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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for DENND2A |
Gene summary |
Gene information | Gene symbol | DENND2A | Gene ID | 27147 |
Gene name | DENN domain containing 2A | |
Synonyms | FAM31D|KIAA1277 | |
Cytomap | 7q34 | |
Type of gene | protein-coding | |
Description | DENN domain-containing protein 2ADENN/MADD domain containing 2A | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DENND2A |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000477488.1 | DENND2A-205:protein_coding:DENND2A | 2.834490e+00 | 1.554364e+00 | 1.274583e-03 | 1.736480e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DENND2A |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_10292 | chr7 | 140544618:140544766:140546799:140546939:140555636:140555713 | 140546799:140546939 |
exon_skip_112486 | chr7 | 140568763:140568813:140569645:140569738:140573808:140574005 | 140569645:140569738 |
exon_skip_149439 | chr7 | 140546813:140546939:140555636:140555713:140558143:140558212 | 140555636:140555713 |
exon_skip_153162 | chr7 | 140573808:140574008:140585589:140585710:140587653:140587780 | 140585589:140585710 |
exon_skip_229980 | chr7 | 140568763:140568813:140569645:140569738:140573808:140573968 | 140569645:140569738 |
exon_skip_265758 | chr7 | 140546799:140546939:140555636:140555713:140558143:140558212 | 140555636:140555713 |
exon_skip_281209 | chr7 | 140527318:140527495:140544618:140544766:140546799:140546939 | 140544618:140544766 |
exon_skip_36875 | chr7 | 140602162:140602542:140605705:140605806:140640504:140640776 | 140605705:140605806 |
exon_skip_74209 | chr7 | 140567086:140567273:140568763:140568813:140569645:140569738 | 140568763:140568813 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DENND2A |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000496613 | 140605705 | 140605806 | 3UTR-3UTR |
ENST00000275884 | 140569645 | 140569738 | Frame-shift |
ENST00000496613 | 140569645 | 140569738 | Frame-shift |
ENST00000537639 | 140569645 | 140569738 | Frame-shift |
ENST00000275884 | 140585589 | 140585710 | Frame-shift |
ENST00000496613 | 140585589 | 140585710 | Frame-shift |
ENST00000537639 | 140585589 | 140585710 | Frame-shift |
ENST00000275884 | 140555636 | 140555713 | In-frame |
ENST00000496613 | 140555636 | 140555713 | In-frame |
ENST00000537639 | 140555636 | 140555713 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000496613 | 140605705 | 140605806 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000496613 | 140605705 | 140605806 | 3UTR-3UTR |
ENST00000275884 | 140544618 | 140544766 | Frame-shift |
ENST00000496613 | 140544618 | 140544766 | Frame-shift |
ENST00000537639 | 140544618 | 140544766 | Frame-shift |
ENST00000275884 | 140569645 | 140569738 | Frame-shift |
ENST00000496613 | 140569645 | 140569738 | Frame-shift |
ENST00000537639 | 140569645 | 140569738 | Frame-shift |
ENST00000275884 | 140585589 | 140585710 | Frame-shift |
ENST00000496613 | 140585589 | 140585710 | Frame-shift |
ENST00000537639 | 140585589 | 140585710 | Frame-shift |
ENST00000275884 | 140546799 | 140546939 | In-frame |
ENST00000496613 | 140546799 | 140546939 | In-frame |
ENST00000537639 | 140546799 | 140546939 | In-frame |
ENST00000275884 | 140555636 | 140555713 | In-frame |
ENST00000496613 | 140555636 | 140555713 | In-frame |
ENST00000537639 | 140555636 | 140555713 | In-frame |
ENST00000275884 | 140568763 | 140568813 | In-frame |
ENST00000496613 | 140568763 | 140568813 | In-frame |
ENST00000537639 | 140568763 | 140568813 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DENND2A |
p-ENSG00000146966_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000275884 | 3752 | 1009 | 140555636 | 140555713 | 2378 | 2454 | 653 | 678 |
ENST00000496613 | 3579 | 1009 | 140555636 | 140555713 | 2249 | 2325 | 653 | 678 |
ENST00000537639 | 3469 | 1009 | 140555636 | 140555713 | 2105 | 2181 | 653 | 678 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000275884 | 3752 | 1009 | 140568763 | 140568813 | 1959 | 2008 | 513 | 530 |
ENST00000496613 | 3579 | 1009 | 140568763 | 140568813 | 1830 | 1879 | 513 | 530 |
ENST00000537639 | 3469 | 1009 | 140568763 | 140568813 | 1686 | 1735 | 513 | 530 |
ENST00000275884 | 3752 | 1009 | 140555636 | 140555713 | 2378 | 2454 | 653 | 678 |
ENST00000496613 | 3579 | 1009 | 140555636 | 140555713 | 2249 | 2325 | 653 | 678 |
ENST00000537639 | 3469 | 1009 | 140555636 | 140555713 | 2105 | 2181 | 653 | 678 |
