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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TMEM184B |
 Gene summary |
| Gene information | Gene symbol | TMEM184B | Gene ID | 25829 |
| Gene name | transmembrane protein 184B | |
| Synonyms | C22orf5|FM08|HS5O6A|HSPC256 | |
| Cytomap | 22q13.1 | |
| Type of gene | protein-coding | |
| Description | transmembrane protein 184Bputative MAPK-activating protein FM08 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TMEM184B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000198792
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000361684.8 | TMEM184B-201:protein_coding:TMEM184B | 2.900263e+02 | 8.462134e-01 | 2.885199e-07 | 1.047076e-04 |
| STG | UP | ENST00000633438.1 | TMEM184B-213:protein_coding:TMEM184B | 4.077466e+01 | 9.227789e-01 | 4.883459e-04 | 2.699733e-02 |
| TC | UP | ENST00000361684.8 | TMEM184B-201:protein_coding:TMEM184B | 6.905175e+02 | 8.590551e-01 | 7.143102e-05 | 1.237502e-03 |
| TC | UP | ENST00000464059.5 | TMEM184B-207:lncRNA:TMEM184B | 1.799528e+00 | 1.088433e+00 | 3.193337e-03 | 2.391847e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TMEM184B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_140093 | chr22 | 38245935:38246100:38246785:38246885:38247770:38247995 | 38246785:38246885 |
| exon_skip_162400 | chr22 | 38245935:38246100:38246806:38246885:38247770:38247804 | 38246806:38246885 |
| exon_skip_174614 | chr22 | 38231331:38231334:38245935:38246100:38247770:38248019 | 38245935:38246100 |
| exon_skip_183651 | chr22 | 38226380:38226870:38230669:38230744:38231244:38231318 | 38230669:38230744 |
| exon_skip_228924 | chr22 | 38245935:38246100:38246785:38246885:38247770:38248019 | 38246785:38246885 |
| exon_skip_242453 | chr22 | 38245935:38246100:38246806:38246885:38247770:38248019 | 38246806:38246885 |
| exon_skip_257052 | chr22 | 38231331:38231334:38245935:38246100:38247770:38247995 | 38245935:38246100 |
| exon_skip_265724 | chr22 | 38245935:38246100:38246806:38246885:38247770:38247995 | 38246806:38246885 |
| exon_skip_266719 | chr22 | 38221145:38221710:38222642:38222662:38224785:38224979 | 38222642:38222662 |
| exon_skip_271527 | chr22 | 38225578:38225593:38226779:38226870:38230669:38230744 | 38226779:38226870 |
| exon_skip_274073 | chr22 | 38231331:38231334:38245935:38246100:38247770:38247804 | 38245935:38246100 |
| exon_skip_288882 | chr22 | 38245935:38246100:38246785:38246885:38247770:38247804 | 38246785:38246885 |
| exon_skip_294510 | chr22 | 38245935:38246100:38246785:38246885:38247770:38248014 | 38246785:38246885 |
| exon_skip_44062 | chr22 | 38245935:38246100:38246806:38246885:38247770:38248014 | 38246806:38246885 |
| exon_skip_47288 | chr22 | 38226804:38226870:38230669:38230744:38231244:38231318 | 38230669:38230744 |
| exon_skip_78267 | chr22 | 38221145:38221710:38222642:38222662:38224785:38224847 | 38222642:38222662 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_266719 | ROSMAP_DLPFC | 3.490991e-01 | 4.573109e-01 | -1.082118e-01 | 3.325540e-05 |
| exon_skip_266719 | ROSMAP_PCC | 4.800000e-01 | 5.905882e-01 | -1.105882e-01 | 2.520240e-05 |
| exon_skip_266719 | MSBB_PG | 4.399074e-01 | 6.358537e-01 | -1.959463e-01 | 6.986436e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for TMEM184B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361684 | 38230669 | 38230744 | Frame-shift |
| ENST00000361906 | 38230669 | 38230744 | Frame-shift |
| ENST00000361684 | 38245935 | 38246100 | Frame-shift |
| ENST00000361906 | 38245935 | 38246100 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361684 | 38230669 | 38230744 | Frame-shift |
| ENST00000361906 | 38230669 | 38230744 | Frame-shift |
| ENST00000361684 | 38245935 | 38246100 | Frame-shift |
| ENST00000361906 | 38245935 | 38246100 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000361684 | 38226779 | 38226870 | Frame-shift |
| ENST00000361906 | 38226779 | 38226870 | Frame-shift |
| ENST00000361684 | 38230669 | 38230744 | Frame-shift |
| ENST00000361906 | 38230669 | 38230744 | Frame-shift |
| ENST00000361684 | 38245935 | 38246100 | Frame-shift |
| ENST00000361906 | 38245935 | 38246100 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TMEM184B |
p-ENSG00000198792_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TMEM184B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TMEM184B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TMEM184B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | ROSMAP | PCC | exon_skip_266719 | -3.436720e-01 | 2.360000e-07 | chr22 | - | 38221145 | 38221710 | 38222642 | 38222662 | 38224785 | 38224979 |
| CDR | MSBB | IFG | exon_skip_266719 | -4.556587e-01 | 1.481982e-02 | chr22 | - | 38221145 | 38221710 | 38222642 | 38222662 | 38224785 | 38224979 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TMEM184B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TMEM184B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | HNRNPL | exon_skip_266719 | 4.503100e-01 | 2.591570e-09 |
| FL | HNRNPL | exon_skip_266719 | 5.665534e-01 | 2.960832e-13 |
| HCC | RBM6 | exon_skip_266719 | -6.030817e-01 | 1.983524e-28 |
| IFG | RBM6 | exon_skip_266719 | -4.015921e-01 | 3.415493e-02 |
| PCC | RBM6 | exon_skip_266719 | -5.043482e-01 | 2.835928e-15 |
| PG | HNRNPL | exon_skip_266719 | 5.992021e-01 | 6.867979e-16 |
| STG | HNRNPL | exon_skip_266719 | 4.349811e-01 | 1.075725e-04 |
| TC | HNRNPL | exon_skip_78267 | 4.168125e-01 | 4.625679e-08 |
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RelatedDrugs for TMEM184B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM184B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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