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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for GAPDH |
 Gene summary |
| Gene information | Gene symbol | GAPDH | Gene ID | 2597 |
| Gene name | glyceraldehyde-3-phosphate dehydrogenase | |
| Synonyms | G3PD|GAPD|HEL-S-162eP | |
| Cytomap | 12p13.31 | |
| Type of gene | protein-coding | |
| Description | glyceraldehyde-3-phosphate dehydrogenaseOCAS, p38 componentOct1 coactivator in S phase, 38 Kd componentaging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDH | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context | - 25246025(Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| GAPDH | GO:0010951 | negative regulation of endopeptidase activity | 22832495 |
| GAPDH | GO:0017148 | negative regulation of translation | 23071094 |
| GAPDH | GO:0031640 | killing of cells of other organism | 22832495 |
| GAPDH | GO:0050715 | positive regulation of cytokine secretion | 22832495 |
| GAPDH | GO:0050832 | defense response to fungus | 22832495 |
| GAPDH | GO:0051873 | killing by host of symbiont cells | 22832495 |
| GAPDH | GO:0052501 | positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction | 22832495 |
| GAPDH | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 22832495 |
| GAPDH | GO:0071346 | cellular response to interferon-gamma | 15479637 |
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Gene structures and expression levels for GAPDH |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000111640
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000619601.1 | GAPDH-211:protein_coding:GAPDH | 6.188231e+03 | -1.076276e+00 | 3.669105e-08 | 9.080881e-07 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GAPDH |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_185379 | chr12 | 6534541:6534569:6534810:6534991:6536494:6536593 | 6534810:6534991 |
| exon_skip_192977 | chr12 | 6537309:6537390:6537584:6537996:6538101:6538314 | 6537584:6537996 |
| exon_skip_227516 | chr12 | 6534541:6534569:6534810:6534861:6536494:6536593 | 6534810:6534861 |
| exon_skip_94701 | chr12 | 6537309:6537390:6537584:6537996:6538101:6538121 | 6537584:6537996 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for GAPDH |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000229239 | 6534810 | 6534861 | 5CDS-5UTR |
| ENST00000229239 | 6537584 | 6537996 | Frame-shift |
| ENST00000396859 | 6537584 | 6537996 | Frame-shift |
| ENST00000396861 | 6537584 | 6537996 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000229239 | 6534810 | 6534861 | 5CDS-5UTR |
| ENST00000229239 | 6537584 | 6537996 | Frame-shift |
| ENST00000396859 | 6537584 | 6537996 | Frame-shift |
| ENST00000396861 | 6537584 | 6537996 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for GAPDH |
p-ENSG00000111640_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in GAPDH |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for GAPDH |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GAPDH |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GAPDH |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for GAPDH |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for GAPDH |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P04406 | approved|withdrawn | DB09092 | Xanthinol | small molecule | P04406 |
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RelatedDiseases for GAPDH |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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