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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TANC2 |
 Gene summary |
| Gene information | Gene symbol | TANC2 | Gene ID | 26115 |
| Gene name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | |
| Synonyms | ROLSA|rols | |
| Cytomap | 17q23.2-q23.3 | |
| Type of gene | protein-coding | |
| Description | protein TANC2putative ankyrin-repeat containing proteinrolling pebbles homolog Btetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TANC2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000170921
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000580466.1 | TANC2-205:protein_coding:TANC2 | 4.012643e+00 | 8.762202e-01 | 8.735653e-05 | 6.605668e-04 |
| CB | UP | ENST00000583356.5 | TANC2-209:protein_coding:TANC2 | 1.754645e+01 | 9.411887e-01 | 8.918074e-04 | 4.689549e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TANC2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_115312 | chr17 | 63009560:63009626:63073943:63074014:63099175:63099246 | 63073943:63074014 |
| exon_skip_140956 | chr17 | 63193994:63194139:63200771:63200957:63237814:63238077 | 63200771:63200957 |
| exon_skip_166188 | chr17 | 63099175:63099357:63151270:63151380:63193991:63194082 | 63151270:63151380 |
| exon_skip_180516 | chr17 | 63415528:63415674:63418307:63418407:63419999:63422025 | 63418307:63418407 |
| exon_skip_18911 | chr17 | 63412084:63412130:63412680:63412709:63413543:63413634 | 63412680:63412709 |
| exon_skip_199224 | chr17 | 63200771:63200957:63237814:63238077:63267748:63267873 | 63237814:63238077 |
| exon_skip_226450 | chr17 | 63237814:63238077:63267748:63267873:63314388:63314669 | 63267748:63267873 |
| exon_skip_264210 | chr17 | 63267748:63267873:63314388:63314669:63318957:63319090 | 63314388:63314669 |
| exon_skip_27336 | chr17 | 63395743:63395928:63398821:63398914:63405122:63405255 | 63398821:63398914 |
| exon_skip_30353 | chr17 | 63415528:63415674:63418307:63418407:63419999:63422356 | 63418307:63418407 |
| exon_skip_41511 | chr17 | 63351250:63351416:63354783:63355390:63379718:63379826 | 63354783:63355390 |
| exon_skip_66344 | chr17 | 63411998:63412130:63412680:63412709:63413543:63413634 | 63412680:63412709 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TANC2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000424789 | 63200771 | 63200957 | Frame-shift |
| ENST00000424789 | 63418307 | 63418407 | Frame-shift |
| ENST00000424789 | 63267748 | 63267873 | In-frame |
| ENST00000424789 | 63314388 | 63314669 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000424789 | 63200771 | 63200957 | Frame-shift |
| ENST00000424789 | 63418307 | 63418407 | Frame-shift |
| ENST00000424789 | 63237814 | 63238077 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000424789 | 63200771 | 63200957 | Frame-shift |
| ENST00000424789 | 63354783 | 63355390 | Frame-shift |
| ENST00000424789 | 63398821 | 63398914 | Frame-shift |
| ENST00000424789 | 63418307 | 63418407 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TANC2 |
p-ENSG00000170921_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000424789 | 11738 | 1990 | 63267748 | 63267873 | 817 | 941 | 271 | 312 |
| ENST00000424789 | 11738 | 1990 | 63314388 | 63314669 | 943 | 1223 | 313 | 406 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000424789 | 11738 | 1990 | 63237814 | 63238077 | 553 | 815 | 183 | 270 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9HCD6 | 271 | 312 | 1 | 1990 | Chain | ID=PRO_0000333811;Note=Protein TANC2 |
| Q9HCD6 | 271 | 312 | 294 | 294 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Q9HCD6 | 313 | 406 | 1 | 1990 | Chain | ID=PRO_0000333811;Note=Protein TANC2 |
| Q9HCD6 | 313 | 406 | 400 | 400 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9HCD6 | 183 | 270 | 1 | 1990 | Chain | ID=PRO_0000333811;Note=Protein TANC2 |
| Q9HCD6 | 183 | 270 | 238 | 238 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TANC2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TANC2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TANC2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_166188 | -4.123847e-01 | 2.920240e-02 | chr17 | + | 63099175 | 63099357 | 63151270 | 63151380 | 63193991 | 63194082 |
| CDR | MSBB | IFG | exon_skip_166188 | -3.901679e-01 | 4.011074e-02 | chr17 | + | 63099175 | 63099357 | 63151270 | 63151380 | 63193991 | 63194082 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TANC2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TANC2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| PCC | RALYL | exon_skip_166188 | 4.098434e-01 | 4.731628e-09 |
| PCC | NOVA1 | exon_skip_166188 | 4.554116e-01 | 4.573234e-11 |
| PG | RALYL | exon_skip_166188 | 4.384071e-01 | 2.006883e-09 |
| TC | RALYL | exon_skip_166188 | 7.247864e-01 | 5.342890e-20 |
| TC | CELF1 | exon_skip_166188 | 4.359456e-01 | 1.117119e-06 |
| TC | NOVA1 | exon_skip_166188 | 5.928370e-01 | 2.947018e-12 |
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RelatedDrugs for TANC2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TANC2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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