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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for KAT6B |
Gene summary |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
KAT6B | GO:0016573 | histone acetylation | 11965546 |
KAT6B | GO:0043966 | histone H3 acetylation | 16387653 |
KAT6B | GO:0045892 | negative regulation of transcription, DNA-templated | 10497217 |
KAT6B | GO:0045893 | positive regulation of transcription, DNA-templated | 10497217|11965546 |
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Gene structures and expression levels for KAT6B |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000649006.1 | KAT6B-227:protein_coding:KAT6B | 1.109590e+01 | 6.625861e+00 | 1.527616e-03 | 4.758420e-02 |
CB | UP | ENST00000287239.10 | KAT6B-201:protein_coding:KAT6B | 3.748235e+02 | 8.343764e-01 | 6.054510e-08 | 1.389576e-06 |
CB | UP | ENST00000647642.1 | KAT6B-210:nonsense_mediated_decay:KAT6B | 3.366260e+00 | 1.502657e+00 | 3.933103e-06 | 4.781320e-05 |
CB | UP | ENST00000649119.1 | KAT6B-228:protein_coding:KAT6B | 6.360381e-01 | 1.095146e+00 | 1.451305e-02 | 4.697662e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KAT6B |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_103265 | chr10 | 74970020:74970101:74977316:74977437:74979224:74979339 | 74977316:74977437 |
exon_skip_118596 | chr10 | 74969660:74969775:74970020:74970101:74972507:74972534 | 74970020:74970101 |
exon_skip_127118 | chr10 | 74826635:74826785:74838683:74838783:74842600:74842880 | 74838683:74838783 |
exon_skip_129262 | chr10 | 74825614:74825674:74838683:74838752:74842600:74842880 | 74838683:74838752 |
exon_skip_16555 | chr10 | 74977316:74977437:74979224:74979339:74981787:74981928 | 74979224:74979339 |
exon_skip_174984 | chr10 | 74972507:74972639:74975399:74975454:74977316:74977437 | 74975399:74975454 |
exon_skip_181790 | chr10 | 74972507:74972639:74975399:74976330:74977316:74977437 | 74975399:74976330 |
exon_skip_186909 | chr10 | 74826635:74826785:74838683:74838752:74842600:74842880 | 74838683:74838752 |
exon_skip_193623 | chr10 | 74985080:74985241:74989019:74989112:75020582:75020813 | 74989019:74989112 |
exon_skip_215980 | chr10 | 74970020:74970101:74972507:74972639:74975399:74975454 | 74972507:74972639 |
exon_skip_223026 | chr10 | 74979224:74979339:74981787:74981928:74989019:74989096 | 74981787:74981928 |
exon_skip_240196 | chr10 | 74825527:74825674:74838683:74838752:74842600:74843478 | 74838683:74838752 |
exon_skip_24691 | chr10 | 74825255:74825356:74838683:74838783:74842600:74842880 | 74838683:74838783 |
exon_skip_263992 | chr10 | 74826603:74826785:74838683:74838752:74842600:74843478 | 74838683:74838752 |
exon_skip_30793 | chr10 | 74842883:74843478:74959970:74960078:74969660:74969775 | 74959970:74960078 |
exon_skip_34546 | chr10 | 74981787:74981928:74985080:74985241:74989019:74989112 | 74985080:74985241 |
exon_skip_41042 | chr10 | 74979224:74979339:74981787:74985241:74989019:74989096 | 74981787:74985241 |
exon_skip_64525 | chr10 | 74826603:74826785:74838683:74838783:74842600:74843478 | 74838683:74838783 |
exon_skip_69298 | chr10 | 74972507:74972639:74975399:74975781:74977316:74977437 | 74975399:74975781 |
exon_skip_69845 | chr10 | 74825255:74825356:74838683:74838752:74842600:74842880 | 74838683:74838752 |
exon_skip_80387 | chr10 | 74981787:74981928:74985080:74985241:74989019:74989096 | 74985080:74985241 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for KAT6B |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for KAT6B |
p-ENSG00000156650_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in KAT6B |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for KAT6B |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for KAT6B |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
CDR | MSBB | IFG | exon_skip_215980 | -4.820650e-01 | 9.384410e-03 | chr10 | + | 74970020 | 74970101 | 74972507 | 74972639 | 74975399 | 74975454 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KAT6B |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for KAT6B |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | DAZAP1 | exon_skip_215980 | -4.151923e-01 | 2.781146e-07 |
CB | RBM3 | exon_skip_215980 | 4.494001e-01 | 2.022196e-08 |
CB | TRA2A | exon_skip_215980 | -5.456636e-01 | 2.181278e-12 |
CB | HNRNPDL | exon_skip_215980 | 4.293614e-01 | 9.724705e-08 |
CB | RBM45 | exon_skip_215980 | 6.178563e-01 | 2.594536e-16 |
CB | NUP42 | exon_skip_215980 | 4.347602e-01 | 6.433233e-08 |
TC | RBM3 | exon_skip_215980 | 4.929331e-01 | 2.260008e-10 |
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RelatedDrugs for KAT6B |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KAT6B |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |