2	exon_skip_113472	4.332152e-01	1.053919e-08
TC	RBM45	exon_skip_113472	4.001528e-01	1.583180e-07
TC	NUP42	exon_skip_113472	6.898092e-01	6.282199e-24
TC	RALYL	exon_skip_113472	8.392434e-01	1.176897e-43
TC	PTBP1	exon_skip_113472	-4.536285e-01	1.700927e-09
TC	PTBP3	exon_skip_113472	4.888728e-01	5.420159e-11
TC	CELF1	exon_skip_113472	5.789747e-01	1.061755e-15
TC	HNRNPH2	exon_skip_113472	6.742253e-01	1.484875e-22
TC	ESRP1	exon_skip_113472	6.050098e-01	2.391323e-17
TC	NOVA1	exon_skip_113472	5.528528e-01	3.453303e-14
TC	RBFOX2	exon_skip_105675	7.216410e-01	5.063134e-27
TC	ZNF326	exon_skip_105675	-4.978715e-01	2.107617e-11
TC	MATR3	exon_skip_105675	4.867413e-01	6.752208e-11
TC	PCBP4	exon_skip_105675	-4.163696e-01	4.346938e-08
TC	G3BP2	exon_skip_105675	5.164388e-01	2.745147e-12
TC	KHDRBS2	exon_skip_105675	6.749594e-01	1.284913e-22
TC	KHDRBS3	exon_skip_105675	5.929925e-01	1.437075e-16
TC	RBM24	exon_skip_105675	7.220741e-01	4.564289e-27
TC	HNRNPA0	exon_skip_105675	4.763027e-01	1.938374e-10
TC	PUM1	exon_skip_105675	5.333927e-01	3.820189e-13
TC	NUP42	exon_skip_105675	5.281204e-01	7.137523e-13
TC	RALYL	exon_skip_105675	7.214201e-01	5.337780e-27
TC	CELF1	exon_skip_105675	5.312769e-01	4.915724e-13
TC	HNRNPH2	exon_skip_105675	4.681919e-01	4.293355e-10
TC	ESRP1	exon_skip_105675	5.499637e-01	4.983074e-14
TC	FXR2	exon_skip_81163	4.063193e-01	9.762853e-08
TC	CELF1	exon_skip_81163	4.190433e-01	3.489365e-08
TC	ESRP1	exon_skip_81163	4.088565e-01	7.979099e-08
TC	PCBP4	exon_skip_176526	-4.447222e-01	3.825758e-09
TC	RBM4	exon_skip_176526	4.437794e-01	4.162889e-09
TC	SRSF2	exon_skip_119180	-4.724130e-01	2.845691e-10
TC	PCBP4	exon_skip_119180	-4.026014e-01	1.308189e-07
TC	MBNL1	exon_skip_66937	4.137906e-01	5.363624e-08
TC	MATR3	exon_skip_66937	5.067212e-01	8.100723e-12
TC	FXR2	exon_skip_66937	4.420628e-01	4.851625e-09
TC	PCBP4	exon_skip_66937	-4.348988e-01	9.108283e-09
TC	PTBP3	exon_skip_66937	4.701919e-01	3.535691e-10
TC	CELF1	exon_skip_66937	5.541518e-01	2.925002e-14
TC	HNRNPH2	exon_skip_66937	5.009207e-01	1.520724e-11
TC	ESRP1	exon_skip_66937	4.721970e-01	2.906604e-10
TC	RBFOX2	exon_skip_194803	4.630613e-01	7.024876e-10
TC	ZNF326	exon_skip_194803	-4.019855e-01	1.372698e-07
TC	PCBP4	exon_skip_194803	-6.018656e-01	3.851000e-17
TC	KHDRBS3	exon_skip_194803	4.053973e-01	1.050123e-07
TC	RBM24	exon_skip_194803	5.039960e-01	1.090618e-11
TC	RALYL	exon_skip_194803	4.859944e-01	7.290073e-11
TC	SRSF2	exon_skip_172610	-4.034432e-01	1.768379e-07
TC	KHDRBS2	exon_skip_200446	7.674145e-01	2.598841e-32
TC	HNRNPA0	exon_skip_200446	5.897828e-01	2.291198e-16
TC	PTBP3	exon_skip_200446	4.882478e-01	5.781825e-11
TC	ESRP1	exon_skip_200446	5.909026e-01	1.948239e-16

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RelatedDrugs for BIN1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for BIN1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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