ENST00000275884 | 3752 | 1009 | 140546799 | 140546939 | 2456 | 2595 | 679 | 725 |
ENST00000496613 | 3579 | 1009 | 140546799 | 140546939 | 2327 | 2466 | 679 | 725 |
ENST00000537639 | 3469 | 1009 | 140546799 | 140546939 | 2183 | 2322 | 679 | 725 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9ULE3 | 653 | 678 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 653 | 678 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 653 | 678 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 653 | 678 | 566 | 715 | Domain | Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
Q9ULE3 | 653 | 678 | 566 | 715 | Domain | Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
Q9ULE3 | 653 | 678 | 566 | 715 | Domain | Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q9ULE3 | 513 | 530 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 513 | 530 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 513 | 530 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 653 | 678 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 653 | 678 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 653 | 678 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 653 | 678 | 566 | 715 | Domain | Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
Q9ULE3 | 653 | 678 | 566 | 715 | Domain | Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
Q9ULE3 | 653 | 678 | 566 | 715 | Domain | Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
Q9ULE3 | 679 | 725 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 679 | 725 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 679 | 725 | 1 | 1009 | Chain | ID=PRO_0000242682;Note=DENN domain-containing protein 2A |
Q9ULE3 | 679 | 725 | 566 | 715 | Domain | Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
Q9ULE3 | 679 | 725 | 566 | 715 | Domain | Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
Q9ULE3 | 679 | 725 | 566 | 715 | Domain | Note=uDENN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00304 |
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3'-UTR located exon skipping events that lost miRNA binding sites in DENND2A |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000496613 | 140605705 | 140605806 | hsa-miR-631 | chr7:140605798-140605805 | 8mer-1a | chr7:140605784-140605805 | 161.00 | -26.87 |
Mayo | ENST00000496613 | 140605705 | 140605806 | hsa-miR-6795-3p | chr7:140605787-140605794 | 8mer-1a | chr7:140605784-140605805 | 161.00 | -26.87 |
Mayo | ENST00000496613 | 140605705 | 140605806 | hsa-miR-3661 | chr7:140605798-140605805 | 8mer-1a | chr7:140605784-140605805 | 161.00 | -26.87 |
Mayo | ENST00000496613 | 140605705 | 140605806 | hsa-miR-888-3p | chr7:140605778-140605785 | 8mer-1a | chr7:140605771-140605791 | 163.00 | -27.09 |
MSBB | ENST00000496613 | 140605705 | 140605806 | hsa-miR-631 | chr7:140605798-140605805 | 8mer-1a | chr7:140605784-140605805 | 161.00 | -26.87 |
MSBB | ENST00000496613 | 140605705 | 140605806 | hsa-miR-6795-3p | chr7:140605787-140605794 | 8mer-1a | chr7:140605784-140605805 | 161.00 | -26.87 |
MSBB | ENST00000496613 | 140605705 | 140605806 | hsa-miR-3661 | chr7:140605798-140605805 | 8mer-1a | chr7:140605784-140605805 | 161.00 | -26.87 |
MSBB | ENST00000496613 | 140605705 | 140605806 | hsa-miR-888-3p | chr7:140605778-140605785 | 8mer-1a | chr7:140605771-140605791 | 163.00 | -27.09 |
ROSMAP | ENST00000496613 | 140605705 | 140605806 | hsa-miR-631 | chr7:140605798-140605805 | 8mer-1a | chr7:140605784-140605805 | 161.00 | -26.87 |
ROSMAP | ENST00000496613 | 140605705 | 140605806 | hsa-miR-6795-3p | chr7:140605787-140605794 | 8mer-1a | chr7:140605784-140605805 | 161.00 | -26.87 |
ROSMAP | ENST00000496613 | 140605705 | 140605806 | hsa-miR-3661 | chr7:140605798-140605805 | 8mer-1a | chr7:140605784-140605805 | 161.00 | -26.87 |
ROSMAP | ENST00000496613 | 140605705 | 140605806 | hsa-miR-888-3p | chr7:140605778-140605785 | 8mer-1a | chr7:140605771-140605791 | 163.00 | -27.09 |
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SNVs in the skipped exons for DENND2A |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DENND2A |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DENND2A |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DENND2A |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for DENND2A |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENND2A |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |