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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for TAB3 |
Gene summary |
Gene information | Gene symbol | TAB3 | Gene ID | 257397 |
Gene name | TGF-beta activated kinase 1 (MAP3K7) binding protein 3 | |
Synonyms | MAP3K7IP3|NAP1 | |
Cytomap | Xp21.2 | |
Type of gene | protein-coding | |
Description | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3NF-kappa-B-activating protein 1NFkB activating protein 1TAB-3TAK1-binding protein 3TGF-beta activated kinase 1 and MAP3K7 binding protein 3TGF-beta-activated kinase 1-binding protein 3mitogen- | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TAB3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TAB3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_107073 | chrX | 30842988:30843049:30846551:30846644:30852778:30852887 | 30846551:30846644 |
exon_skip_115688 | chrX | 30830331:30831575:30834051:30834152:30842966:30843049 | 30834051:30834152 |
exon_skip_126024 | chrX | 30842988:30843049:30845933:30846071:30846551:30846644 | 30845933:30846071 |
exon_skip_281863 | chrX | 30867115:30867218:30867465:30867549:30871699:30871801 | 30867465:30867549 |
exon_skip_40049 | chrX | 30834051:30834152:30842966:30843049:30846551:30846644 | 30842966:30843049 |
exon_skip_49260 | chrX | 30834051:30834152:30846551:30846644:30852778:30852887 | 30846551:30846644 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TAB3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000378933 | 30867465 | 30867549 | 3UTR-3UTR |
ENST00000378930 | 30846551 | 30846644 | Frame-shift |
ENST00000378933 | 30846551 | 30846644 | Frame-shift |
ENST00000378930 | 30834051 | 30834152 | In-frame |
ENST00000378933 | 30834051 | 30834152 | In-frame |
ENST00000378930 | 30842966 | 30843049 | In-frame |
ENST00000378933 | 30842966 | 30843049 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000378933 | 30867465 | 30867549 | 3UTR-3UTR |
ENST00000378930 | 30846551 | 30846644 | Frame-shift |
ENST00000378933 | 30846551 | 30846644 | Frame-shift |
ENST00000378930 | 30834051 | 30834152 | In-frame |
ENST00000378933 | 30834051 | 30834152 | In-frame |
ENST00000378930 | 30842966 | 30843049 | In-frame |
ENST00000378933 | 30842966 | 30843049 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000378933 | 30867465 | 30867549 | 3UTR-3UTR |
ENST00000378930 | 30846551 | 30846644 | Frame-shift |
ENST00000378933 | 30846551 | 30846644 | Frame-shift |
ENST00000378930 | 30834051 | 30834152 | In-frame |
ENST00000378933 | 30834051 | 30834152 | In-frame |
ENST00000378930 | 30842966 | 30843049 | In-frame |
ENST00000378933 | 30842966 | 30843049 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TAB3 |
p-ENSG00000157625_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000378930 | 6272 | 712 | 30842966 | 30843049 | 1937 | 2019 | 601 | 629 |
ENST00000378933 | 6688 | 712 | 30842966 | 30843049 | 2352 | 2434 | 601 | 629 |
ENST00000378930 | 6272 | 712 | 30834051 | 30834152 | 2021 | 2121 | 629 | 663 |
ENST00000378933 | 6688 | 712 | 30834051 | 30834152 | 2436 | 2536 | 629 | 663 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000378930 | 6272 | 712 | 30842966 | 30843049 | 1937 | 2019 | 601 | 629 |
ENST00000378933 | 6688 | 712 | 30842966 | 30843049 | 2352 | 2434 | 601 | 629 |
ENST00000378930 | 6272 | 712 | 30834051 | 30834152 | 2021 | 2121 | 629 | 663 |
ENST00000378933 | 6688 | 712 | 30834051 | 30834152 | 2436 | 2536 | 629 | 663 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000378930 | 6272 | 712 | 30842966 | 30843049 | 1937 | 2019 | 601 | 629 |
ENST00000378933 | 6688 | 712 | 30842966 | 30843049 | 2352 | 2434 | 601 | 629 |
ENST00000378930 | 6272 | 712 | 30834051 | 30834152 | 2021 | 2121 | 629 | 663 |
ENST00000378933 | 6688 | 712 | 30834051 | 30834152 | 2436 | 2536 | 629 | 663 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q8N5C8 | 601 | 629 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 601 | 629 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 601 | 629 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 601 | 629 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 629 | 663 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 629 | 663 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 629 | 663 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 629 | 663 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 629 | 663 | 659 | 662 | Compositional bias | Note=Poly-Ala |
Q8N5C8 | 629 | 663 | 659 | 662 | Compositional bias | Note=Poly-Ala |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q8N5C8 | 601 | 629 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 601 | 629 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 601 | 629 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 601 | 629 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 629 | 663 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 629 | 663 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 629 | 663 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 629 | 663 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 629 | 663 | 659 | 662 | Compositional bias | Note=Poly-Ala |
Q8N5C8 | 629 | 663 | 659 | 662 | Compositional bias | Note=Poly-Ala |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q8N5C8 | 601 | 629 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 601 | 629 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 601 | 629 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 601 | 629 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 629 | 663 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 629 | 663 | 602 | 629 | Alternative sequence | ID=VSP_017516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14766965;Dbxref=PMID:14766965 |
Q8N5C8 | 629 | 663 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 629 | 663 | 2 | 712 | Chain | ID=PRO_0000226972;Note=TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
Q8N5C8 | 629 | 663 | 659 | 662 | Compositional bias | Note=Poly-Ala |
Q8N5C8 | 629 | 663 | 659 | 662 | Compositional bias | Note=Poly-Ala |
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3'-UTR located exon skipping events that lost miRNA binding sites in TAB3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000378933 | 30867465 | 30867549 | hsa-miR-6889-3p | chrX:30867487-30867494 | 8mer-1a | chrX:30867474-30867494 | 142.00 | -18.61 |
Mayo | ENST00000378933 | 30867465 | 30867549 | hsa-miR-6529-3p | chrX:30867487-30867494 | 8mer-1a | chrX:30867474-30867494 | 142.00 | -18.61 |
Mayo | ENST00000378933 | 30867465 | 30867549 | hsa-miR-4282 | chrX:30867494-30867501 | 8mer-1a | chrX:30867489-30867511 | 167.00 | -14.86 |
MSBB | ENST00000378933 | 30867465 | 30867549 | hsa-miR-6889-3p | chrX:30867487-30867494 | 8mer-1a | chrX:30867474-30867494 | 142.00 | -18.61 |
MSBB | ENST00000378933 | 30867465 | 30867549 | hsa-miR-6529-3p | chrX:30867487-30867494 | 8mer-1a | chrX:30867474-30867494 | 142.00 | -18.61 |
MSBB | ENST00000378933 | 30867465 | 30867549 | hsa-miR-4282 | chrX:30867494-30867501 | 8mer-1a | chrX:30867489-30867511 | 167.00 | -14.86 |
ROSMAP | ENST00000378933 | 30867465 | 30867549 | hsa-miR-6889-3p | chrX:30867487-30867494 | 8mer-1a | chrX:30867474-30867494 | 142.00 | -18.61 |
ROSMAP | ENST00000378933 | 30867465 | 30867549 | hsa-miR-6529-3p | chrX:30867487-30867494 | 8mer-1a | chrX:30867474-30867494 | 142.00 | -18.61 |
ROSMAP | ENST00000378933 | 30867465 | 30867549 | hsa-miR-4282 | chrX:30867494-30867501 | 8mer-1a | chrX:30867489-30867511 | 167.00 | -14.86 |
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SNVs in the skipped exons for TAB3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TAB3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TAB3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TAB3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | UNK | exon_skip_115688 | 4.564887e-01 | 6.890772e-08 |
CB | TRA2A | exon_skip_115688 | -4.712645e-01 | 2.244764e-08 |
CB | RBM45 | exon_skip_115688 | 5.537165e-01 | 1.456527e-11 |
CB | NUP42 | exon_skip_115688 | 5.464490e-01 | 3.019793e-11 |
CB | RBM6 | exon_skip_107073 | -5.443818e-01 | 1.559723e-10 |
CB | CNOT4 | exon_skip_107073 | -4.828555e-01 | 2.675468e-08 |
CB | TRA2A | exon_skip_107073 | -6.179024e-01 | 7.098794e-14 |
CB | NUP42 | exon_skip_107073 | 5.868957e-01 | 2.308024e-12 |
TC | NUP42 | exon_skip_115688 | 4.210066e-01 | 1.374456e-06 |
TC | RBM6 | exon_skip_107073 | -5.088299e-01 | 2.959063e-09 |
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RelatedDrugs for TAB3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAB3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |