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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for GBP2 |
Gene summary |
Gene information | Gene symbol | GBP2 | Gene ID | 2634 |
Gene name | guanylate binding protein 2 | |
Synonyms | - | |
Cytomap | 1p22.2 | |
Type of gene | protein-coding | |
Description | guanylate-binding protein 2GTP-binding protein 2guanine nucleotide-binding protein 2guanylate binding protein 2, interferon-inducibleinterferon-induced guanylate-binding protein 2 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
GBP2 | GO:0034504 | protein localization to nucleus | 21151871 |
GBP2 | GO:0071346 | cellular response to interferon-gamma | 17266443 |
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Gene structures and expression levels for GBP2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
PG | UP | 1.634390e+02 | 1.053234e+00 | 3.795055e-14 | 3.539110e-11 |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000370466.4 | GBP2-201:protein_coding:GBP2 | 7.720642e+01 | 9.613566e-01 | 1.285588e-05 | 3.223208e-03 |
PG | UP | ENST00000370466.4 | GBP2-201:protein_coding:GBP2 | 9.290057e+01 | 1.145330e+00 | 4.969647e-11 | 3.955706e-08 |
PG | UP | ENST00000493802.5 | GBP2-204:lncRNA:GBP2 | 9.659750e+00 | 1.507672e+00 | 2.255720e-06 | 1.660674e-04 |
TC | UP | ENST00000370466.4 | GBP2-201:protein_coding:GBP2 | 2.303611e+02 | 1.103819e+00 | 1.426724e-09 | 1.776165e-07 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GBP2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_224579 | chr1 | 89106132:89107052:89108023:89108291:89109677:89109870 | 89108023:89108291 |
exon_skip_276965 | chr1 | 89114016:89114296:89116992:89117234:89117577:89117773 | 89116992:89117234 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for GBP2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000370466 | 89116992 | 89117234 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000370466 | 89116992 | 89117234 | In-frame |
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Infer the effects of exon skipping event on protein functional features for GBP2 |
p-ENSG00000162645_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000370466 | 2237 | 591 | 89116992 | 89117234 | 895 | 1136 | 208 | 289 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000370466 | 2237 | 591 | 89116992 | 89117234 | 895 | 1136 | 208 | 289 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P32456 | 208 | 289 | 1 | 588 | Chain | ID=PRO_0000190964;Note=Guanylate-binding protein 2 |
P32456 | 208 | 289 | 35 | 276 | Domain | Note=GB1/RHD3-type G |
P32456 | 208 | 289 | 281 | 281 | Natural variant | ID=VAR_054815;Note=S->P;Dbxref=dbSNP:rs2230336 |
P32456 | 208 | 289 | 285 | 285 | Natural variant | ID=VAR_054816;Note=P->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:1715024,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.5,ECO:0000269|Ref.7;Dbxref=dbSNP:rs1803632,PMID:1 |
P32456 | 208 | 289 | 1 | 309 | Region | Note=GTPase domain (Globular);Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
P32456 | 208 | 289 | 1 | 588 | Chain | ID=PRO_0000190964;Note=Guanylate-binding protein 2 |
P32456 | 208 | 289 | 35 | 276 | Domain | Note=GB1/RHD3-type G |
P32456 | 208 | 289 | 281 | 281 | Natural variant | ID=VAR_054815;Note=S->P;Dbxref=dbSNP:rs2230336 |
P32456 | 208 | 289 | 285 | 285 | Natural variant | ID=VAR_054816;Note=P->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:1715024,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.5,ECO:0000269|Ref.7;Dbxref=dbSNP:rs1803632,PMID:1 |
P32456 | 208 | 289 | 1 | 309 | Region | Note=GTPase domain (Globular);Ontology_term=ECO:0000250;evidence=ECO:0000250 |
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3'-UTR located exon skipping events that lost miRNA binding sites in GBP2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for GBP2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GBP2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GBP2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for GBP2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for GBP2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GBP2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |