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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZNF521 |
Gene summary |
Gene information | Gene symbol | ZNF521 | Gene ID | 25925 |
Gene name | zinc finger protein 521 | |
Synonyms | EHZF|Evi3 | |
Cytomap | 18q11.2 | |
Type of gene | protein-coding | |
Description | zinc finger protein 521LYST-interacting protein 3early hematopoietic zinc finger protein | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZNF521 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000538137.6 | ZNF521-203:protein_coding:ZNF521 | 1.252583e+02 | 1.256601e+00 | 4.094779e-08 | 9.943379e-07 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZNF521 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_114952 | chr18 | 25195160:25195244:25224036:25224115:25224345:25224789 | 25224036:25224115 |
exon_skip_190493 | chr18 | 25322008:25322187:25327406:25327448:25350907:25350947 | 25327406:25327448 |
exon_skip_195589 | chr18 | 25322137:25322187:25345252:25345347:25350907:25350947 | 25345252:25345347 |
exon_skip_203245 | chr18 | 25322137:25322187:25350907:25350947:25352005:25352071 | 25350907:25350947 |
exon_skip_217606 | chr18 | 25227620:25227697:25322008:25322187:25350907:25350947 | 25322008:25322187 |
exon_skip_288727 | chr18 | 25062593:25062741:25089465:25089580:25091950:25092081 | 25089465:25089580 |
exon_skip_296086 | chr18 | 25322137:25322187:25350907:25350993:25352005:25352155 | 25350907:25350993 |
exon_skip_35658 | chr18 | 25322137:25322187:25327406:25327448:25350907:25350947 | 25327406:25327448 |
exon_skip_81848 | chr18 | 25322137:25322187:25350907:25350947:25351729:25351747 | 25350907:25350947 |
exon_skip_90184 | chr18 | 25322137:25322187:25350907:25350993:25352005:25352071 | 25350907:25350993 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF521 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000538137 | 25350907 | 25350993 | 3UTR-3CDS |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000538137 | 25350907 | 25350993 | 3UTR-3CDS |
ENST00000361524 | 25089465 | 25089580 | Frame-shift |
ENST00000538137 | 25089465 | 25089580 | Frame-shift |
ENST00000361524 | 25322008 | 25322187 | In-frame |
ENST00000538137 | 25322008 | 25322187 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF521 |
p-ENSG00000198795_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000361524 | 4888 | 1311 | 25322008 | 25322187 | 190 | 368 | 13 | 73 |
ENST00000538137 | 4270 | 1311 | 25322008 | 25322187 | 239 | 417 | 13 | 73 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q96K83 | 13 | 73 | 1 | 1311 | Chain | ID=PRO_0000306871;Note=Zinc finger protein 521 |
Q96K83 | 13 | 73 | 1 | 1311 | Chain | ID=PRO_0000306871;Note=Zinc finger protein 521 |
Q96K83 | 13 | 73 | 72 | 73 | Site | Note=Breakpoint for translocation to form PAX5-ZNF521 |
Q96K83 | 13 | 73 | 72 | 73 | Site | Note=Breakpoint for translocation to form PAX5-ZNF521 |
Q96K83 | 13 | 73 | 47 | 67 | Zinc finger | Note=C2H2-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
Q96K83 | 13 | 73 | 47 | 67 | Zinc finger | Note=C2H2-type 1%3B degenerate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZNF521 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ZNF521 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZNF521 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF521 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZNF521 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZNF521 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF521 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |