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![]() | Open reading frame (ORF) annotation in the exon skipping event |
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![]() | 3'-UTR located exon skipping events lost miRNA binding sites |
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![]() | Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TMEM245 |
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Gene information | Gene symbol | TMEM245 | Gene ID | 23731 |
Gene name | transmembrane protein 245 | |
Synonyms | C9orf5|CG-2|CG2 | |
Cytomap | 9q31.3 | |
Type of gene | protein-coding | |
Description | transmembrane protein 245protein CG-2transmembrane protein C9orf5 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
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Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TMEM245 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
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Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
TC | UP | ENST00000491854.1 | TMEM245-205:nonsense_mediated_decay:TMEM245 | 2.541958e+01 | 9.002283e-01 | 6.409883e-07 | 2.808913e-05 |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TMEM245 |
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Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_104305 | chr9 | 109073356:109073438:109080839:109080943:109087173:109087293 | 109080839:109080943 |
exon_skip_150036 | chr9 | 109090922:109091155:109093475:109093591:109106508:109106609 | 109093475:109093591 |
exon_skip_151698 | chr9 | 109064477:109064567:109073356:109073438:109080839:109080943 | 109073356:109073438 |
exon_skip_163142 | chr9 | 109050570:109050692:109057191:109057322:109060354:109060452 | 109057191:109057322 |
exon_skip_177296 | chr9 | 109073356:109073438:109080839:109080943:109085997:109086020 | 109080839:109080943 |
exon_skip_184089 | chr9 | 109080914:109080943:109085997:109086020:109087173:109087293 | 109085997:109086020 |
exon_skip_221017 | chr9 | 109080839:109080943:109085997:109086020:109087173:109087293 | 109085997:109086020 |
exon_skip_227352 | chr9 | 109073402:109073438:109080839:109080943:109085997:109086020 | 109080839:109080943 |
exon_skip_241735 | chr9 | 109020088:109020505:109033307:109033501:109036206:109036380 | 109033307:109033501 |
exon_skip_242214 | chr9 | 109087173:109087342:109090922:109091155:109093475:109093591 | 109090922:109091155 |
exon_skip_5718 | chr9 | 109064477:109064567:109073248:109073438:109080839:109080943 | 109073248:109073438 |
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Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_221017 | MSBB_PG | 5.943165e-01 | 7.394444e-01 | -1.451279e-01 | 5.888506e-05 |
exon_skip_221017 | Mayo_TC | 3.107317e-01 | 4.390323e-01 | -1.283006e-01 | 1.318384e-06 |
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Open reading frame (ORF) annotation in the exon skipping event for TMEM245 |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for TMEM245 |
p-ENSG00000106771_img4.png![]() |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TMEM245 |
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Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for TMEM245 |
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Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TMEM245 |
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AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TMEM245 |
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Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TMEM245 |
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Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | HNRNPC | exon_skip_177296 | -4.903685e-01 | 2.653210e-08 |
CB | NUP42 | exon_skip_177296 | 4.407231e-01 | 8.251208e-07 |
CB | SRSF1 | exon_skip_177296 | -4.087483e-01 | 5.755229e-06 |
CB | NUP42 | exon_skip_221017 | 4.535900e-01 | 4.709872e-08 |
HCC | PABPN1 | exon_skip_221017 | -5.830034e-01 | 6.887255e-26 |
HCC | TRA2A | exon_skip_221017 | -4.244600e-01 | 3.433782e-13 |
HCC | KHDRBS3 | exon_skip_221017 | -6.176175e-01 | 1.105053e-29 |
IFG | KHDRBS3 | exon_skip_221017 | 4.516517e-01 | 1.583667e-02 |
PG | KHDRBS2 | exon_skip_221017 | 5.765016e-01 | 1.737014e-18 |
PG | KHDRBS3 | exon_skip_221017 | 5.637895e-01 | 1.380523e-17 |
STG | KHDRBS2 | exon_skip_221017 | 5.110566e-01 | 4.238965e-07 |
STG | KHDRBS3 | exon_skip_221017 | 5.881576e-01 | 2.096630e-09 |
STG | HNRNPDL | exon_skip_221017 | 4.068318e-01 | 9.216358e-05 |
STG | NUP42 | exon_skip_221017 | 4.338526e-01 | 2.692551e-05 |
TC | RBM3 | exon_skip_221017 | 4.140013e-01 | 2.495122e-07 |
TC | MBNL1 | exon_skip_221017 | 4.295429e-01 | 7.769803e-08 |
TC | KHDRBS2 | exon_skip_221017 | 7.596528e-01 | 2.553433e-28 |
TC | KHDRBS3 | exon_skip_221017 | 7.034154e-01 | 8.338826e-23 |
TC | HNRNPDL | exon_skip_221017 | 5.578775e-01 | 3.762210e-13 |
TC | NUP42 | exon_skip_221017 | 6.411022e-01 | 4.914061e-18 |
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RelatedDrugs for TMEM245 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TMEM245 |
![]() (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |