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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CERS6 |
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Gene information | Gene symbol | CERS6 | Gene ID | 253782 |
Gene name | ceramide synthase 6 | |
Synonyms | CERS5|LASS6 | |
Cytomap | 2q24.3 | |
Type of gene | protein-coding | |
Description | ceramide synthase 6LAG1 homolog, ceramide synthase 6longevity assurance homolog 6 | |
Modification date | 20200313 | |
UniProtAcc | Q6ZMG9, | |
Context |
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Gene | GO ID | GO term | PubMed ID |
CERS6 | GO:0046513 | ceramide biosynthetic process | 17609214|17977534 |
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Gene structures and expression levels for CERS6 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CERS6 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_145765 | chr2 | 168765592:168765748:168766322:168766345:168769510:168771426 | 168766322:168766345 |
exon_skip_208217 | chr2 | 168765592:168765748:168766322:168766345:168769510:168771447 | 168766322:168766345 |
exon_skip_247198 | chr2 | 168765592:168765748:168766322:168766345:168769510:168771438 | 168766322:168766345 |
exon_skip_292651 | chr2 | 168765592:168765748:168766322:168766345:168769510:168775134 | 168766322:168766345 |
exon_skip_39464 | chr2 | 168765690:168765748:168766322:168766345:168769510:168775134 | 168766322:168766345 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_292651 | MSBB_PG | 7.331579e-01 | 9.034694e-01 | -1.703115e-01 | 1.094992e-02 |
exon_skip_39464 | Mayo_TC | 5.785000e-01 | 7.653448e-01 | -1.868448e-01 | 2.040787e-08 |
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Open reading frame (ORF) annotation in the exon skipping event for CERS6 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for CERS6 |
p-ENSG00000172292_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CERS6 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CERS6 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CERS6 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CERS6 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
HCC | exon_skip_292651 | rs1863144 | chr2:168691481 | 9.105419e-06 | 1.153577e-03 |
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Correlation with RNA binding proteins (RBPs) for CERS6 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
STG | ESRP2 | exon_skip_145765 | -4.225831e-01 | 1.046592e-04 |
TC | RBM25 | exon_skip_39464 | 4.162990e-01 | 3.806657e-07 |
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RelatedDrugs for CERS6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CERS6 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |