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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for GOLIM4 |
 Gene summary |
| Gene information | Gene symbol | GOLIM4 | Gene ID | 27333 |
| Gene name | golgi integral membrane protein 4 | |
| Synonyms | GIMPC|GOLPH4|GPP130|P138 | |
| Cytomap | 3q26.2 | |
| Type of gene | protein-coding | |
| Description | Golgi integral membrane protein 4130 kDa golgi-localized phosphoproteincis Golgi-localized calcium-binding proteingolgi integral membrane protein, cisgolgi phosphoprotein 4golgi phosphoprotein of 130 kDagolgi-localized phosphoprotein of 130 kDatype | |
| Modification date | 20200313 | |
| UniProtAcc | F8W785, O00461, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for GOLIM4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000173905
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000309027.4 | GOLIM4-201:protein_coding:GOLIM4 | 1.207355e+02 | 1.525795e+00 | 4.469779e-07 | 2.908372e-04 |
| TC | UP | ENST00000309027.4 | GOLIM4-201:protein_coding:GOLIM4 | 5.275854e+02 | 8.473525e-01 | 3.203280e-07 | 1.598804e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GOLIM4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_141580 | chr3 | 168032724:168032852:168036836:168036994:168041392:168041474 | 168036836:168036994 |
| exon_skip_144484 | chr3 | 168036836:168036994:168041392:168041474:168043379:168043529 | 168041392:168041474 |
| exon_skip_152826 | chr3 | 168032807:168032852:168036836:168036994:168041392:168041474 | 168036836:168036994 |
| exon_skip_166462 | chr3 | 168032520:168032852:168036836:168036994:168040786:168040869 | 168036836:168036994 |
| exon_skip_234594 | chr3 | 168036836:168036994:168041392:168041474:168043379:168043461 | 168041392:168041474 |
| exon_skip_236182 | chr3 | 168010743:168010823:168024526:168024594:168024928:168025095 | 168024526:168024594 |
| exon_skip_27248 | chr3 | 168032520:168032852:168036836:168036994:168041392:168041474 | 168036836:168036994 |
| exon_skip_84892 | chr3 | 168010235:168010418:168010743:168010823:168024526:168024594 | 168010743:168010823 |
| exon_skip_91604 | chr3 | 168036836:168036994:168040786:168040869:168041392:168041474 | 168040786:168040869 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for GOLIM4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000470487 | 168010743 | 168010823 | In-frame |
| ENST00000470487 | 168024526 | 168024594 | In-frame |
| ENST00000470487 | 168040786 | 168040869 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000470487 | 168040786 | 168040869 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000470487 | 168010743 | 168010823 | In-frame |
| ENST00000470487 | 168024526 | 168024594 | In-frame |
| ENST00000470487 | 168036836 | 168036994 | In-frame |
| ENST00000470487 | 168040786 | 168040869 | In-frame |
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Infer the effects of exon skipping event on protein functional features for GOLIM4 |
p-ENSG00000173905_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000470487 | 4390 | 696 | 168040786 | 168040869 | 1291 | 1373 | 200 | 227 |
| ENST00000470487 | 4390 | 696 | 168024526 | 168024594 | 2482 | 2549 | 597 | 619 |
| ENST00000470487 | 4390 | 696 | 168010743 | 168010823 | 2551 | 2630 | 620 | 646 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000470487 | 4390 | 696 | 168040786 | 168040869 | 1291 | 1373 | 200 | 227 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000470487 | 4390 | 696 | 168040786 | 168040869 | 1291 | 1373 | 200 | 227 |
| ENST00000470487 | 4390 | 696 | 168036836 | 168036994 | 1375 | 1532 | 228 | 280 |
| ENST00000470487 | 4390 | 696 | 168024526 | 168024594 | 2482 | 2549 | 597 | 619 |
| ENST00000470487 | 4390 | 696 | 168010743 | 168010823 | 2551 | 2630 | 620 | 646 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O00461 | 200 | 227 | 2 | 696 | Chain | ID=PRO_0000285097;Note=Golgi integral membrane protein 4 |
| O00461 | 200 | 227 | 35 | 244 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 200 | 227 | 176 | 248 | Region | Note=Golgi targeting |
| O00461 | 200 | 227 | 34 | 696 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 597 | 619 | 2 | 696 | Chain | ID=PRO_0000285097;Note=Golgi integral membrane protein 4 |
| O00461 | 597 | 619 | 311 | 681 | Compositional bias | Note=Glu-rich |
| O00461 | 597 | 619 | 613 | 613 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| O00461 | 597 | 619 | 34 | 696 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 620 | 646 | 2 | 696 | Chain | ID=PRO_0000285097;Note=Golgi integral membrane protein 4 |
| O00461 | 620 | 646 | 311 | 681 | Compositional bias | Note=Glu-rich |
| O00461 | 620 | 646 | 626 | 626 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| O00461 | 620 | 646 | 34 | 696 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O00461 | 200 | 227 | 2 | 696 | Chain | ID=PRO_0000285097;Note=Golgi integral membrane protein 4 |
| O00461 | 200 | 227 | 35 | 244 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 200 | 227 | 176 | 248 | Region | Note=Golgi targeting |
| O00461 | 200 | 227 | 34 | 696 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O00461 | 200 | 227 | 2 | 696 | Chain | ID=PRO_0000285097;Note=Golgi integral membrane protein 4 |
| O00461 | 200 | 227 | 35 | 244 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 200 | 227 | 176 | 248 | Region | Note=Golgi targeting |
| O00461 | 200 | 227 | 34 | 696 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 228 | 280 | 2 | 696 | Chain | ID=PRO_0000285097;Note=Golgi integral membrane protein 4 |
| O00461 | 228 | 280 | 35 | 244 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 228 | 280 | 257 | 257 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 228 | 280 | 176 | 248 | Region | Note=Golgi targeting |
| O00461 | 228 | 280 | 34 | 696 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 597 | 619 | 2 | 696 | Chain | ID=PRO_0000285097;Note=Golgi integral membrane protein 4 |
| O00461 | 597 | 619 | 311 | 681 | Compositional bias | Note=Glu-rich |
| O00461 | 597 | 619 | 613 | 613 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| O00461 | 597 | 619 | 34 | 696 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| O00461 | 620 | 646 | 2 | 696 | Chain | ID=PRO_0000285097;Note=Golgi integral membrane protein 4 |
| O00461 | 620 | 646 | 311 | 681 | Compositional bias | Note=Glu-rich |
| O00461 | 620 | 646 | 626 | 626 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| O00461 | 620 | 646 | 34 | 696 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in GOLIM4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for GOLIM4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GOLIM4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GOLIM4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for GOLIM4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for GOLIM4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GOLIM4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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