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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZNF385A |
 Gene summary |
| Gene information | Gene symbol | ZNF385A | Gene ID | 25946 |
| Gene name | zinc finger protein 385A | |
| Synonyms | HZF|RZF|ZFP385|ZNF385 | |
| Cytomap | 12q13.13 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 385Ahematopoietic zinc finger proteinretinal zinc finger proteinzinc finger protein 385 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF385A |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000161642
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000551109.5 | ZNF385A-212:protein_coding:ZNF385A | 6.857715e+01 | 1.291786e+00 | 1.072991e-06 | 5.530272e-04 |
| TC | UP | ENST00000549962.5 | ZNF385A-208:protein_coding:ZNF385A | 6.466609e+00 | 9.469096e-01 | 1.342583e-03 | 1.236395e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF385A |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_121640 | chr12 | 54371024:54371096:54371473:54371642:54373973:54374135 | 54371473:54371642 |
| exon_skip_129309 | chr12 | 54374090:54374135:54375844:54375954:54384428:54384460 | 54375844:54375954 |
| exon_skip_133962 | chr12 | 54371703:54371715:54372894:54373031:54373973:54374135 | 54372894:54373031 |
| exon_skip_138352 | chr12 | 54371684:54371715:54372894:54373031:54373973:54374051 | 54372894:54373031 |
| exon_skip_14748 | chr12 | 54371024:54371096:54371473:54371715:54373973:54374135 | 54371473:54371715 |
| exon_skip_171985 | chr12 | 54371684:54371715:54373973:54374135:54375844:54375954 | 54373973:54374135 |
| exon_skip_188287 | chr12 | 54384428:54384564:54384859:54385002:54385673:54385767 | 54384859:54385002 |
| exon_skip_204235 | chr12 | 54375844:54375954:54384428:54384564:54391235:54391281 | 54384428:54384564 |
| exon_skip_220430 | chr12 | 54371684:54371715:54373973:54374135:54384428:54384460 | 54373973:54374135 |
| exon_skip_254531 | chr12 | 54373973:54374135:54375844:54375954:54384428:54384460 | 54375844:54375954 |
| exon_skip_25837 | chr12 | 54371684:54371715:54372894:54373031:54373973:54374129 | 54372894:54373031 |
| exon_skip_260702 | chr12 | 54371703:54371715:54373973:54374135:54384428:54384460 | 54373973:54374135 |
| exon_skip_2716 | chr12 | 54371684:54371715:54372894:54373031:54373973:54374133 | 54372894:54373031 |
| exon_skip_285781 | chr12 | 54373973:54374135:54375844:54375954:54379066:54379189 | 54375844:54375954 |
| exon_skip_286717 | chr12 | 54374111:54374135:54375844:54375954:54384428:54384460 | 54375844:54375954 |
| exon_skip_54805 | chr12 | 54371684:54371715:54372894:54373031:54373973:54374135 | 54372894:54373031 |
| exon_skip_60269 | chr12 | 54375844:54375954:54384428:54384560:54391235:54391281 | 54384428:54384560 |
| exon_skip_6917 | chr12 | 54371024:54371096:54371473:54371715:54373973:54374129 | 54371473:54371715 |
| exon_skip_73299 | chr12 | 54371473:54371715:54372894:54373031:54373973:54374135 | 54372894:54373031 |
| exon_skip_81231 | chr12 | 54370263:54370486:54370626:54370721:54370927:54371096 | 54370626:54370721 |
| exon_skip_95882 | chr12 | 54371024:54371096:54371473:54371642:54373973:54374129 | 54371473:54371642 |
| exon_skip_97624 | chr12 | 54371024:54371096:54373973:54374135:54375844:54375954 | 54373973:54374135 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_121640 | ROSMAP_HCC | 6.098529e-01 | 5.095775e-01 | 1.002755e-01 | 2.761910e-02 |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF385A |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000546970 | 54384859 | 54385002 | 3UTR-3UTR |
| ENST00000394313 | 54373973 | 54374135 | Frame-shift |
| ENST00000546970 | 54373973 | 54374135 | Frame-shift |
| ENST00000551109 | 54373973 | 54374135 | Frame-shift |
| ENST00000394313 | 54371473 | 54371715 | In-frame |
| ENST00000546970 | 54371473 | 54371715 | In-frame |
| ENST00000551109 | 54371473 | 54371715 | In-frame |
| ENST00000394313 | 54375844 | 54375954 | In-frame |
| ENST00000546970 | 54375844 | 54375954 | In-frame |
| ENST00000551109 | 54375844 | 54375954 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000546970 | 54384859 | 54385002 | 3UTR-3UTR |
| ENST00000394313 | 54371473 | 54371715 | In-frame |
| ENST00000546970 | 54371473 | 54371715 | In-frame |
| ENST00000551109 | 54371473 | 54371715 | In-frame |
| ENST00000394313 | 54375844 | 54375954 | In-frame |
| ENST00000546970 | 54375844 | 54375954 | In-frame |
| ENST00000551109 | 54375844 | 54375954 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000546970 | 54384859 | 54385002 | 3UTR-3UTR |
| ENST00000394313 | 54373973 | 54374135 | Frame-shift |
| ENST00000546970 | 54373973 | 54374135 | Frame-shift |
| ENST00000551109 | 54373973 | 54374135 | Frame-shift |
| ENST00000394313 | 54370626 | 54370721 | In-frame |
| ENST00000546970 | 54370626 | 54370721 | In-frame |
| ENST00000551109 | 54370626 | 54370721 | In-frame |
| ENST00000394313 | 54371473 | 54371715 | In-frame |
| ENST00000546970 | 54371473 | 54371715 | In-frame |
| ENST00000551109 | 54371473 | 54371715 | In-frame |
| ENST00000394313 | 54375844 | 54375954 | In-frame |
| ENST00000546970 | 54375844 | 54375954 | In-frame |
| ENST00000551109 | 54375844 | 54375954 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF385A |
p-ENSG00000161642_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF385A |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-761 | chr12:54384874-54384881 | 8mer-1a | chr12:54384860-54384881 | 168.00 | -31.03 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-214-3p | chr12:54384874-54384881 | 8mer-1a | chr12:54384860-54384881 | 168.00 | -31.03 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-1343-3p | chr12:54384969-54384976 | 8mer-1a | chr12:54384959-54384980 | 152.00 | -19.81 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-331-3p | chr12:54384942-54384949 | 8mer-1a | chr12:54384929-54384949 | 145.00 | -20.17 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-625-5p | chr12:54384937-54384944 | 8mer-1a | chr12:54384927-54384948 | 158.00 | -30.96 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-370-3p | chr12:54384884-54384891 | 8mer-1a | chr12:54384881-54384903 | 151.00 | -29.25 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-485-5p | chr12:54384896-54384903 | 8mer-1a | chr12:54384888-54384911 | 156.00 | -31.91 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-6884-5p | chr12:54384896-54384903 | 8mer-1a | chr12:54384888-54384911 | 156.00 | -31.91 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-6783-3p | chr12:54384969-54384976 | 8mer-1a | chr12:54384959-54384980 | 152.00 | -19.81 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-4778-3p | chr12:54384974-54384981 | 8mer-1a | chr12:54384960-54384981 | 153.00 | -18.13 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-3619-5p | chr12:54384874-54384881 | 8mer-1a | chr12:54384860-54384881 | 168.00 | -31.03 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-4661-3p | chr12:54384947-54384954 | 8mer-1a | chr12:54384933-54384954 | 146.00 | -13.68 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-6893-3p | chr12:54384884-54384891 | 8mer-1a | chr12:54384881-54384903 | 151.00 | -29.25 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-4291 | chr12:54384875-54384882 | 8mer-1a | chr12:54384866-54384890 | 158.00 | -31.40 |
| Mayo | ENST00000546970 | 54384859 | 54385002 | hsa-miR-651-5p | chr12:54384949-54384956 | 8mer-1a | chr12:54384949-54384970 | 143.00 | -19.29 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-761 | chr12:54384874-54384881 | 8mer-1a | chr12:54384860-54384881 | 168.00 | -31.03 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-214-3p | chr12:54384874-54384881 | 8mer-1a | chr12:54384860-54384881 | 168.00 | -31.03 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-1343-3p | chr12:54384969-54384976 | 8mer-1a | chr12:54384959-54384980 | 152.00 | -19.81 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-331-3p | chr12:54384942-54384949 | 8mer-1a | chr12:54384929-54384949 | 145.00 | -20.17 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-625-5p | chr12:54384937-54384944 | 8mer-1a | chr12:54384927-54384948 | 158.00 | -30.96 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-370-3p | chr12:54384884-54384891 | 8mer-1a | chr12:54384881-54384903 | 151.00 | -29.25 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-485-5p | chr12:54384896-54384903 | 8mer-1a | chr12:54384888-54384911 | 156.00 | -31.91 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-6884-5p | chr12:54384896-54384903 | 8mer-1a | chr12:54384888-54384911 | 156.00 | -31.91 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-6783-3p | chr12:54384969-54384976 | 8mer-1a | chr12:54384959-54384980 | 152.00 | -19.81 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-4778-3p | chr12:54384974-54384981 | 8mer-1a | chr12:54384960-54384981 | 153.00 | -18.13 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-3619-5p | chr12:54384874-54384881 | 8mer-1a | chr12:54384860-54384881 | 168.00 | -31.03 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-4661-3p | chr12:54384947-54384954 | 8mer-1a | chr12:54384933-54384954 | 146.00 | -13.68 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-6893-3p | chr12:54384884-54384891 | 8mer-1a | chr12:54384881-54384903 | 151.00 | -29.25 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-4291 | chr12:54384875-54384882 | 8mer-1a | chr12:54384866-54384890 | 158.00 | -31.40 |
| MSBB | ENST00000546970 | 54384859 | 54385002 | hsa-miR-651-5p | chr12:54384949-54384956 | 8mer-1a | chr12:54384949-54384970 | 143.00 | -19.29 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-761 | chr12:54384874-54384881 | 8mer-1a | chr12:54384860-54384881 | 168.00 | -31.03 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-214-3p | chr12:54384874-54384881 | 8mer-1a | chr12:54384860-54384881 | 168.00 | -31.03 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-1343-3p | chr12:54384969-54384976 | 8mer-1a | chr12:54384959-54384980 | 152.00 | -19.81 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-331-3p | chr12:54384942-54384949 | 8mer-1a | chr12:54384929-54384949 | 145.00 | -20.17 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-625-5p | chr12:54384937-54384944 | 8mer-1a | chr12:54384927-54384948 | 158.00 | -30.96 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-370-3p | chr12:54384884-54384891 | 8mer-1a | chr12:54384881-54384903 | 151.00 | -29.25 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-485-5p | chr12:54384896-54384903 | 8mer-1a | chr12:54384888-54384911 | 156.00 | -31.91 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-6884-5p | chr12:54384896-54384903 | 8mer-1a | chr12:54384888-54384911 | 156.00 | -31.91 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-6783-3p | chr12:54384969-54384976 | 8mer-1a | chr12:54384959-54384980 | 152.00 | -19.81 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-4778-3p | chr12:54384974-54384981 | 8mer-1a | chr12:54384960-54384981 | 153.00 | -18.13 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-3619-5p | chr12:54384874-54384881 | 8mer-1a | chr12:54384860-54384881 | 168.00 | -31.03 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-4661-3p | chr12:54384947-54384954 | 8mer-1a | chr12:54384933-54384954 | 146.00 | -13.68 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-6893-3p | chr12:54384884-54384891 | 8mer-1a | chr12:54384881-54384903 | 151.00 | -29.25 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-4291 | chr12:54384875-54384882 | 8mer-1a | chr12:54384866-54384890 | 158.00 | -31.40 |
| ROSMAP | ENST00000546970 | 54384859 | 54385002 | hsa-miR-651-5p | chr12:54384949-54384956 | 8mer-1a | chr12:54384949-54384970 | 143.00 | -19.29 |
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SNVs in the skipped exons for ZNF385A |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF385A |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_254531 | -3.907782e-01 | 3.977295e-02 | chr12 | - | 54373973 | 54374135 | 54375844 | 54375954 | 54384428 | 54384460 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF385A |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF385A |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| HCC | RBM3 | exon_skip_121640 | -4.678998e-01 | 1.171917e-12 |
| PCC | RBM3 | exon_skip_95882 | -4.973057e-01 | 4.000034e-11 |
| TC | RBM3 | exon_skip_121640 | -6.153769e-01 | 5.245999e-15 |
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RelatedDrugs for ZNF385A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF385A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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