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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for COG4 |
 Gene summary |
| Gene information | Gene symbol | COG4 | Gene ID | 25839 |
| Gene name | component of oligomeric golgi complex 4 | |
| Synonyms | CDG2J|COD1|SWILS | |
| Cytomap | 16q22.1 | |
| Type of gene | protein-coding | |
| Description | conserved oligomeric Golgi complex subunit 4COG complex subunit 4complexed with Dor1pconserved oligomeric Golgi complex protein 4 | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for COG4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000103051
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000526700.5 | COG4-205:retained_intron:COG4 | 1.746113e+02 | -1.840983e+00 | 3.018195e-15 | 1.363890e-12 |
| CB | DOWN | ENST00000565715.1 | COG4-213:protein_coding:COG4 | 2.426580e+01 | -2.212009e+00 | 1.814225e-03 | 8.503089e-03 |
| TC | DOWN | ENST00000526700.5 | COG4-205:retained_intron:COG4 | 1.086358e+02 | -1.508757e+00 | 4.431709e-11 | 9.722618e-09 |
| TC | DOWN | ENST00000565715.1 | COG4-213:protein_coding:COG4 | 1.358247e+01 | -1.729129e+00 | 3.663487e-03 | 2.649638e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for COG4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_113614 | chr16 | 70514366:70514509:70519649:70519731:70523373:70523518 | 70519649:70519731 |
| exon_skip_125818 | chr16 | 70514366:70514509:70517626:70517740:70519649:70519727 | 70517626:70517740 |
| exon_skip_13253 | chr16 | 70514366:70514509:70515868:70516040:70517626:70517637 | 70515868:70516040 |
| exon_skip_14159 | chr16 | 70517626:70517740:70519677:70519731:70523373:70523539 | 70519677:70519731 |
| exon_skip_14517 | chr16 | 70517626:70517740:70519649:70519731:70523373:70523518 | 70519649:70519731 |
| exon_skip_145175 | chr16 | 70514335:70514509:70517626:70517740:70519649:70519730 | 70517626:70517740 |
| exon_skip_14980 | chr16 | 70497221:70497387:70497937:70498055:70500958:70501091 | 70497937:70498055 |
| exon_skip_16121 | chr16 | 70497221:70497387:70497937:70498055:70500958:70501089 | 70497937:70498055 |
| exon_skip_203960 | chr16 | 70508406:70508464:70508666:70508824:70509231:70509388 | 70508666:70508824 |
| exon_skip_217230 | chr16 | 70483853:70483969:70490330:70490392:70496266:70496372 | 70490330:70490392 |
| exon_skip_228831 | chr16 | 70514366:70514509:70517626:70517740:70523373:70523518 | 70517626:70517740 |
| exon_skip_238970 | chr16 | 70514366:70514509:70515868:70516040:70517626:70517740 | 70515868:70516040 |
| exon_skip_253059 | chr16 | 70517626:70517740:70519649:70519731:70523373:70523539 | 70519649:70519731 |
| exon_skip_263861 | chr16 | 70512374:70512432:70514335:70514509:70517626:70517740 | 70514335:70514509 |
| exon_skip_265750 | chr16 | 70500958:70501091:70508406:70508464:70509231:70509388 | 70508406:70508464 |
| exon_skip_26952 | chr16 | 70514366:70514509:70517626:70517740:70519649:70519731 | 70517626:70517740 |
| exon_skip_275041 | chr16 | 70517626:70517740:70519677:70519731:70523373:70523518 | 70519677:70519731 |
| exon_skip_37846 | chr16 | 70480867:70481144:70481359:70481487:70481764:70481865 | 70481359:70481487 |
| exon_skip_45847 | chr16 | 70497973:70498055:70500958:70501091:70508406:70508464 | 70500958:70501091 |
| exon_skip_66847 | chr16 | 70514335:70514509:70517626:70517740:70519649:70519731 | 70517626:70517740 |
| exon_skip_67631 | chr16 | 70481764:70481865:70482092:70482175:70482729:70482794 | 70482092:70482175 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for COG4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for COG4 |
p-ENSG00000103051_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in COG4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for COG4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for COG4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for COG4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for COG4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for COG4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COG4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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