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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DNM3 |
 Gene summary |
| Gene information | Gene symbol | DNM3 | Gene ID | 26052 |
| Gene name | dynamin 3 | |
| Synonyms | Dyna III | |
| Cytomap | 1q24.3 | |
| Type of gene | protein-coding | |
| Description | dynamin-3T-dynamindynamin family memberdynamin, testicular | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DNM3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000197959
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000627582.3 | DNM3-208:protein_coding:DNM3 | 1.435275e+03 | -8.245049e-01 | 2.853244e-04 | 5.912186e-03 |
| CB | DOWN | ENST00000367731.5 | DNM3-202:protein_coding:DNM3 | 9.919705e+02 | -1.073425e+00 | 4.389436e-06 | 5.252589e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DNM3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_112388 | chr1 | 172387188:172387359:172388573:172388809:172407772:172408354 | 172388573:172388809 |
| exon_skip_124962 | chr1 | 172308728:172308839:172323329:172323340:172379018:172379076 | 172323329:172323340 |
| exon_skip_13314 | chr1 | 172092824:172092875:172093696:172093725:172131175:172131288 | 172093696:172093725 |
| exon_skip_169765 | chr1 | 172038319:172038461:172042009:172042144:172044385:172044452 | 172042009:172042144 |
| exon_skip_268998 | chr1 | 172081832:172081902:172092824:172092875:172131175:172131288 | 172092824:172092875 |
| exon_skip_38603 | chr1 | 172068819:172068905:172081832:172081902:172092824:172092875 | 172081832:172081902 |
| exon_skip_89953 | chr1 | 172308728:172308839:172323329:172323340:172379018:172379182 | 172323329:172323340 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_13314 | MSBB_PG | 3.292414e-01 | 2.207273e-01 | 1.085141e-01 | 3.129438e-04 |
| exon_skip_124962 | MSBB_PG | 3.902703e-01 | 6.201786e-01 | -2.299083e-01 | 4.062514e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for DNM3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355305 | 172093696 | 172093725 | In-frame |
| ENST00000355305 | 172388573 | 172388809 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355305 | 172081832 | 172081902 | Frame-shift |
| ENST00000355305 | 172093696 | 172093725 | In-frame |
| ENST00000355305 | 172388573 | 172388809 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000355305 | 172042009 | 172042144 | Frame-shift |
| ENST00000355305 | 172081832 | 172081902 | Frame-shift |
| ENST00000355305 | 172093696 | 172093725 | In-frame |
| ENST00000355305 | 172388573 | 172388809 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DNM3 |
p-ENSG00000197959_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355305 | 3297 | 869 | 172093696 | 172093725 | 1704 | 1732 | 515 | 525 |
| ENST00000355305 | 3297 | 869 | 172388573 | 172388809 | 2462 | 2697 | 768 | 846 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355305 | 3297 | 869 | 172093696 | 172093725 | 1704 | 1732 | 515 | 525 |
| ENST00000355305 | 3297 | 869 | 172388573 | 172388809 | 2462 | 2697 | 768 | 846 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000355305 | 3297 | 869 | 172093696 | 172093725 | 1704 | 1732 | 515 | 525 |
| ENST00000355305 | 3297 | 869 | 172388573 | 172388809 | 2462 | 2697 | 768 | 846 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UQ16 | 515 | 525 | 516 | 525 | Alternative sequence | ID=VSP_034053;Note=In isoform 2%2C isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10048485,ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:15489334;Dbxref=PMID:10048485,PMID:11230166,PMID:1548 |
| Q9UQ16 | 515 | 525 | 1 | 869 | Chain | ID=PRO_0000206573;Note=Dynamin-3 |
| Q9UQ16 | 515 | 525 | 515 | 621 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
| Q9UQ16 | 768 | 846 | 566 | 869 | Alternative sequence | ID=VSP_054547;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q9UQ16 | 768 | 846 | 1 | 869 | Chain | ID=PRO_0000206573;Note=Dynamin-3 |
| Q9UQ16 | 768 | 846 | 769 | 769 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q08877 |
| Q9UQ16 | 768 | 846 | 773 | 773 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39052 |
| Q9UQ16 | 768 | 846 | 844 | 844 | Sequence conflict | Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UQ16 | 515 | 525 | 516 | 525 | Alternative sequence | ID=VSP_034053;Note=In isoform 2%2C isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10048485,ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:15489334;Dbxref=PMID:10048485,PMID:11230166,PMID:1548 |
| Q9UQ16 | 515 | 525 | 1 | 869 | Chain | ID=PRO_0000206573;Note=Dynamin-3 |
| Q9UQ16 | 515 | 525 | 515 | 621 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
| Q9UQ16 | 768 | 846 | 566 | 869 | Alternative sequence | ID=VSP_054547;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q9UQ16 | 768 | 846 | 1 | 869 | Chain | ID=PRO_0000206573;Note=Dynamin-3 |
| Q9UQ16 | 768 | 846 | 769 | 769 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q08877 |
| Q9UQ16 | 768 | 846 | 773 | 773 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39052 |
| Q9UQ16 | 768 | 846 | 844 | 844 | Sequence conflict | Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UQ16 | 515 | 525 | 516 | 525 | Alternative sequence | ID=VSP_034053;Note=In isoform 2%2C isoform 3 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10048485,ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:15489334;Dbxref=PMID:10048485,PMID:11230166,PMID:1548 |
| Q9UQ16 | 515 | 525 | 1 | 869 | Chain | ID=PRO_0000206573;Note=Dynamin-3 |
| Q9UQ16 | 515 | 525 | 515 | 621 | Domain | Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 |
| Q9UQ16 | 768 | 846 | 566 | 869 | Alternative sequence | ID=VSP_054547;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q9UQ16 | 768 | 846 | 1 | 869 | Chain | ID=PRO_0000206573;Note=Dynamin-3 |
| Q9UQ16 | 768 | 846 | 769 | 769 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q08877 |
| Q9UQ16 | 768 | 846 | 773 | 773 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P39052 |
| Q9UQ16 | 768 | 846 | 844 | 844 | Sequence conflict | Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in DNM3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DNM3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DNM3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_13314 | 3.875748e-01 | 4.157161e-02 | chr1 | + | 172092824 | 172092875 | 172093696 | 172093725 | 172131175 | 172131288 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DNM3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DNM3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | HNRNPA1 | exon_skip_89953 | 4.251879e-01 | 3.872654e-08 |
| CB | SRSF9 | exon_skip_89953 | 4.725556e-01 | 6.101188e-10 |
| FL | SRSF9 | exon_skip_124962 | 4.498367e-01 | 2.960695e-11 |
| HCC | HNRNPA2B1 | exon_skip_89953 | -4.080199e-01 | 4.714714e-12 |
| STG | IGF2BP3 | exon_skip_124962 | -4.061391e-01 | 7.135514e-05 |
| STG | SRSF9 | exon_skip_124962 | 4.649426e-01 | 3.897164e-06 |
| TC | HNRNPA1L2 | exon_skip_124962 | 4.070414e-01 | 1.220778e-07 |
| TC | SRSF9 | exon_skip_124962 | 4.819164e-01 | 1.656587e-10 |
| TC | YBX2 | exon_skip_124962 | 4.100691e-01 | 9.631226e-08 |
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RelatedDrugs for DNM3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNM3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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