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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for TENM4 |
Gene summary |
Gene information | Gene symbol | TENM4 | Gene ID | 26011 |
Gene name | teneurin transmembrane protein 4 | |
Synonyms | Doc4|ETM5|ODZ4|TEN4|TNM4|Ten-M4|ten-4 | |
Cytomap | 11q14.1 | |
Type of gene | protein-coding | |
Description | teneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TENM4 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TENM4 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_112632 | chr11 | 79215808:79215909:79220980:79221123:79297488:79297543 | 79220980:79221123 |
exon_skip_120918 | chr11 | 79069942:79070009:79148710:79148806:79215808:79215904 | 79148710:79148806 |
exon_skip_153638 | chr11 | 78805292:78805492:78812122:78812316:78814294:78814395 | 78812122:78812316 |
exon_skip_173014 | chr11 | 78855964:78856178:78862962:78863132:78889785:78890020 | 78862962:78863132 |
exon_skip_175239 | chr11 | 79069942:79070009:79148710:79148806:79215808:79215909 | 79148710:79148806 |
exon_skip_235999 | chr11 | 78889933:78890020:78891238:78891336:78903268:78903523 | 78891238:78891336 |
exon_skip_24141 | chr11 | 78756805:78757021:78770992:78771138:78778602:78778628 | 78770992:78771138 |
exon_skip_263377 | chr11 | 78738451:78738570:78756805:78757021:78770992:78771138 | 78756805:78757021 |
exon_skip_280262 | chr11 | 78712482:78712714:78720370:78720390:78722668:78722917 | 78720370:78720390 |
exon_skip_285633 | chr11 | 79148801:79148806:79215808:79215909:79297488:79297543 | 79215808:79215909 |
exon_skip_286093 | chr11 | 78770992:78771138:78778602:78778628:78786898:78787083 | 78778602:78778628 |
exon_skip_58220 | chr11 | 79069942:79070009:79148710:79148806:79215808:79215908 | 79148710:79148806 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TENM4 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000278550 | 79148710 | 79148806 | 3UTR-3UTR |
ENST00000278550 | 79215808 | 79215909 | 3UTR-3UTR |
ENST00000278550 | 78720370 | 78720390 | In-frame |
ENST00000278550 | 78770992 | 78771138 | In-frame |
ENST00000278550 | 78778602 | 78778628 | In-frame |
ENST00000278550 | 78812122 | 78812316 | In-frame |
ENST00000278550 | 78862962 | 78863132 | In-frame |
ENST00000278550 | 78891238 | 78891336 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000278550 | 79148710 | 79148806 | 3UTR-3UTR |
ENST00000278550 | 78720370 | 78720390 | In-frame |
ENST00000278550 | 78778602 | 78778628 | In-frame |
ENST00000278550 | 78812122 | 78812316 | In-frame |
ENST00000278550 | 78862962 | 78863132 | In-frame |
ENST00000278550 | 78891238 | 78891336 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000278550 | 79148710 | 79148806 | 3UTR-3UTR |
ENST00000278550 | 78756805 | 78757021 | Frame-shift |
ENST00000278550 | 78720370 | 78720390 | In-frame |
ENST00000278550 | 78778602 | 78778628 | In-frame |
ENST00000278550 | 78862962 | 78863132 | In-frame |
ENST00000278550 | 78891238 | 78891336 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TENM4 |
p-ENSG00000149256_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TENM4 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000278550 | 79148710 | 79148806 | hsa-miR-4499 | chr11:79148798-79148805 | 8mer-1a | chr11:79148785-79148806 | 161.00 | -17.38 |
Mayo | ENST00000278550 | 79148710 | 79148806 | hsa-miR-561-5p | chr11:79148758-79148765 | 8mer-1a | chr11:79148744-79148766 | 141.00 | -19.86 |
MSBB | ENST00000278550 | 79148710 | 79148806 | hsa-miR-4499 | chr11:79148798-79148805 | 8mer-1a | chr11:79148785-79148806 | 161.00 | -17.38 |
MSBB | ENST00000278550 | 79148710 | 79148806 | hsa-miR-561-5p | chr11:79148758-79148765 | 8mer-1a | chr11:79148744-79148766 | 141.00 | -19.86 |
ROSMAP | ENST00000278550 | 79148710 | 79148806 | hsa-miR-4499 | chr11:79148798-79148805 | 8mer-1a | chr11:79148785-79148806 | 161.00 | -17.38 |
ROSMAP | ENST00000278550 | 79215808 | 79215909 | hsa-miR-4306 | chr11:79215865-79215872 | 8mer-1a | chr11:79215849-79215872 | 151.00 | -22.61 |
ROSMAP | ENST00000278550 | 79215808 | 79215909 | hsa-miR-9718 | chr11:79215836-79215843 | 8mer-1a | chr11:79215834-79215858 | 148.00 | -28.23 |
ROSMAP | ENST00000278550 | 79215808 | 79215909 | hsa-miR-628-5p | chr11:79215836-79215843 | 8mer-1a | chr11:79215834-79215858 | 148.00 | -28.23 |
ROSMAP | ENST00000278550 | 79148710 | 79148806 | hsa-miR-561-5p | chr11:79148758-79148765 | 8mer-1a | chr11:79148744-79148766 | 141.00 | -19.86 |
ROSMAP | ENST00000278550 | 79215808 | 79215909 | hsa-miR-185-5p | chr11:79215865-79215872 | 8mer-1a | chr11:79215849-79215872 | 151.00 | -22.61 |
ROSMAP | ENST00000278550 | 79215808 | 79215909 | hsa-miR-4644 | chr11:79215865-79215872 | 8mer-1a | chr11:79215849-79215872 | 151.00 | -22.61 |
ROSMAP | ENST00000278550 | 79215808 | 79215909 | hsa-miR-6836-5p | chr11:79215853-79215860 | 8mer-1a | chr11:79215844-79215867 | 162.00 | -27.90 |
ROSMAP | ENST00000278550 | 79215808 | 79215909 | hsa-miR-6132 | chr11:79215853-79215860 | 8mer-1a | chr11:79215844-79215867 | 162.00 | -27.90 |
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SNVs in the skipped exons for TENM4 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TENM4 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TENM4 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
PCC | exon_skip_175239 | rs17137691 | chr11:79092295 | 1.468767e-04 | 2.348926e-02 |
PCC | exon_skip_175239 | rs11603285 | chr11:79095866 | 1.468767e-04 | 2.348926e-02 |
PCC | exon_skip_175239 | rs17137687 | chr11:79090416 | 2.552425e-04 | 3.623683e-02 |
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Correlation with RNA binding proteins (RBPs) for TENM4 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
HCC | KHDRBS2 | exon_skip_280262 | 5.262839e-01 | 8.737817e-19 |
HCC | MSI1 | exon_skip_286093 | -5.464602e-01 | 3.049327e-20 |
HCC | PTBP1 | exon_skip_286093 | -4.944187e-01 | 2.532225e-16 |
IFG | IGF2BP3 | exon_skip_175239 | 4.105819e-01 | 4.626941e-02 |
PCC | MSI1 | exon_skip_286093 | -4.406268e-01 | 4.315074e-10 |
PCC | PTBP1 | exon_skip_286093 | -5.322227e-01 | 8.928307e-15 |
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RelatedDrugs for TENM4 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TENM4 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |