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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for RASGEF1C |
 Gene summary |
| Gene information | Gene symbol | RASGEF1C | Gene ID | 255426 |
| Gene name | RasGEF domain family member 1C | |
| Synonyms | - | |
| Cytomap | 5q35.3 | |
| Type of gene | protein-coding | |
| Description | ras-GEF domain-containing family member 1C | |
| Modification date | 20200313 | |
| UniProtAcc | I6L9E5, Q8N431, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for RASGEF1C |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000146090
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000520209.5 | RASGEF1C-205:nonsense_mediated_decay:RASGEF1C | 4.211540e+01 | -2.263558e+00 | 1.007006e-04 | 7.447148e-04 |
| CB | DOWN | ENST00000522500.5 | RASGEF1C-206:protein_coding:RASGEF1C | 3.313577e+01 | -9.158525e-01 | 6.737544e-03 | 2.513214e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RASGEF1C |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100210 | chr5 | 180114446:180114541:180115247:180115284:180118609:180118704 | 180115247:180115284 |
| exon_skip_183274 | chr5 | 180137590:180137712:180137876:180138058:180209028:180209145 | 180137876:180138058 |
| exon_skip_22298 | chr5 | 180118832:180118866:180119346:180119444:180121060:180121149 | 180119346:180119444 |
| exon_skip_244884 | chr5 | 180118832:180118866:180119346:180119448:180121060:180121149 | 180119346:180119448 |
| exon_skip_57646 | chr5 | 180102071:180102143:180111457:180111580:180114446:180114521 | 180111457:180111580 |
| exon_skip_63306 | chr5 | 180102071:180102143:180111457:180111580:180114446:180114541 | 180111457:180111580 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |