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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for DDAH2 |
Gene summary |
Gene information | Gene symbol | DDAH2 | Gene ID | 23564 |
Gene name | dimethylarginine dimethylaminohydrolase 2 | |
Synonyms | DDAH|DDAHII|G6a|HEL-S-277|NG30 | |
Cytomap | 6p21.33 | |
Type of gene | protein-coding | |
Description | N(G),N(G)-dimethylarginine dimethylaminohydrolase 2S-phase proteindimethylargininase-2dimethylarginine dimethylaminohydrolase IIepididymis secretory protein Li 277testis tissue sperm-binding protein Li 54e | |
Modification date | 20200313 | |
UniProtAcc | ||
Context | - 25147500(Interleukin-18 Alters Protein Expressions of Neurodegenerative Diseases-Linked Proteins in Human SH-SY5Y Neuron-Like Cells) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
DDAH2 | GO:0000052 | citrulline metabolic process | 10493931 |
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Gene structures and expression levels for DDAH2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PCC | UP | ENST00000436437.1 | DDAH2-215:protein_coding:DDAH2 | 2.663712e+01 | 1.021291e+00 | 1.016165e-03 | 2.583537e-02 |
CB | DOWN | ENST00000437288.5 | DDAH2-216:protein_coding:DDAH2 | 3.472288e+00 | -9.747361e-01 | 5.166221e-03 | 2.021928e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DDAH2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_107110 | chr6 | 31727606:31727692:31728173:31728292:31728646:31728745 | 31728173:31728292 |
exon_skip_148581 | chr6 | 31728646:31728745:31728865:31729221:31730051:31730263 | 31728865:31729221 |
exon_skip_152818 | chr6 | 31728646:31728745:31728865:31729221:31730051:31730227 | 31728865:31729221 |
exon_skip_205010 | chr6 | 31728734:31728745:31728865:31729221:31730051:31730227 | 31728865:31729221 |
exon_skip_215609 | chr6 | 31728173:31728292:31728451:31728524:31728646:31728666 | 31728451:31728524 |
exon_skip_28549 | chr6 | 31728734:31728745:31728865:31729225:31730051:31730227 | 31728865:31729225 |
exon_skip_51425 | chr6 | 31727543:31727643:31728173:31728292:31728451:31728524 | 31728173:31728292 |
exon_skip_62706 | chr6 | 31727606:31727692:31728173:31728292:31728451:31728524 | 31728173:31728292 |
exon_skip_66715 | chr6 | 31728646:31728745:31728865:31729225:31730051:31730227 | 31728865:31729225 |
exon_skip_89508 | chr6 | 31728173:31728292:31728451:31728524:31728646:31728745 | 31728451:31728524 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DDAH2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for DDAH2 |
p-ENSG00000213722_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DDAH2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DDAH2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DDAH2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DDAH2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
TC | exon_skip_28549 | rs707974 | chr6:31661722 | 6.862348e-05 | 1.213650e-02 |
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Correlation with RNA binding proteins (RBPs) for DDAH2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for DDAH2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDAH2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |