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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for WSB1 |
 Gene summary |
| Gene information | Gene symbol | WSB1 | Gene ID | 26118 |
| Gene name | WD repeat and SOCS box containing 1 | |
| Synonyms | SWIP1|WSB-1 | |
| Cytomap | 17q11.1 | |
| Type of gene | protein-coding | |
| Description | WD repeat and SOCS box-containing protein 1SOCS box-containing WD protein SWiP-1 | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for WSB1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000109046
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000583096.1 | WSB1-212:retained_intron:WSB1 | 1.532811e+01 | 1.726432e+00 | 7.314359e-04 | 3.972105e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for WSB1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_123152 | chr17 | 27301881:27301956:27303367:27303635:27304780:27304903 | 27303367:27303635 |
| exon_skip_132484 | chr17 | 27309100:27309272:27310061:27310174:27311509:27311616 | 27310061:27310174 |
| exon_skip_189058 | chr17 | 27294346:27294435:27301788:27301956:27304780:27304903 | 27301788:27301956 |
| exon_skip_220193 | chr17 | 27309216:27309272:27310061:27310174:27311509:27311616 | 27310061:27310174 |
| exon_skip_237132 | chr17 | 27303367:27303635:27304780:27304911:27306782:27306858 | 27304780:27304911 |
| exon_skip_261646 | chr17 | 27294346:27294435:27301881:27301956:27303367:27303411 | 27301881:27301956 |
| exon_skip_267012 | chr17 | 27301788:27301956:27303367:27303635:27304780:27304911 | 27303367:27303635 |
| exon_skip_268341 | chr17 | 27294346:27294435:27297187:27297308:27301788:27301956 | 27297187:27297308 |
| exon_skip_271969 | chr17 | 27297187:27297308:27301788:27301956:27303367:27303411 | 27301788:27301956 |
| exon_skip_280553 | chr17 | 27294112:27294435:27304780:27304911:27306782:27306882 | 27304780:27304911 |
| exon_skip_291176 | chr17 | 27294346:27294435:27301788:27301956:27303367:27303411 | 27301788:27301956 |
| exon_skip_46146 | chr17 | 27294346:27294435:27301818:27301956:27303367:27303411 | 27301818:27301956 |
| exon_skip_53679 | chr17 | 27294114:27294435:27301881:27301956:27303367:27303411 | 27301881:27301956 |
| exon_skip_70701 | chr17 | 27294087:27294435:27301818:27301956:27303367:27303411 | 27301818:27301956 |
| exon_skip_7561 | chr17 | 27294346:27294435:27304780:27304911:27306782:27306858 | 27304780:27304911 |
| exon_skip_79007 | chr17 | 27294346:27294435:27301788:27301956:27304780:27304911 | 27301788:27301956 |
| exon_skip_99706 | chr17 | 27310061:27310174:27311509:27311616:27312210:27312887 | 27311509:27311616 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_194207 | Mayo_CB | 1.341250e-01 | 2.348485e-01 | -1.007235e-01 | 1.274800e-04 |
| exon_skip_43613 | Mayo_CB | 1.544444e-01 | 2.976471e-01 | -1.432026e-01 | 4.639811e-07 |
| exon_skip_224125 | Mayo_TC | 3.547436e-01 | 4.713636e-01 | -1.166200e-01 | 3.825093e-05 |
| exon_skip_194207 | Mayo_TC | 4.291358e-01 | 5.329032e-01 | -1.037674e-01 | 1.635406e-05 |
| exon_skip_60205 | Mayo_TC | 3.882927e-01 | 5.358730e-01 | -1.475803e-01 | 1.718267e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for WSB1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262394 | 27301788 | 27301956 | Frame-shift |
| ENST00000262394 | 27303367 | 27303635 | Frame-shift |
| ENST00000262394 | 27304780 | 27304911 | In-frame |
| ENST00000262394 | 27310061 | 27310174 | In-frame |
| ENST00000262394 | 27311509 | 27311616 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262394 | 27301788 | 27301956 | Frame-shift |
| ENST00000262394 | 27304780 | 27304911 | In-frame |
| ENST00000262394 | 27310061 | 27310174 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262394 | 27301788 | 27301956 | Frame-shift |
| ENST00000262394 | 27303367 | 27303635 | Frame-shift |
| ENST00000262394 | 27304780 | 27304911 | In-frame |
| ENST00000262394 | 27310061 | 27310174 | In-frame |
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Infer the effects of exon skipping event on protein functional features for WSB1 |
p-ENSG00000109046_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262394 | 5156 | 421 | 27304780 | 27304911 | 796 | 926 | 160 | 203 |
| ENST00000262394 | 5156 | 421 | 27310061 | 27310174 | 1202 | 1314 | 295 | 332 |
| ENST00000262394 | 5156 | 421 | 27311509 | 27311616 | 1316 | 1422 | 333 | 368 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262394 | 5156 | 421 | 27304780 | 27304911 | 796 | 926 | 160 | 203 |
| ENST00000262394 | 5156 | 421 | 27310061 | 27310174 | 1202 | 1314 | 295 | 332 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262394 | 5156 | 421 | 27304780 | 27304911 | 796 | 926 | 160 | 203 |
| ENST00000262394 | 5156 | 421 | 27310061 | 27310174 | 1202 | 1314 | 295 | 332 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y6I7 | 160 | 203 | 36 | 237 | Alternative sequence | ID=VSP_053403;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9Y6I7 | 160 | 203 | 1 | 421 | Chain | ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1 |
| Q9Y6I7 | 160 | 203 | 124 | 165 | Repeat | Note=WD 2 |
| Q9Y6I7 | 160 | 203 | 168 | 208 | Repeat | Note=WD 3 |
| Q9Y6I7 | 160 | 203 | 171 | 171 | Sequence conflict | Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y6I7 | 160 | 203 | 178 | 178 | Sequence conflict | Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y6I7 | 160 | 203 | 201 | 201 | Sequence conflict | Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y6I7 | 295 | 332 | 245 | 421 | Alternative sequence | ID=VSP_039112;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9Y6I7 | 295 | 332 | 1 | 421 | Chain | ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1 |
| Q9Y6I7 | 295 | 332 | 309 | 346 | Repeat | Note=WD 6 |
| Q9Y6I7 | 333 | 368 | 245 | 421 | Alternative sequence | ID=VSP_039112;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9Y6I7 | 333 | 368 | 1 | 421 | Chain | ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1 |
| Q9Y6I7 | 333 | 368 | 309 | 346 | Repeat | Note=WD 6 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y6I7 | 160 | 203 | 36 | 237 | Alternative sequence | ID=VSP_053403;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9Y6I7 | 160 | 203 | 1 | 421 | Chain | ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1 |
| Q9Y6I7 | 160 | 203 | 124 | 165 | Repeat | Note=WD 2 |
| Q9Y6I7 | 160 | 203 | 168 | 208 | Repeat | Note=WD 3 |
| Q9Y6I7 | 160 | 203 | 171 | 171 | Sequence conflict | Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y6I7 | 160 | 203 | 178 | 178 | Sequence conflict | Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y6I7 | 160 | 203 | 201 | 201 | Sequence conflict | Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y6I7 | 295 | 332 | 245 | 421 | Alternative sequence | ID=VSP_039112;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9Y6I7 | 295 | 332 | 1 | 421 | Chain | ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1 |
| Q9Y6I7 | 295 | 332 | 309 | 346 | Repeat | Note=WD 6 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y6I7 | 160 | 203 | 36 | 237 | Alternative sequence | ID=VSP_053403;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 |
| Q9Y6I7 | 160 | 203 | 1 | 421 | Chain | ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1 |
| Q9Y6I7 | 160 | 203 | 124 | 165 | Repeat | Note=WD 2 |
| Q9Y6I7 | 160 | 203 | 168 | 208 | Repeat | Note=WD 3 |
| Q9Y6I7 | 160 | 203 | 171 | 171 | Sequence conflict | Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y6I7 | 160 | 203 | 178 | 178 | Sequence conflict | Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y6I7 | 160 | 203 | 201 | 201 | Sequence conflict | Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9Y6I7 | 295 | 332 | 245 | 421 | Alternative sequence | ID=VSP_039112;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 |
| Q9Y6I7 | 295 | 332 | 1 | 421 | Chain | ID=PRO_0000051457;Note=WD repeat and SOCS box-containing protein 1 |
| Q9Y6I7 | 295 | 332 | 309 | 346 | Repeat | Note=WD 6 |
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3'-UTR located exon skipping events that lost miRNA binding sites in WSB1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for WSB1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for WSB1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WSB1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for WSB1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_146457 | -5.228760e-01 | 3.337058e-09 |
| CB | CNOT4 | exon_skip_146457 | -4.057078e-01 | 9.086784e-06 |
| CB | TRA2A | exon_skip_146457 | -4.253877e-01 | 2.933112e-06 |
| CB | KHSRP | exon_skip_146457 | -4.389607e-01 | 1.288784e-06 |
| CB | PABPC1 | exon_skip_146457 | 4.132031e-01 | 5.956865e-06 |
| CB | SRSF4 | exon_skip_146457 | -4.323738e-01 | 1.929450e-06 |
| CB | HNRNPDL | exon_skip_204122 | 4.102099e-01 | 3.287579e-07 |
| CB | RBM45 | exon_skip_204122 | 5.145545e-01 | 4.185944e-11 |
| CB | ZNF638 | exon_skip_194207 | -4.262938e-01 | 8.100019e-08 |
| CB | U2AF2 | exon_skip_194207 | -5.251690e-01 | 1.009065e-11 |
| CB | TRA2A | exon_skip_194207 | -4.529775e-01 | 9.420856e-09 |
| CB | RBM45 | exon_skip_194207 | 4.440436e-01 | 1.976604e-08 |
| CB | TARDBP | exon_skip_43613 | -4.433490e-01 | 1.491914e-08 |
| CB | ZNF638 | exon_skip_43613 | -4.544081e-01 | 5.844725e-09 |
| CB | RBM6 | exon_skip_43613 | -4.790903e-01 | 6.375052e-10 |
| CB | SAMD4A | exon_skip_43613 | -4.027397e-01 | 3.543368e-07 |
| CB | U2AF2 | exon_skip_43613 | -6.407147e-01 | 1.369354e-18 |
| CB | CNOT4 | exon_skip_43613 | -4.684537e-01 | 1.692615e-09 |
| CB | RBM3 | exon_skip_43613 | 4.876040e-01 | 2.847234e-10 |
| CB | PCBP4 | exon_skip_43613 | 5.155429e-01 | 1.720276e-11 |
| CB | TRA2A | exon_skip_43613 | -4.753459e-01 | 9.024622e-10 |
| CB | FUBP1 | exon_skip_43613 | -4.456338e-01 | 1.232661e-08 |
| CB | RBM45 | exon_skip_43613 | 6.477441e-01 | 4.341901e-19 |
| CB | HNRNPAB | exon_skip_43613 | -4.241356e-01 | 7.033774e-08 |
| CB | HNRNPC | exon_skip_43613 | -4.183080e-01 | 1.104883e-07 |
| CB | SRSF4 | exon_skip_43613 | -4.761914e-01 | 8.346498e-10 |
| DLPFC | RBM6 | exon_skip_268341 | 4.332276e-01 | 6.759958e-17 |
| DLPFC | SRSF11 | exon_skip_268341 | 7.047315e-01 | 5.056056e-52 |
| DLPFC | MBNL1 | exon_skip_268341 | -4.679783e-01 | 8.487606e-20 |
| DLPFC | PCBP4 | exon_skip_268341 | 4.366008e-01 | 3.653055e-17 |
| DLPFC | SNRNP70 | exon_skip_268341 | 5.255174e-01 | 2.155991e-25 |
| TC | PCBP4 | exon_skip_194207 | 4.280775e-01 | 9.653430e-08 |
| TC | HNRNPDL | exon_skip_194207 | 4.199368e-01 | 1.778926e-07 |
| TC | SRSF5 | exon_skip_194207 | 4.416996e-01 | 3.346200e-08 |
| TC | RBM3 | exon_skip_60205 | 4.810731e-01 | 9.081802e-10 |
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RelatedDrugs for WSB1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WSB1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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