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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TIMM9 |
 Gene summary |
| Gene information | Gene symbol | TIMM9 | Gene ID | 26520 |
| Gene name | translocase of inner mitochondrial membrane 9 | |
| Synonyms | TIM9|TIM9A | |
| Cytomap | 14q23.1 | |
| Type of gene | protein-coding | |
| Description | mitochondrial import inner membrane translocase subunit Tim9translocase of inner mitochondrial membrane 9 homolog | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TIMM9 | GO:0045039 | protein import into mitochondrial inner membrane | 16387659 |
| TIMM9 | GO:0072321 | chaperone-mediated protein transport | 16387659 |
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Gene structures and expression levels for TIMM9 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100575
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000555593.5 | TIMM9-206:protein_coding:TIMM9 | 1.400381e+02 | -8.106510e-01 | 1.292109e-07 | 2.640268e-06 |
| CB | DOWN | ENST00000555061.5 | TIMM9-203:protein_coding:TIMM9 | 1.514418e+01 | -8.634342e-01 | 4.526650e-06 | 5.388684e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TIMM9 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_15664 | chr14 | 58411907:58411971:58424008:58424095:58427054:58427114 | 58424008:58424095 |
| exon_skip_265074 | chr14 | 58410845:58410938:58424008:58424095:58427054:58427114 | 58424008:58424095 |
| exon_skip_267230 | chr14 | 58410845:58410938:58411907:58411971:58424008:58424095 | 58411907:58411971 |
| exon_skip_26774 | chr14 | 58424008:58424095:58427054:58427242:58427392:58427505 | 58427054:58427242 |
| exon_skip_282411 | chr14 | 58410843:58410938:58411907:58411971:58427054:58427171 | 58411907:58411971 |
| exon_skip_31585 | chr14 | 58411907:58411971:58423828:58423849:58424008:58424095 | 58423828:58423849 |
| exon_skip_36070 | chr14 | 58409034:58409168:58410843:58410938:58424008:58424095 | 58410843:58410938 |
| exon_skip_37387 | chr14 | 58410845:58410938:58411907:58411971:58427054:58427114 | 58411907:58411971 |
| exon_skip_62799 | chr14 | 58409034:58409168:58410843:58410938:58411907:58411971 | 58410843:58410938 |
| exon_skip_8961 | chr14 | 58410843:58410938:58424008:58424095:58427054:58427171 | 58424008:58424095 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TIMM9 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395159 | 58411907 | 58411971 | 3UTR-3CDS |
| ENST00000555404 | 58411907 | 58411971 | 3UTR-3CDS |
| ENST00000395159 | 58424008 | 58424095 | 3UTR-3UTR |
| ENST00000395159 | 58410843 | 58410938 | In-frame |
| ENST00000555061 | 58410843 | 58410938 | In-frame |
| ENST00000555404 | 58410843 | 58410938 | In-frame |
| ENST00000555593 | 58410843 | 58410938 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395159 | 58411907 | 58411971 | 3UTR-3CDS |
| ENST00000555404 | 58411907 | 58411971 | 3UTR-3CDS |
| ENST00000395159 | 58424008 | 58424095 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000395159 | 58411907 | 58411971 | 3UTR-3CDS |
| ENST00000555404 | 58411907 | 58411971 | 3UTR-3CDS |
| ENST00000395159 | 58424008 | 58424095 | 3UTR-3UTR |
| ENST00000395159 | 58410843 | 58410938 | In-frame |
| ENST00000555061 | 58410843 | 58410938 | In-frame |
| ENST00000555404 | 58410843 | 58410938 | In-frame |
| ENST00000555593 | 58410843 | 58410938 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TIMM9 |
p-ENSG00000100575_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000395159 | 1353 | 89 | 58410843 | 58410938 | 566 | 660 | 13 | 44 |
| ENST00000555061 | 615 | 89 | 58410843 | 58410938 | 208 | 302 | 13 | 44 |
| ENST00000555404 | 447 | 89 | 58410843 | 58410938 | 200 | 294 | 13 | 44 |
| ENST00000555593 | 813 | 89 | 58410843 | 58410938 | 180 | 274 | 13 | 44 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000395159 | 1353 | 89 | 58410843 | 58410938 | 566 | 660 | 13 | 44 |
| ENST00000555061 | 615 | 89 | 58410843 | 58410938 | 208 | 302 | 13 | 44 |
| ENST00000555404 | 447 | 89 | 58410843 | 58410938 | 200 | 294 | 13 | 44 |
| ENST00000555593 | 813 | 89 | 58410843 | 58410938 | 180 | 274 | 13 | 44 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y5J7 | 13 | 44 | 37 | 40 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 37 | 40 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 37 | 40 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 37 | 40 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 2 | 89 | Chain | ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9 |
| Q9Y5J7 | 13 | 44 | 2 | 89 | Chain | ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9 |
| Q9Y5J7 | 13 | 44 | 2 | 89 | Chain | ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9 |
