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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ABL2 |
 Gene summary |
| Gene information | Gene symbol | ABL2 | Gene ID | 27 |
| Gene name | ABL proto-oncogene 2, non-receptor tyrosine kinase | |
| Synonyms | ABLL|ARG | |
| Cytomap | 1q25.2 | |
| Type of gene | protein-coding | |
| Description | tyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2 | |
| Modification date | 20200327 | |
| UniProtAcc | P42684, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ABL2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 15886098 |
| ABL2 | GO:0051353 | positive regulation of oxidoreductase activity | 12893824 |
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Gene structures and expression levels for ABL2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000143322
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000507173.5 | ABL2-207:protein_coding:ABL2 | 3.942467e+01 | 1.354937e+00 | 3.744181e-11 | 2.814805e-09 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ABL2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_121309 | chr1 | 179131436:179131481:179133312:179133374:179229241:179229397 | 179133312:179133374 |
| exon_skip_124808 | chr1 | 179110282:179110455:179112309:179112398:179114878:179115030 | 179112309:179112398 |
| exon_skip_135992 | chr1 | 179118587:179118764:179120190:179120274:179121595:179121867 | 179120190:179120274 |
| exon_skip_153854 | chr1 | 179131311:179131481:179133312:179133374:179142933:179143044 | 179133312:179133374 |
| exon_skip_204368 | chr1 | 179114878:179115030:179117332:179117516:179118587:179118764 | 179117332:179117516 |
| exon_skip_238756 | chr1 | 179131311:179131481:179133312:179133374:179229241:179229306 | 179133312:179133374 |
| exon_skip_266783 | chr1 | 179131436:179131481:179133312:179133374:179142933:179143044 | 179133312:179133374 |
| exon_skip_93801 | chr1 | 179131311:179131481:179133312:179133374:179142933:179143056 | 179133312:179133374 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ABL2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000502732 | 179117332 | 179117516 | Frame-shift |
| ENST00000502732 | 179120190 | 179120274 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000502732 | 179117332 | 179117516 | Frame-shift |
| ENST00000502732 | 179120190 | 179120274 | Frame-shift |
| ENST00000502732 | 179112309 | 179112398 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ABL2 |
p-ENSG00000143322_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000502732 | 12161 | 1182 | 179112309 | 179112398 | 1766 | 1854 | 520 | 550 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P42684 | 520 | 550 | 550 | 564 | Alternative sequence | ID=VSP_041773;Note=In isoform 8. EEVAEELGRAASSSS->EVLLHCANQTCITL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P42684 | 520 | 550 | 2 | 1182 | Chain | ID=PRO_0000088052;Note=Tyrosine-protein kinase ABL2 |
| P42684 | 520 | 550 | 288 | 539 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P42684 | 520 | 550 | 512 | 521 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HMI |
| P42684 | 520 | 550 | 526 | 528 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HMI |
| P42684 | 520 | 550 | 532 | 545 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3HMI |
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3'-UTR located exon skipping events that lost miRNA binding sites in ABL2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ABL2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ABL2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ABL2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ABL2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ABL2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P42684 | approved|investigational | DB01254 | Dasatinib | small molecule | P42684 |
| P42684 | approved|investigational | DB12010 | Fostamatinib | small molecule | P42684 |
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RelatedDiseases for ABL2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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