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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TIAM2 |
 Gene summary |
| Gene information | Gene symbol | TIAM2 | Gene ID | 26230 |
| Gene name | TIAM Rac1 associated GEF 2 | |
| Synonyms | STEF|TIAM-2 | |
| Cytomap | 6q25.2-q25.3 | |
| Type of gene | protein-coding | |
| Description | T-lymphoma invasion and metastasis-inducing protein 2SIF and TIAM1-like exchange factorT cell lymphoma invasion and metastasis 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TIAM2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000146426
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000546145.1 | TIAM2-220:retained_intron:TIAM2 | 1.300013e+01 | -8.248393e-01 | 3.440455e-03 | 3.512399e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TIAM2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_108750 | chr6 | 155251945:155252003:155252948:155253053:155253973:155254060 | 155252948:155253053 |
| exon_skip_165405 | chr6 | 155249851:155249969:155250913:155251021:155251945:155251985 | 155250913:155251021 |
| exon_skip_177932 | chr6 | 155249854:155249969:155250538:155250624:155250913:155251021 | 155250538:155250624 |
| exon_skip_203104 | chr6 | 155165263:155165409:155168845:155168916:155176816:155176977 | 155168845:155168916 |
| exon_skip_237074 | chr6 | 155183315:155183500:155211204:155211307:155240530:155240709 | 155211204:155211307 |
| exon_skip_25330 | chr6 | 155253973:155254060:155254419:155254573:155256484:155256686 | 155254419:155254573 |
| exon_skip_283888 | chr6 | 155249851:155249969:155250538:155250624:155250913:155251021 | 155250538:155250624 |
| exon_skip_73560 | chr6 | 155179378:155179456:155182226:155182318:155183237:155183500 | 155182226:155182318 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TIAM2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000461783 | 155211204 | 155211307 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000461783 | 155211204 | 155211307 | Frame-shift |
| ENST00000461783 | 155250913 | 155251021 | Frame-shift |
| ENST00000461783 | 155252948 | 155253053 | Frame-shift |
| ENST00000461783 | 155254419 | 155254573 | Frame-shift |
| ENST00000461783 | 155182226 | 155182318 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TIAM2 |
p-ENSG00000146426_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000461783 | 6998 | 1701 | 155182226 | 155182318 | 3982 | 4073 | 903 | 933 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IVF5 | 903 | 933 | 1 | 1075 | Alternative sequence | ID=VSP_030971;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10512681,ECO:0000303|PubMed:15489334;Dbxref=PMID:10512681,PMID:15489334 |
| Q8IVF5 | 903 | 933 | 2 | 1701 | Chain | ID=PRO_0000317467;Note=T-lymphoma invasion and metastasis-inducing protein 2 |
| Q8IVF5 | 903 | 933 | 890 | 976 | Domain | Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 |
| Q8IVF5 | 903 | 933 | 913 | 913 | Natural variant | ID=VAR_051995;Note=R->H;Dbxref=dbSNP:rs7770537 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TIAM2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TIAM2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TIAM2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TIAM2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TIAM2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TIAM2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TIAM2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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