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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for RASGRP3 |
 Gene summary |
| Gene information | Gene symbol | RASGRP3 | Gene ID | 25780 |
| Gene name | RAS guanyl releasing protein 3 | |
| Synonyms | GRP3 | |
| Cytomap | 2p22.3 | |
| Type of gene | protein-coding | |
| Description | ras guanyl-releasing protein 3CalDAG-GEFIIIRAS guanyl releasing protein 3 (calcium and DAG-regulated)calcium and DAG-regulated guanine nucleotide exchange factor IIIcalcium- and diacylglycerol-regulated guanine nucleotide exchange factor IIIguanine n | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for RASGRP3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000152689
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000477927.1 | RASGRP3-211:lncRNA:RASGRP3 | 3.901596e+00 | 1.321261e+00 | 2.123397e-03 | 2.492634e-02 |
| PG | UP | ENST00000437184.5 | RASGRP3-207:protein_coding:RASGRP3 | 1.365354e+01 | 9.910291e-01 | 3.375315e-03 | 3.465937e-02 |
| TC | UP | ENST00000479528.5 | RASGRP3-212:retained_intron:RASGRP3 | 2.617970e+00 | 9.319843e-01 | 3.162000e-03 | 2.374175e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RASGRP3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116056 | chr2 | 33549604:33549751:33555531:33555567:33558211:33558336 | 33555531:33555567 |
| exon_skip_150350 | chr2 | 33476649:33476707:33481183:33481304:33511812:33511842 | 33481183:33481304 |
| exon_skip_160538 | chr2 | 33447820:33447943:33481183:33481304:33511710:33511842 | 33481183:33481304 |
| exon_skip_175505 | chr2 | 33534323:33534400:33539097:33539210:33543512:33543627 | 33539097:33539210 |
| exon_skip_18098 | chr2 | 33539097:33539210:33543512:33543627:33549604:33549751 | 33543512:33543627 |
| exon_skip_261659 | chr2 | 33558211:33558336:33558672:33559030:33562729:33564605 | 33558672:33559030 |
| exon_skip_263640 | chr2 | 33519952:33520014:33520553:33520684:33521955:33522102 | 33520553:33520684 |
| exon_skip_277740 | chr2 | 33476665:33476707:33481183:33481304:33511812:33511842 | 33481183:33481304 |
| exon_skip_28867 | chr2 | 33527203:33527412:33534323:33534400:33539094:33539210 | 33534323:33534400 |
| exon_skip_39213 | chr2 | 33476665:33476707:33493054:33493172:33511710:33511842 | 33493054:33493172 |
| exon_skip_40194 | chr2 | 33520553:33520684:33521955:33522102:33523879:33524052 | 33521955:33522102 |
| exon_skip_66311 | chr2 | 33534323:33534400:33539094:33539210:33543512:33543627 | 33539094:33539210 |
| exon_skip_85572 | chr2 | 33476649:33476707:33493054:33493172:33511710:33511842 | 33493054:33493172 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RASGRP3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402538 | 33555531 | 33555567 | Frame-shift |
| ENST00000403687 | 33555531 | 33555567 | Frame-shift |
| ENST00000402538 | 33534323 | 33534400 | In-frame |
| ENST00000403687 | 33534323 | 33534400 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402538 | 33521955 | 33522102 | Frame-shift |
| ENST00000403687 | 33521955 | 33522102 | Frame-shift |
| ENST00000402538 | 33543512 | 33543627 | Frame-shift |
| ENST00000403687 | 33543512 | 33543627 | Frame-shift |
| ENST00000402538 | 33555531 | 33555567 | Frame-shift |
| ENST00000403687 | 33555531 | 33555567 | Frame-shift |
| ENST00000402538 | 33558672 | 33559030 | Frame-shift |
| ENST00000403687 | 33558672 | 33559030 | Frame-shift |
| ENST00000402538 | 33520553 | 33520684 | In-frame |
| ENST00000403687 | 33520553 | 33520684 | In-frame |
| ENST00000402538 | 33534323 | 33534400 | In-frame |
| ENST00000403687 | 33534323 | 33534400 | In-frame |
| ENST00000402538 | 33539094 | 33539210 | In-frame |
| ENST00000403687 | 33539094 | 33539210 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RASGRP3 |
p-ENSG00000152689_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402538 | 4755 | 690 | 33534323 | 33534400 | 1737 | 1813 | 361 | 387 |
| ENST00000403687 | 4824 | 690 | 33534323 | 33534400 | 1825 | 1901 | 361 | 387 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402538 | 4755 | 690 | 33520553 | 33520684 | 890 | 1020 | 79 | 122 |
| ENST00000403687 | 4824 | 690 | 33520553 | 33520684 | 978 | 1108 | 79 | 122 |
| ENST00000402538 | 4755 | 690 | 33534323 | 33534400 | 1737 | 1813 | 361 | 387 |
| ENST00000403687 | 4824 | 690 | 33534323 | 33534400 | 1825 | 1901 | 361 | 387 |
| ENST00000402538 | 4755 | 690 | 33539094 | 33539210 | 1815 | 1930 | 387 | 426 |
| ENST00000403687 | 4824 | 690 | 33539094 | 33539210 | 1903 | 2018 | 387 | 426 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IV61 | 361 | 387 | 1 | 690 | Chain | ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3 |
| Q8IV61 | 361 | 387 | 1 | 690 | Chain | ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3 |
| Q8IV61 | 361 | 387 | 152 | 383 | Domain | Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168 |
| Q8IV61 | 361 | 387 | 152 | 383 | Domain | Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IV61 | 79 | 122 | 1 | 690 | Chain | ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3 |
| Q8IV61 | 79 | 122 | 1 | 690 | Chain | ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3 |
| Q8IV61 | 79 | 122 | 3 | 125 | Domain | Note=N-terminal Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00135 |
| Q8IV61 | 79 | 122 | 3 | 125 | Domain | Note=N-terminal Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00135 |
| Q8IV61 | 361 | 387 | 1 | 690 | Chain | ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3 |
| Q8IV61 | 361 | 387 | 1 | 690 | Chain | ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3 |
| Q8IV61 | 361 | 387 | 152 | 383 | Domain | Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168 |
| Q8IV61 | 361 | 387 | 152 | 383 | Domain | Note=Ras-GEF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00168 |
| Q8IV61 | 387 | 426 | 388 | 388 | Alternative sequence | ID=VSP_047371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10048485;Dbxref=PMID:10048485 |
| Q8IV61 | 387 | 426 | 388 | 388 | Alternative sequence | ID=VSP_047371;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10048485;Dbxref=PMID:10048485 |
| Q8IV61 | 387 | 426 | 1 | 690 | Chain | ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3 |
| Q8IV61 | 387 | 426 | 1 | 690 | Chain | ID=PRO_0000068883;Note=Ras guanyl-releasing protein 3 |
| Q8IV61 | 387 | 426 | 420 | 455 | Domain | Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 |
| Q8IV61 | 387 | 426 | 420 | 455 | Domain | Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 |
| Q8IV61 | 387 | 426 | 393 | 393 | Natural variant | ID=VAR_051901;Note=T->A;Dbxref=dbSNP:rs13388394 |
| Q8IV61 | 387 | 426 | 393 | 393 | Natural variant | ID=VAR_051901;Note=T->A;Dbxref=dbSNP:rs13388394 |
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3'-UTR located exon skipping events that lost miRNA binding sites in RASGRP3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for RASGRP3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RASGRP3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RASGRP3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RASGRP3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for RASGRP3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RASGRP3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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