| Q9Y5J7 | 13 | 44 | 2 | 89 | Chain | ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9 |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 32 | 48 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 32 | 48 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 32 | 48 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 32 | 48 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 15 | 32 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 15 | 32 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 15 | 32 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 15 | 32 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 43 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 43 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 43 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 43 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Motif | Note=Twin CX3C motif |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Motif | Note=Twin CX3C motif |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Motif | Note=Twin CX3C motif |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Motif | Note=Twin CX3C motif |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y5J7 | 13 | 44 | 37 | 40 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 37 | 40 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 37 | 40 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 37 | 40 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 2 | 89 | Chain | ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9 |
| Q9Y5J7 | 13 | 44 | 2 | 89 | Chain | ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9 |
| Q9Y5J7 | 13 | 44 | 2 | 89 | Chain | ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9 |
| Q9Y5J7 | 13 | 44 | 2 | 89 | Chain | ID=PRO_0000193595;Note=Mitochondrial import inner membrane translocase subunit Tim9 |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 32 | 48 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 32 | 48 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 32 | 48 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 32 | 48 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16387659;Dbxref=PMID:16387659 |
| Q9Y5J7 | 13 | 44 | 15 | 32 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 15 | 32 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 15 | 32 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 15 | 32 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 43 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 43 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 43 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 43 | 71 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2BSK |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Motif | Note=Twin CX3C motif |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Motif | Note=Twin CX3C motif |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Motif | Note=Twin CX3C motif |
| Q9Y5J7 | 13 | 44 | 28 | 52 | Motif | Note=Twin CX3C motif |
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3'-UTR located exon skipping events that lost miRNA binding sites in TIMM9 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000395159 | 58424008 | 58424095 | hsa-miR-3180-5p | chr14:58424037-58424044 | 8mer-1a | chr14:58424028-58424048 | 152.00 | -18.92 |
| Mayo | ENST00000395159 | 58424008 | 58424095 | hsa-miR-5003-3p | chr14:58424041-58424048 | 8mer-1a | chr14:58424028-58424048 | 152.00 | -18.92 |
| Mayo | ENST00000395159 | 58424008 | 58424095 | hsa-miR-4650-5p | chr14:58424081-58424088 | 8mer-1a | chr14:58424070-58424088 | 144.00 | -15.05 |
| MSBB | ENST00000395159 | 58424008 | 58424095 | hsa-miR-3180-5p | chr14:58424037-58424044 | 8mer-1a | chr14:58424028-58424048 | 152.00 | -18.92 |
| MSBB | ENST00000395159 | 58424008 | 58424095 | hsa-miR-5003-3p | chr14:58424041-58424048 | 8mer-1a | chr14:58424028-58424048 | 152.00 | -18.92 |
| MSBB | ENST00000395159 | 58424008 | 58424095 | hsa-miR-4650-5p | chr14:58424081-58424088 | 8mer-1a | chr14:58424070-58424088 | 144.00 | -15.05 |
| ROSMAP | ENST00000395159 | 58424008 | 58424095 | hsa-miR-3180-5p | chr14:58424037-58424044 | 8mer-1a | chr14:58424028-58424048 | 152.00 | -18.92 |
| ROSMAP | ENST00000395159 | 58424008 | 58424095 | hsa-miR-5003-3p | chr14:58424041-58424048 | 8mer-1a | chr14:58424028-58424048 | 152.00 | -18.92 |
| ROSMAP | ENST00000395159 | 58424008 | 58424095 | hsa-miR-4650-5p | chr14:58424081-58424088 | 8mer-1a | chr14:58424070-58424088 | 144.00 | -15.05 |
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SNVs in the skipped exons for TIMM9 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TIMM9 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TIMM9 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TIMM9 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_15664 | -4.580210e-01 | 1.275693e-09 |
| CB | NUP42 | exon_skip_15664 | 4.995849e-01 | 2.032332e-11 |
| TC | PTBP1 | exon_skip_15664 | -4.552026e-01 | 1.470295e-09 |
| TC | NOVA1 | exon_skip_15664 | 4.774508e-01 | 1.729088e-10 |
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RelatedDrugs for TIMM9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TIMM9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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