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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for HSPBP1 |
 Gene summary |
| Gene information | Gene symbol | HSPBP1 | Gene ID | 23640 |
| Gene name | HSPA (Hsp70) binding protein 1 | |
| Synonyms | FES1 | |
| Cytomap | 19q13.42 | |
| Type of gene | protein-coding | |
| Description | hsp70-binding protein 1HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1heat shock protein-binding protein 1hsp70 interacting protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HSPBP1 | GO:0031398 | positive regulation of protein ubiquitination | 16831871 |
| HSPBP1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 16831871 |
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Gene structures and expression levels for HSPBP1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000133265
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HSPBP1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101243 | chr19 | 55266236:55266286:55274398:55274622:55277642:55277705 | 55274398:55274622 |
| exon_skip_105849 | chr19 | 55274472:55274622:55277642:55277780:55279399:55279702 | 55277642:55277780 |
| exon_skip_162360 | chr19 | 55274472:55274622:55277642:55277780:55279399:55279704 | 55277642:55277780 |
| exon_skip_166936 | chr19 | 55265278:55265389:55265886:55265982:55266131:55266161 | 55265886:55265982 |
| exon_skip_173527 | chr19 | 55265886:55265982:55266131:55266286:55274398:55274622 | 55266131:55266286 |
| exon_skip_180793 | chr19 | 55274472:55274622:55277642:55277846:55279399:55279702 | 55277642:55277846 |
| exon_skip_260644 | chr19 | 55279514:55279702:55280035:55280108:55280218:55280332 | 55280035:55280108 |
| exon_skip_44118 | chr19 | 55265278:55265389:55265886:55265982:55266131:55266286 | 55265886:55265982 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for HSPBP1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000255631 | 55280035 | 55280108 | 3UTR-3UTR |
| ENST00000255631 | 55265886 | 55265982 | Frame-shift |
| ENST00000433386 | 55265886 | 55265982 | Frame-shift |
| ENST00000587922 | 55265886 | 55265982 | Frame-shift |
| ENST00000255631 | 55277642 | 55277846 | Frame-shift |
| ENST00000433386 | 55277642 | 55277846 | Frame-shift |
| ENST00000587922 | 55277642 | 55277846 | Frame-shift |
| ENST00000255631 | 55266131 | 55266286 | In-frame |
| ENST00000433386 | 55266131 | 55266286 | In-frame |
| ENST00000587922 | 55266131 | 55266286 | In-frame |
| ENST00000255631 | 55274398 | 55274622 | In-frame |
| ENST00000433386 | 55274398 | 55274622 | In-frame |
| ENST00000587922 | 55274398 | 55274622 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000255631 | 55265886 | 55265982 | Frame-shift |
| ENST00000433386 | 55265886 | 55265982 | Frame-shift |
| ENST00000587922 | 55265886 | 55265982 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000255631 | 55280035 | 55280108 | 3UTR-3UTR |
| ENST00000255631 | 55265886 | 55265982 | Frame-shift |
| ENST00000433386 | 55265886 | 55265982 | Frame-shift |
| ENST00000587922 | 55265886 | 55265982 | Frame-shift |
| ENST00000255631 | 55277642 | 55277846 | Frame-shift |
| ENST00000433386 | 55277642 | 55277846 | Frame-shift |
| ENST00000587922 | 55277642 | 55277846 | Frame-shift |
| ENST00000255631 | 55266131 | 55266286 | In-frame |
| ENST00000433386 | 55266131 | 55266286 | In-frame |
| ENST00000587922 | 55266131 | 55266286 | In-frame |
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Infer the effects of exon skipping event on protein functional features for HSPBP1 |
p-ENSG00000133265_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000255631 | 1785 | 359 | 55274398 | 55274622 | 727 | 950 | 138 | 213 |
| ENST00000433386 | 1589 | 359 | 55274398 | 55274622 | 653 | 876 | 138 | 213 |
| ENST00000587922 | 1466 | 359 | 55274398 | 55274622 | 664 | 887 | 138 | 213 |
| ENST00000255631 | 1785 | 359 | 55266131 | 55266286 | 952 | 1106 | 213 | 265 |
| ENST00000433386 | 1589 | 359 | 55266131 | 55266286 | 878 | 1032 | 213 | 265 |
| ENST00000587922 | 1466 | 359 | 55266131 | 55266286 | 889 | 1043 | 213 | 265 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000255631 | 1785 | 359 | 55266131 | 55266286 | 952 | 1106 | 213 | 265 |
| ENST00000433386 | 1589 | 359 | 55266131 | 55266286 | 878 | 1032 | 213 | 265 |
| ENST00000587922 | 1466 | 359 | 55266131 | 55266286 | 889 | 1043 | 213 | 265 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NZL4 | 138 | 213 | 204 | 306 | Alternative sequence | ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NZL4 | 138 | 213 | 204 | 306 | Alternative sequence | ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NZL4 | 138 | 213 | 204 | 306 | Alternative sequence | ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NZL4 | 138 | 213 | 1 | 359 | Chain | ID=PRO_0000084035;Note=Hsp70-binding protein 1 |
| Q9NZL4 | 138 | 213 | 1 | 359 | Chain | ID=PRO_0000084035;Note=Hsp70-binding protein 1 |
| Q9NZL4 | 138 | 213 | 1 | 359 | Chain | ID=PRO_0000084035;Note=Hsp70-binding protein 1 |
| Q9NZL4 | 138 | 213 | 134 | 142 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 134 | 142 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 134 | 142 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 145 | 151 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 145 | 151 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 145 | 151 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 159 | 173 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 159 | 173 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 159 | 173 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 177 | 185 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 177 | 185 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 177 | 185 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 188 | 198 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 188 | 198 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 188 | 198 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 202 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 202 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 202 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 132 | 174 | Repeat | Note=ARM 1 |
| Q9NZL4 | 138 | 213 | 132 | 174 | Repeat | Note=ARM 1 |
| Q9NZL4 | 138 | 213 | 132 | 174 | Repeat | Note=ARM 1 |
| Q9NZL4 | 138 | 213 | 177 | 217 | Repeat | Note=ARM 2 |
| Q9NZL4 | 138 | 213 | 177 | 217 | Repeat | Note=ARM 2 |
| Q9NZL4 | 138 | 213 | 177 | 217 | Repeat | Note=ARM 2 |
| Q9NZL4 | 138 | 213 | 152 | 155 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 152 | 155 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 138 | 213 | 152 | 155 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 204 | 306 | Alternative sequence | ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NZL4 | 213 | 265 | 204 | 306 | Alternative sequence | ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NZL4 | 213 | 265 | 204 | 306 | Alternative sequence | ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NZL4 | 213 | 265 | 1 | 359 | Chain | ID=PRO_0000084035;Note=Hsp70-binding protein 1 |
| Q9NZL4 | 213 | 265 | 1 | 359 | Chain | ID=PRO_0000084035;Note=Hsp70-binding protein 1 |
| Q9NZL4 | 213 | 265 | 1 | 359 | Chain | ID=PRO_0000084035;Note=Hsp70-binding protein 1 |
| Q9NZL4 | 213 | 265 | 202 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 202 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 202 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 220 | 228 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 220 | 228 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 220 | 228 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 231 | 240 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 231 | 240 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 231 | 240 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 244 | 260 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 244 | 260 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 244 | 260 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 262 | 264 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 262 | 264 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 262 | 264 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 265 | 270 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 265 | 270 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 265 | 270 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 177 | 217 | Repeat | Note=ARM 2 |
| Q9NZL4 | 213 | 265 | 177 | 217 | Repeat | Note=ARM 2 |
| Q9NZL4 | 213 | 265 | 177 | 217 | Repeat | Note=ARM 2 |
| Q9NZL4 | 213 | 265 | 220 | 259 | Repeat | Note=ARM 3 |
| Q9NZL4 | 213 | 265 | 220 | 259 | Repeat | Note=ARM 3 |
| Q9NZL4 | 213 | 265 | 220 | 259 | Repeat | Note=ARM 3 |
| Q9NZL4 | 213 | 265 | 262 | 301 | Repeat | Note=ARM 4 |
| Q9NZL4 | 213 | 265 | 262 | 301 | Repeat | Note=ARM 4 |
| Q9NZL4 | 213 | 265 | 262 | 301 | Repeat | Note=ARM 4 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NZL4 | 213 | 265 | 204 | 306 | Alternative sequence | ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NZL4 | 213 | 265 | 204 | 306 | Alternative sequence | ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NZL4 | 213 | 265 | 204 | 306 | Alternative sequence | ID=VSP_015945;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9NZL4 | 213 | 265 | 1 | 359 | Chain | ID=PRO_0000084035;Note=Hsp70-binding protein 1 |
| Q9NZL4 | 213 | 265 | 1 | 359 | Chain | ID=PRO_0000084035;Note=Hsp70-binding protein 1 |
| Q9NZL4 | 213 | 265 | 1 | 359 | Chain | ID=PRO_0000084035;Note=Hsp70-binding protein 1 |
| Q9NZL4 | 213 | 265 | 202 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 202 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 202 | 216 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 220 | 228 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 220 | 228 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 220 | 228 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 231 | 240 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 231 | 240 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 231 | 240 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 244 | 260 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 244 | 260 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 244 | 260 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 262 | 264 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 262 | 264 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 262 | 264 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 265 | 270 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 265 | 270 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 265 | 270 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1XQR |
| Q9NZL4 | 213 | 265 | 177 | 217 | Repeat | Note=ARM 2 |
| Q9NZL4 | 213 | 265 | 177 | 217 | Repeat | Note=ARM 2 |
| Q9NZL4 | 213 | 265 | 177 | 217 | Repeat | Note=ARM 2 |
| Q9NZL4 | 213 | 265 | 220 | 259 | Repeat | Note=ARM 3 |
| Q9NZL4 | 213 | 265 | 220 | 259 | Repeat | Note=ARM 3 |
| Q9NZL4 | 213 | 265 | 220 | 259 | Repeat | Note=ARM 3 |
| Q9NZL4 | 213 | 265 | 262 | 301 | Repeat | Note=ARM 4 |
| Q9NZL4 | 213 | 265 | 262 | 301 | Repeat | Note=ARM 4 |
| Q9NZL4 | 213 | 265 | 262 | 301 | Repeat | Note=ARM 4 |
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3'-UTR located exon skipping events that lost miRNA binding sites in HSPBP1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000255631 | 55280035 | 55280108 | hsa-miR-4467 | chr19:55280100-55280107 | 8mer-1a | chr19:55280086-55280107 | 144.00 | -24.81 |
| Mayo | ENST00000255631 | 55280035 | 55280108 | hsa-miR-10400-5p | chr19:55280100-55280107 | 8mer-1a | chr19:55280086-55280107 | 144.00 | -24.81 |
| Mayo | ENST00000255631 | 55280035 | 55280108 | hsa-miR-764 | chr19:55280082-55280089 | 8mer-1a | chr19:55280081-55280099 | 151.00 | -29.23 |
| ROSMAP | ENST00000255631 | 55280035 | 55280108 | hsa-miR-4467 | chr19:55280100-55280107 | 8mer-1a | chr19:55280086-55280107 | 144.00 | -24.81 |
| ROSMAP | ENST00000255631 | 55280035 | 55280108 | hsa-miR-10400-5p | chr19:55280100-55280107 | 8mer-1a | chr19:55280086-55280107 | 144.00 | -24.81 |
| ROSMAP | ENST00000255631 | 55280035 | 55280108 | hsa-miR-764 | chr19:55280082-55280089 | 8mer-1a | chr19:55280081-55280099 | 151.00 | -29.23 |
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SNVs in the skipped exons for HSPBP1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for HSPBP1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HSPBP1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for HSPBP1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for HSPBP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HSPBP1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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