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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for GK5 |
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Gene information | Gene symbol | GK5 | Gene ID | 256356 |
Gene name | glycerol kinase 5 | |
Synonyms | - | |
Cytomap | 3q23 | |
Type of gene | protein-coding | |
Description | putative glycerol kinase 5ATP:glycerol 3-phosphotransferase 5GK 5glycerokinase 5glycerol kinase 5 (putative) | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for GK5 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for GK5 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_20135 | chr3 | 142187704:142187779:142198802:142198933:142204695:142204788 | 142198802:142198933 |
exon_skip_232698 | chr3 | 142172353:142172456:142173076:142173197:142177482:142177509 | 142173076:142173197 |
exon_skip_248187 | chr3 | 142182923:142183049:142184711:142185793:142185929:142185989 | 142184711:142185793 |
exon_skip_255605 | chr3 | 142198857:142198933:142204217:142204788:142213526:142213601 | 142204217:142204788 |
exon_skip_38783 | chr3 | 142198857:142198933:142204695:142204788:142213526:142213601 | 142204695:142204788 |
exon_skip_77388 | chr3 | 142185929:142185989:142186194:142186267:142186452:142186513 | 142186194:142186267 |
exon_skip_84408 | chr3 | 142186452:142186513:142187704:142187779:142198802:142198933 | 142187704:142187779 |
exon_skip_93088 | chr3 | 142213526:142213601:142215599:142215692:142225309:142225416 | 142215599:142215692 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_248187 | Mayo_CB | 4.697531e-01 | 6.118750e-01 | -1.421219e-01 | 1.962972e-07 |
exon_skip_77388 | Mayo_CB | 4.592500e-01 | 5.833846e-01 | -1.241346e-01 | 6.415868e-07 |
exon_skip_248187 | Mayo_TC | 4.852500e-01 | 6.061290e-01 | -1.208790e-01 | 1.018779e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for GK5 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392993 | 142186194 | 142186267 | Frame-shift |
ENST00000392993 | 142187704 | 142187779 | Frame-shift |
ENST00000392993 | 142198802 | 142198933 | In-frame |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392993 | 142186194 | 142186267 | Frame-shift |
ENST00000392993 | 142204695 | 142204788 | Frame-shift |
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ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000392993 | 142186194 | 142186267 | Frame-shift |
ENST00000392993 | 142187704 | 142187779 | Frame-shift |
ENST00000392993 | 142204695 | 142204788 | Frame-shift |
ENST00000392993 | 142198802 | 142198933 | In-frame |
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Infer the effects of exon skipping event on protein functional features for GK5 |
p-ENSG00000175066_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000392993 | 9854 | 529 | 142198802 | 142198933 | 564 | 694 | 137 | 180 |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000392993 | 9854 | 529 | 142198802 | 142198933 | 564 | 694 | 137 | 180 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q6ZS86 | 137 | 180 | 1 | 279 | Alternative sequence | ID=VSP_032121;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
Q6ZS86 | 137 | 180 | 1 | 529 | Chain | ID=PRO_0000323754;Note=Putative glycerol kinase 5 |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q6ZS86 | 137 | 180 | 1 | 279 | Alternative sequence | ID=VSP_032121;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
Q6ZS86 | 137 | 180 | 1 | 529 | Chain | ID=PRO_0000323754;Note=Putative glycerol kinase 5 |
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3'-UTR located exon skipping events that lost miRNA binding sites in GK5 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for GK5 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for GK5 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for GK5 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for GK5 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | TARDBP | exon_skip_248187 | -4.181275e-01 | 1.666809e-07 |
CB | ELAVL1 | exon_skip_248187 | -4.609038e-01 | 5.420104e-09 |
CB | ZNF638 | exon_skip_248187 | -4.904333e-01 | 3.807665e-10 |
CB | SAMD4A | exon_skip_248187 | -5.858382e-01 | 9.916266e-15 |
CB | U2AF2 | exon_skip_248187 | -6.457942e-01 | 1.786312e-18 |
CB | CNOT4 | exon_skip_248187 | -5.759023e-01 | 3.503322e-14 |
CB | RBM3 | exon_skip_248187 | 5.346108e-01 | 4.325407e-12 |
CB | PCBP1 | exon_skip_248187 | -4.229291e-01 | 1.161237e-07 |
CB | TRA2A | exon_skip_248187 | -5.089969e-01 | 6.271252e-11 |
CB | HNRNPC | exon_skip_248187 | -5.307984e-01 | 6.532734e-12 |
CB | NUP42 | exon_skip_248187 | 4.324008e-01 | 5.598226e-08 |
CB | EIF4G2 | exon_skip_248187 | -4.339127e-01 | 4.972403e-08 |
CB | PTBP1 | exon_skip_248187 | -4.055436e-01 | 4.186400e-07 |
CB | RBM23 | exon_skip_248187 | -4.902541e-01 | 3.872502e-10 |
CB | PABPC4 | exon_skip_248187 | 4.045276e-01 | 4.502196e-07 |
CB | TARDBP | exon_skip_77388 | -4.063090e-01 | 3.962589e-07 |
CB | RBM3 | exon_skip_77388 | 4.153797e-01 | 2.044653e-07 |
CB | PTBP1 | exon_skip_77388 | -4.113428e-01 | 2.751402e-07 |
TC | RBM3 | exon_skip_248187 | 4.816712e-01 | 1.290484e-09 |
TC | SRSF5 | exon_skip_248187 | 4.730980e-01 | 2.756902e-09 |
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RelatedDrugs for GK5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GK5 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |