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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TFIP11 |
 Gene summary |
| Gene information | Gene symbol | TFIP11 | Gene ID | 24144 |
| Gene name | tuftelin interacting protein 11 | |
| Synonyms | NTR1|STIP|STIP-1|Spp382|TIP39|bK445C9.6 | |
| Cytomap | 22q12.1 | |
| Type of gene | protein-coding | |
| Description | tuftelin-interacting protein 11septin and tuftelin-interacting protein 1sip1/tuftelin interacting protein | |
| Modification date | 20200327 | |
| UniProtAcc | A0A024R1I7, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TFIP11 | GO:0031333 | negative regulation of protein complex assembly | 17389648 |
| TFIP11 | GO:0032091 | negative regulation of protein binding | 17389648 |
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Gene structures and expression levels for TFIP11 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000100109
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000492137.1 | TFIP11-214:retained_intron:TFIP11 | 1.655744e+02 | -9.005827e-01 | 1.702166e-08 | 4.740885e-07 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TFIP11 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_194107 | chr22 | 26510145:26510281:26512099:26512175:26512394:26512460 | 26512099:26512175 |
| exon_skip_23665 | chr22 | 26510145:26510281:26510617:26510702:26512099:26512175 | 26510617:26510702 |
| exon_skip_237007 | chr22 | 26510617:26510702:26511119:26511153:26512099:26512175 | 26511119:26511153 |
| exon_skip_244133 | chr22 | 26510617:26510702:26511119:26511317:26512099:26512175 | 26511119:26511317 |
| exon_skip_35585 | chr22 | 26510617:26510702:26511119:26511195:26512099:26512175 | 26511119:26511195 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TFIP11 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000405938 | 26511119 | 26511195 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000405938 | 26511119 | 26511195 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000407431 | 26510617 | 26510702 | 3UTR-3UTR |
| ENST00000407690 | 26510617 | 26510702 | 3UTR-3UTR |
| ENST00000405938 | 26511119 | 26511195 | 3UTR-3UTR |
| ENST00000407148 | 26512099 | 26512175 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for TFIP11 |
p-ENSG00000100109_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TFIP11 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000407690 | 26510617 | 26510702 | hsa-miR-488-5p | chr22:26510683-26510690 | 8mer-1a | chr22:26510676-26510695 | 152.00 | -13.89 |
| Mayo | ENST00000407690 | 26510617 | 26510702 | hsa-miR-3124-3p | chr22:26510671-26510678 | 8mer-1a | chr22:26510657-26510678 | 152.00 | -14.96 |
| Mayo | ENST00000407690 | 26510617 | 26510702 | hsa-miR-670-3p | chr22:26510669-26510676 | 8mer-1a | chr22:26510657-26510678 | 152.00 | -14.96 |
| Mayo | ENST00000405938 | 26511119 | 26511195 | hsa-miR-3166 | chr22:26511144-26511151 | 8mer-1a | chr22:26511142-26511164 | 161.00 | -20.35 |
| Mayo | ENST00000407148 | 26512099 | 26512175 | hsa-miR-6505-3p | chr22:26512140-26512147 | 8mer-1a | chr22:26512127-26512147 | 160.00 | -19.16 |
| Mayo | ENST00000407690 | 26510617 | 26510702 | hsa-miR-619-5p | chr22:26510645-26510652 | 8mer-1a | chr22:26510632-26510652 | 154.00 | -14.27 |
| Mayo | ENST00000407148 | 26512099 | 26512175 | hsa-miR-1233-3p | chr22:26512118-26512125 | 8mer-1a | chr22:26512105-26512128 | 173.00 | -24.41 |
| Mayo | ENST00000407690 | 26510617 | 26510702 | hsa-miR-6506-5p | chr22:26510645-26510652 | 8mer-1a | chr22:26510632-26510652 | 154.00 | -14.27 |
| Mayo | ENST00000405938 | 26511119 | 26511195 | hsa-miR-6772-3p | chr22:26511157-26511164 | 8mer-1a | chr22:26511150-26511175 | 159.00 | -24.14 |
| Mayo | ENST00000405938 | 26511119 | 26511195 | hsa-miR-4268 | chr22:26511156-26511163 | 8mer-1a | chr22:26511150-26511175 | 159.00 | -24.14 |
| MSBB | ENST00000405938 | 26511119 | 26511195 | hsa-miR-3166 | chr22:26511144-26511151 | 8mer-1a | chr22:26511142-26511164 | 161.00 | -20.35 |
| MSBB | ENST00000405938 | 26511119 | 26511195 | hsa-miR-6772-3p | chr22:26511157-26511164 | 8mer-1a | chr22:26511150-26511175 | 159.00 | -24.14 |
| MSBB | ENST00000405938 | 26511119 | 26511195 | hsa-miR-4268 | chr22:26511156-26511163 | 8mer-1a | chr22:26511150-26511175 | 159.00 | -24.14 |
| ROSMAP | ENST00000405938 | 26511119 | 26511195 | hsa-miR-3166 | chr22:26511144-26511151 | 8mer-1a | chr22:26511142-26511164 | 161.00 | -20.35 |
| ROSMAP | ENST00000405938 | 26511119 | 26511195 | hsa-miR-6772-3p | chr22:26511157-26511164 | 8mer-1a | chr22:26511150-26511175 | 159.00 | -24.14 |
| ROSMAP | ENST00000405938 | 26511119 | 26511195 | hsa-miR-4268 | chr22:26511156-26511163 | 8mer-1a | chr22:26511150-26511175 | 159.00 | -24.14 |
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SNVs in the skipped exons for TFIP11 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TFIP11 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TFIP11 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| CB | exon_skip_244133 | rs134143 | chr22:26511933 | 3.074945e-14 | 6.430203e-11 |
| CB | exon_skip_244133 | rs1000815 | chr22:26435111 | 4.840951e-08 | 2.550481e-05 |
| CB | exon_skip_244133 | rs5761552 | chr22:26474536 | 5.004114e-07 | 1.973497e-04 |
| CB | exon_skip_244133 | rs4275 | chr22:26525759 | 7.200867e-06 | 1.976842e-03 |
| CB | exon_skip_244133 | rs2283824 | chr22:26528490 | 1.214234e-05 | 3.062872e-03 |
| CB | exon_skip_244133 | rs1011312 | chr22:26531255 | 4.894835e-05 | 9.674525e-03 |
| TC | exon_skip_244133 | rs134143 | chr22:26511933 | 1.203954e-10 | 1.183161e-07 |
| TC | exon_skip_244133 | rs1000815 | chr22:26435111 | 1.485246e-07 | 6.237846e-05 |
| TC | exon_skip_244133 | rs5761552 | chr22:26474536 | 3.117814e-06 | 9.187374e-04 |
| TC | exon_skip_244133 | rs4275 | chr22:26525759 | 5.988130e-05 | 1.090234e-02 |
| TC | exon_skip_244133 | rs2283824 | chr22:26528490 | 6.152113e-05 | 1.115736e-02 |
| TC | exon_skip_35585 | rs134143 | chr22:26511933 | 1.519509e-04 | 2.260751e-02 |
| HCC | exon_skip_244133 | rs5761549 | chr22:26471524 | 2.081079e-07 | 3.916126e-05 |
| HCC | exon_skip_244133 | rs6519650 | chr22:26440814 | 2.466134e-07 | 4.571311e-05 |
| HCC | exon_skip_244133 | rs134143 | chr22:26511933 | 2.513297e-06 | 3.757707e-04 |
| HCC | exon_skip_244133 | rs1000815 | chr22:26435111 | 1.538929e-05 | 1.838207e-03 |
| HCC | exon_skip_244133 | rs5761552 | chr22:26474536 | 8.298704e-05 | 7.812106e-03 |
| HCC | exon_skip_244133 | rs5761562 | chr22:26496932 | 6.522594e-04 | 4.183089e-02 |
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Correlation with RNA binding proteins (RBPs) for TFIP11 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| TC | ENOX1 | exon_skip_35585 | -4.143978e-01 | 1.994357e-07 |
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RelatedDrugs for TFIP11 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TFIP11 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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