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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ANAPC15 |
 Gene summary |
| Gene information | Gene symbol | ANAPC15 | Gene ID | 25906 |
| Gene name | anaphase promoting complex subunit 15 | |
| Synonyms | APC15|C11orf51|HSPC020 | |
| Cytomap | 11q13.4 | |
| Type of gene | protein-coding | |
| Description | anaphase-promoting complex subunit 15 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ANAPC15 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000110200
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000543015.1 | ANAPC15-212:lncRNA:ANAPC15 | 1.371159e+01 | -2.770965e+00 | 3.241033e-05 | 2.845986e-04 |
| TC | DOWN | ENST00000543015.1 | ANAPC15-212:lncRNA:ANAPC15 | 4.571706e+01 | -1.746524e+00 | 5.520812e-04 | 6.217116e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ANAPC15 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104014 | chr11 | 72110590:72110603:72111157:72111281:72111412:72111443 | 72111157:72111281 |
| exon_skip_16333 | chr11 | 72111157:72111286:72111442:72111496:72112650:72112686 | 72111442:72111496 |
| exon_skip_17510 | chr11 | 72110211:72110225:72110544:72110603:72111157:72111281 | 72110544:72110603 |
| exon_skip_176201 | chr11 | 72111157:72111286:72111412:72111496:72112274:72112451 | 72111412:72111496 |
| exon_skip_18307 | chr11 | 72110544:72110603:72111157:72111286:72112650:72112704 | 72111157:72111286 |
| exon_skip_200978 | chr11 | 72111157:72111281:72111412:72111496:72112650:72112686 | 72111412:72111496 |
| exon_skip_230422 | chr11 | 72111157:72111286:72111412:72111496:72112650:72112686 | 72111412:72111496 |
| exon_skip_287036 | chr11 | 72110590:72110603:72111157:72111286:72112650:72112686 | 72111157:72111286 |
| exon_skip_6360 | chr11 | 72111252:72111286:72111412:72111496:72112650:72112686 | 72111412:72111496 |
| exon_skip_65119 | chr11 | 72111252:72111286:72111442:72111496:72112650:72112686 | 72111442:72111496 |
| exon_skip_72109 | chr11 | 72110590:72110603:72111157:72111286:72111412:72111443 | 72111157:72111286 |
| exon_skip_76975 | chr11 | 72108818:72108875:72109229:72109341:72110088:72110225 | 72109229:72109341 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ANAPC15 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000227618 | 72111157 | 72111286 | 3UTR-3CDS |
| ENST00000535503 | 72111157 | 72111281 | 3UTR-3CDS |
| ENST00000538393 | 72111157 | 72111281 | 3UTR-3CDS |
| ENST00000538919 | 72111157 | 72111286 | 3UTR-3CDS |
| ENST00000542531 | 72111157 | 72111281 | 3UTR-3CDS |
| ENST00000545944 | 72111157 | 72111286 | 3UTR-3CDS |
| ENST00000227618 | 72111412 | 72111496 | 3UTR-3UTR |
| ENST00000538393 | 72111412 | 72111496 | 3UTR-3UTR |
| ENST00000535234 | 72111442 | 72111496 | 3UTR-3UTR |
| ENST00000227618 | 72110544 | 72110603 | In-frame |
| ENST00000535234 | 72110544 | 72110603 | In-frame |
| ENST00000535503 | 72110544 | 72110603 | In-frame |
| ENST00000538393 | 72110544 | 72110603 | In-frame |
| ENST00000538919 | 72110544 | 72110603 | In-frame |
| ENST00000542531 | 72110544 | 72110603 | In-frame |
| ENST00000545944 | 72110544 | 72110603 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000227618 | 72111412 | 72111496 | 3UTR-3UTR |
| ENST00000535234 | 72111442 | 72111496 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000545944 | 72111157 | 72111286 | 3UTR-3CDS |
| ENST00000227618 | 72111412 | 72111496 | 3UTR-3UTR |
| ENST00000538393 | 72111412 | 72111496 | 3UTR-3UTR |
| ENST00000535234 | 72111442 | 72111496 | 3UTR-3UTR |
| ENST00000227618 | 72110544 | 72110603 | In-frame |
| ENST00000535234 | 72110544 | 72110603 | In-frame |
| ENST00000535503 | 72110544 | 72110603 | In-frame |
| ENST00000538393 | 72110544 | 72110603 | In-frame |
| ENST00000538919 | 72110544 | 72110603 | In-frame |
| ENST00000542531 | 72110544 | 72110603 | In-frame |
| ENST00000545944 | 72110544 | 72110603 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ANAPC15 |
p-ENSG00000110200_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000227618 | 903 | 121 | 72110544 | 72110603 | 347 | 405 | 40 | 59 |
| ENST00000535234 | 865 | 121 | 72110544 | 72110603 | 311 | 369 | 40 | 59 |
| ENST00000535503 | 751 | 121 | 72110544 | 72110603 | 258 | 316 | 40 | 59 |
| ENST00000538393 | 884 | 121 | 72110544 | 72110603 | 331 | 389 | 40 | 59 |
| ENST00000538919 | 866 | 121 | 72110544 | 72110603 | 525 | 583 | 40 | 59 |
| ENST00000542531 | 829 | 121 | 72110544 | 72110603 | 275 | 333 | 40 | 59 |
| ENST00000545944 | 721 | 121 | 72110544 | 72110603 | 168 | 226 | 40 | 59 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000227618 | 903 | 121 | 72110544 | 72110603 | 347 | 405 | 40 | 59 |
| ENST00000535234 | 865 | 121 | 72110544 | 72110603 | 311 | 369 | 40 | 59 |
| ENST00000535503 | 751 | 121 | 72110544 | 72110603 | 258 | 316 | 40 | 59 |
| ENST00000538393 | 884 | 121 | 72110544 | 72110603 | 331 | 389 | 40 | 59 |
| ENST00000538919 | 866 | 121 | 72110544 | 72110603 | 525 | 583 | 40 | 59 |
| ENST00000542531 | 829 | 121 | 72110544 | 72110603 | 275 | 333 | 40 | 59 |
| ENST00000545944 | 721 | 121 | 72110544 | 72110603 | 168 | 226 | 40 | 59 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 49 | 51 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 1 | 121 | Chain | ID=PRO_0000084072;Note=Anaphase-promoting complex subunit 15 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 27 | 45 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
| P60006 | 40 | 59 | 46 | 48 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5G05 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ANAPC15 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000538393 | 72111412 | 72111496 | hsa-miR-6880-5p | chr11:72111429-72111436 | 8mer-1a | chr11:72111425-72111445 | 160.00 | -23.12 |
| Mayo | ENST00000538393 | 72111412 | 72111496 | hsa-miR-2467-5p | chr11:72111479-72111486 | 8mer-1a | chr11:72111464-72111486 | 148.00 | -18.30 |
| Mayo | ENST00000535234 | 72111442 | 72111496 | hsa-miR-2467-5p | chr11:72111479-72111486 | 8mer-1a | chr11:72111464-72111486 | 148.00 | -18.30 |
| MSBB | ENST00000227618 | 72111412 | 72111496 | hsa-miR-6880-5p | chr11:72111429-72111436 | 8mer-1a | chr11:72111425-72111445 | 160.00 | -23.12 |
| MSBB | ENST00000227618 | 72111412 | 72111496 | hsa-miR-2467-5p | chr11:72111479-72111486 | 8mer-1a | chr11:72111464-72111486 | 148.00 | -18.30 |
| MSBB | ENST00000535234 | 72111442 | 72111496 | hsa-miR-2467-5p | chr11:72111479-72111486 | 8mer-1a | chr11:72111464-72111486 | 148.00 | -18.30 |
| ROSMAP | ENST00000538393 | 72111412 | 72111496 | hsa-miR-6880-5p | chr11:72111429-72111436 | 8mer-1a | chr11:72111425-72111445 | 160.00 | -23.12 |
| ROSMAP | ENST00000538393 | 72111412 | 72111496 | hsa-miR-2467-5p | chr11:72111479-72111486 | 8mer-1a | chr11:72111464-72111486 | 148.00 | -18.30 |
| ROSMAP | ENST00000535234 | 72111442 | 72111496 | hsa-miR-2467-5p | chr11:72111479-72111486 | 8mer-1a | chr11:72111464-72111486 | 148.00 | -18.30 |
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SNVs in the skipped exons for ANAPC15 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ANAPC15 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ANAPC15 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ANAPC15 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ANAPC15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANAPC15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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