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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DAAM2 |
 Gene summary |
| Gene information | Gene symbol | DAAM2 | Gene ID | 23500 |
| Gene name | dishevelled associated activator of morphogenesis 2 | |
| Synonyms | dJ90A20A.1 | |
| Cytomap | 6p21.2 | |
| Type of gene | protein-coding | |
| Description | disheveled-associated activator of morphogenesis 2 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DAAM2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000146122
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000475489.5 | DAAM2-204:retained_intron:DAAM2 | 1.110550e+01 | -8.695915e-01 | 4.822431e-06 | 5.675922e-05 |
| CB | DOWN | ENST00000496787.1 | DAAM2-207:retained_intron:DAAM2 | 2.345825e+00 | -1.013260e+00 | 4.359546e-03 | 1.758233e-02 |
| TC | DOWN | ENST00000475489.5 | DAAM2-204:retained_intron:DAAM2 | 3.592183e+01 | -8.129937e-01 | 4.610963e-07 | 2.158100e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DAAM2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116500 | chr6 | 39896881:39896980:39897175:39897282:39898877:39898937 | 39897175:39897282 |
| exon_skip_123744 | chr6 | 39887486:39887592:39888679:39888763:39891341:39891361 | 39888679:39888763 |
| exon_skip_160106 | chr6 | 39864433:39864507:39864980:39865074:39867510:39867521 | 39864980:39865074 |
| exon_skip_201519 | chr6 | 39870340:39870443:39871506:39871572:39873238:39873355 | 39871506:39871572 |
| exon_skip_208019 | chr6 | 39878404:39878588:39879178:39879477:39883962:39884069 | 39879178:39879477 |
| exon_skip_222225 | chr6 | 39856247:39856470:39860928:39861017:39864433:39864507 | 39860928:39861017 |
| exon_skip_247234 | chr6 | 39898877:39898937:39900077:39900208:39901302:39901472 | 39900077:39900208 |
| exon_skip_274263 | chr6 | 39883962:39884069:39886421:39886447:39887486:39887592 | 39886421:39886447 |
| exon_skip_286159 | chr6 | 39860928:39861017:39861123:39861328:39864433:39864507 | 39861123:39861328 |
| exon_skip_288887 | chr6 | 39884007:39884069:39886421:39886447:39887486:39887592 | 39886421:39886447 |
| exon_skip_294729 | chr6 | 39867510:39867843:39868823:39868933:39870340:39870443 | 39868823:39868933 |
| exon_skip_43136 | chr6 | 39896812:39896980:39897175:39897282:39898877:39898937 | 39897175:39897282 |
| exon_skip_87556 | chr6 | 39898877:39898937:39900080:39900208:39901302:39901472 | 39900080:39900208 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DAAM2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for DAAM2 |
p-ENSG00000146122_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DAAM2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DAAM2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DAAM2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DAAM2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DAAM2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| IFG | SRSF2 | exon_skip_274263 | -4.848495e-01 | 8.924568e-03 |
| IFG | PCBP4 | exon_skip_274263 | -4.017560e-01 | 3.407499e-02 |
| IFG | RBM42 | exon_skip_274263 | -5.786383e-01 | 1.256557e-03 |
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RelatedDrugs for DAAM2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DAAM2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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