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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for QPCT |
 Gene summary |
| Gene information | Gene symbol | QPCT | Gene ID | 25797 |
| Gene name | glutaminyl-peptide cyclotransferase | |
| Synonyms | GCT|QC|sQC | |
| Cytomap | 2p22.2 | |
| Type of gene | protein-coding | |
| Description | glutaminyl-peptide cyclotransferaseECglutaminyl cyclaseglutaminyl-tRNA cyclotransferaseglutamyl cyclase | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| QPCT | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase | 21288892 |
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Gene structures and expression levels for QPCT |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000115828
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for QPCT |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_214690 | chr2 | 37344728:37344851:37352789:37352935:37359580:37359858 | 37352789:37352935 |
| exon_skip_220 | chr2 | 37344594:37344851:37352789:37352935:37359580:37359858 | 37352789:37352935 |
| exon_skip_261953 | chr2 | 37352789:37352935:37358821:37358888:37359580:37360053 | 37358821:37358888 |
| exon_skip_89798 | chr2 | 37352789:37352935:37359580:37359858:37367232:37367290 | 37359580:37359858 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for QPCT |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000338415 | 37352789 | 37352935 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000338415 | 37352789 | 37352935 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000338415 | 37352789 | 37352935 | In-frame |
| ENST00000338415 | 37359580 | 37359858 | In-frame |
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Infer the effects of exon skipping event on protein functional features for QPCT |
p-ENSG00000115828_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000338415 | 1756 | 361 | 37352789 | 37352935 | 280 | 425 | 40 | 89 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000338415 | 1756 | 361 | 37352789 | 37352935 | 280 | 425 | 40 | 89 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000338415 | 1756 | 361 | 37352789 | 37352935 | 280 | 425 | 40 | 89 |
| ENST00000338415 | 1756 | 361 | 37359580 | 37359858 | 427 | 704 | 89 | 182 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q16769 | 40 | 89 | 41 | 89 | Alternative sequence | ID=VSP_038487;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q16769 | 40 | 89 | 29 | 361 | Chain | ID=PRO_0000022195;Note=Glutaminyl-peptide cyclotransferase |
| Q16769 | 40 | 89 | 49 | 49 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21671571;Dbxref=PMID:21671571 |
| Q16769 | 40 | 89 | 39 | 42 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 50 | 59 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 62 | 68 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 71 | 73 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 82 | 96 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 54 | 54 | Natural variant | ID=VAR_053956;Note=Lowers activity by approximately 30%25. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16135565;Dbxref=dbSNP:rs2255991,PMID:16135565 |
| Q16769 | 40 | 89 | 71 | 71 | Natural variant | ID=VAR_005569;Note=Q->R;Dbxref=dbSNP:rs895245310 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q16769 | 40 | 89 | 41 | 89 | Alternative sequence | ID=VSP_038487;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q16769 | 40 | 89 | 29 | 361 | Chain | ID=PRO_0000022195;Note=Glutaminyl-peptide cyclotransferase |
| Q16769 | 40 | 89 | 49 | 49 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21671571;Dbxref=PMID:21671571 |
| Q16769 | 40 | 89 | 39 | 42 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 50 | 59 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 62 | 68 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 71 | 73 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 82 | 96 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 54 | 54 | Natural variant | ID=VAR_053956;Note=Lowers activity by approximately 30%25. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16135565;Dbxref=dbSNP:rs2255991,PMID:16135565 |
| Q16769 | 40 | 89 | 71 | 71 | Natural variant | ID=VAR_005569;Note=Q->R;Dbxref=dbSNP:rs895245310 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q16769 | 40 | 89 | 41 | 89 | Alternative sequence | ID=VSP_038487;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q16769 | 40 | 89 | 29 | 361 | Chain | ID=PRO_0000022195;Note=Glutaminyl-peptide cyclotransferase |
| Q16769 | 40 | 89 | 49 | 49 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21671571;Dbxref=PMID:21671571 |
| Q16769 | 40 | 89 | 39 | 42 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 50 | 59 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 62 | 68 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 71 | 73 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 82 | 96 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 40 | 89 | 54 | 54 | Natural variant | ID=VAR_053956;Note=Lowers activity by approximately 30%25. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16135565;Dbxref=dbSNP:rs2255991,PMID:16135565 |
| Q16769 | 40 | 89 | 71 | 71 | Natural variant | ID=VAR_005569;Note=Q->R;Dbxref=dbSNP:rs895245310 |
| Q16769 | 89 | 182 | 41 | 89 | Alternative sequence | ID=VSP_038487;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q16769 | 89 | 182 | 98 | 100 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 89 | 182 | 103 | 111 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 89 | 182 | 116 | 128 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 89 | 182 | 131 | 140 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 89 | 182 | 29 | 361 | Chain | ID=PRO_0000022195;Note=Glutaminyl-peptide cyclotransferase |
| Q16769 | 89 | 182 | 139 | 164 | Disulfide bond | Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21671571;Dbxref=PMID:21671571 |
| Q16769 | 89 | 182 | 82 | 96 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 89 | 182 | 149 | 151 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3PBB |
| Q16769 | 89 | 182 | 161 | 173 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 89 | 182 | 175 | 179 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
| Q16769 | 89 | 182 | 180 | 182 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4YWY |
| Q16769 | 89 | 182 | 159 | 159 | Metal binding | Note=Zinc%3B catalytic |
| Q16769 | 89 | 182 | 144 | 144 | Mutagenesis | Note=Lowers activity by approximately 40%25. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16135565;Dbxref=PMID:16135565 |
| Q16769 | 89 | 182 | 146 | 146 | Mutagenesis | Note=Lowers activity by approximately 30%25. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16135565;Dbxref=PMID:16135565 |
| Q16769 | 89 | 182 | 160 | 160 | Mutagenesis | Note=Reduces activity by about 50%25. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18072935;Dbxref=PMID:18072935 |
| Q16769 | 89 | 182 | 160 | 160 | Mutagenesis | Note=Reduces activity by 96%25. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18072935;Dbxref=PMID:18072935 |
| Q16769 | 89 | 182 | 157 | 160 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2AFW |
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3'-UTR located exon skipping events that lost miRNA binding sites in QPCT |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for QPCT |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for QPCT |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for QPCT |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for QPCT |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for QPCT |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for QPCT |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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