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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MTCH2 |
 Gene summary |
| Gene information | Gene symbol | MTCH2 | Gene ID | 23788 |
| Gene name | mitochondrial carrier 2 | |
| Synonyms | HSPC032|MIMP|SLC25A50 | |
| Cytomap | 11p11.2 | |
| Type of gene | protein-coding | |
| Description | mitochondrial carrier homolog 22310034D24Rikmet-induced mitochondrial proteinsolute carrier family 25, member 50 | |
| Modification date | 20200313 | |
| UniProtAcc | E9PIE4, Q9Y6C9, | |
| Context | - 28276496(Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MTCH2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000109919
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MTCH2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_102577 | chr11 | 47627080:47627127:47628953:47629046:47630555:47630614 | 47628953:47629046 |
| exon_skip_117892 | chr11 | 47631654:47631711:47634672:47634734:47638699:47638791 | 47634672:47634734 |
| exon_skip_132974 | chr11 | 47622744:47622776:47625674:47625741:47627080:47627127 | 47625674:47625741 |
| exon_skip_142703 | chr11 | 47631036:47631087:47635545:47635571:47638699:47638791 | 47635545:47635571 |
| exon_skip_151933 | chr11 | 47631036:47631087:47631654:47631711:47634672:47634734 | 47631654:47631711 |
| exon_skip_169005 | chr11 | 47631068:47631087:47631654:47631711:47634672:47634734 | 47631654:47631711 |
| exon_skip_174558 | chr11 | 47622711:47622776:47625674:47625741:47627080:47627127 | 47625674:47625741 |
| exon_skip_200479 | chr11 | 47634672:47634734:47635545:47635571:47638699:47638791 | 47635545:47635571 |
| exon_skip_208733 | chr11 | 47618839:47618919:47622701:47622776:47625674:47625740 | 47622701:47622776 |
| exon_skip_233925 | chr11 | 47631036:47631087:47631654:47631711:47634672:47634731 | 47631654:47631711 |
| exon_skip_258025 | chr11 | 47625674:47625741:47627080:47627127:47628953:47629046 | 47627080:47627127 |
| exon_skip_4536 | chr11 | 47634672:47634734:47635545:47635571:47638699:47638716 | 47635545:47635571 |
| exon_skip_54036 | chr11 | 47618839:47618919:47622701:47622776:47625674:47625741 | 47622701:47622776 |
| exon_skip_74704 | chr11 | 47622711:47622776:47625674:47625741:47627080:47627126 | 47625674:47625741 |
| exon_skip_98382 | chr11 | 47628953:47629046:47630555:47630614:47631036:47631087 | 47630555:47630614 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_151933 | Mayo_CB | 7.676829e-01 | 8.693506e-01 | -1.016677e-01 | 5.125413e-08 |
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Open reading frame (ORF) annotation in the exon skipping event for MTCH2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for MTCH2 |
p-ENSG00000109919_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MTCH2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MTCH2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MTCH2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MTCH2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MTCH2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_74704 | -4.297836e-01 | 1.572398e-08 |
| CB | RBM6 | exon_skip_151933 | -5.242160e-01 | 1.326412e-12 |
| CB | CNOT4 | exon_skip_151933 | -5.483799e-01 | 7.297335e-14 |
| CB | PCBP1 | exon_skip_151933 | -4.222000e-01 | 2.971199e-08 |
| CB | PCBP4 | exon_skip_151933 | 5.344469e-01 | 3.995923e-13 |
| CB | SRSF4 | exon_skip_151933 | -5.304647e-01 | 6.404920e-13 |
| HCC | HNRNPF | exon_skip_200479 | -4.664745e-01 | 3.718811e-16 |
| TC | RBM24 | exon_skip_4536 | 4.015178e-01 | 1.423707e-07 |
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RelatedDrugs for MTCH2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTCH2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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